Click here to switch to the map view.

The map label for this gene is glmS [H]

Identifier: 218532581

GI number: 218532581

Start: 4975828

End: 4976838

Strand: Reverse

Name: glmS [H]

Synonym: Mchl_4695

Alternate gene names: 218532581

Gene position: 4976838-4975828 (Counterclockwise)

Preceding gene: 218532582

Following gene: 218532580

Centisome position: 86.14

GC content: 74.38

Gene sequence:

>1011_bases
ATGAGCGCAACGACCTTCATGGCGCGGGAGATCGCCGAGATCCCCGACGCCGCCTCTCTGCTGGTAGCCGGCGAAGCAGC
CCGGATCGGCGCGACGCTGCGGGCCAGGAGCTTCCCCTTCGTGGTTGTGTGCGGACGGGGCAGTTCGGGCCATGCCGGCG
TGCATCTGCGCTACCTGATCGAGACGCGGCTCAGCCTGCCGGTTTCGGCCGCCGCGCCCTCGGTGGTGACGGGCTATGAC
CGTCCGCCGAACGTGGCGGGCGCGCTCTTCATCGTGGTCTCGCAATCGGGCCGCTCGCCCGATCTCGTCGCGGCGACGGA
AGCGGCGCGGGCCGGCGGGGCGCTGACATTGGCCCTCGTCAACGATCCCGACTCCCCGGCCGCGCGGGCGAGCGACCTCG
TCCTGCCGATCCTCGCCGGGCCGGAGCATGCGGTCGCCGCCACCAAGACGGTGACGAATTCAGCCATCGCGGGGGCGGCG
CTGGTTTCGGCCTGGGCCGGCGACGGCGAGCTGGAACGGGGCCTCGCCGCCCTTCCGGAGCGGCTGAGACAGGCACTCGC
CCTCGACTGGTCCGCCTGGAGCGCCGACCTCGCGGGCGCGCCTGCGGCCTTCGTCACCGGGCGCGGCCACGGTCTCGGGC
CGCTGCGCGAAATCGCCCTCAAGCTCGCCGAGACCCTGCGCCTCCCCGCGCTCGGCTACTCGGCGGCGGAGCTGCGCCAC
GGCCCCCGCGCCTCCGTCTCAGTCGCAACGCCGGTCCTAGCCCTGCGCCAGGCCGATCCGCTGGCCGAGGGCGTGGACGC
GCTCGTGCGCGACCTCAGCCGCGACGGAATGCGGGTCCATGCCTGCGGCGGCCCCCTCGGCACTCTGCCCTGGCTCGGCG
ACGGCCATCCGGCCTGCGACCCCATCGCCATGCTGGTGCCGGCCTACCGCGCCATCGAGGCCGAGGCCCGCCGCCGCGGC
CTCGACCCGGACAAGCCGGCCGGCCTCACCAAGGTGACGGAGACGCTGTGA

Upstream 100 bases:

>100_bases
CGGTGCTGCTCGCAGGGGGGATGAGCGCCATGCGGGCCGACGACCTGCTCCTGCGCCATGACGGCAACCTGCGCCGGGCG
CTTCGTGAGGTGGGCCGATC

Downstream 100 bases:

>100_bases
TGACGAGTCCGGGTTTCGAAAGGGCGAGCCCTTTCGCGGCTCCAGGGCGGACCCCTGGGACGACATCGGGGCGCTGCCCC
GAGACCCCGCCAAAGGGATG

Product: glutamine--fructose-6-phosphate transaminase (isomerizing)

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSATTFMAREIAEIPDAASLLVAGEAARIGATLRARSFPFVVVCGRGSSGHAGVHLRYLIETRLSLPVSAAAPSVVTGYD
RPPNVAGALFIVVSQSGRSPDLVAATEAARAGGALTLALVNDPDSPAARASDLVLPILAGPEHAVAATKTVTNSAIAGAA
LVSAWAGDGELERGLAALPERLRQALALDWSAWSADLAGAPAAFVTGRGHGLGPLREIALKLAETLRLPALGYSAAELRH
GPRASVSVATPVLALRQADPLAEGVDALVRDLSRDGMRVHACGGPLGTLPWLGDGHPACDPIAMLVPAYRAIEAEARRRG
LDPDKPAGLTKVTETL

Sequences:

>Translated_336_residues
MSATTFMAREIAEIPDAASLLVAGEAARIGATLRARSFPFVVVCGRGSSGHAGVHLRYLIETRLSLPVSAAAPSVVTGYD
RPPNVAGALFIVVSQSGRSPDLVAATEAARAGGALTLALVNDPDSPAARASDLVLPILAGPEHAVAATKTVTNSAIAGAA
LVSAWAGDGELERGLAALPERLRQALALDWSAWSADLAGAPAAFVTGRGHGLGPLREIALKLAETLRLPALGYSAAELRH
GPRASVSVATPVLALRQADPLAEGVDALVRDLSRDGMRVHACGGPLGTLPWLGDGHPACDPIAMLVPAYRAIEAEARRRG
LDPDKPAGLTKVTETL
>Mature_335_residues
SATTFMAREIAEIPDAASLLVAGEAARIGATLRARSFPFVVVCGRGSSGHAGVHLRYLIETRLSLPVSAAAPSVVTGYDR
PPNVAGALFIVVSQSGRSPDLVAATEAARAGGALTLALVNDPDSPAARASDLVLPILAGPEHAVAATKTVTNSAIAGAAL
VSAWAGDGELERGLAALPERLRQALALDWSAWSADLAGAPAAFVTGRGHGLGPLREIALKLAETLRLPALGYSAAELRHG
PRASVSVATPVLALRQADPLAEGVDALVRDLSRDGMRVHACGGPLGTLPWLGDGHPACDPIAMLVPAYRAIEAEARRRGL
DPDKPAGLTKVTETL

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG2222

COG function: function code M; Predicted phosphosugar isomerases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=301, Percent_Identity=29.2358803986711, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI205277386, Length=305, Percent_Identity=27.8688524590164, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1790167, Length=361, Percent_Identity=27.9778393351801, Blast_Score=95, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17532897, Length=311, Percent_Identity=27.0096463022508, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17532899, Length=311, Percent_Identity=27.0096463022508, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17539970, Length=299, Percent_Identity=26.7558528428094, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6322745, Length=304, Percent_Identity=27.6315789473684, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357745, Length=301, Percent_Identity=28.9036544850498, Blast_Score=98, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 34421; Mature: 34290

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATTFMAREIAEIPDAASLLVAGEAARIGATLRARSFPFVVVCGRGSSGHAGVHLRYLI
CCCHHHHHHHHHHCCCHHHEEEECCHHHHCHHEEECCCCEEEEECCCCCCCCCEEEEEEE
ETRLSLPVSAAAPSVVTGYDRPPNVAGALFIVVSQSGRSPDLVAATEAARAGGALTLALV
HHHHCCCHHHCCCCEEECCCCCCCCCEEEEEEEECCCCCCCEEEHHHHHHCCCEEEEEEE
NDPDSPAARASDLVLPILAGPEHAVAATKTVTNSAIAGAALVSAWAGDGELERGLAALPE
CCCCCCCHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RLRQALALDWSAWSADLAGAPAAFVTGRGHGLGPLREIALKLAETLRLPALGYSAAELRH
HHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCC
GPRASVSVATPVLALRQADPLAEGVDALVRDLSRDGMRVHACGGPLGTLPWLGDGHPACD
CCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCC
PIAMLVPAYRAIEAEARRRGLDPDKPAGLTKVTETL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCC
>Mature Secondary Structure 
SATTFMAREIAEIPDAASLLVAGEAARIGATLRARSFPFVVVCGRGSSGHAGVHLRYLI
CCHHHHHHHHHHCCCHHHEEEECCHHHHCHHEEECCCCEEEEECCCCCCCCCEEEEEEE
ETRLSLPVSAAAPSVVTGYDRPPNVAGALFIVVSQSGRSPDLVAATEAARAGGALTLALV
HHHHCCCHHHCCCCEEECCCCCCCCCEEEEEEEECCCCCCCEEEHHHHHHCCCEEEEEEE
NDPDSPAARASDLVLPILAGPEHAVAATKTVTNSAIAGAALVSAWAGDGELERGLAALPE
CCCCCCCHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RLRQALALDWSAWSADLAGAPAAFVTGRGHGLGPLREIALKLAETLRLPALGYSAAELRH
HHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCC
GPRASVSVATPVLALRQADPLAEGVDALVRDLSRDGMRVHACGGPLGTLPWLGDGHPACD
CCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCC
PIAMLVPAYRAIEAEARRRGLDPDKPAGLTKVTETL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA