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The map label for this gene is hemA [H]

Identifier: 218533145

GI number: 218533145

Start: 5645048

End: 5646265

Strand: Reverse

Name: hemA [H]

Synonym: Mchl_5271

Alternate gene names: 218533145

Gene position: 5646265-5645048 (Counterclockwise)

Preceding gene: 218533146

Following gene: 218533141

Centisome position: 97.72

GC content: 67.32

Gene sequence:

>1218_bases
ATGGATTACGAAGCGTTCTTCGGCAATGCGATCACCGGCCTCCACCGGGAGGGGCGCTACCGCGTCTTCACCGATCTGGA
GCGGCAGGCGGGGCGGTTTCCCTACGCGACGCATCACAGCCCCGGCGGCGCGCGCGAGGTCACCGTCTGGTGCTCCAACG
ACTATCTCGGCATGGGCCAGCATCCGTCTGTGTTGCAAGCGATGCACGAGGCAATCGACCGATGTGGAGCCGGCGCGGGC
GGCACCCGCAACATCTCCGGCACCAACCATTATCACGTGCTCTTGGAGCAGGAACTCGCCGACCTCCACGGAAAGGAAGC
GGCGCTGATCTTCTCCTCCGGCTACGTCTCGAACTGGGCGGCGCTCGGCACGCTCGCCTCGAAACTGCCGGGCTGCGTCG
TCTTCTCCGACGAGGGCAACCACGCCTCGATGATCGAGGGCATCCGTTCGAGCCGGGCCGAACGCCAGATCTTCCGCCAC
AACGATCCGGAGGATCTGGATCGCAAGCTCGGGCTGATCGAGCCCGGCCGGGCCAAACTCGTCGCCTTCGAGTCGGTCTA
TTCGATGGATGGCGACATCGCTCCGATCGACGAGATCTGCGACGTGGCCGAGGCGCACGGGGCGCTCACCTATCTCGACG
AGGTGCACGCGGTCGGCCTCTACGGCGCGCGGGGCGGCGGCATCTCGGAGCGGATGGGGCTCGCCCACCGGCTCGACGTG
ATCGAGGGAACGCTCGGCAAGGCGTTCGCCGTCCATGGCGGCTACATCACCGGCTCGACGCAGCTCTGCGACTTCGTGCG
CAGCTTCGCCTCGGGCTTCATCTTCACGACCTCGCTGCCGCCGGCGGTCGCGGCCGGCGCCGCGGCGAGCATCCGCCACC
TCAAGGCGAGCAGTGTCGAGCGGGCTAGGCATCAGGAGCGGGTGGCGCGGGTCCGGCACGTGCTGGATGCGGCGGGCATC
CCGACTTTGGCCAACCGCAGCCACATCGTGCCGGTAATGGTTTGCGACCCCGTGCTGTGCAAGGCGATCAGCGATACCCT
GCTCGACGAGTTCGGCATCTACGTGCAGCCGATCAACTACCCGACCGTCCCGCGTGGGACGGAGCGCCTGCGGATCACGC
CCTCGCCGCTGCATTCGAATGCCGACATCGACCATCTGGTGGACGCGCTGAGCACGATCTGGCGTCGGATCGGGCTGAGC
AAGGCGGCGGCGGAGTAG

Upstream 100 bases:

>100_bases
AGAGCGGCCGAGATGCCCGAAACCCGGGCAGTGCACCGCGAATGAGGTGAGGCGGACGCAAGATCTGCCCACCGGCATCA
TCTTCTTCGGGGAGGACGGC

Downstream 100 bases:

>100_bases
GGCGCCCGCGCCTTACATCTTCTTCTCGAGCGCGGCTTTCACCTGCATGAGCTGATCCCACACCACGCCGGGGCTCGTGC
CCATCGCCTCGAGGACCGCG

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MDYEAFFGNAITGLHREGRYRVFTDLERQAGRFPYATHHSPGGAREVTVWCSNDYLGMGQHPSVLQAMHEAIDRCGAGAG
GTRNISGTNHYHVLLEQELADLHGKEAALIFSSGYVSNWAALGTLASKLPGCVVFSDEGNHASMIEGIRSSRAERQIFRH
NDPEDLDRKLGLIEPGRAKLVAFESVYSMDGDIAPIDEICDVAEAHGALTYLDEVHAVGLYGARGGGISERMGLAHRLDV
IEGTLGKAFAVHGGYITGSTQLCDFVRSFASGFIFTTSLPPAVAAGAAASIRHLKASSVERARHQERVARVRHVLDAAGI
PTLANRSHIVPVMVCDPVLCKAISDTLLDEFGIYVQPINYPTVPRGTERLRITPSPLHSNADIDHLVDALSTIWRRIGLS
KAAAE

Sequences:

>Translated_405_residues
MDYEAFFGNAITGLHREGRYRVFTDLERQAGRFPYATHHSPGGAREVTVWCSNDYLGMGQHPSVLQAMHEAIDRCGAGAG
GTRNISGTNHYHVLLEQELADLHGKEAALIFSSGYVSNWAALGTLASKLPGCVVFSDEGNHASMIEGIRSSRAERQIFRH
NDPEDLDRKLGLIEPGRAKLVAFESVYSMDGDIAPIDEICDVAEAHGALTYLDEVHAVGLYGARGGGISERMGLAHRLDV
IEGTLGKAFAVHGGYITGSTQLCDFVRSFASGFIFTTSLPPAVAAGAAASIRHLKASSVERARHQERVARVRHVLDAAGI
PTLANRSHIVPVMVCDPVLCKAISDTLLDEFGIYVQPINYPTVPRGTERLRITPSPLHSNADIDHLVDALSTIWRRIGLS
KAAAE
>Mature_405_residues
MDYEAFFGNAITGLHREGRYRVFTDLERQAGRFPYATHHSPGGAREVTVWCSNDYLGMGQHPSVLQAMHEAIDRCGAGAG
GTRNISGTNHYHVLLEQELADLHGKEAALIFSSGYVSNWAALGTLASKLPGCVVFSDEGNHASMIEGIRSSRAERQIFRH
NDPEDLDRKLGLIEPGRAKLVAFESVYSMDGDIAPIDEICDVAEAHGALTYLDEVHAVGLYGARGGGISERMGLAHRLDV
IEGTLGKAFAVHGGYITGSTQLCDFVRSFASGFIFTTSLPPAVAAGAAASIRHLKASSVERARHQERVARVRHVLDAAGI
PTLANRSHIVPVMVCDPVLCKAISDTLLDEFGIYVQPINYPTVPRGTERLRITPSPLHSNADIDHLVDALSTIWRRIGLS
KAAAE

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=403, Percent_Identity=52.8535980148883, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI83977440, Length=403, Percent_Identity=52.8535980148883, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI83977444, Length=403, Percent_Identity=52.8535980148883, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI4502025, Length=403, Percent_Identity=51.6129032258064, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI40316939, Length=403, Percent_Identity=51.6129032258064, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI7657118, Length=348, Percent_Identity=39.6551724137931, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=39.6551724137931, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI119220554, Length=418, Percent_Identity=27.0334928229665, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI4758668, Length=398, Percent_Identity=29.3969849246231, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI5454084, Length=256, Percent_Identity=28.515625, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI1790046, Length=359, Percent_Identity=35.6545961002786, Blast_Score=207, Evalue=7e-55,
Organism=Escherichia coli, GI1786993, Length=348, Percent_Identity=33.9080459770115, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71994529, Length=400, Percent_Identity=34.25, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI32566772, Length=385, Percent_Identity=28.051948051948, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17560912, Length=376, Percent_Identity=28.7234042553192, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17560914, Length=376, Percent_Identity=28.7234042553192, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982617, Length=233, Percent_Identity=30.4721030042918, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71982625, Length=233, Percent_Identity=30.4721030042918, Blast_Score=111, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320438, Length=423, Percent_Identity=47.2813238770686, Blast_Score=381, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6320267, Length=373, Percent_Identity=27.3458445040214, Blast_Score=136, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6323954, Length=273, Percent_Identity=22.7106227106227, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17137420, Length=402, Percent_Identity=49.5024875621891, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24662918, Length=362, Percent_Identity=36.4640883977901, Blast_Score=241, Evalue=8e-64,
Organism=Drosophila melanogaster, GI17136286, Length=332, Percent_Identity=28.9156626506024, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24653280, Length=251, Percent_Identity=27.4900398406374, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24653276, Length=251, Percent_Identity=27.4900398406374, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24653278, Length=251, Percent_Identity=27.4900398406374, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 43800; Mature: 43800

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYEAFFGNAITGLHREGRYRVFTDLERQAGRFPYATHHSPGGAREVTVWCSNDYLGMGQ
CCCHHHHCHHHHHHCCCCCEEEEEHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCC
HPSVLQAMHEAIDRCGAGAGGTRNISGTNHYHVLLEQELADLHGKEAALIFSSGYVSNWA
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHCCCCCEEEEEECCCHHHHH
ALGTLASKLPGCVVFSDEGNHASMIEGIRSSRAERQIFRHNDPEDLDRKLGLIEPGRAKL
HHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEE
VAFESVYSMDGDIAPIDEICDVAEAHGALTYLDEVHAVGLYGARGGGISERMGLAHRLDV
EEEHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHH
IEGTLGKAFAVHGGYITGSTQLCDFVRSFASGFIFTTSLPPAVAAGAAASIRHLKASSVE
HHCCCCCEEEEECCEEECHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
RARHQERVARVRHVLDAAGIPTLANRSHIVPVMVCDPVLCKAISDTLLDEFGIYVQPINY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCC
PTVPRGTERLRITPSPLHSNADIDHLVDALSTIWRRIGLSKAAAE
CCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MDYEAFFGNAITGLHREGRYRVFTDLERQAGRFPYATHHSPGGAREVTVWCSNDYLGMGQ
CCCHHHHCHHHHHHCCCCCEEEEEHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCC
HPSVLQAMHEAIDRCGAGAGGTRNISGTNHYHVLLEQELADLHGKEAALIFSSGYVSNWA
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHCCCCCEEEEEECCCHHHHH
ALGTLASKLPGCVVFSDEGNHASMIEGIRSSRAERQIFRHNDPEDLDRKLGLIEPGRAKL
HHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEE
VAFESVYSMDGDIAPIDEICDVAEAHGALTYLDEVHAVGLYGARGGGISERMGLAHRLDV
EEEHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHH
IEGTLGKAFAVHGGYITGSTQLCDFVRSFASGFIFTTSLPPAVAAGAAASIRHLKASSVE
HHCCCCCEEEEECCEEECHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
RARHQERVARVRHVLDAAGIPTLANRSHIVPVMVCDPVLCKAISDTLLDEFGIYVQPINY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCC
PTVPRGTERLRITPSPLHSNADIDHLVDALSTIWRRIGLSKAAAE
CCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034217 [H]