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The map label for this gene is hisN [H]

Identifier: 218531956

GI number: 218531956

Start: 4259845

End: 4260651

Strand: Reverse

Name: hisN [H]

Synonym: Mchl_4044

Alternate gene names: 218531956

Gene position: 4260651-4259845 (Counterclockwise)

Preceding gene: 218531957

Following gene: 218531955

Centisome position: 73.74

GC content: 71.5

Gene sequence:

>807_bases
ATGGATCTGGCTTTGCCCGCGACCGACCCTCTCGCCCCGGAAACCATCCTCGCCTTTGCCGCCGAACTGGCCGAGGCCGC
GCGGCCGATCGCGCTCGCCTATTTCCGCACCCCGCTCGACATCGTGACGAAGGCCGACGAGAGCCCGGTGACGTTGGCCG
ACCGCGCCATCGAGGTGCGCCTGCGCGGCCTGATCGAGGCGCGGTTTCCCGATCACGGCATTTTCGGCGAGGAGATGGGG
GTGAAGCCCGGAGCCACGCCCGGCAGCGGCCCGGTCTGGGTGATCGACCCGATCGACGGCACCAAGAGCTTCGTCACCGG
CCTGCCGCTGTTCGGCACCCTAGTCGCCTTCCTCGACGGCGGCGTACCGGTCGCCGGGCTGATCGACATGCCGGCTTTGG
GCGAGCGCTGGACCGGCGTGCCGGGGCAGGCACGGTTCGGGGCCGAGCCCGCCCGCACCAGCACCTGCCGGAGCCTGTCC
GCGGCGCGCTTCTTCACGACCTCGCCCGAGGGCTTCACCGGGGCGGACGAGGCGCGCTACTGCCGCCTCAGCGCAGCGAC
AGCCCTGCGCCGCTTCGGCGGCGATTGCTACGCCTACGGCCTGCTGGCTTCAGGCCATTGCGACCTGATCGCCGAGACCG
GCCTGCAACCTTACGATTACATGGCCCTGGTGCCGGTGATCCGGGCGGCGGGCGGGGTCATCACCGATTGGAGCGGCGAA
GACCTCACCCTCGCCTCCGACGGGCGGGTGCTCGCGGCGGCGACGCCGGACCTGCACGCCGAGGCTTTGGCGATCCTGCG
GGCGTAG

Upstream 100 bases:

>100_bases
CGACTTCGATTTCTACAAATACGGAATCTGGAAGCACATGCGCGCCCGCTCGATCATGAACGACCCGCGCTGGCCGCTCT
TCCTGAAGGCGCTCTGAGCG

Downstream 100 bases:

>100_bases
GGAGACCTGAGACCGCCGGCTTCCCCGCGTCGCGGTTTGCCAAGGGGATGTCGCTGAGGTGGAAGCGACGGGGGGCCCGC
CGAACAATAATTCCCGACAG

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MDLALPATDPLAPETILAFAAELAEAARPIALAYFRTPLDIVTKADESPVTLADRAIEVRLRGLIEARFPDHGIFGEEMG
VKPGATPGSGPVWVIDPIDGTKSFVTGLPLFGTLVAFLDGGVPVAGLIDMPALGERWTGVPGQARFGAEPARTSTCRSLS
AARFFTTSPEGFTGADEARYCRLSAATALRRFGGDCYAYGLLASGHCDLIAETGLQPYDYMALVPVIRAAGGVITDWSGE
DLTLASDGRVLAAATPDLHAEALAILRA

Sequences:

>Translated_268_residues
MDLALPATDPLAPETILAFAAELAEAARPIALAYFRTPLDIVTKADESPVTLADRAIEVRLRGLIEARFPDHGIFGEEMG
VKPGATPGSGPVWVIDPIDGTKSFVTGLPLFGTLVAFLDGGVPVAGLIDMPALGERWTGVPGQARFGAEPARTSTCRSLS
AARFFTTSPEGFTGADEARYCRLSAATALRRFGGDCYAYGLLASGHCDLIAETGLQPYDYMALVPVIRAAGGVITDWSGE
DLTLASDGRVLAAATPDLHAEALAILRA
>Mature_268_residues
MDLALPATDPLAPETILAFAAELAEAARPIALAYFRTPLDIVTKADESPVTLADRAIEVRLRGLIEARFPDHGIFGEEMG
VKPGATPGSGPVWVIDPIDGTKSFVTGLPLFGTLVAFLDGGVPVAGLIDMPALGERWTGVPGQARFGAEPARTSTCRSLS
AARFFTTSPEGFTGADEARYCRLSAATALRRFGGDCYAYGLLASGHCDLIAETGLQPYDYMALVPVIRAAGGVITDWSGE
DLTLASDGRVLAAATPDLHAEALAILRA

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=264, Percent_Identity=24.6212121212121, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI221625487, Length=264, Percent_Identity=24.6212121212121, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI7657236, Length=228, Percent_Identity=29.8245614035088, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1788882, Length=263, Percent_Identity=29.277566539924, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790659, Length=107, Percent_Identity=31.7757009345794, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI193202570, Length=260, Percent_Identity=28.8461538461538, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193202572, Length=262, Percent_Identity=28.2442748091603, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320493, Length=218, Percent_Identity=26.1467889908257, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357303, Length=255, Percent_Identity=32.156862745098, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357329, Length=262, Percent_Identity=30.1526717557252, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24664922, Length=243, Percent_Identity=29.2181069958848, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24664918, Length=228, Percent_Identity=28.9473684210526, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24664926, Length=236, Percent_Identity=27.1186440677966, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28060; Mature: 28060

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLALPATDPLAPETILAFAAELAEAARPIALAYFRTPLDIVTKADESPVTLADRAIEVR
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHCCHHHHCCCCCCCCCHHHHHHHHH
LRGLIEARFPDHGIFGEEMGVKPGATPGSGPVWVIDPIDGTKSFVTGLPLFGTLVAFLDG
HHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHHCC
GVPVAGLIDMPALGERWTGVPGQARFGAEPARTSTCRSLSAARFFTTSPEGFTGADEARY
CCCEEHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCCCCHHH
CRLSAATALRRFGGDCYAYGLLASGHCDLIAETGLQPYDYMALVPVIRAAGGVITDWSGE
HHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHCCCCCHHHHHHHHHHHHCCCEEECCCCC
DLTLASDGRVLAAATPDLHAEALAILRA
EEEEECCCEEEEEECCCHHHHHHHHHCC
>Mature Secondary Structure
MDLALPATDPLAPETILAFAAELAEAARPIALAYFRTPLDIVTKADESPVTLADRAIEVR
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHCCHHHHCCCCCCCCCHHHHHHHHH
LRGLIEARFPDHGIFGEEMGVKPGATPGSGPVWVIDPIDGTKSFVTGLPLFGTLVAFLDG
HHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHHCC
GVPVAGLIDMPALGERWTGVPGQARFGAEPARTSTCRSLSAARFFTTSPEGFTGADEARY
CCCEEHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCCCCHHH
CRLSAATALRRFGGDCYAYGLLASGHCDLIAETGLQPYDYMALVPVIRAAGGVITDWSGE
HHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHCCCCCHHHHHHHHHHHHCCCEEECCCCC
DLTLASDGRVLAAATPDLHAEALAILRA
EEEEECCCEEEEEECCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]