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The map label for this gene is proC [H]

Identifier: 218531975

GI number: 218531975

Start: 4284809

End: 4285642

Strand: Reverse

Name: proC [H]

Synonym: Mchl_4063

Alternate gene names: 218531975

Gene position: 4285642-4284809 (Counterclockwise)

Preceding gene: 218531976

Following gene: 218531974

Centisome position: 74.17

GC content: 76.62

Gene sequence:

>834_bases
ATGACGCGCGCGCCCGATGATCCGACCGCCTTTCCCACGCCCCTGGTTCTGGCCGGCGCCGGCAAGATGGGAGCGGCGCT
GCTGCGGGGCTGGCTCGCGGGCGGCCTCGACCCCGCCGCCGTGACCGTCGTCGATCCGCAGCCCTCCGCGGAGATCGCGA
CACTCTGTGCCGAGCGGGCCTTGCGCCTCAATCCCGAAGCCGCCGTCCCGGCCGGAGCGCTGGTGCTCGGCATCAAGCCG
CAGGTTCTCGACGCGGCGGCACCGGCGCTGGCCGGATGGATCGGCCCGGACACCCTCGTCGTCTCGATCCTGGCCGGCAA
GACCATCGCCGACCTCAAGCGCCGCCTGCCGACCGCCCGCGCCGTGGTGCGCGCCATGCCCAACCTGCCCGCCAGCATCG
GCCGGGGCGCGACCGGCGCCGTCGGCAGCCCGGAGGTCGGACCGCAGGCGCGGGCGGGCGCGGAGGCGTTGCTCGCCAGC
TCCGGCCTCGTGGCGTGGCTCGACGACGAAGCGTTGATCGATGCAGTGACCGCGGTCTCGGGCTCCGGCCCGGCCTACGT
CTTCCTGCTGGCGGAAGCACTCGCGGAGGCCGGCGTGGCGGCGGGCCTGCCGCCCGACCTGTCGGCGCAGCTCGCCCGCG
CCACCGTCGCGGGGGCCGGTGCCCTGCTCGACGCCGATGCCCGCCAGGCCGGGCAATTGCGCCGCGACGTGACCTCGCCC
GGCGGCACCACCGCAGCCGCCCTCGCCGTGCTGATGCGCGAGGGCGCGCTGCCCGACCTGATGCGCGAGGCGGTCGAGGC
GGCGCGGCGGCGGGCGGGCGAATTGTCCGGCTGA

Upstream 100 bases:

>100_bases
GACCGAGGGCGAGGCGTAAGCTGCCGGTCCTGCGGGATCGCGCCGCCGTCCTCGAGCCCTCGCCCTTGATTCGGCGCGGC
TGCGGTGGGATCGAGGGCCT

Downstream 100 bases:

>100_bases
GAGGCCCGGCGGTTTCAAGCGGGCGACACTGACCCTACATGAGACGTGAACCGAATGCGGAGCACGGACCATGGAAACAG
CCCCCGAGCCCAACACCGGC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MTRAPDDPTAFPTPLVLAGAGKMGAALLRGWLAGGLDPAAVTVVDPQPSAEIATLCAERALRLNPEAAVPAGALVLGIKP
QVLDAAAPALAGWIGPDTLVVSILAGKTIADLKRRLPTARAVVRAMPNLPASIGRGATGAVGSPEVGPQARAGAEALLAS
SGLVAWLDDEALIDAVTAVSGSGPAYVFLLAEALAEAGVAAGLPPDLSAQLARATVAGAGALLDADARQAGQLRRDVTSP
GGTTAAALAVLMREGALPDLMREAVEAARRRAGELSG

Sequences:

>Translated_277_residues
MTRAPDDPTAFPTPLVLAGAGKMGAALLRGWLAGGLDPAAVTVVDPQPSAEIATLCAERALRLNPEAAVPAGALVLGIKP
QVLDAAAPALAGWIGPDTLVVSILAGKTIADLKRRLPTARAVVRAMPNLPASIGRGATGAVGSPEVGPQARAGAEALLAS
SGLVAWLDDEALIDAVTAVSGSGPAYVFLLAEALAEAGVAAGLPPDLSAQLARATVAGAGALLDADARQAGQLRRDVTSP
GGTTAAALAVLMREGALPDLMREAVEAARRRAGELSG
>Mature_276_residues
TRAPDDPTAFPTPLVLAGAGKMGAALLRGWLAGGLDPAAVTVVDPQPSAEIATLCAERALRLNPEAAVPAGALVLGIKPQ
VLDAAAPALAGWIGPDTLVVSILAGKTIADLKRRLPTARAVVRAMPNLPASIGRGATGAVGSPEVGPQARAGAEALLASS
GLVAWLDDEALIDAVTAVSGSGPAYVFLLAEALAEAGVAAGLPPDLSAQLARATVAGAGALLDADARQAGQLRRDVTSPG
GTTAAALAVLMREGALPDLMREAVEAARRRAGELSG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=274, Percent_Identity=36.1313868613139, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI24797095, Length=274, Percent_Identity=36.1313868613139, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI21361454, Length=273, Percent_Identity=35.8974358974359, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=33.0827067669173, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI1786585, Length=261, Percent_Identity=32.9501915708812, Blast_Score=110, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17569021, Length=265, Percent_Identity=35.0943396226415, Blast_Score=120, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17540664, Length=285, Percent_Identity=29.8245614035088, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320861, Length=281, Percent_Identity=29.1814946619217, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21358587, Length=269, Percent_Identity=36.8029739776952, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24647700, Length=174, Percent_Identity=43.6781609195402, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24648116, Length=211, Percent_Identity=32.7014218009479, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27477; Mature: 27346

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRAPDDPTAFPTPLVLAGAGKMGAALLRGWLAGGLDPAAVTVVDPQPSAEIATLCAERA
CCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHH
LRLNPEAAVPAGALVLGIKPQVLDAAAPALAGWIGPDTLVVSILAGKTIADLKRRLPTAR
HHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHCCHHH
AVVRAMPNLPASIGRGATGAVGSPEVGPQARAGAEALLASSGLVAWLDDEALIDAVTAVS
HHHHHCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHC
GSGPAYVFLLAEALAEAGVAAGLPPDLSAQLARATVAGAGALLDADARQAGQLRRDVTSP
CCCCHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHCCC
GGTTAAALAVLMREGALPDLMREAVEAARRRAGELSG
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TRAPDDPTAFPTPLVLAGAGKMGAALLRGWLAGGLDPAAVTVVDPQPSAEIATLCAERA
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHH
LRLNPEAAVPAGALVLGIKPQVLDAAAPALAGWIGPDTLVVSILAGKTIADLKRRLPTAR
HHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHCCHHH
AVVRAMPNLPASIGRGATGAVGSPEVGPQARAGAEALLASSGLVAWLDDEALIDAVTAVS
HHHHHCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHC
GSGPAYVFLLAEALAEAGVAAGLPPDLSAQLARATVAGAGALLDADARQAGQLRRDVTSP
CCCCHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHCCC
GGTTAAALAVLMREGALPDLMREAVEAARRRAGELSG
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]