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The map label for this gene is pepA [H]

Identifier: 218531152

GI number: 218531152

Start: 3381162

End: 3382571

Strand: Reverse

Name: pepA [H]

Synonym: Mchl_3202

Alternate gene names: 218531152

Gene position: 3382571-3381162 (Counterclockwise)

Preceding gene: 218531157

Following gene: 218531149

Centisome position: 58.54

GC content: 72.41

Gene sequence:

>1410_bases
ATGTCCGCACCTCTCTCGCAGCACGGCCCCTCCCTTCTCGATGCAGGCGCGGATGCGGTCCCGATCCGCTGCGCGACGGA
GGAAGGATGGGGCGCCGTCGCCGCCGGATTGCCGCCGCTCCAGCGCAGCTTTGCCGACGCCACCGGCTTTGCCCCCAAGG
CCGGTCGCGTCGCCCTCCTACCCGGAGAGGACGGTGGTCTCGGCCGCGTGCTGTTCGGCCTGGGCGACGCGAAGGCAGGC
GGTCGCGATCGCTTTCTCGCCGGCAAGCTGCCGGGCGCCCTGCCGCCCGGTAATTACCGGTTCGAGCCCTCCGACGGTTT
CGATGAGAGCGAGGCGACGCTGGCGTGGCTGCTCGGCAGCTACCGGTTCGAGCGCTACCGCAAGCCGGGCGATCCGCGCC
CGCGCCTCGTCGCCCCTGACGGAATCGACGCGGCGGCGATCGAACGGCTCGCGGCTGCGGTCGCGGCCGGACGCGACCTC
GTCAACACCCCGGCGAACGATCTCGGGCCGGCCGAAGTCGAGGCCGCCGTGCGGGCGCTGGGCGAGCGGTTCGGTGCGAC
GGTTTCCGTGACCGTCGGCGCGGATCTCGAGAAAGAGTTTCCTCTCGTCCATGCCGTCGGCGCCGCCTCGCCGCGGGCGC
CCCGCCTCATCGATCTCACCTGGGGGGCCGAGGGCGCGCCGCGGGTGACGCTGGTCGGCAAGGGCGTCGTGTTCGACACC
GGCGGGCTCGACATCAAGCCGGCCTCCAACATGCTGCTGATGAAGAAGGATCTGGGCGGCGCCGCCGCGGCCCTGGCGGC
GGCCGAGATGATCATGGGCGCCGGCCTGCCCGTGCGGCTGCGGCTGATCGTGCCCAGCGTTGAGAACGCCATTGCCGGCG
ACGCCTTCCGGCCCGGCGACGTCATCCGCTCCCGCGCCGGCCTCACCGTCGAGATCGGCAACACCGACGCGGAGGGGCGC
CTGATCCTCGCCGACGCGCTGGCGCTGGCCGATGCCGAGGCGCCGGACCTCATCCTCGATTTCGCGACGCTGACCGGCGC
CGCCCGCGTAGCGCTGGGTCCCGATCTGCCGGCCTTCTTCACCGAGGACGAGGGGTTGGCGGCTGCGGTCGCGGAAGCGG
GCCTGCGCGTCAACGATCCGGTCTGGCGCCTGCCCCTGCACCTACCCTATGCGAGCCTACTCGATTCGAAGGTCGCCGAC
CTCAATAACGCGCCGGGCGGTGGCTTTGCCGGGGCGATCACCGCCGCCCTGTTCCTGCGCCGCTTCGTGCGCCGGACCCA
GGCGCACGTACATTTCGACCTCTACGGCTGGAACCCCTCGACCAAGCCCGGCCGGCCGGAGGGCGGGGAGGTCCAGACCG
CCCGCCTTGCCTACGCCCTGGTGGCCGAACGCTACGGCCGCGACGTCTGA

Upstream 100 bases:

>100_bases
CATGGTGTCCTCTCCCCCCAATGCCACGGCCGGCGCTTGCGCCGTACCGATGGCGGGGTGATAGAGCGTTAACCCTAATG
GCCGGTTAAGCTTATTTTCC

Downstream 100 bases:

>100_bases
CGGCCTTCCGGGGCGGCGGTCGCCGGCTCGGCCCTGTTCTGCGATGGGGCGCTCGCTGTTCAGCGGCGCCCGGTCGGATG
CGGAGGAGCCGGCAATTGTC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSAPLSQHGPSLLDAGADAVPIRCATEEGWGAVAAGLPPLQRSFADATGFAPKAGRVALLPGEDGGLGRVLFGLGDAKAG
GRDRFLAGKLPGALPPGNYRFEPSDGFDESEATLAWLLGSYRFERYRKPGDPRPRLVAPDGIDAAAIERLAAAVAAGRDL
VNTPANDLGPAEVEAAVRALGERFGATVSVTVGADLEKEFPLVHAVGAASPRAPRLIDLTWGAEGAPRVTLVGKGVVFDT
GGLDIKPASNMLLMKKDLGGAAAALAAAEMIMGAGLPVRLRLIVPSVENAIAGDAFRPGDVIRSRAGLTVEIGNTDAEGR
LILADALALADAEAPDLILDFATLTGAARVALGPDLPAFFTEDEGLAAAVAEAGLRVNDPVWRLPLHLPYASLLDSKVAD
LNNAPGGGFAGAITAALFLRRFVRRTQAHVHFDLYGWNPSTKPGRPEGGEVQTARLAYALVAERYGRDV

Sequences:

>Translated_469_residues
MSAPLSQHGPSLLDAGADAVPIRCATEEGWGAVAAGLPPLQRSFADATGFAPKAGRVALLPGEDGGLGRVLFGLGDAKAG
GRDRFLAGKLPGALPPGNYRFEPSDGFDESEATLAWLLGSYRFERYRKPGDPRPRLVAPDGIDAAAIERLAAAVAAGRDL
VNTPANDLGPAEVEAAVRALGERFGATVSVTVGADLEKEFPLVHAVGAASPRAPRLIDLTWGAEGAPRVTLVGKGVVFDT
GGLDIKPASNMLLMKKDLGGAAAALAAAEMIMGAGLPVRLRLIVPSVENAIAGDAFRPGDVIRSRAGLTVEIGNTDAEGR
LILADALALADAEAPDLILDFATLTGAARVALGPDLPAFFTEDEGLAAAVAEAGLRVNDPVWRLPLHLPYASLLDSKVAD
LNNAPGGGFAGAITAALFLRRFVRRTQAHVHFDLYGWNPSTKPGRPEGGEVQTARLAYALVAERYGRDV
>Mature_468_residues
SAPLSQHGPSLLDAGADAVPIRCATEEGWGAVAAGLPPLQRSFADATGFAPKAGRVALLPGEDGGLGRVLFGLGDAKAGG
RDRFLAGKLPGALPPGNYRFEPSDGFDESEATLAWLLGSYRFERYRKPGDPRPRLVAPDGIDAAAIERLAAAVAAGRDLV
NTPANDLGPAEVEAAVRALGERFGATVSVTVGADLEKEFPLVHAVGAASPRAPRLIDLTWGAEGAPRVTLVGKGVVFDTG
GLDIKPASNMLLMKKDLGGAAAALAAAEMIMGAGLPVRLRLIVPSVENAIAGDAFRPGDVIRSRAGLTVEIGNTDAEGRL
ILADALALADAEAPDLILDFATLTGAARVALGPDLPAFFTEDEGLAAAVAEAGLRVNDPVWRLPLHLPYASLLDSKVADL
NNAPGGGFAGAITAALFLRRFVRRTQAHVHFDLYGWNPSTKPGRPEGGEVQTARLAYALVAERYGRDV

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=299, Percent_Identity=36.7892976588629, Blast_Score=175, Evalue=9e-44,
Organism=Homo sapiens, GI47155554, Length=271, Percent_Identity=35.4243542435424, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI87082123, Length=324, Percent_Identity=40.7407407407407, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1790710, Length=284, Percent_Identity=37.3239436619718, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17556903, Length=285, Percent_Identity=38.2456140350877, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17565172, Length=225, Percent_Identity=32.4444444444444, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24661038, Length=316, Percent_Identity=33.5443037974684, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21355725, Length=326, Percent_Identity=32.8220858895706, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI221379063, Length=287, Percent_Identity=36.5853658536585, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI221379062, Length=287, Percent_Identity=36.5853658536585, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI21357381, Length=287, Percent_Identity=36.5853658536585, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24662227, Length=362, Percent_Identity=28.1767955801105, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI20129969, Length=283, Percent_Identity=30.7420494699647, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21355645, Length=295, Percent_Identity=28.135593220339, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24662223, Length=295, Percent_Identity=28.135593220339, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI161077148, Length=295, Percent_Identity=29.8305084745763, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI20130057, Length=295, Percent_Identity=29.8305084745763, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646701, Length=200, Percent_Identity=35.5, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646703, Length=200, Percent_Identity=35.5, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21358201, Length=200, Percent_Identity=35.5, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922386, Length=337, Percent_Identity=27.893175074184, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI20129963, Length=320, Percent_Identity=29.0625, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 48595; Mature: 48464

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPLSQHGPSLLDAGADAVPIRCATEEGWGAVAAGLPPLQRSFADATGFAPKAGRVALL
CCCCCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEE
PGEDGGLGRVLFGLGDAKAGGRDRFLAGKLPGALPPGNYRFEPSDGFDESEATLAWLLGS
CCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHH
YRFERYRKPGDPRPRLVAPDGIDAAAIERLAAAVAAGRDLVNTPANDLGPAEVEAAVRAL
HHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHH
GERFGATVSVTVGADLEKEFPLVHAVGAASPRAPRLIDLTWGAEGAPRVTLVGKGVVFDT
HHHHCCEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCEEEEEECCEEEEC
GGLDIKPASNMLLMKKDLGGAAAALAAAEMIMGAGLPVRLRLIVPSVENAIAGDAFRPGD
CCCEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHCCCCCCCHH
VIRSRAGLTVEIGNTDAEGRLILADALALADAEAPDLILDFATLTGAARVALGPDLPAFF
HHHHCCCCEEEECCCCCCCCEEEEEHHHHCCCCCCHHEEEHHHHCCCEEEEECCCCCCEE
TEDEGLAAAVAEAGLRVNDPVWRLPLHLPYASLLDSKVADLNNAPGGGFAGAITAALFLR
ECCCCHHHHHHHCCCEECCCEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
RFVRRTQAHVHFDLYGWNPSTKPGRPEGGEVQTARLAYALVAERYGRDV
HHHHHHHCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SAPLSQHGPSLLDAGADAVPIRCATEEGWGAVAAGLPPLQRSFADATGFAPKAGRVALL
CCCCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEE
PGEDGGLGRVLFGLGDAKAGGRDRFLAGKLPGALPPGNYRFEPSDGFDESEATLAWLLGS
CCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHH
YRFERYRKPGDPRPRLVAPDGIDAAAIERLAAAVAAGRDLVNTPANDLGPAEVEAAVRAL
HHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHH
GERFGATVSVTVGADLEKEFPLVHAVGAASPRAPRLIDLTWGAEGAPRVTLVGKGVVFDT
HHHHCCEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCEEEEEECCEEEEC
GGLDIKPASNMLLMKKDLGGAAAALAAAEMIMGAGLPVRLRLIVPSVENAIAGDAFRPGD
CCCEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHCCCCCCCHH
VIRSRAGLTVEIGNTDAEGRLILADALALADAEAPDLILDFATLTGAARVALGPDLPAFF
HHHHCCCCEEEECCCCCCCCEEEEEHHHHCCCCCCHHEEEHHHHCCCEEEEECCCCCCEE
TEDEGLAAAVAEAGLRVNDPVWRLPLHLPYASLLDSKVADLNNAPGGGFAGAITAALFLR
ECCCCHHHHHHHCCCEECCCEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
RFVRRTQAHVHFDLYGWNPSTKPGRPEGGEVQTARLAYALVAERYGRDV
HHHHHHHCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA