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The map label for this gene is livM [H]

Identifier: 218531619

GI number: 218531619

Start: 3886030

End: 3887211

Strand: Reverse

Name: livM [H]

Synonym: Mchl_3688

Alternate gene names: 218531619

Gene position: 3887211-3886030 (Counterclockwise)

Preceding gene: 218531620

Following gene: 218531618

Centisome position: 67.28

GC content: 64.72

Gene sequence:

>1182_bases
ATGACGAACCAGAAGACAAGTCCCATGCAGTCCCTGTCGAAGGCGGTTACCGTCAACGACAACCCCTTCATGAAGCCGGT
CGAGTGGGTCAGCCTCGCGCTGCTGGCCGGCGTGATCCTGGTGGTCCTGCCGCTCGTGCTCGACGGCTTCCGCCTCAACC
TCGTCGGCAAGTATCTCACCTACGCCTTCGTCGCCCTCGGCCTCGTCATCTGCTGGGGCTATGCCGGCATCCTCTCGCTC
GGCCAGGGCGTGTTCTTCGGCCTCGGCGGCTACTGCATGGCGATGTACTTGAAGCTGGAGGCTTCGAGCGTCGAAAATAC
GAAAATCCAGTCAACGCCGGGCATTCCCGACTTCATGGACTGGAACCAGATCACGGAGCTTCCGTGGTTCTGGCACCCGT
TCCAGAGTCTGCCGCTGACGCTGCTCCTCGTCGTCGCGGTGCCGGTGGCCTTCGCCTTCCTCATCTCGGTGGCGATGTTC
AAGCGCCGCGTTGGCGGCACCTACTTCGCCATCATCACCCAGGCCATCGCCGCGATCCTGACGATCCTGATCGTCGGCCA
GCAGGGCTACACCGGCGGCATCAACGGCATCACCGATCTGCGCACCCTCCACGGCTGGGACATCCGCCAGGATAGCGCGA
AGTTCGTCCTCTACTTCGTCAATGGCGGCCTGCTGATCGGCTGTATCCTGATGGCGCAGTACGTGAAGAAGTCGAAGCTC
GGGCGCATTCTCGTCGCCATGCGCGAAAAGGAGGACCGGGTCCGGTTCTCGGGCTACTCGGTGGCGGGCTTCAAGGTGTT
CGCCTACTGCCTCGCGGCTGCCTTCGCCGCGATCGGCGGGGCGATGTTCACCCTCCAAGTCGGGTTCATGTCACCCTCCT
TCGTCGGCATCGTGCCCTCGGTCGAGATGGTGATCTACACCGCGGTCGGCGGGCGCCTCTCGCTCTTCGGCGCGGTCTGG
GGAACGCTGCTGGTCAACTGGGCCAAGACGAGCTTCTCCGAATCCTTCCCCGACCTCTGGCTGTTCGGCCTCGGCGGCCT
GTTCATCGCCGTGGTGCTGATCTTCCCCAACGGTCTCGCCGGCATCTGGCGCGAGCACATCGAACCCCGCCTGTTCCGCA
AGGCCAAGGGTCTGGCCCCCGTCGCCGGCCCCGCCCTGCCCCACGGCACCCCGGCCGAGTGA

Upstream 100 bases:

>100_bases
ATGGCCAAGGTGCTCACCCTGCTCGCGGTGGTGGGAATCCTGATGCTGCGGCCGCAGGGCCTGTTCACCCTCAAGGTCCG
TCGCTGAGGAGCGCGCCCCG

Downstream 100 bases:

>100_bases
GGACGAAACCCATGAACGCGGCCATCCTTCCTTCATCCGCCCCCATCGGTACGCCCGCCGACGAGAAGGACTTCCTGCTG
GCGGTCGAGGCGCTGACCGT

Product: urea ABC transporter permease UrtC

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTNQKTSPMQSLSKAVTVNDNPFMKPVEWVSLALLAGVILVVLPLVLDGFRLNLVGKYLTYAFVALGLVICWGYAGILSL
GQGVFFGLGGYCMAMYLKLEASSVENTKIQSTPGIPDFMDWNQITELPWFWHPFQSLPLTLLLVVAVPVAFAFLISVAMF
KRRVGGTYFAIITQAIAAILTILIVGQQGYTGGINGITDLRTLHGWDIRQDSAKFVLYFVNGGLLIGCILMAQYVKKSKL
GRILVAMREKEDRVRFSGYSVAGFKVFAYCLAAAFAAIGGAMFTLQVGFMSPSFVGIVPSVEMVIYTAVGGRLSLFGAVW
GTLLVNWAKTSFSESFPDLWLFGLGGLFIAVVLIFPNGLAGIWREHIEPRLFRKAKGLAPVAGPALPHGTPAE

Sequences:

>Translated_393_residues
MTNQKTSPMQSLSKAVTVNDNPFMKPVEWVSLALLAGVILVVLPLVLDGFRLNLVGKYLTYAFVALGLVICWGYAGILSL
GQGVFFGLGGYCMAMYLKLEASSVENTKIQSTPGIPDFMDWNQITELPWFWHPFQSLPLTLLLVVAVPVAFAFLISVAMF
KRRVGGTYFAIITQAIAAILTILIVGQQGYTGGINGITDLRTLHGWDIRQDSAKFVLYFVNGGLLIGCILMAQYVKKSKL
GRILVAMREKEDRVRFSGYSVAGFKVFAYCLAAAFAAIGGAMFTLQVGFMSPSFVGIVPSVEMVIYTAVGGRLSLFGAVW
GTLLVNWAKTSFSESFPDLWLFGLGGLFIAVVLIFPNGLAGIWREHIEPRLFRKAKGLAPVAGPALPHGTPAE
>Mature_392_residues
TNQKTSPMQSLSKAVTVNDNPFMKPVEWVSLALLAGVILVVLPLVLDGFRLNLVGKYLTYAFVALGLVICWGYAGILSLG
QGVFFGLGGYCMAMYLKLEASSVENTKIQSTPGIPDFMDWNQITELPWFWHPFQSLPLTLLLVVAVPVAFAFLISVAMFK
RRVGGTYFAIITQAIAAILTILIVGQQGYTGGINGITDLRTLHGWDIRQDSAKFVLYFVNGGLLIGCILMAQYVKKSKLG
RILVAMREKEDRVRFSGYSVAGFKVFAYCLAAAFAAIGGAMFTLQVGFMSPSFVGIVPSVEMVIYTAVGGRLSLFGAVWG
TLLVNWAKTSFSESFPDLWLFGLGGLFIAVVLIFPNGLAGIWREHIEPRLFRKAKGLAPVAGPALPHGTPAE

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=332, Percent_Identity=25.6024096385542, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 42699; Mature: 42568

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQKTSPMQSLSKAVTVNDNPFMKPVEWVSLALLAGVILVVLPLVLDGFRLNLVGKYLT
CCCCCCCHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
YAFVALGLVICWGYAGILSLGQGVFFGLGGYCMAMYLKLEASSVENTKIQSTPGIPDFMD
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCC
WNQITELPWFWHPFQSLPLTLLLVVAVPVAFAFLISVAMFKRRVGGTYFAIITQAIAAIL
CHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
TILIVGQQGYTGGINGITDLRTLHGWDIRQDSAKFVLYFVNGGLLIGCILMAQYVKKSKL
HHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHH
GRILVAMREKEDRVRFSGYSVAGFKVFAYCLAAAFAAIGGAMFTLQVGFMSPSFVGIVPS
HHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCC
VEMVIYTAVGGRLSLFGAVWGTLLVNWAKTSFSESFPDLWLFGLGGLFIAVVLIFPNGLA
HHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHH
GIWREHIEPRLFRKAKGLAPVAGPALPHGTPAE
HHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TNQKTSPMQSLSKAVTVNDNPFMKPVEWVSLALLAGVILVVLPLVLDGFRLNLVGKYLT
CCCCCCHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
YAFVALGLVICWGYAGILSLGQGVFFGLGGYCMAMYLKLEASSVENTKIQSTPGIPDFMD
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCC
WNQITELPWFWHPFQSLPLTLLLVVAVPVAFAFLISVAMFKRRVGGTYFAIITQAIAAIL
CHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
TILIVGQQGYTGGINGITDLRTLHGWDIRQDSAKFVLYFVNGGLLIGCILMAQYVKKSKL
HHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHH
GRILVAMREKEDRVRFSGYSVAGFKVFAYCLAAAFAAIGGAMFTLQVGFMSPSFVGIVPS
HHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCC
VEMVIYTAVGGRLSLFGAVWGTLLVNWAKTSFSESFPDLWLFGLGGLFIAVVLIFPNGLA
HHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHH
GIWREHIEPRLFRKAKGLAPVAGPALPHGTPAE
HHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]