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The map label for this gene is crp [H]

Identifier: 218532454

GI number: 218532454

Start: 4833748

End: 4834452

Strand: Reverse

Name: crp [H]

Synonym: Mchl_4566

Alternate gene names: 218532454

Gene position: 4834452-4833748 (Counterclockwise)

Preceding gene: 218532457

Following gene: 218532453

Centisome position: 83.67

GC content: 68.94

Gene sequence:

>705_bases
GTGGCGACAGCCCGGTTGGCGAGCATCCCGTTCTTCAAGGAACCGGGTGTCGATCTTTCCCCATTCGAGACGCGCTGCCA
TTGGCGGCGCTTCGACGAGAACGAGACGCTCGTCGATTACGACGACATCTCCACCGACGTGTACTTCCTCGCCATGGGGG
AAGTGCGGATCCTCAACCGCTCGCAATCCGGCAAGGAGGTCATCCTCGGCGAGATGCGCGTGGGCGCCTTCTTCGGCGAG
CTGGCGGCACTGGACGGCATCGGCCGCTCGGCCAACGTCACGGCGCTGACCCGGGGCGAGGTCTGTGTCGTACCCGCCCC
CGTCTTCCGCCAGATCGTGTTCGCTTCCGAGGTCATTGCCGACCGGCTGTTCCGCCTGCTCGCCAAGCGCGTGCGCGAAC
TGAACACCCGGCTGATGGAGCACGCGCTGCTCGACCTGCGCCACCGTCTCTACGCCGAGCTGCTGCGCCTCTCCGTGCCG
CGGGCCGGGCAGGGGAACGATTCCGTGGGCGAGCGGGTGGTGACGCCGCCGCCCTACCACCACGTGCTGGCCGCCCGCAT
CGGCTGCCGCCGGGAGCAGGTGACCCGCGAGTTCACGGTGATGGCGGGCGAAGGCCTGATCGACCGTACCCGTGGCGCCC
TCGTCATCCGCCGTCCCGACCTGTTGGAGGCTCGGGTGCAGGAGGCGCTGCGGGAGGACGCCTAG

Upstream 100 bases:

>100_bases
CGTCCACGTCAATCGTCCGCCCCCCGCGCCCGGCGACTTGACCCGCCCCGGCCGGAGCCTCACCATTCAGTCTACGCGCG
TAGACTAAGGTACAAGAGGC

Downstream 100 bases:

>100_bases
AAAACGCTCCCGATGCGGGCGCTTCTCAGGGGCCATTTCCCACGCTACGTCGCCAAGATCCGTCGCGGCACTGGTCCGAA
GATCCATCTTGCACGCCAGC

Product: cyclic nucleotide-binding protein

Products: NA

Alternate protein names: cAMP receptor protein; cAMP regulatory protein [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MATARLASIPFFKEPGVDLSPFETRCHWRRFDENETLVDYDDISTDVYFLAMGEVRILNRSQSGKEVILGEMRVGAFFGE
LAALDGIGRSANVTALTRGEVCVVPAPVFRQIVFASEVIADRLFRLLAKRVRELNTRLMEHALLDLRHRLYAELLRLSVP
RAGQGNDSVGERVVTPPPYHHVLAARIGCRREQVTREFTVMAGEGLIDRTRGALVIRRPDLLEARVQEALREDA

Sequences:

>Translated_234_residues
MATARLASIPFFKEPGVDLSPFETRCHWRRFDENETLVDYDDISTDVYFLAMGEVRILNRSQSGKEVILGEMRVGAFFGE
LAALDGIGRSANVTALTRGEVCVVPAPVFRQIVFASEVIADRLFRLLAKRVRELNTRLMEHALLDLRHRLYAELLRLSVP
RAGQGNDSVGERVVTPPPYHHVLAARIGCRREQVTREFTVMAGEGLIDRTRGALVIRRPDLLEARVQEALREDA
>Mature_233_residues
ATARLASIPFFKEPGVDLSPFETRCHWRRFDENETLVDYDDISTDVYFLAMGEVRILNRSQSGKEVILGEMRVGAFFGEL
AALDGIGRSANVTALTRGEVCVVPAPVFRQIVFASEVIADRLFRLLAKRVRELNTRLMEHALLDLRHRLYAELLRLSVPR
AGQGNDSVGERVVTPPPYHHVLAARIGCRREQVTREFTVMAGEGLIDRTRGALVIRRPDLLEARVQEALREDA

Specific function: This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of one or more genes involved in the induction of competence [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789756, Length=207, Percent_Identity=28.0193236714976, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 26369; Mature: 26238

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS50042 CNMP_BINDING_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATARLASIPFFKEPGVDLSPFETRCHWRRFDENETLVDYDDISTDVYFLAMGEVRILNR
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEECCCCCCCEEEEEECCEEEECC
SQSGKEVILGEMRVGAFFGELAALDGIGRSANVTALTRGEVCVVPAPVFRQIVFASEVIA
CCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECHHHHHHHHHHHHHHH
DRLFRLLAKRVRELNTRLMEHALLDLRHRLYAELLRLSVPRAGQGNDSVGERVVTPPPYH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
HVLAARIGCRREQVTREFTVMAGEGLIDRTRGALVIRRPDLLEARVQEALREDA
HHHHHHHCCCHHHHHHHHHEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATARLASIPFFKEPGVDLSPFETRCHWRRFDENETLVDYDDISTDVYFLAMGEVRILNR
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEECCCCCCCEEEEEECCEEEECC
SQSGKEVILGEMRVGAFFGELAALDGIGRSANVTALTRGEVCVVPAPVFRQIVFASEVIA
CCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECHHHHHHHHHHHHHHH
DRLFRLLAKRVRELNTRLMEHALLDLRHRLYAELLRLSVPRAGQGNDSVGERVVTPPPYH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
HVLAARIGCRREQVTREFTVMAGEGLIDRTRGALVIRRPDLLEARVQEALREDA
HHHHHHHCCCHHHHHHHHHEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1542653; 7542800 [H]