Click here to switch to the map view.

The map label for this gene is clcA [H]

Identifier: 218532044

GI number: 218532044

Start: 4361588

End: 4362955

Strand: Reverse

Name: clcA [H]

Synonym: Mchl_4138

Alternate gene names: 218532044

Gene position: 4362955-4361588 (Counterclockwise)

Preceding gene: 218532045

Following gene: 218532037

Centisome position: 75.51

GC content: 69.01

Gene sequence:

>1368_bases
ATGAAGCCGGCAGATCAACCCGCGCCGCCCTGGCAGCAGGCACGCTTCGTCGCCGTGGCCCTGATCACCGGTGCCCTCAC
GGGTGTGTTCGGCGGCCTCTTCCACCTCGCCATCGACACGATCATCGATTGGCCGACATGGCTCGCCGGCCAGACCGCCG
GCTGGCGGTTGGTCGCGGCGAGCGCCGTCATCACCATGGCGGCTACGGTCTTTGCCGTGTTCATCACTCGGCGATTCGCC
CCGGAAGCGAGCGGGAGCGGGGTTCCGGAGATCGAGGGGGCCATCGCCGGCATCCGGCATGTGCGCTGGGAGCGCGTGCT
GCCGGTGAAGTTCATCGCCGGCATCGCGGCGATCGGCTCGGGTCTGGTGCTTGGCCGCGAGGGGCCGACCATTCACATGG
GCGGCTCGGCGGCGCTCGCGGCGTCCGAGATGTTCCGGGTGAAGGACGTCGACCGGCGGGCTCTGCTGGCGGCCGGCGCG
GGGGCGGGTCTCGCCTGCGCCTTCAATGCCCCGATGGCGGCCGTGCTGTTCGTCATCGAGGAAACGCGCAAGCAGTTCCC
CTACAGCTTCCGGAACTACATGGGGGTGTTCGCCGCGGCGATCACCGGAACCGCGGTGACCCAGATGATCTCGGGCGCGC
GGCCGGACCTGCCGCTGTCGGCCGGGGCAGCGGCGCTGGCTTCGTTGCCGGCCTTCGCCGTGCTGGGCATCATCCTGGGT
GCGGTGGGCGTGCTCTTCAATCGATGCATCCTGACGATGCTGGACCTCGCCGCCGCTTGGCAGAAGCGTGCCCCGTATGT
CTGGCCTGCCCTGGTCGGATTGCTCGTGGGCGCCCTGCTGATCCTCGCGCCGCGCACCGCGACGGGCGGGGAACAGGTGA
TTTCACAGATCGCCGTTCTGACCCCGAGTGCGGGCGTGCTGCTGATGCTGGCGGTCGCCCGGCTGTTCACATCGGTTGTC
TGTTACTCCGTTGGTACGCCGGGCGGCATTTTCGCGCCGATCTTGTCGCTGGCGACCTGCATCGGTCTGGCCTTCGGCCT
GCTCGCGCAGATGGTGTTCCCCGAGGTCTTGTCCGGCCTCGGGGTGACGCCGGTCTCCTTCGGCATCGTGGCGATGGCCG
CGCTCTTCAGCGCGACGGTGCACGCACCGGCCGTGGGTGTGGTCTTGGTGCTTGAACTCACCACCGCCTACGCGCTCGTC
CTGCCCATGCTGACGGCCTGCCTCACGGCCAGCCTTGTGGCCCAATGGCTCGGCGGCCGTCCGATTTATGGACAGATGCT
GGAGCGCGCCCTGGCCCAGGCCGGCAGGGTGCCGGTCAAGGGCTCGGATATCGGTCTGGCTGCCGATCGGGATCGTGCGA
CCCAGTGA

Upstream 100 bases:

>100_bases
CCTCCGCGGGGCTTCGGTAGTCCCACCGAGACATCCGTTCCGGGGACGGACCGCGTGAAGTCTAGGGTTTGCCGGCGATC
AGCGAGAGGAAGGGGCGAGG

Downstream 100 bases:

>100_bases
ACCGCTTCAAGGCCTGCAAGGCGATCGCTGAAGGCTCTCAGCCGCAACGTCATACGGGTGGGGGCGGTGGTGGCGGAGGC
GGAGGCGGTGGTGGCGGCAG

Product: chloride channel core

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKPADQPAPPWQQARFVAVALITGALTGVFGGLFHLAIDTIIDWPTWLAGQTAGWRLVAASAVITMAATVFAVFITRRFA
PEASGSGVPEIEGAIAGIRHVRWERVLPVKFIAGIAAIGSGLVLGREGPTIHMGGSAALAASEMFRVKDVDRRALLAAGA
GAGLACAFNAPMAAVLFVIEETRKQFPYSFRNYMGVFAAAITGTAVTQMISGARPDLPLSAGAAALASLPAFAVLGIILG
AVGVLFNRCILTMLDLAAAWQKRAPYVWPALVGLLVGALLILAPRTATGGEQVISQIAVLTPSAGVLLMLAVARLFTSVV
CYSVGTPGGIFAPILSLATCIGLAFGLLAQMVFPEVLSGLGVTPVSFGIVAMAALFSATVHAPAVGVVLVLELTTAYALV
LPMLTACLTASLVAQWLGGRPIYGQMLERALAQAGRVPVKGSDIGLAADRDRATQ

Sequences:

>Translated_455_residues
MKPADQPAPPWQQARFVAVALITGALTGVFGGLFHLAIDTIIDWPTWLAGQTAGWRLVAASAVITMAATVFAVFITRRFA
PEASGSGVPEIEGAIAGIRHVRWERVLPVKFIAGIAAIGSGLVLGREGPTIHMGGSAALAASEMFRVKDVDRRALLAAGA
GAGLACAFNAPMAAVLFVIEETRKQFPYSFRNYMGVFAAAITGTAVTQMISGARPDLPLSAGAAALASLPAFAVLGIILG
AVGVLFNRCILTMLDLAAAWQKRAPYVWPALVGLLVGALLILAPRTATGGEQVISQIAVLTPSAGVLLMLAVARLFTSVV
CYSVGTPGGIFAPILSLATCIGLAFGLLAQMVFPEVLSGLGVTPVSFGIVAMAALFSATVHAPAVGVVLVLELTTAYALV
LPMLTACLTASLVAQWLGGRPIYGQMLERALAQAGRVPVKGSDIGLAADRDRATQ
>Mature_455_residues
MKPADQPAPPWQQARFVAVALITGALTGVFGGLFHLAIDTIIDWPTWLAGQTAGWRLVAASAVITMAATVFAVFITRRFA
PEASGSGVPEIEGAIAGIRHVRWERVLPVKFIAGIAAIGSGLVLGREGPTIHMGGSAALAASEMFRVKDVDRRALLAAGA
GAGLACAFNAPMAAVLFVIEETRKQFPYSFRNYMGVFAAAITGTAVTQMISGARPDLPLSAGAAALASLPAFAVLGIILG
AVGVLFNRCILTMLDLAAAWQKRAPYVWPALVGLLVGALLILAPRTATGGEQVISQIAVLTPSAGVLLMLAVARLFTSVV
CYSVGTPGGIFAPILSLATCIGLAFGLLAQMVFPEVLSGLGVTPVSFGIVAMAALFSATVHAPAVGVVLVLELTTAYALV
LPMLTACLTASLVAQWLGGRPIYGQMLERALAQAGRVPVKGSDIGLAADRDRATQ

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI119433677, Length=411, Percent_Identity=26.7639902676399, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI156104869, Length=414, Percent_Identity=28.5024154589372, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI283806622, Length=413, Percent_Identity=28.5714285714286, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI283806618, Length=414, Percent_Identity=28.5024154589372, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI283806616, Length=410, Percent_Identity=28.0487804878049, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI153252026, Length=413, Percent_Identity=26.634382566586, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI4557473, Length=454, Percent_Identity=25.7709251101322, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI189217923, Length=453, Percent_Identity=25.8278145695364, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI189217921, Length=453, Percent_Identity=25.8278145695364, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI55770840, Length=457, Percent_Identity=24.2888402625821, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI55770838, Length=457, Percent_Identity=24.2888402625821, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1786350, Length=385, Percent_Identity=42.8571428571429, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI87081943, Length=331, Percent_Identity=29.0030211480363, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71996455, Length=473, Percent_Identity=24.9471458773784, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71996452, Length=473, Percent_Identity=24.9471458773784, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71985148, Length=420, Percent_Identity=27.3809523809524, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71985141, Length=420, Percent_Identity=27.6190476190476, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17532615, Length=406, Percent_Identity=23.8916256157635, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71980824, Length=251, Percent_Identity=28.6852589641434, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71980828, Length=251, Percent_Identity=28.6852589641434, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71980820, Length=251, Percent_Identity=28.6852589641434, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24665008, Length=403, Percent_Identity=25.8064516129032, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281361606, Length=391, Percent_Identity=25.0639386189258, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573073, Length=391, Percent_Identity=25.5754475703325, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161078208, Length=391, Percent_Identity=25.5754475703325, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281361608, Length=391, Percent_Identity=25.0639386189258, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573075, Length=391, Percent_Identity=25.5754475703325, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573071, Length=391, Percent_Identity=25.5754475703325, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45551566, Length=393, Percent_Identity=24.9363867684478, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 46905; Mature: 46905

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPADQPAPPWQQARFVAVALITGALTGVFGGLFHLAIDTIIDWPTWLAGQTAGWRLVAA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHH
SAVITMAATVFAVFITRRFAPEASGSGVPEIEGAIAGIRHVRWERVLPVKFIAGIAAIGS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
GLVLGREGPTIHMGGSAALAASEMFRVKDVDRRALLAAGAGAGLACAFNAPMAAVLFVIE
CEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHH
ETRKQFPYSFRNYMGVFAAAITGTAVTQMISGARPDLPLSAGAAALASLPAFAVLGIILG
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AVGVLFNRCILTMLDLAAAWQKRAPYVWPALVGLLVGALLILAPRTATGGEQVISQIAVL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TPSAGVLLMLAVARLFTSVVCYSVGTPGGIFAPILSLATCIGLAFGLLAQMVFPEVLSGL
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GVTPVSFGIVAMAALFSATVHAPAVGVVLVLELTTAYALVLPMLTACLTASLVAQWLGGR
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PIYGQMLERALAQAGRVPVKGSDIGLAADRDRATQ
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKPADQPAPPWQQARFVAVALITGALTGVFGGLFHLAIDTIIDWPTWLAGQTAGWRLVAA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHH
SAVITMAATVFAVFITRRFAPEASGSGVPEIEGAIAGIRHVRWERVLPVKFIAGIAAIGS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
GLVLGREGPTIHMGGSAALAASEMFRVKDVDRRALLAAGAGAGLACAFNAPMAAVLFVIE
CEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHH
ETRKQFPYSFRNYMGVFAAAITGTAVTQMISGARPDLPLSAGAAALASLPAFAVLGIILG
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AVGVLFNRCILTMLDLAAAWQKRAPYVWPALVGLLVGALLILAPRTATGGEQVISQIAVL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TPSAGVLLMLAVARLFTSVVCYSVGTPGGIFAPILSLATCIGLAFGLLAQMVFPEVLSGL
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GVTPVSFGIVAMAALFSATVHAPAVGVVLVLELTTAYALVLPMLTACLTASLVAQWLGGR
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PIYGQMLERALAQAGRVPVKGSDIGLAADRDRATQ
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA