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The map label for this gene is nhaR [H]

Identifier: 218547455

GI number: 218547455

Start: 15886

End: 16815

Strand: Direct

Name: nhaR [H]

Synonym: EFER_0014

Alternate gene names: 218547455

Gene position: 15886-16815 (Clockwise)

Preceding gene: 218547454

Following gene: 218547457

Centisome position: 0.35

GC content: 46.67

Gene sequence:

>930_bases
TTGTGGTACATATCAGGGAGAGAAAAAAGAATGTCTCATATGAATTACAACCATCTTTATTATTTCTGGCATGTGTATAA
AGAAGGTTCGGTGGTTGGTGCGGCTGAGGCACTTTACTTAACGCCACAAACCATTACCGGTCAGATTAAGGCGCTGGAAG
AACGCTTGCAGGGAAAACTGTTCAAACGTAAAGGGCGCGGCCTTGAGCCCAGCGAGTTGGGAGAGTTAGTTTTCCGTTAT
GCTGACAAAATGTTCACATTAAGCCAGGAAATGTTGGATATTGTGAACTATCGCAAAGAGTCTAACTTACTGTTTGACGT
CGGTGTTGCCGATGCGTTGTCGAAGCGCCTGGTCAGCAGTGTGCTGAATGCAGCAGTGGTGGAGGAAGAGCAGATCCATC
TGCGCTGTTTTGAATCGACGCATGAGATGCTATTGGAGCAGTTGAGTCAGCATAAACTGGATATGATCATCTCTGACTGT
CCGATCGATTCCACTCAGCAGGAAGGTCTGTTTTCCATGAAGATAGGCGAGTGTGGTATCAGTTTCTGGTGTACTAATCC
ACTGCCAGAAAAACCGTTTCCTGCCTGTCTTGAAGAGCGCCGTTTACTTATTCCGGGGCGTCGCTCAATGTTGGGGCGTA
AGCTATTAAACTGGTTTAACTCCCAGGGCTTGAACGTCGAAATTTTGGGTGAGTTTGATGATGCTGCGTTGATGAAAGCC
TTTGGGGCGGCGCATAACGCTATTTTCGTTGCACCTTCGCTTTACGCTAATGATTTCTATAACGATGACTCGGTTGTGGA
GATAGGCCGCGTTGAGAACGTGATGGAAGAGTACCACGCTATTTTCGCCGAAAGGATGATTCAGCACCCTGCAGTACAGC
GTATTTGCAATACAGACTACTCAGCGCTGTTTACTCCAGCTTCAAAATAA

Upstream 100 bases:

>100_bases
TCACTACTTTCGGCGCTAATTGGTTATAGCTGGTTACGTCTTCGTTTAAACGCGACGACATGATCGGTACAAGAGAGCAG
GGAGCCATGATCGGCTCCCT

Downstream 100 bases:

>100_bases
ACATTTATACTTTGCAGGCCGAATTTTGGCCTGCAGGTGGACATAAAAAAACCCGCCAGAGCGGGTTTTTTTACAAAGCT
GACAACAACAGGCGATTAAG

Product: transcriptional activator NhaR

Products: NA

Alternate protein names: Na(+)/H(+) antiporter regulatory protein [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MWYISGREKRMSHMNYNHLYYFWHVYKEGSVVGAAEALYLTPQTITGQIKALEERLQGKLFKRKGRGLEPSELGELVFRY
ADKMFTLSQEMLDIVNYRKESNLLFDVGVADALSKRLVSSVLNAAVVEEEQIHLRCFESTHEMLLEQLSQHKLDMIISDC
PIDSTQQEGLFSMKIGECGISFWCTNPLPEKPFPACLEERRLLIPGRRSMLGRKLLNWFNSQGLNVEILGEFDDAALMKA
FGAAHNAIFVAPSLYANDFYNDDSVVEIGRVENVMEEYHAIFAERMIQHPAVQRICNTDYSALFTPASK

Sequences:

>Translated_309_residues
MWYISGREKRMSHMNYNHLYYFWHVYKEGSVVGAAEALYLTPQTITGQIKALEERLQGKLFKRKGRGLEPSELGELVFRY
ADKMFTLSQEMLDIVNYRKESNLLFDVGVADALSKRLVSSVLNAAVVEEEQIHLRCFESTHEMLLEQLSQHKLDMIISDC
PIDSTQQEGLFSMKIGECGISFWCTNPLPEKPFPACLEERRLLIPGRRSMLGRKLLNWFNSQGLNVEILGEFDDAALMKA
FGAAHNAIFVAPSLYANDFYNDDSVVEIGRVENVMEEYHAIFAERMIQHPAVQRICNTDYSALFTPASK
>Mature_309_residues
MWYISGREKRMSHMNYNHLYYFWHVYKEGSVVGAAEALYLTPQTITGQIKALEERLQGKLFKRKGRGLEPSELGELVFRY
ADKMFTLSQEMLDIVNYRKESNLLFDVGVADALSKRLVSSVLNAAVVEEEQIHLRCFESTHEMLLEQLSQHKLDMIISDC
PIDSTQQEGLFSMKIGECGISFWCTNPLPEKPFPACLEERRLLIPGRRSMLGRKLLNWFNSQGLNVEILGEFDDAALMKA
FGAAHNAIFVAPSLYANDFYNDDSVVEIGRVENVMEEYHAIFAERMIQHPAVQRICNTDYSALFTPASK

Specific function: Plays a role in the positive regulation of nhaA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786202, Length=299, Percent_Identity=93.9799331103679, Blast_Score=592, Evalue=1e-171,
Organism=Escherichia coli, GI1788297, Length=251, Percent_Identity=23.1075697211155, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35352; Mature: 35352

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWYISGREKRMSHMNYNHLYYFWHVYKEGSVVGAAEALYLTPQTITGQIKALEERLQGKL
CCCCCCHHHHHHHCCCCEEEEEEEEEECCCEEECCCEEEECCHHHHHHHHHHHHHHHHHH
FKRKGRGLEPSELGELVFRYADKMFTLSQEMLDIVNYRKESNLLFDVGVADALSKRLVSS
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHH
VLNAAVVEEEQIHLRCFESTHEMLLEQLSQHKLDMIISDCPIDSTQQEGLFSMKIGECGI
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCEEEEEECCCCE
SFWCTNPLPEKPFPACLEERRLLIPGRRSMLGRKLLNWFNSQGLNVEILGEFDDAALMKA
EEEECCCCCCCCCHHHHHCCEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
FGAAHNAIFVAPSLYANDFYNDDSVVEIGRVENVMEEYHAIFAERMIQHPAVQRICNTDY
HHCCCCEEEEECHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCC
SALFTPASK
CEEECCCCC
>Mature Secondary Structure
MWYISGREKRMSHMNYNHLYYFWHVYKEGSVVGAAEALYLTPQTITGQIKALEERLQGKL
CCCCCCHHHHHHHCCCCEEEEEEEEEECCCEEECCCEEEECCHHHHHHHHHHHHHHHHHH
FKRKGRGLEPSELGELVFRYADKMFTLSQEMLDIVNYRKESNLLFDVGVADALSKRLVSS
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHH
VLNAAVVEEEQIHLRCFESTHEMLLEQLSQHKLDMIISDCPIDSTQQEGLFSMKIGECGI
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCEEEEEECCCCE
SFWCTNPLPEKPFPACLEERRLLIPGRRSMLGRKLLNWFNSQGLNVEILGEFDDAALMKA
EEEECCCCCCCCCHHHHHCCEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
FGAAHNAIFVAPSLYANDFYNDDSVVEIGRVENVMEEYHAIFAERMIQHPAVQRICNTDY
HHCCCCEEEEECHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCC
SALFTPASK
CEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2429258; 1630901; 9278503; 3413113; 1316901; 8168494 [H]