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The map label for this gene is deoA [H]

Identifier: 218531140

GI number: 218531140

Start: 3371033

End: 3372343

Strand: Reverse

Name: deoA [H]

Synonym: Mchl_3190

Alternate gene names: 218531140

Gene position: 3372343-3371033 (Counterclockwise)

Preceding gene: 218531141

Following gene: 218531135

Centisome position: 58.37

GC content: 72.46

Gene sequence:

>1311_bases
ATGAGACTTCCCCAGGAGATCATCCGCGACAAGCGCGACGGACACGCGCTGTCGGAGGCCGACATCGCCGGCTTCATCGA
GGGGCTGACGCAGGATCAGGTCACCGAGGGGCAGGCCGCGGCGTTTGCCATGGCAGTGTTCTTCCGCGGCCTCTCGCTCG
ACGAGCGCGTGGCGCTGACCCGCGCCATGACGCATTCGGGCACGGTGCTCGCGTGGGATCTGCCCGGCCCCGTCCTCGAC
AAGCACTCCACCGGCGGCGTCGGTGACACCGTAAGCCTTCCGCTCGCGGCGATGGTCTCCGCCTGCGGCGGCTACGTGCC
GATGATCTCCGGGCGCGGCCTGGGGCATACCGGCGGCACGCTGGACAAGCTCGCGAGCATCCCCGGCTACGACGTGACGC
CGGGCCTCGATCGCTTCCGCAAGGTCACGGCCGAGGCCGGCTGCGCCATCATCGGCCAGACCGCCGAGCTCGCGCCGGCC
GACCGGCGCCTGTACGCGATCCGCGACGTCACCGGGACGGTGGAATCGCTCGATCTTATCACCGCATCGATCCTGTCGAA
GAAGCTCGCGGCGGGGCTCCAGGGCCTCGTCATGGATGTGAAGACCGGCTCCGGCGCCTTCATGGCCCGCCGCGAGGATG
CGCGGGCGCTTGCCGACAGCATCGTAACGGTCGCGAACGCGGCGGGCTTGCGCACGCGCGCGCTCATCACCGACATGGAT
GCCCCGCTGGCCTCCTGCGCCGGCAACGCGGTCGAGGTGGCCTATGCCGTCGATTACCTCACCGGTCGCGCCCGCGAACC
GCGCTTCCACGCCGTGACGATGGCGCTGGCCGTCGAGATGCTGGTGATCGGGGGGCTGGCTGCAAACATCGCGGAGGCAG
AGGGGCGGCTGACGGCGGCGCTCGAATCGGGCCGGGCCTGCGAGGCCTTCGCACGGATGGTGGCGGCGCTGGGCGGCCCC
GGTGACTTCATCGAGGCAGCGGACCGGCACCTGCCCCGGGCGCCGGTCGTGCGGCCGGTGCCGGCGCAGGAAGCGGGCGT
GGTGGAGGCGGTGGAGACCCGCGCCATCGGCCTCGCGGTGATCGGCCTCGGCGGCGGGCGCACCCGGCCGCAGGACGCCA
TCGACGCCCGCGTCGGTTTCACCGGCCTCGCGCGGCCGGGCGACCAACTGTCACCGAACGATCCGATCGGCATCGTCCAC
GCCGCGGACGAGGCCGCCGCCGAGCGGGCAGCGGCATCGCTCCGGGCGGCCTATCGGATCGGTGCAACGCCGCCGGAGCC
ACGCGCGGCCGTAGGGGAGCGTTTGGGCTGA

Upstream 100 bases:

>100_bases
CCGACCGGATGATGGGGCCGGATTGGGTGAGCCCGAACACCTTCCGCATCGGAGCCAGCGCGCTCCACGCCGAACTCGTG
CGCGCCGGTGAGGCTGCCCG

Downstream 100 bases:

>100_bases
GCGAGCGGCTTCAGCCCACCTCACGCCTACCAGTGGTGGCGGTGGCTCCAATGCCGGCGGTGATGGCCCCAGTGGCCGTG
ATGGTGATGGCGGTGGCCCC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MRLPQEIIRDKRDGHALSEADIAGFIEGLTQDQVTEGQAAAFAMAVFFRGLSLDERVALTRAMTHSGTVLAWDLPGPVLD
KHSTGGVGDTVSLPLAAMVSACGGYVPMISGRGLGHTGGTLDKLASIPGYDVTPGLDRFRKVTAEAGCAIIGQTAELAPA
DRRLYAIRDVTGTVESLDLITASILSKKLAAGLQGLVMDVKTGSGAFMARREDARALADSIVTVANAAGLRTRALITDMD
APLASCAGNAVEVAYAVDYLTGRAREPRFHAVTMALAVEMLVIGGLAANIAEAEGRLTAALESGRACEAFARMVAALGGP
GDFIEAADRHLPRAPVVRPVPAQEAGVVEAVETRAIGLAVIGLGGGRTRPQDAIDARVGFTGLARPGDQLSPNDPIGIVH
AADEAAAERAAASLRAAYRIGATPPEPRAAVGERLG

Sequences:

>Translated_436_residues
MRLPQEIIRDKRDGHALSEADIAGFIEGLTQDQVTEGQAAAFAMAVFFRGLSLDERVALTRAMTHSGTVLAWDLPGPVLD
KHSTGGVGDTVSLPLAAMVSACGGYVPMISGRGLGHTGGTLDKLASIPGYDVTPGLDRFRKVTAEAGCAIIGQTAELAPA
DRRLYAIRDVTGTVESLDLITASILSKKLAAGLQGLVMDVKTGSGAFMARREDARALADSIVTVANAAGLRTRALITDMD
APLASCAGNAVEVAYAVDYLTGRAREPRFHAVTMALAVEMLVIGGLAANIAEAEGRLTAALESGRACEAFARMVAALGGP
GDFIEAADRHLPRAPVVRPVPAQEAGVVEAVETRAIGLAVIGLGGGRTRPQDAIDARVGFTGLARPGDQLSPNDPIGIVH
AADEAAAERAAASLRAAYRIGATPPEPRAAVGERLG
>Mature_436_residues
MRLPQEIIRDKRDGHALSEADIAGFIEGLTQDQVTEGQAAAFAMAVFFRGLSLDERVALTRAMTHSGTVLAWDLPGPVLD
KHSTGGVGDTVSLPLAAMVSACGGYVPMISGRGLGHTGGTLDKLASIPGYDVTPGLDRFRKVTAEAGCAIIGQTAELAPA
DRRLYAIRDVTGTVESLDLITASILSKKLAAGLQGLVMDVKTGSGAFMARREDARALADSIVTVANAAGLRTRALITDMD
APLASCAGNAVEVAYAVDYLTGRAREPRFHAVTMALAVEMLVIGGLAANIAEAEGRLTAALESGRACEAFARMVAALGGP
GDFIEAADRHLPRAPVVRPVPAQEAGVVEAVETRAIGLAVIGLGGGRTRPQDAIDARVGFTGLARPGDQLSPNDPIGIVH
AADEAAAERAAASLRAAYRIGATPPEPRAAVGERLG

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=409, Percent_Identity=44.7432762836186, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI4503445, Length=409, Percent_Identity=44.7432762836186, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI166158922, Length=409, Percent_Identity=44.7432762836186, Blast_Score=267, Evalue=1e-71,
Organism=Escherichia coli, GI1790842, Length=438, Percent_Identity=56.3926940639269, Blast_Score=473, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 44963; Mature: 44963

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLPQEIIRDKRDGHALSEADIAGFIEGLTQDQVTEGQAAAFAMAVFFRGLSLDERVALT
CCCCHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCCHHHHHHH
RAMTHSGTVLAWDLPGPVLDKHSTGGVGDTVSLPLAAMVSACGGYVPMISGRGLGHTGGT
HHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCC
LDKLASIPGYDVTPGLDRFRKVTAEAGCAIIGQTAELAPADRRLYAIRDVTGTVESLDLI
HHHHHCCCCCCCCCCHHHHHHHHHHCCCEEECCCHHCCCCCCEEEEEEHHHCCHHHHHHH
TASILSKKLAAGLQGLVMDVKTGSGAFMARREDARALADSIVTVANAAGLRTRALITDMD
HHHHHHHHHHHCHHHEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC
APLASCAGNAVEVAYAVDYLTGRAREPRFHAVTMALAVEMLVIGGLAANIAEAEGRLTAA
CCHHHHCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LESGRACEAFARMVAALGGPGDFIEAADRHLPRAPVVRPVPAQEAGVVEAVETRAIGLAV
HHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEE
IGLGGGRTRPQDAIDARVGFTGLARPGDQLSPNDPIGIVHAADEAAAERAAASLRAAYRI
EECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHC
GATPPEPRAAVGERLG
CCCCCCCHHHHHHCCC
>Mature Secondary Structure
MRLPQEIIRDKRDGHALSEADIAGFIEGLTQDQVTEGQAAAFAMAVFFRGLSLDERVALT
CCCCHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCCHHHHHHH
RAMTHSGTVLAWDLPGPVLDKHSTGGVGDTVSLPLAAMVSACGGYVPMISGRGLGHTGGT
HHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCC
LDKLASIPGYDVTPGLDRFRKVTAEAGCAIIGQTAELAPADRRLYAIRDVTGTVESLDLI
HHHHHCCCCCCCCCCHHHHHHHHHHCCCEEECCCHHCCCCCCEEEEEEHHHCCHHHHHHH
TASILSKKLAAGLQGLVMDVKTGSGAFMARREDARALADSIVTVANAAGLRTRALITDMD
HHHHHHHHHHHCHHHEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC
APLASCAGNAVEVAYAVDYLTGRAREPRFHAVTMALAVEMLVIGGLAANIAEAEGRLTAA
CCHHHHCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LESGRACEAFARMVAALGGPGDFIEAADRHLPRAPVVRPVPAQEAGVVEAVETRAIGLAV
HHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEE
IGLGGGRTRPQDAIDARVGFTGLARPGDQLSPNDPIGIVHAADEAAAERAAASLRAAYRI
EECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHC
GATPPEPRAAVGERLG
CCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA