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The map label for this gene is ilvA [H]

Identifier: 218531205

GI number: 218531205

Start: 3436758

End: 3438290

Strand: Reverse

Name: ilvA [H]

Synonym: Mchl_3256

Alternate gene names: 218531205

Gene position: 3438290-3436758 (Counterclockwise)

Preceding gene: 218531206

Following gene: 218531202

Centisome position: 59.51

GC content: 69.41

Gene sequence:

>1533_bases
GTGACCGACTACATCAAGAAGATCCTCTCCGCCCGCGTCTACGACGTGGCGATCGAGAGCCCCCTCGATCCGATGCCCCG
CCTGACGAAGCGGCTCGGCCGTCCCGTGCTGCTCAAGCGCGAGGATCTGCAGCCGGTCTTCTCGTTCAAGCTGCGCGGCG
CCTACAACAAGATGGCCTCGCTGCCCCAAGAGCGGCTCGAGAGCGGCGTGATCTGCGCCTCGGCCGGCAACCACGCGCAG
GGCGTGGCCCTGGCGGCGGCCAAGCTCGGCGTGCGGGCGGTGATCGTGATGCCGCGCACGACGCCCGCGATCAAGGTCGA
TGCCTGCCGGGCCCGCGGCGCCGAGGTCGTGCTGCACGGCGACGCCTTCGACGAGGCTCTGGCGGAGGCTCGGCGCCTCG
AAGCGCAGTGGGGCCTGACCTTCCTGCACCCGTTCGACGATCCCGAGGTGATCGCCGGACAGGGTACGATCGGCATGGAG
ATCTTGCATCAGCATACCGGACCGATCGAGGCGATCTTCGTGCCGATCGGCGGCGGTGGCTTGGCCGCCGGCATCGCCAC
CTTCGTGAAATATCTGCGCCCCGAGACCAAGGTGATCGGCGTCGAGCCGGACGACGCCGCCACCATGTCCGAGGCGCTCC
GGGCGGGCGACCGGGTGATGCTGCCGAGCGTCGGGCTGTTCGCCGACGGCGTCGCGGTGCGGCAGGCCGGCGAGGAGACC
TTCCGGCTGTGCCGCGAGCATCTCGACGCGGTCATCACCGTCGATACCGATGCGATGTGCGCCGCGGTCAAGGACATCTT
CGACGATACCCGCGCTATCTCCGAGCCGTCGGGCGCGCTGAGTCTGGCCGGCGCGAAGGCTTGGTCGGCGAAGAATCCCG
GTGCCGGGCCGCTGGTGGCGATCTCGTCGGGCGCCAACCTCAACTTCGACCGCCTGCGCCACATCGCCGAGCGGGCGGAG
ATCGGCGAGGAACGCGAGGTGTTGCTCGGCGTCACCATCCCCGAACGGCCGGGCGCCTACCGCGCCTTCATCGGCGCGCT
CGGGCCCCGCGCGATCACCGAATTCAACTACCGCTACGCGCAGGGCAGCGACGCGCGCATCTTCGTCGGCATCAACCTGC
CCGGCGGCAAGCCCGAGAAGCGCGACCTGATCGCGGCCCTGGAGAGCGCCGGCTACCGCGTCGCCGATATGAGCGACAAC
GAGATGGCCAAGGTGCATGTCCGCTACATGGTGGGTGGACGCGCGGCGGGGCTCGCCGACGAGCGGCTCTACCGCTTCCA
GTTCCCCGAGCGGCCCGGCGCGCTGATGAAGTTCCTCGAAGCGCTCGGCGACGGCTTCAACATCAGCTTGTTCCACTACC
GCAATCACGGCGCCGATTACGGCCGCGTGCTCGCGGGGATCGAGGTGCCGGCGGCGGAGCGCGCCCGTTTCGACGCCGCC
CTCGAAGCGCTCGCCTATCCCTATGTCGATGAGACCGACAACCCGGCTTACCGGCTGTTCCTCGACAACGGCATCGGCGC
AGCCGGCCACTGA

Upstream 100 bases:

>100_bases
CGGTGCGGCCTCTCCCCTCGCATCCCGCCCTCGCATCCCGGCCGCGGAAGGACTAAGTCCCGGGCGTGCCCTGCCCGATG
ACGCGGCCGAAAGCCTGCCC

Downstream 100 bases:

>100_bases
CGCACCGTCGCGCCCGGCCCGCCTCCGTCACGGGGGCCTTTGCCGGTCCTCCGGCGCGGACCGGATCGCGTCACGCCGTG
GCGTGAGCGGGCTGGCTGCG

Product: threonine dehydratase, biosynthetic

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MTDYIKKILSARVYDVAIESPLDPMPRLTKRLGRPVLLKREDLQPVFSFKLRGAYNKMASLPQERLESGVICASAGNHAQ
GVALAAAKLGVRAVIVMPRTTPAIKVDACRARGAEVVLHGDAFDEALAEARRLEAQWGLTFLHPFDDPEVIAGQGTIGME
ILHQHTGPIEAIFVPIGGGGLAAGIATFVKYLRPETKVIGVEPDDAATMSEALRAGDRVMLPSVGLFADGVAVRQAGEET
FRLCREHLDAVITVDTDAMCAAVKDIFDDTRAISEPSGALSLAGAKAWSAKNPGAGPLVAISSGANLNFDRLRHIAERAE
IGEEREVLLGVTIPERPGAYRAFIGALGPRAITEFNYRYAQGSDARIFVGINLPGGKPEKRDLIAALESAGYRVADMSDN
EMAKVHVRYMVGGRAAGLADERLYRFQFPERPGALMKFLEALGDGFNISLFHYRNHGADYGRVLAGIEVPAAERARFDAA
LEALAYPYVDETDNPAYRLFLDNGIGAAGH

Sequences:

>Translated_510_residues
MTDYIKKILSARVYDVAIESPLDPMPRLTKRLGRPVLLKREDLQPVFSFKLRGAYNKMASLPQERLESGVICASAGNHAQ
GVALAAAKLGVRAVIVMPRTTPAIKVDACRARGAEVVLHGDAFDEALAEARRLEAQWGLTFLHPFDDPEVIAGQGTIGME
ILHQHTGPIEAIFVPIGGGGLAAGIATFVKYLRPETKVIGVEPDDAATMSEALRAGDRVMLPSVGLFADGVAVRQAGEET
FRLCREHLDAVITVDTDAMCAAVKDIFDDTRAISEPSGALSLAGAKAWSAKNPGAGPLVAISSGANLNFDRLRHIAERAE
IGEEREVLLGVTIPERPGAYRAFIGALGPRAITEFNYRYAQGSDARIFVGINLPGGKPEKRDLIAALESAGYRVADMSDN
EMAKVHVRYMVGGRAAGLADERLYRFQFPERPGALMKFLEALGDGFNISLFHYRNHGADYGRVLAGIEVPAAERARFDAA
LEALAYPYVDETDNPAYRLFLDNGIGAAGH
>Mature_509_residues
TDYIKKILSARVYDVAIESPLDPMPRLTKRLGRPVLLKREDLQPVFSFKLRGAYNKMASLPQERLESGVICASAGNHAQG
VALAAAKLGVRAVIVMPRTTPAIKVDACRARGAEVVLHGDAFDEALAEARRLEAQWGLTFLHPFDDPEVIAGQGTIGMEI
LHQHTGPIEAIFVPIGGGGLAAGIATFVKYLRPETKVIGVEPDDAATMSEALRAGDRVMLPSVGLFADGVAVRQAGEETF
RLCREHLDAVITVDTDAMCAAVKDIFDDTRAISEPSGALSLAGAKAWSAKNPGAGPLVAISSGANLNFDRLRHIAERAEI
GEEREVLLGVTIPERPGAYRAFIGALGPRAITEFNYRYAQGSDARIFVGINLPGGKPEKRDLIAALESAGYRVADMSDNE
MAKVHVRYMVGGRAAGLADERLYRFQFPERPGALMKFLEALGDGFNISLFHYRNHGADYGRVLAGIEVPAAERARFDAAL
EALAYPYVDETDNPAYRLFLDNGIGAAGH

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=302, Percent_Identity=32.7814569536424, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI33469958, Length=315, Percent_Identity=28.2539682539683, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI19923959, Length=273, Percent_Identity=31.8681318681319, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1790207, Length=500, Percent_Identity=55.8, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI1789505, Length=315, Percent_Identity=36.5079365079365, Blast_Score=173, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17537387, Length=321, Percent_Identity=34.8909657320872, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71991565, Length=312, Percent_Identity=33.6538461538462, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17508781, Length=253, Percent_Identity=32.4110671936759, Blast_Score=125, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6320930, Length=514, Percent_Identity=50.9727626459144, Blast_Score=484, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6322631, Length=303, Percent_Identity=35.973597359736, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6319788, Length=263, Percent_Identity=26.9961977186312, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355833, Length=326, Percent_Identity=34.0490797546012, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24645328, Length=251, Percent_Identity=32.2709163346614, Blast_Score=102, Evalue=9e-22,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 54946; Mature: 54815

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYIKKILSARVYDVAIESPLDPMPRLTKRLGRPVLLKREDLQPVFSFKLRGAYNKMAS
CCHHHHHHHHHHHHEEEECCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHC
LPQERLESGVICASAGNHAQGVALAAAKLGVRAVIVMPRTTPAIKVDACRARGAEVVLHG
CCHHHHHCCEEEECCCCCCCHHHHHHHHCCEEEEEEECCCCCCEEEEHHHCCCCEEEEEC
DAFDEALAEARRLEAQWGLTFLHPFDDPEVIAGQGTIGMEILHQHTGPIEAIFVPIGGGG
CHHHHHHHHHHHHHHHCCEEEECCCCCCCEEECCCCHHHHHHHCCCCCEEEEEEEECCCH
LAAGIATFVKYLRPETKVIGVEPDDAATMSEALRAGDRVMLPSVGLFADGVAVRQAGEET
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCEEECCCCCHHHCCHHHHHCCHHH
FRLCREHLDAVITVDTDAMCAAVKDIFDDTRAISEPSGALSLAGAKAWSAKNPGAGPLVA
HHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCEEE
ISSGANLNFDRLRHIAERAEIGEEREVLLGVTIPERPGAYRAFIGALGPRAITEFNYRYA
EECCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHHCCEEEC
QGSDARIFVGINLPGGKPEKRDLIAALESAGYRVADMSDNEMAKVHVRYMVGGRAAGLAD
CCCCCEEEEEEECCCCCCHHHHHHHHHHHCCEEEEECCCCCEEEEEEEEEECCCCCCCHH
ERLYRFQFPERPGALMKFLEALGDGFNISLFHYRNHGADYGRVLAGIEVPAAERARFDAA
HHEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCHHHEEECCCCCCHHHHHHHHH
LEALAYPYVDETDNPAYRLFLDNGIGAAGH
HHHHHCCCCCCCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure 
TDYIKKILSARVYDVAIESPLDPMPRLTKRLGRPVLLKREDLQPVFSFKLRGAYNKMAS
CHHHHHHHHHHHHEEEECCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHC
LPQERLESGVICASAGNHAQGVALAAAKLGVRAVIVMPRTTPAIKVDACRARGAEVVLHG
CCHHHHHCCEEEECCCCCCCHHHHHHHHCCEEEEEEECCCCCCEEEEHHHCCCCEEEEEC
DAFDEALAEARRLEAQWGLTFLHPFDDPEVIAGQGTIGMEILHQHTGPIEAIFVPIGGGG
CHHHHHHHHHHHHHHHCCEEEECCCCCCCEEECCCCHHHHHHHCCCCCEEEEEEEECCCH
LAAGIATFVKYLRPETKVIGVEPDDAATMSEALRAGDRVMLPSVGLFADGVAVRQAGEET
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCEEECCCCCHHHCCHHHHHCCHHH
FRLCREHLDAVITVDTDAMCAAVKDIFDDTRAISEPSGALSLAGAKAWSAKNPGAGPLVA
HHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCEEE
ISSGANLNFDRLRHIAERAEIGEEREVLLGVTIPERPGAYRAFIGALGPRAITEFNYRYA
EECCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHHCCEEEC
QGSDARIFVGINLPGGKPEKRDLIAALESAGYRVADMSDNEMAKVHVRYMVGGRAAGLAD
CCCCCEEEEEEECCCCCCHHHHHHHHHHHCCEEEEECCCCCEEEEEEEEEECCCCCCCHH
ERLYRFQFPERPGALMKFLEALGDGFNISLFHYRNHGADYGRVLAGIEVPAAERARFDAA
HHEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCHHHEEECCCCCCHHHHHHHHH
LEALAYPYVDETDNPAYRLFLDNGIGAAGH
HHHHHCCCCCCCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA