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The map label for this gene is etfA [H]

Identifier: 218531951

GI number: 218531951

Start: 4251844

End: 4253064

Strand: Reverse

Name: etfA [H]

Synonym: Mchl_4039

Alternate gene names: 218531951

Gene position: 4253064-4251844 (Counterclockwise)

Preceding gene: 218531952

Following gene: 218531950

Centisome position: 73.61

GC content: 75.68

Gene sequence:

>1221_bases
ATGAGCCGCCCGCGCCGCGACCCGAGGGCCGAGCGGGCGGCTTCCCTCGTCGCCGGCGAGGGCCCGCGTCCGCGCTACGA
CCGCACCCGCCGCGCGACCGCCTCCGGCCGGCCCCGCCGCGATCCGCGGGCCGAGCGGGCGGCGCAGCGCATCGATGGCC
TTGCGCGGGCGCGCTACGATCTCAGCCAGATCGGCCGCCCTGTCGGCGAGGCCGTCACCGCTACACCCCGGACCGCGCCC
GTGGCCGAGGCGCCGAAGACGATCATCGTCGAGACCCCCGCCTTCCTCGTCGCGGTGGTGCCGGACGCCCCCGGCGGGCG
CCTCTCGAGCCATGACCGGCAGGTGATCGGTGCGGCGCGCGCGCTCGCCGGGCGCGAGGGCGCCGTCGCGGTCATCGTGG
AGGGGGAGTGCGAGGGGCTGGGTGCGGCCGGTGCCGACCGGATGCTCCGGCTCGAGCGCGCGAAGGGCTACGACCCGGCA
GGCCGGGCCGCCCGCATCGAGGCCGCGCTCGCAGGCGTCGGGGCACGCCACGTCCTGTTCCCGGAATCGCTCGACGGCGG
CGATCTCGCCCGCCGCGTCGCGGTGGGTCTCGGTGAGGCGCTGTTCACCAATGCCGAGGTGGTGGCCGCCAAGGGTCTGG
TCCGCCCGGCCCGGGGCCGCCGGGTCGAGCAGAGCCTCGCTCCGCCCCGCCTCGCCACCGTGGCACCCGACGCGGTCGCC
GACTATGCCGGCCCGCCGCGGGAGGCGCGCCCCCTACCCTACGAAGGGTCTGCGCTGGAAATCCCCAAAAGCATCGTCTC
GGCGACGCGCATCCCGGCCGACCCTGCGACGGTGCCGCTCTCGCTCGCCGAGTTCGTGGTGTCGGCCGGCAACGGCCTCT
CCGATCTCGACACCTTCCGCCAAGTGGTGAGCGCGCTGCACGCGACACCCGGCGCCAGCCGCGTGCTGTGCGATGCCGGG
CTGATGCCGCGCCATACCCAGGTCGGCGCCTCGGGCACGGTGCTCGCGGCGACCTGCTACTTCGCGCTCGGCATCTCCGG
CGCGCCGCAGCATCTCCAAGGTGTGGCCGGCTGCGAGCACGTGGTGGCGGTCAACACCGATCTCCACGCGGCGATGATCG
AGCGGGCCGGCCTTGCCGTGGTGCAGGATGCCCAGGCCGTGATGCCGGCCCTGCTGCGGCTGTTGGCGGAAGAGGCCGCC
GGGTCGGGGAAGGCGTCATGA

Upstream 100 bases:

>100_bases
CCTGCCCCTCCTGCACGGCGATGCTGGAGGGCGTGACCGACCGCAAGGCGGAGATCCGCGACGTGGCCGAACTCCTGCTC
CAGGCGGTGGAGGCGGGCCG

Downstream 100 bases:

>100_bases
GAATCGTGGTCCTTCTCTCCGCCGGGCTCCATCCAGTCTCCGGGGCACCCGTGCTGCCGCGGCTCGAAGCGCAGGCGATC
CGCATGGCCGCCGCGCTCGG

Product: electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSRPRRDPRAERAASLVAGEGPRPRYDRTRRATASGRPRRDPRAERAAQRIDGLARARYDLSQIGRPVGEAVTATPRTAP
VAEAPKTIIVETPAFLVAVVPDAPGGRLSSHDRQVIGAARALAGREGAVAVIVEGECEGLGAAGADRMLRLERAKGYDPA
GRAARIEAALAGVGARHVLFPESLDGGDLARRVAVGLGEALFTNAEVVAAKGLVRPARGRRVEQSLAPPRLATVAPDAVA
DYAGPPREARPLPYEGSALEIPKSIVSATRIPADPATVPLSLAEFVVSAGNGLSDLDTFRQVVSALHATPGASRVLCDAG
LMPRHTQVGASGTVLAATCYFALGISGAPQHLQGVAGCEHVVAVNTDLHAAMIERAGLAVVQDAQAVMPALLRLLAEEAA
GSGKAS

Sequences:

>Translated_406_residues
MSRPRRDPRAERAASLVAGEGPRPRYDRTRRATASGRPRRDPRAERAAQRIDGLARARYDLSQIGRPVGEAVTATPRTAP
VAEAPKTIIVETPAFLVAVVPDAPGGRLSSHDRQVIGAARALAGREGAVAVIVEGECEGLGAAGADRMLRLERAKGYDPA
GRAARIEAALAGVGARHVLFPESLDGGDLARRVAVGLGEALFTNAEVVAAKGLVRPARGRRVEQSLAPPRLATVAPDAVA
DYAGPPREARPLPYEGSALEIPKSIVSATRIPADPATVPLSLAEFVVSAGNGLSDLDTFRQVVSALHATPGASRVLCDAG
LMPRHTQVGASGTVLAATCYFALGISGAPQHLQGVAGCEHVVAVNTDLHAAMIERAGLAVVQDAQAVMPALLRLLAEEAA
GSGKAS
>Mature_405_residues
SRPRRDPRAERAASLVAGEGPRPRYDRTRRATASGRPRRDPRAERAAQRIDGLARARYDLSQIGRPVGEAVTATPRTAPV
AEAPKTIIVETPAFLVAVVPDAPGGRLSSHDRQVIGAARALAGREGAVAVIVEGECEGLGAAGADRMLRLERAKGYDPAG
RAARIEAALAGVGARHVLFPESLDGGDLARRVAVGLGEALFTNAEVVAAKGLVRPARGRRVEQSLAPPRLATVAPDAVAD
YAGPPREARPLPYEGSALEIPKSIVSATRIPADPATVPLSLAEFVVSAGNGLSDLDTFRQVVSALHATPGASRVLCDAGL
MPRHTQVGASGTVLAATCYFALGISGAPQHLQGVAGCEHVVAVNTDLHAAMIERAGLAVVQDAQAVMPALLRLLAEEAAG
SGKAS

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI189181759, Length=122, Percent_Identity=38.5245901639344, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4503607, Length=122, Percent_Identity=38.5245901639344, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1787990, Length=125, Percent_Identity=36, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17506929, Length=115, Percent_Identity=39.1304347826087, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6325261, Length=122, Percent_Identity=36.0655737704918, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17136898, Length=112, Percent_Identity=37.5, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24652801, Length=112, Percent_Identity=37.5, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 41983; Mature: 41852

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPRRDPRAERAASLVAGEGPRPRYDRTRRATASGRPRRDPRAERAAQRIDGLARARYD
CCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LSQIGRPVGEAVTATPRTAPVAEAPKTIIVETPAFLVAVVPDAPGGRLSSHDRQVIGAAR
HHHHCCHHHHHHCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHH
ALAGREGAVAVIVEGECEGLGAAGADRMLRLERAKGYDPAGRAARIEAALAGVGARHVLF
HHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEC
PESLDGGDLARRVAVGLGEALFTNAEVVAAKGLVRPARGRRVEQSLAPPRLATVAPDAVA
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHCCCCCEECCCCHHHH
DYAGPPREARPLPYEGSALEIPKSIVSATRIPADPATVPLSLAEFVVSAGNGLSDLDTFR
HCCCCCCCCCCCCCCCCHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHH
QVVSALHATPGASRVLCDAGLMPRHTQVGASGTVLAATCYFALGISGAPQHLQGVAGCEH
HHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCE
VVAVNTDLHAAMIERAGLAVVQDAQAVMPALLRLLAEEAAGSGKAS
EEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SRPRRDPRAERAASLVAGEGPRPRYDRTRRATASGRPRRDPRAERAAQRIDGLARARYD
CCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LSQIGRPVGEAVTATPRTAPVAEAPKTIIVETPAFLVAVVPDAPGGRLSSHDRQVIGAAR
HHHHCCHHHHHHCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHH
ALAGREGAVAVIVEGECEGLGAAGADRMLRLERAKGYDPAGRAARIEAALAGVGARHVLF
HHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEC
PESLDGGDLARRVAVGLGEALFTNAEVVAAKGLVRPARGRRVEQSLAPPRLATVAPDAVA
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHCCCCCEECCCCHHHH
DYAGPPREARPLPYEGSALEIPKSIVSATRIPADPATVPLSLAEFVVSAGNGLSDLDTFR
HCCCCCCCCCCCCCCCCHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHH
QVVSALHATPGASRVLCDAGLMPRHTQVGASGTVLAATCYFALGISGAPQHLQGVAGCEH
HHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCE
VVAVNTDLHAAMIERAGLAVVQDAQAVMPALLRLLAEEAAGSGKAS
EEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]