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The map label for this gene is gyaR [H]

Identifier: 218532642

GI number: 218532642

Start: 5045873

End: 5046847

Strand: Reverse

Name: gyaR [H]

Synonym: Mchl_4756

Alternate gene names: 218532642

Gene position: 5046847-5045873 (Counterclockwise)

Preceding gene: 218532644

Following gene: 218532641

Centisome position: 87.35

GC content: 72.41

Gene sequence:

>975_bases
GTGCCACCAGCCGAGACGCCCGACATCCTCCTGATCCGGCAGACCCGCCCCGACGTGGCCGGGCGGCTCGCCGAGCGCTT
CCGCCTGCACCGCCTGGAGGAGGCGCCCGACCGCGAGGCGTTCCTCGACGCCGTGGGACCGCGCATCCGAGGGCTCGCGG
TCGGCGCGATGTGCCCGATCGATGCGAGGCTGTTCGATCGGCTGCCGCAGCTCGAGATCGTGGCGAGCTTCGGCGTCGGC
TACGATACGATCGATGCGGGCGAGGCGCATCGCCGCGGCATCGTCGTGACCCACACGCCGGACGTGCTCTCGGACGAGGT
AGCCGACCTCGCGCTGGGCCTCCTGCTCGCCACCCTCCGCCAGATCCCGCAGGCCGACCGCTACCTGCGCGCCGGGCGTT
GGCGGGAGGGCAGCTTCCCACTCACCACGAGCCTGCGGGAGCGCCGGGTCGGCATCCTCGGGCTCGGCCGGATCGGGCGG
GCGATCGCCCAGCGGCTCGAAGGGTTCGGCGTGAGGATCGCCTATCACGGGCGCACGCCGCAGGCCGACGTCGCCTACAC
CTACCACGACAGCCTGCTCGGGCTGGCGCAGGCGGTCGACACGCTGATCGTGGCGGCACCCGGCGGACCGGGCACGAACG
GGATCGTCGATGCCGGGGTGCTGGCGGCGCTCGGGGCTGACGGCGTCGTCGTCAACATCGCCCGCGGCAGCGTCATCGAC
GAGGCGGCGCTGATCGCCGCGTTGCAAGCGGGGACGATCCTCGGGGCGGGGCTCGACGTGTTCGCGAACGAGCCGCAGGT
GCCGCAGGCGCTGATCGATCTCGATCGGACCGTGCTGCTGCCGCATGTCGGCTCGGGCTCGCACTACACCCGCGCGGCGA
TGGGCCGGCTGCTCACTGACAATCTGTTTTCGTGGTTCGACGGCAAGGGGCCGGTGACGCCGGTGCCGGAAACGCCCTGG
AAGGGCCAGCGATGA

Upstream 100 bases:

>100_bases
CCGCTCGCCCCACCGGCTGGACCGGCGCGCGGCGCAGCGATACTCCCGGCCTATCCTTTGTTGACCTCTTCCTTGCCGAC
CTCTGGGAGGCCGTGAGCCG

Downstream 100 bases:

>100_bases
GGGGCCCGACGATGATGCGCATGGCATGGTCAGGCGCTTGGGCAGGCGCTTTAGCGGGAGCGTTGGTCGCCGCCCTGGCG
GCCCTGCCGCCGAGCGCGGC

Product: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MPPAETPDILLIRQTRPDVAGRLAERFRLHRLEEAPDREAFLDAVGPRIRGLAVGAMCPIDARLFDRLPQLEIVASFGVG
YDTIDAGEAHRRGIVVTHTPDVLSDEVADLALGLLLATLRQIPQADRYLRAGRWREGSFPLTTSLRERRVGILGLGRIGR
AIAQRLEGFGVRIAYHGRTPQADVAYTYHDSLLGLAQAVDTLIVAAPGGPGTNGIVDAGVLAALGADGVVVNIARGSVID
EAALIAALQAGTILGAGLDVFANEPQVPQALIDLDRTVLLPHVGSGSHYTRAAMGRLLTDNLFSWFDGKGPVTPVPETPW
KGQR

Sequences:

>Translated_324_residues
MPPAETPDILLIRQTRPDVAGRLAERFRLHRLEEAPDREAFLDAVGPRIRGLAVGAMCPIDARLFDRLPQLEIVASFGVG
YDTIDAGEAHRRGIVVTHTPDVLSDEVADLALGLLLATLRQIPQADRYLRAGRWREGSFPLTTSLRERRVGILGLGRIGR
AIAQRLEGFGVRIAYHGRTPQADVAYTYHDSLLGLAQAVDTLIVAAPGGPGTNGIVDAGVLAALGADGVVVNIARGSVID
EAALIAALQAGTILGAGLDVFANEPQVPQALIDLDRTVLLPHVGSGSHYTRAAMGRLLTDNLFSWFDGKGPVTPVPETPW
KGQR
>Mature_323_residues
PPAETPDILLIRQTRPDVAGRLAERFRLHRLEEAPDREAFLDAVGPRIRGLAVGAMCPIDARLFDRLPQLEIVASFGVGY
DTIDAGEAHRRGIVVTHTPDVLSDEVADLALGLLLATLRQIPQADRYLRAGRWREGSFPLTTSLRERRVGILGLGRIGRA
IAQRLEGFGVRIAYHGRTPQADVAYTYHDSLLGLAQAVDTLIVAAPGGPGTNGIVDAGVLAALGADGVVVNIARGSVIDE
AALIAALQAGTILGAGLDVFANEPQVPQALIDLDRTVLLPHVGSGSHYTRAAMGRLLTDNLFSWFDGKGPVTPVPETPWK
GQR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=259, Percent_Identity=37.8378378378378, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI23308577, Length=264, Percent_Identity=32.9545454545455, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI145580578, Length=282, Percent_Identity=26.241134751773, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4557499, Length=282, Percent_Identity=26.241134751773, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI61743967, Length=266, Percent_Identity=27.0676691729323, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4557497, Length=266, Percent_Identity=27.0676691729323, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI145580575, Length=271, Percent_Identity=26.5682656826568, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87082289, Length=311, Percent_Identity=33.4405144694534, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1789279, Length=270, Percent_Identity=27.4074074074074, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787645, Length=211, Percent_Identity=27.4881516587678, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081824, Length=230, Percent_Identity=27.3913043478261, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=242, Percent_Identity=30.5785123966942, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25147481, Length=271, Percent_Identity=26.9372693726937, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324055, Length=252, Percent_Identity=36.1111111111111, Blast_Score=139, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6322116, Length=290, Percent_Identity=24.1379310344828, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320925, Length=341, Percent_Identity=22.8739002932551, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6325144, Length=352, Percent_Identity=26.9886363636364, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321253, Length=345, Percent_Identity=24.6376811594203, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45552429, Length=304, Percent_Identity=32.2368421052632, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24585514, Length=304, Percent_Identity=32.2368421052632, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28574282, Length=304, Percent_Identity=32.2368421052632, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28574284, Length=304, Percent_Identity=32.2368421052632, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI45551003, Length=304, Percent_Identity=32.2368421052632, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28571528, Length=254, Percent_Identity=37.4015748031496, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24585516, Length=286, Percent_Identity=32.1678321678322, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28574286, Length=256, Percent_Identity=33.203125, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI19921140, Length=248, Percent_Identity=31.0483870967742, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24646446, Length=268, Percent_Identity=27.2388059701493, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646448, Length=268, Percent_Identity=27.2388059701493, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646452, Length=268, Percent_Identity=27.2388059701493, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646450, Length=268, Percent_Identity=27.2388059701493, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI62472511, Length=268, Percent_Identity=27.2388059701493, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34621; Mature: 34490

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPAETPDILLIRQTRPDVAGRLAERFRLHRLEEAPDREAFLDAVGPRIRGLAVGAMCPI
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHEEECCCCCC
DARLFDRLPQLEIVASFGVGYDTIDAGEAHRRGIVVTHTPDVLSDEVADLALGLLLATLR
CHHHHHCCCCEEEEHHCCCCCCCCCCCCHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHH
QIPQADRYLRAGRWREGSFPLTTSLRERRVGILGLGRIGRAIAQRLEGFGVRIAYHGRTP
HCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEHHHHHHHHHHHHCCCCEEEEECCCCC
QADVAYTYHDSLLGLAQAVDTLIVAAPGGPGTNGIVDAGVLAALGADGVVVNIARGSVID
CCCEEEEHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHH
EAALIAALQAGTILGAGLDVFANEPQVPQALIDLDRTVLLPHVGSGSHYTRAAMGRLLTD
HHHHHHHHHHCHHEECCCHHHCCCCCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH
NLFSWFDGKGPVTPVPETPWKGQR
HHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PPAETPDILLIRQTRPDVAGRLAERFRLHRLEEAPDREAFLDAVGPRIRGLAVGAMCPI
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHEEECCCCCC
DARLFDRLPQLEIVASFGVGYDTIDAGEAHRRGIVVTHTPDVLSDEVADLALGLLLATLR
CHHHHHCCCCEEEEHHCCCCCCCCCCCCHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHH
QIPQADRYLRAGRWREGSFPLTTSLRERRVGILGLGRIGRAIAQRLEGFGVRIAYHGRTP
HCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEHHHHHHHHHHHHCCCCEEEEECCCCC
QADVAYTYHDSLLGLAQAVDTLIVAAPGGPGTNGIVDAGVLAALGADGVVVNIARGSVID
CCCEEEEHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHH
EAALIAALQAGTILGAGLDVFANEPQVPQALIDLDRTVLLPHVGSGSHYTRAAMGRLLTD
HHHHHHHHHHCHHEECCCHHHCCCCCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH
NLFSWFDGKGPVTPVPETPWKGQR
HHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA