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The map label for this gene is zraS [C]

Identifier: 218532021

GI number: 218532021

Start: 4334529

End: 4336250

Strand: Reverse

Name: zraS [C]

Synonym: Mchl_4112

Alternate gene names: 218532021

Gene position: 4336250-4334529 (Counterclockwise)

Preceding gene: 218532023

Following gene: 218532013

Centisome position: 75.05

GC content: 63.94

Gene sequence:

>1722_bases
ATGATGCGACGGGGACAATACGAAGACACGTGGTTCACGTTCTCGTACTCACCAGTGCGCGAGGAAGATGGCCGCGTAGC
AGGCATGTTCTGCTGCTGTGTGGAAACGACAGCAGGAGTTCGGTCACAAGCCGAACTCGCTGAGCTGAACATCGACCTTG
AACGGCAGGTGACTGAACGATCCCGTGAGCGGGATCGGCTCTGGCGTAACACCCAAGACATTCAGGTCATCATTGACGGT
GCGGGCGTCTTTCACGCCGTCAATCCAGCTTTCACGGCGATCCTCGGCTGGACACCTGAAGATGTGATTGGCAGGCCGGT
GTTCGACTTTGTACTTCCAGATGATGAGGCGTTGACCAGCCGCGCGTTAGAGCATGCGCGCGTCGAGAGCCTGCCGGTCG
TTGAGAACCGCTACCGCCACAAGAACGGGGGTTTCCGCTGGATCTCGTGGGTCGCTGCTCCTGAGGCGAAGCTGATCTAC
GCGAGTGGACGGCACATCACGGCGGAGAAGGAGCAGGCCGAGGCTCTGAGCAGGACCGAGGAGGCCCTTCGCCAAGCGCA
GAAGATGGAGGCTGTTGGGCAACTCACCGGAGGGCTGGCCCACGACTTCAACAACCTGCTGGCGGGCATCTCCGGCTCAC
TGGAACTGATGCAGACCCGCATGCTACAGGGCCGCCTCACGGATGTGGACCGCTACATGACGGCCGCGCAGGGGGCAGCA
AAGCGCGCCGCTGCGCTGACCCATCGGCTGCTCGCGTTCTCCCGTCGCCAGACCCTCGACCCGAAGCCCACCGATGTCAG
CCGGCTTGCCATGGGCATGCACGAGCTGATCCAGCGTACGGTCGGACCCGGCATCCTGGTCGAGGTCGTGGGCGCGACCG
GTGCTTGGCCGGCCTTGGTGGACCCGCCGCAGCTTGAGAACGCCCTTCTGAACCTCTGCATCAACGCCCGCGACGCGATG
CCGGATGGCGGCATCATCACCATCGAGACCGCGAATAAGTGGATGGACGAACGCGCAGCCCGCCAGCACGATATGCCGGA
AGGCCAGTACCTCAGCCTCGCCGTGACCGATACCGGGACCGGCATGCCGCCGGGGGTCGTCGCCAGGGCATTCGACCCGT
TCTTCACGACGAAGCCTATCGGTGAGGGCACGGGGCTGGGCCTGTCGATGATCTACGGGTTCGCGCAGCAGTCAGGCGGG
CAGGTCCGCATCTACTCGGAAGTCGGGCAGGGCACCACCGTATGCATCTACCTGCCGCGCTACTACGGGGTTGTTGAAGA
TGACACCGCAGGCGAGCAGATTGCCGAACTACCACGCTCGGAGGCTGGCGAGACGGTCCTGATTGTGGACGACGAGCCGA
CCGTGCGCATGCTGATCACCGACATCCTCGAAGACCTTGGCTATGCGGCCATTGAGGCGGGTGACAGCGCGACCGGCCTC
AAGGTGCTGCAATCGGACGTACGCATCGACCTGCTGGTGACGGACGTAGGCCTGCCCGGCGGCATGAACGGGCGACAGAT
GGCGGACGCGGCGCGGAACCATCGACCCGACCTGAAGGTGCTGTTCATCACCGGCTACGCGGAGAACGCGATCCTCGGCA
ACGGGACGCTTCCACCGGGGATGGCAGTGCTGACCAAGCCGTTCGCGATGGACAACATGGCCGCGCGCATCCGCTCGATG
ATCGAGGCGGGGCGGGAGACGAGGCTGCAACGTCGAAGCTGA

Upstream 100 bases:

>100_bases
ATTTGAAGTAATCTGGTCTGAGATCTGGCCTGACATCAATCCGCTAATCCAGCGTGCTATGGCCGGTGAGGCGACGTTCT
CAGCAGATCTACCTTTGCGC

Downstream 100 bases:

>100_bases
TGGTCCGCTATGGGTGGGGAGCCAGCATTCAGCGGCGTGATCGCGAGGGACTGCATAGCCATTGGAAGCGGACGTTCGCC
GACTGGGAGCTATGGAGCGT

Product: PAS/PAC sensor hybrid histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MMRRGQYEDTWFTFSYSPVREEDGRVAGMFCCCVETTAGVRSQAELAELNIDLERQVTERSRERDRLWRNTQDIQVIIDG
AGVFHAVNPAFTAILGWTPEDVIGRPVFDFVLPDDEALTSRALEHARVESLPVVENRYRHKNGGFRWISWVAAPEAKLIY
ASGRHITAEKEQAEALSRTEEALRQAQKMEAVGQLTGGLAHDFNNLLAGISGSLELMQTRMLQGRLTDVDRYMTAAQGAA
KRAAALTHRLLAFSRRQTLDPKPTDVSRLAMGMHELIQRTVGPGILVEVVGATGAWPALVDPPQLENALLNLCINARDAM
PDGGIITIETANKWMDERAARQHDMPEGQYLSLAVTDTGTGMPPGVVARAFDPFFTTKPIGEGTGLGLSMIYGFAQQSGG
QVRIYSEVGQGTTVCIYLPRYYGVVEDDTAGEQIAELPRSEAGETVLIVDDEPTVRMLITDILEDLGYAAIEAGDSATGL
KVLQSDVRIDLLVTDVGLPGGMNGRQMADAARNHRPDLKVLFITGYAENAILGNGTLPPGMAVLTKPFAMDNMAARIRSM
IEAGRETRLQRRS

Sequences:

>Translated_573_residues
MMRRGQYEDTWFTFSYSPVREEDGRVAGMFCCCVETTAGVRSQAELAELNIDLERQVTERSRERDRLWRNTQDIQVIIDG
AGVFHAVNPAFTAILGWTPEDVIGRPVFDFVLPDDEALTSRALEHARVESLPVVENRYRHKNGGFRWISWVAAPEAKLIY
ASGRHITAEKEQAEALSRTEEALRQAQKMEAVGQLTGGLAHDFNNLLAGISGSLELMQTRMLQGRLTDVDRYMTAAQGAA
KRAAALTHRLLAFSRRQTLDPKPTDVSRLAMGMHELIQRTVGPGILVEVVGATGAWPALVDPPQLENALLNLCINARDAM
PDGGIITIETANKWMDERAARQHDMPEGQYLSLAVTDTGTGMPPGVVARAFDPFFTTKPIGEGTGLGLSMIYGFAQQSGG
QVRIYSEVGQGTTVCIYLPRYYGVVEDDTAGEQIAELPRSEAGETVLIVDDEPTVRMLITDILEDLGYAAIEAGDSATGL
KVLQSDVRIDLLVTDVGLPGGMNGRQMADAARNHRPDLKVLFITGYAENAILGNGTLPPGMAVLTKPFAMDNMAARIRSM
IEAGRETRLQRRS
>Mature_573_residues
MMRRGQYEDTWFTFSYSPVREEDGRVAGMFCCCVETTAGVRSQAELAELNIDLERQVTERSRERDRLWRNTQDIQVIIDG
AGVFHAVNPAFTAILGWTPEDVIGRPVFDFVLPDDEALTSRALEHARVESLPVVENRYRHKNGGFRWISWVAAPEAKLIY
ASGRHITAEKEQAEALSRTEEALRQAQKMEAVGQLTGGLAHDFNNLLAGISGSLELMQTRMLQGRLTDVDRYMTAAQGAA
KRAAALTHRLLAFSRRQTLDPKPTDVSRLAMGMHELIQRTVGPGILVEVVGATGAWPALVDPPQLENALLNLCINARDAM
PDGGIITIETANKWMDERAARQHDMPEGQYLSLAVTDTGTGMPPGVVARAFDPFFTTKPIGEGTGLGLSMIYGFAQQSGG
QVRIYSEVGQGTTVCIYLPRYYGVVEDDTAGEQIAELPRSEAGETVLIVDDEPTVRMLITDILEDLGYAAIEAGDSATGL
KVLQSDVRIDLLVTDVGLPGGMNGRQMADAARNHRPDLKVLFITGYAENAILGNGTLPPGMAVLTKPFAMDNMAARIRSM
IEAGRETRLQRRS

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=241, Percent_Identity=26.1410788381743, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788549, Length=395, Percent_Identity=25.0632911392405, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI145693157, Length=272, Percent_Identity=26.1029411764706, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790300, Length=253, Percent_Identity=29.6442687747036, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87081816, Length=247, Percent_Identity=23.4817813765182, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788713, Length=271, Percent_Identity=26.9372693726937, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 62775; Mature: 62775

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS50112 PAS ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRRGQYEDTWFTFSYSPVREEDGRVAGMFCCCVETTAGVRSQAELAELNIDLERQVTER
CCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEEEHHHCCCCCHHHHHHHCCCHHHHHHHH
SRERDRLWRNTQDIQVIIDGAGVFHAVNPAFTAILGWTPEDVIGRPVFDFVLPDDEALTS
HHHHHHHHCCCCCEEEEEECCCCEEECCHHHHHEECCCHHHHHCCCEEEEECCCCHHHHH
RALEHARVESLPVVENRYRHKNGGFRWISWVAAPEAKLIYASGRHITAEKEQAEALSRTE
HHHHHHHHHCCCCHHHHHHCCCCCEEEEEEEECCCCEEEEECCCEEECCHHHHHHHHHHH
EALRQAQKMEAVGQLTGGLAHDFNNLLAGISGSLELMQTRMLQGRLTDVDRYMTAAQGAA
HHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KRAAALTHRLLAFSRRQTLDPKPTDVSRLAMGMHELIQRTVGPGILVEVVGATGAWPALV
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
DPPQLENALLNLCINARDAMPDGGIITIETANKWMDERAARQHDMPEGQYLSLAVTDTGT
CCHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCEEEEEEECCCC
GMPPGVVARAFDPFFTTKPIGEGTGLGLSMIYGFAQQSGGQVRIYSEVGQGTTVCIYLPR
CCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCC
YYGVVEDDTAGEQIAELPRSEAGETVLIVDDEPTVRMLITDILEDLGYAAIEAGDSATGL
CCCEECCCCCHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCHHH
KVLQSDVRIDLLVTDVGLPGGMNGRQMADAARNHRPDLKVLFITGYAENAILGNGTLPPG
HHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCCCC
MAVLTKPFAMDNMAARIRSMIEAGRETRLQRRS
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMRRGQYEDTWFTFSYSPVREEDGRVAGMFCCCVETTAGVRSQAELAELNIDLERQVTER
CCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEEEHHHCCCCCHHHHHHHCCCHHHHHHHH
SRERDRLWRNTQDIQVIIDGAGVFHAVNPAFTAILGWTPEDVIGRPVFDFVLPDDEALTS
HHHHHHHHCCCCCEEEEEECCCCEEECCHHHHHEECCCHHHHHCCCEEEEECCCCHHHHH
RALEHARVESLPVVENRYRHKNGGFRWISWVAAPEAKLIYASGRHITAEKEQAEALSRTE
HHHHHHHHHCCCCHHHHHHCCCCCEEEEEEEECCCCEEEEECCCEEECCHHHHHHHHHHH
EALRQAQKMEAVGQLTGGLAHDFNNLLAGISGSLELMQTRMLQGRLTDVDRYMTAAQGAA
HHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KRAAALTHRLLAFSRRQTLDPKPTDVSRLAMGMHELIQRTVGPGILVEVVGATGAWPALV
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
DPPQLENALLNLCINARDAMPDGGIITIETANKWMDERAARQHDMPEGQYLSLAVTDTGT
CCHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCEEEEEEECCCC
GMPPGVVARAFDPFFTTKPIGEGTGLGLSMIYGFAQQSGGQVRIYSEVGQGTTVCIYLPR
CCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCC
YYGVVEDDTAGEQIAELPRSEAGETVLIVDDEPTVRMLITDILEDLGYAAIEAGDSATGL
CCCEECCCCCHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCHHH
KVLQSDVRIDLLVTDVGLPGGMNGRQMADAARNHRPDLKVLFITGYAENAILGNGTLPPG
HHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCCCC
MAVLTKPFAMDNMAARIRSMIEAGRETRLQRRS
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA