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The map label for this gene is rnd [H]

Identifier: 218531091

GI number: 218531091

Start: 3316877

End: 3318031

Strand: Reverse

Name: rnd [H]

Synonym: Mchl_3141

Alternate gene names: 218531091

Gene position: 3318031-3316877 (Counterclockwise)

Preceding gene: 218531092

Following gene: 218531090

Centisome position: 57.43

GC content: 68.4

Gene sequence:

>1155_bases
ATGGAACTGATCTCCGCAACGCAGGCTCTGTCCGACGCCTGCACCCAATTCGCCGCGCAGCCGTTCGTGACCGTCGATAC
GGAGTTCATGCGCGAGACGACCTACTATCCGAAGCTCTGCCTGATTCAGATGGCTGGGCCCGACGGATTCGCCTGCCTCG
TCGATCCGCTCGCAAAAGATCTCGATCTCAAGCCGTTCTTCGACCTGATGGCCGATGAGAGCACCGTGAAGGTGTTCCAT
TCGGCCCGGCAGGATCTGGAGATCATCTGGCTGCTCGGCGGGCTGCTGCCGCAGCCGTTCTTCGACACGCAGGTCGCGGC
CATGGTCTGCGGCTACGGCGACTCGGTCTCCTACGAGCAGCTGGTCAACGATGTCGCCAAGGCGCGCATCGACAAATCCT
CCCGCTTCACCGATTGGTCGCGGCGCCCCCTGTCCGAGGCGCAGCTCGCCTACGCCCTGTCGGACGTCACCCATCTCGTG
ACGATCTATCAGGTGCTCGCGGCCGAACTGCTGAGCACCGACCGCGGCCTCTGGCTCGACGAGGAGATGGCGGTCCTCAC
CTCGCCGGAGACCTATCAGGCCGAGCCCGCCCAGGCCTGGCGCCGGCTCTCGGGGCGGATGCGCAAGCCGCGCGAGATTG
CCGTGCTGATGGAAGTGGCCGCGTGGCGCGAGGCGGAGGCCCAGAGCCGCAACGTCCCCCGCGGGCGCATCCTCAAGGAC
GAGGCGGTGATCGACATCGCCACCGCCGGCCCCCGCAGCGTCGAGGCCCTGGGGCGCCTGCGCACCATCCCGGCCGGCTT
CGAGCGCTCGCGCACCGGCACCGAAATCCTCGCGGCGGTCGAGCGGGGCTTTGCCCGCGACCCCTCGCAGATCGCCGTGC
CCGAGCGCAGCCGCTCCCGCGGTGGCGGCAACGGCGCGCTCATCGATCTTCTCAAGGTGCTGCTCAAGGCGGTGGCCGAG
GCCGAGGGCGTGGCGCCCAAGATCATCGCCACCGTCGATGACCTCGAAGCACTCGCCGAGGACGACGCCGCGGATGTGGC
CGTGCTCCAGGGTTGGCGCCGCTCCCTGTTCGGCGACAAGGCTCTGGCACTCAAGCACGGGCGCATGGCGCTTTCGGTCG
AGCGTGGCCGGGTCACCGTGCGCGAACTGCCTTAG

Upstream 100 bases:

>100_bases
CGTGAAGGAGCGAAGTTTTCGTCGTGAAGCGCAATCGCGTGGGGACAAGAGGCCCCTCGTCGTCTCGCGGTGACGCGCGT
CCTTCGGTATAGCCGGTTCT

Downstream 100 bases:

>100_bases
CCGTTCACCGTCGCGGCGGACGGCGCCCCGATGTCCCGATGCAGGCTGGGAGAAGCGGGGAACTGTCATTGCAGCATCTT
GGCGTTGGAACGCGGGTGCC

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MELISATQALSDACTQFAAQPFVTVDTEFMRETTYYPKLCLIQMAGPDGFACLVDPLAKDLDLKPFFDLMADESTVKVFH
SARQDLEIIWLLGGLLPQPFFDTQVAAMVCGYGDSVSYEQLVNDVAKARIDKSSRFTDWSRRPLSEAQLAYALSDVTHLV
TIYQVLAAELLSTDRGLWLDEEMAVLTSPETYQAEPAQAWRRLSGRMRKPREIAVLMEVAAWREAEAQSRNVPRGRILKD
EAVIDIATAGPRSVEALGRLRTIPAGFERSRTGTEILAAVERGFARDPSQIAVPERSRSRGGGNGALIDLLKVLLKAVAE
AEGVAPKIIATVDDLEALAEDDAADVAVLQGWRRSLFGDKALALKHGRMALSVERGRVTVRELP

Sequences:

>Translated_384_residues
MELISATQALSDACTQFAAQPFVTVDTEFMRETTYYPKLCLIQMAGPDGFACLVDPLAKDLDLKPFFDLMADESTVKVFH
SARQDLEIIWLLGGLLPQPFFDTQVAAMVCGYGDSVSYEQLVNDVAKARIDKSSRFTDWSRRPLSEAQLAYALSDVTHLV
TIYQVLAAELLSTDRGLWLDEEMAVLTSPETYQAEPAQAWRRLSGRMRKPREIAVLMEVAAWREAEAQSRNVPRGRILKD
EAVIDIATAGPRSVEALGRLRTIPAGFERSRTGTEILAAVERGFARDPSQIAVPERSRSRGGGNGALIDLLKVLLKAVAE
AEGVAPKIIATVDDLEALAEDDAADVAVLQGWRRSLFGDKALALKHGRMALSVERGRVTVRELP
>Mature_384_residues
MELISATQALSDACTQFAAQPFVTVDTEFMRETTYYPKLCLIQMAGPDGFACLVDPLAKDLDLKPFFDLMADESTVKVFH
SARQDLEIIWLLGGLLPQPFFDTQVAAMVCGYGDSVSYEQLVNDVAKARIDKSSRFTDWSRRPLSEAQLAYALSDVTHLV
TIYQVLAAELLSTDRGLWLDEEMAVLTSPETYQAEPAQAWRRLSGRMRKPREIAVLMEVAAWREAEAQSRNVPRGRILKD
EAVIDIATAGPRSVEALGRLRTIPAGFERSRTGTEILAAVERGFARDPSQIAVPERSRSRGGGNGALIDLLKVLLKAVAE
AEGVAPKIIATVDDLEALAEDDAADVAVLQGWRRSLFGDKALALKHGRMALSVERGRVTVRELP

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=271, Percent_Identity=23.9852398523985, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI50301240, Length=271, Percent_Identity=23.9852398523985, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788105, Length=334, Percent_Identity=30.2395209580838, Blast_Score=141, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6324574, Length=221, Percent_Identity=29.8642533936652, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 42234; Mature: 42234

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELISATQALSDACTQFAAQPFVTVDTEFMRETTYYPKLCLIQMAGPDGFACLVDPLAKD
CCHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHC
LDLKPFFDLMADESTVKVFHSARQDLEIIWLLGGLLPQPFFDTQVAAMVCGYGDSVSYEQ
CCCCHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHH
LVNDVAKARIDKSSRFTDWSRRPLSEAQLAYALSDVTHLVTIYQVLAAELLSTDRGLWLD
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EEMAVLTSPETYQAEPAQAWRRLSGRMRKPREIAVLMEVAAWREAEAQSRNVPRGRILKD
CCHHEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECC
EAVIDIATAGPRSVEALGRLRTIPAGFERSRTGTEILAAVERGFARDPSQIAVPERSRSR
CCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCCCCCC
GGGNGALIDLLKVLLKAVAEAEGVAPKIIATVDDLEALAEDDAADVAVLQGWRRSLFGDK
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCH
ALALKHGRMALSVERGRVTVRELP
HHEEECCCEEEEEECCCEEEECCC
>Mature Secondary Structure
MELISATQALSDACTQFAAQPFVTVDTEFMRETTYYPKLCLIQMAGPDGFACLVDPLAKD
CCHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHC
LDLKPFFDLMADESTVKVFHSARQDLEIIWLLGGLLPQPFFDTQVAAMVCGYGDSVSYEQ
CCCCHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHH
LVNDVAKARIDKSSRFTDWSRRPLSEAQLAYALSDVTHLVTIYQVLAAELLSTDRGLWLD
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EEMAVLTSPETYQAEPAQAWRRLSGRMRKPREIAVLMEVAAWREAEAQSRNVPRGRILKD
CCHHEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECC
EAVIDIATAGPRSVEALGRLRTIPAGFERSRTGTEILAAVERGFARDPSQIAVPERSRSR
CCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCCCCCC
GGGNGALIDLLKVLLKAVAEAEGVAPKIIATVDDLEALAEDDAADVAVLQGWRRSLFGDK
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCH
ALALKHGRMALSVERGRVTVRELP
HHEEECCCEEEEEECCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]