Click here to switch to the map view.

The map label for this gene is ywrD [H]

Identifier: 218533208

GI number: 218533208

Start: 5717226

End: 5718842

Strand: Reverse

Name: ywrD [H]

Synonym: Mchl_5336

Alternate gene names: 218533208

Gene position: 5718842-5717226 (Counterclockwise)

Preceding gene: 218533209

Following gene: 218533204

Centisome position: 98.98

GC content: 67.78

Gene sequence:

>1617_bases
ATGCCGAGCCGTCTCTTCGCTGAAGCGAGCGCCCCGCGCGGCGCTCTCGCCCAGTCCCGCCAGGGCATGGTGACGAGCCC
GCACGAACTCGCCAGCGAAGCCGGGCGGGAGGTGCTGCGGGGGGGCGGCAACGCGATCGAGGCGGCGATCGCCATCAACG
CCACCCTCTGCGTGACCTACCCGCATTTCTGCGGCCTGGGCGGTGACGCGTTCATGATCGTCAGCGATCGCAACGGTGCG
AGCTTCACCCTGTCCGGCATCGGGCAGGCGGCGGCGAAGCTGCCGCAGAACGGACGGCCGATTCCATTGCGCGGACCCGG
CTCGGCGATCACCGCCGCGGCCGCCGTCGATACCTGGGAGCAAGCCTTCACCTACAGCCAGCGGGCCTGGGGCGGGCGGC
AATCTTGGAAGGGGCTGTTCCAGCGCGCGATCACCTATGCGGCAGAGGGCTTTCCCCTGACGCCCTCGCAACGCTTCTGG
GCGAACTTCCGCGCCAAGGAGATCGGCAACTGGCCCGATATCGTGCGCGTGTTCACAGCCGAAGGCCGCATCCCCGAGGC
CGGGGAGACGTTTCGGCAGCCCGATCTCGCCCGCACACTGACGATGCTCGCGGAGAATGGCGGCCGCGACTTCTACGTGG
GCGAGTTGGCCCAGCGGATCGCGCGGGGGCTGGAGCAGGCGGGCGCGCCCCTGACGGCGGACGACCTCGCCCGCTGCCGC
GCACGCAACGAAAGCGCGCTGCGCGTGCCCTACCGGGGCGGGGAACTCATCAGCCTGCGCCCGCCGACACAGGGCCTCAC
CACCCTCGAAATCATGGGCGTTCTCGACCGCTACGACGTGGCTTCCCTTCCCGAGGGCAGCGCCGATTACTACCACCTCC
TCGTCGAGGCGGTGAAGCTGGCCTTCATCGACCGCAACCGCTTCATCGCCGATCCCGATTTCGTCGATGTGCCCGTCGAG
CGGCTGCTATCGGCCCCGCACCTCGATGCGCAGGCCCGGAGCATCGATCCGCGCAAGGCTGCGCCCTGGCCCGATGTCTT
CAAGACCGGTGATACCGTCTTCATCGGAGCGGCCGACCCGGACGGCAATTGTGTCAGCCTGCTGCAGACGGTCTATTTCG
ATTGGGGCAGCGGCGTCGTCGCGGGCGATACCGGCATCCTCTGGCACAATCGCGGTGCGTCCTTCAGCGTGGACGCCAAC
AGCATCAACGTGCTGCGCCCCGGAAAGCGCCCGTTCCACACGCTCAATCCCGGCATGTACTTCAAGAACGGCCGTCCGAA
CTTGTTGTACGGAACGCAGGGCGCAGATGGGCAACCACAGACCCTGTCGGCGGTGCTGACGCGCCTGATCGATTACGGGA
TGGATCCCCTCACCGCCCTCGCGCGCCCTCGGTTCCTTCTGGGCAAGACCTTCTCGGACAGCCGCGACAGCCTGAAGCTC
GAACTCGATGCGGGTCAGGCCGTGTTCGAAGAGCTGAAGGCGCGAGGGCACGAGATCAGCCCCATTCCCGCCCAGAGCCC
CCTAGCCGGCCATCCCGGCGCAATCCAAATCGAGGATGACGGCCACTTCGTCGGCGCCCACGATCCGCGCAGTGATGGCT
TGGCCCTCGGCCTTTGA

Upstream 100 bases:

>100_bases
CGCGGTCATGGATCATAGCGAAAACCCTCACCATCCCGCGTCGGCCGGTTCGCGGCGCGCACTTCTCCTGACCTCTGCGG
CTGCCCTGGGGGCGACGACC

Downstream 100 bases:

>100_bases
TCAGGATGCTGATTGCCTCGACGGCGGCCCGTCAACGAGTACAGGCGACATTTGGGATGGCGCTGGATGGAGTACGATCA
ACTAGTGCCGGGTGGAAGAC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MPSRLFAEASAPRGALAQSRQGMVTSPHELASEAGREVLRGGGNAIEAAIAINATLCVTYPHFCGLGGDAFMIVSDRNGA
SFTLSGIGQAAAKLPQNGRPIPLRGPGSAITAAAAVDTWEQAFTYSQRAWGGRQSWKGLFQRAITYAAEGFPLTPSQRFW
ANFRAKEIGNWPDIVRVFTAEGRIPEAGETFRQPDLARTLTMLAENGGRDFYVGELAQRIARGLEQAGAPLTADDLARCR
ARNESALRVPYRGGELISLRPPTQGLTTLEIMGVLDRYDVASLPEGSADYYHLLVEAVKLAFIDRNRFIADPDFVDVPVE
RLLSAPHLDAQARSIDPRKAAPWPDVFKTGDTVFIGAADPDGNCVSLLQTVYFDWGSGVVAGDTGILWHNRGASFSVDAN
SINVLRPGKRPFHTLNPGMYFKNGRPNLLYGTQGADGQPQTLSAVLTRLIDYGMDPLTALARPRFLLGKTFSDSRDSLKL
ELDAGQAVFEELKARGHEISPIPAQSPLAGHPGAIQIEDDGHFVGAHDPRSDGLALGL

Sequences:

>Translated_538_residues
MPSRLFAEASAPRGALAQSRQGMVTSPHELASEAGREVLRGGGNAIEAAIAINATLCVTYPHFCGLGGDAFMIVSDRNGA
SFTLSGIGQAAAKLPQNGRPIPLRGPGSAITAAAAVDTWEQAFTYSQRAWGGRQSWKGLFQRAITYAAEGFPLTPSQRFW
ANFRAKEIGNWPDIVRVFTAEGRIPEAGETFRQPDLARTLTMLAENGGRDFYVGELAQRIARGLEQAGAPLTADDLARCR
ARNESALRVPYRGGELISLRPPTQGLTTLEIMGVLDRYDVASLPEGSADYYHLLVEAVKLAFIDRNRFIADPDFVDVPVE
RLLSAPHLDAQARSIDPRKAAPWPDVFKTGDTVFIGAADPDGNCVSLLQTVYFDWGSGVVAGDTGILWHNRGASFSVDAN
SINVLRPGKRPFHTLNPGMYFKNGRPNLLYGTQGADGQPQTLSAVLTRLIDYGMDPLTALARPRFLLGKTFSDSRDSLKL
ELDAGQAVFEELKARGHEISPIPAQSPLAGHPGAIQIEDDGHFVGAHDPRSDGLALGL
>Mature_537_residues
PSRLFAEASAPRGALAQSRQGMVTSPHELASEAGREVLRGGGNAIEAAIAINATLCVTYPHFCGLGGDAFMIVSDRNGAS
FTLSGIGQAAAKLPQNGRPIPLRGPGSAITAAAAVDTWEQAFTYSQRAWGGRQSWKGLFQRAITYAAEGFPLTPSQRFWA
NFRAKEIGNWPDIVRVFTAEGRIPEAGETFRQPDLARTLTMLAENGGRDFYVGELAQRIARGLEQAGAPLTADDLARCRA
RNESALRVPYRGGELISLRPPTQGLTTLEIMGVLDRYDVASLPEGSADYYHLLVEAVKLAFIDRNRFIADPDFVDVPVER
LLSAPHLDAQARSIDPRKAAPWPDVFKTGDTVFIGAADPDGNCVSLLQTVYFDWGSGVVAGDTGILWHNRGASFSVDANS
INVLRPGKRPFHTLNPGMYFKNGRPNLLYGTQGADGQPQTLSAVLTRLIDYGMDPLTALARPRFLLGKTFSDSRDSLKLE
LDAGQAVFEELKARGHEISPIPAQSPLAGHPGAIQIEDDGHFVGAHDPRSDGLALGL

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=499, Percent_Identity=27.8557114228457, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI73915090, Length=499, Percent_Identity=27.8557114228457, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI73915096, Length=499, Percent_Identity=27.8557114228457, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI73915094, Length=499, Percent_Identity=27.8557114228457, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI113429324, Length=495, Percent_Identity=27.4747474747475, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI113429326, Length=500, Percent_Identity=27.2, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI109148539, Length=544, Percent_Identity=26.2867647058824, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI153266901, Length=386, Percent_Identity=25.9067357512953, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI153266885, Length=386, Percent_Identity=25.9067357512953, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI153266907, Length=379, Percent_Identity=26.3852242744063, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1789856, Length=558, Percent_Identity=29.2114695340502, Blast_Score=233, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17506189, Length=468, Percent_Identity=25.6410256410256, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193208245, Length=501, Percent_Identity=26.7465069860279, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193208247, Length=501, Percent_Identity=26.7465069860279, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI72000294, Length=439, Percent_Identity=26.1958997722096, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI212646519, Length=477, Percent_Identity=25.1572327044025, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45551474, Length=528, Percent_Identity=24.0530303030303, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI161077878, Length=528, Percent_Identity=24.0530303030303, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI161077880, Length=528, Percent_Identity=24.0530303030303, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24642670, Length=528, Percent_Identity=24.0530303030303, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24642666, Length=528, Percent_Identity=24.0530303030303, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI18859893, Length=542, Percent_Identity=25.830258302583, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI161077496, Length=478, Percent_Identity=25.5230125523013, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI18859741, Length=469, Percent_Identity=23.454157782516, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 57942; Mature: 57811

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSRLFAEASAPRGALAQSRQGMVTSPHELASEAGREVLRGGGNAIEAAIAINATLCVTY
CCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEC
PHFCGLGGDAFMIVSDRNGASFTLSGIGQAAAKLPQNGRPIPLRGPGSAITAAAAVDTWE
HHHHCCCCCEEEEEECCCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
QAFTYSQRAWGGRQSWKGLFQRAITYAAEGFPLTPSQRFWANFRAKEIGNWPDIVRVFTA
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHCCCCHHHEEEEEC
EGRIPEAGETFRQPDLARTLTMLAENGGRDFYVGELAQRIARGLEQAGAPLTADDLARCR
CCCCCCCCHHHCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ARNESALRVPYRGGELISLRPPTQGLTTLEIMGVLDRYDVASLPEGSADYYHLLVEAVKL
CCCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
AFIDRNRFIADPDFVDVPVERLLSAPHLDAQARSIDPRKAAPWPDVFKTGDTVFIGAADP
HHEECCCEECCCCCCHHHHHHHHCCCCCCCHHCCCCCCCCCCCCHHHCCCCEEEEECCCC
DGNCVSLLQTVYFDWGSGVVAGDTGILWHNRGASFSVDANSINVLRPGKRPFHTLNPGMY
CCHHHHHHHHHHHHCCCCEEECCCEEEECCCCCEEEECCCCEEEECCCCCCCEECCCCEE
FKNGRPNLLYGTQGADGQPQTLSAVLTRLIDYGMDPLTALARPRFLLGKTFSDSRDSLKL
EECCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCEEECCCCCCCCCCEEE
ELDAGQAVFEELKARGHEISPIPAQSPLAGHPGAIQIEDDGHFVGAHDPRSDGLALGL
EECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCEECCCCCCCCCEEECC
>Mature Secondary Structure 
PSRLFAEASAPRGALAQSRQGMVTSPHELASEAGREVLRGGGNAIEAAIAINATLCVTY
CCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEC
PHFCGLGGDAFMIVSDRNGASFTLSGIGQAAAKLPQNGRPIPLRGPGSAITAAAAVDTWE
HHHHCCCCCEEEEEECCCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
QAFTYSQRAWGGRQSWKGLFQRAITYAAEGFPLTPSQRFWANFRAKEIGNWPDIVRVFTA
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHCCCCHHHEEEEEC
EGRIPEAGETFRQPDLARTLTMLAENGGRDFYVGELAQRIARGLEQAGAPLTADDLARCR
CCCCCCCCHHHCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ARNESALRVPYRGGELISLRPPTQGLTTLEIMGVLDRYDVASLPEGSADYYHLLVEAVKL
CCCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
AFIDRNRFIADPDFVDVPVERLLSAPHLDAQARSIDPRKAAPWPDVFKTGDTVFIGAADP
HHEECCCEECCCCCCHHHHHHHHCCCCCCCHHCCCCCCCCCCCCHHHCCCCEEEEECCCC
DGNCVSLLQTVYFDWGSGVVAGDTGILWHNRGASFSVDANSINVLRPGKRPFHTLNPGMY
CCHHHHHHHHHHHHCCCCEEECCCEEEECCCCCEEEECCCCEEEECCCCCCCEECCCCEE
FKNGRPNLLYGTQGADGQPQTLSAVLTRLIDYGMDPLTALARPRFLLGKTFSDSRDSLKL
EECCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCEEECCCCCCCCCCEEE
ELDAGQAVFEELKARGHEISPIPAQSPLAGHPGAIQIEDDGHFVGAHDPRSDGLALGL
EECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCEECCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]