Click here to switch to the map view.

The map label for this gene is uvrC [H]

Identifier: 218531054

GI number: 218531054

Start: 3283849

End: 3285897

Strand: Reverse

Name: uvrC [H]

Synonym: Mchl_3104

Alternate gene names: 218531054

Gene position: 3285897-3283849 (Counterclockwise)

Preceding gene: 218531055

Following gene: 218531053

Centisome position: 56.87

GC content: 68.03

Gene sequence:

>2049_bases
ATGAGCCGCGCGACCCGATCCGCCTTCGACGACGTCCCGCCCGACGGGTTCGACGAGGACGAGACCGAGGCTGCCTCCCT
CGACGAGGCGCCCGAGATCGACTTCGATTTCGAGCCCGGTGCCGTCCAGGCGGGCACCGAGATCATCCGCCGATTCTGGT
CGACCCTACCGAACTCGCCGGGCGTGTACCGGATGTTCGACGCCAAGGGCGACGTGCTCTACGTCGGCAAGGCCAAGAAC
CTAAAGGCCCGCGTCGGCTCCTACGCCCGCGGCCAGGCGCATTCCAACCGTATCGCCCGCATGATCGCCCAGACGGCGGC
GATGGAGTTCGTCACCACGGCGACCGAGACGGAAGCGCTGCTGCTGGAGGCCAACCTCATCAAGCAGTTGAAGCCGCGCT
TCAACGTGCTGATGCGCGACGACAAGTCGTTCCCCTACATCCTGCTGACCAGCGACGGGCCGGCGCCGCAGATCGTCAAG
CATCGCGGCGCGCGCCGCCGCAAGGGCAACTACTACGGCCCCTTCGCCAATGTCTGGGCGGTCAACCGCACGGTGAACGC
GCTCCAGCGCGCCTTCCTGATGCGGACCTGCTCGGACAGCTATTACGAGAACCGCACCCGGCCCTGCCTGCTCTACCAGA
TCAAGCGCTGCTCCGGCCCCTGCACCGGCGAAATTGCCCTCGAGGACTATAGCGCGCTCGCCGACAGCGCCCGCGCCTTC
CTCTCGGGCAAGTCGAACGCGGTGAAGGACCGGATGCGCGAGGAAATGCAGCGCGCCTCCGAGGCGCTTGAATTCGAGCG
TGCCGCGCGCTTCCGCGACCGTATCGCCGCGCTCTCGGCGATCCAGGGCGTGCAGGGGGTGAACACCCAGGGGGTCGAGG
AGGCCGACGTGTTCGCCATCGACGAGCAGGCGGGCCAGTTCTGCATCGAGGTGTTCTTCTTCCGCAACTTCCAGAACTGG
GGCAACCGCGCCTACTTCCCGAAGGCCGACCGCTCGATGAGCGCGGACGAGGTGCTGGCCTCGTTCATCTCGCAGTTCTA
CGACGACAAGCCTGCCCCGAAACTCGTCCTCGTCAGCCACACGATCGAGGATGCCGAACTCGTGGCCGCCGCCCTGTCGA
GCCGGGTCGAGCACCGCGTCGAGGTCCACCAGCCGCAGCGGGGCGAGCGCAAGAACCTCGTCGATTACGCGCAGCGCAAC
GCCAAGGAGGCGCTTGGACGCCGGCTCGCCGACACCGCGTCGCAGGGCAAGCTGCTGACGGCGCTGGGCCAAGCCTTCGG
CCTCGACAAGCCGCCGCGCCGTGTCGAGGTCTACGACAACTCGCACATTTCCGGCACGGCCGCGGTCGGCGGCATGATCG
TCGCCGGGCCGACCGGCTTCATGAAGACGCATTACCGCACCTTCAACATCAAGTCGGAGGAGCTGAGCCCCGGCGACGAT
TTCGGGATGATGCGCGAGGTGCTGACCCGCCGCTTCAAGCGGCTGGCCAAGGAGGCGCCGCGCACCCCGCGGGAGGGTGA
TGCCGGCGAACCGCAGGCCCCGGAAAAGGCCGTTCCAACGGTGGCCGAGGTGCAAGACGATCCCGACGCTTTCCCCGCCT
GGCCCGACCTCGTTCTGATCGACGGCGGCGCCGGGCAGTTGGAGGCGGCCCGCGCCTCGCTCGCCGAGATCGGCGTGACC
GGCGTGCCGTTGGTCGGCATCGCCAAGGGCCGTGACCGCGATGCCGGCCGCGAGACGTTCTTCGTGCCCGGCCGCAGCCC
GTTCAAGCTGCCGCCGCGCGATCCCGTGCTCTATTTCGTGCAGCGCCTGCGTGACGAGGCCCATCGTTTCGCCATCGGCA
CCCATCGGGCACGGCGCAAGCGCGAGATGACGAAAAACCCGCTCGACGAGATTGCCGGGATCGGCCCCACTCGCAAGCGC
GCGCTGCTGCACCATTTCGGCACGGTGAAAGCCATCGAACGCGCCGCCTTGGAGGATCTCGCCAAGGCGCCGGGCGTGAA
CGCCGCCACCGCGCGGGCGGTCTACGACTTCTTCCATGCCAATGCTTGA

Upstream 100 bases:

>100_bases
ACTGACGCTCCCCGTCGCAAGGCAATCGCGCGAAGCGATTGTCCTGGCTCAGGCCGCCGCGGCCCTTTCAACCGGAATCG
CCGCGGCTTACATCGGGGCC

Downstream 100 bases:

>100_bases
GCCGAGCCCCGTGCCGAGAGAGCCCGCACCCGATGCAGCGACGCCGCGGTTGACGCCCCCCGCCGCCCGTGATTTCACCC
CGGCGATGAACGCCGTCCTC

Product: excinuclease ABC, C subunit

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 682; Mature: 681

Protein sequence:

>682_residues
MSRATRSAFDDVPPDGFDEDETEAASLDEAPEIDFDFEPGAVQAGTEIIRRFWSTLPNSPGVYRMFDAKGDVLYVGKAKN
LKARVGSYARGQAHSNRIARMIAQTAAMEFVTTATETEALLLEANLIKQLKPRFNVLMRDDKSFPYILLTSDGPAPQIVK
HRGARRRKGNYYGPFANVWAVNRTVNALQRAFLMRTCSDSYYENRTRPCLLYQIKRCSGPCTGEIALEDYSALADSARAF
LSGKSNAVKDRMREEMQRASEALEFERAARFRDRIAALSAIQGVQGVNTQGVEEADVFAIDEQAGQFCIEVFFFRNFQNW
GNRAYFPKADRSMSADEVLASFISQFYDDKPAPKLVLVSHTIEDAELVAAALSSRVEHRVEVHQPQRGERKNLVDYAQRN
AKEALGRRLADTASQGKLLTALGQAFGLDKPPRRVEVYDNSHISGTAAVGGMIVAGPTGFMKTHYRTFNIKSEELSPGDD
FGMMREVLTRRFKRLAKEAPRTPREGDAGEPQAPEKAVPTVAEVQDDPDAFPAWPDLVLIDGGAGQLEAARASLAEIGVT
GVPLVGIAKGRDRDAGRETFFVPGRSPFKLPPRDPVLYFVQRLRDEAHRFAIGTHRARRKREMTKNPLDEIAGIGPTRKR
ALLHHFGTVKAIERAALEDLAKAPGVNAATARAVYDFFHANA

Sequences:

>Translated_682_residues
MSRATRSAFDDVPPDGFDEDETEAASLDEAPEIDFDFEPGAVQAGTEIIRRFWSTLPNSPGVYRMFDAKGDVLYVGKAKN
LKARVGSYARGQAHSNRIARMIAQTAAMEFVTTATETEALLLEANLIKQLKPRFNVLMRDDKSFPYILLTSDGPAPQIVK
HRGARRRKGNYYGPFANVWAVNRTVNALQRAFLMRTCSDSYYENRTRPCLLYQIKRCSGPCTGEIALEDYSALADSARAF
LSGKSNAVKDRMREEMQRASEALEFERAARFRDRIAALSAIQGVQGVNTQGVEEADVFAIDEQAGQFCIEVFFFRNFQNW
GNRAYFPKADRSMSADEVLASFISQFYDDKPAPKLVLVSHTIEDAELVAAALSSRVEHRVEVHQPQRGERKNLVDYAQRN
AKEALGRRLADTASQGKLLTALGQAFGLDKPPRRVEVYDNSHISGTAAVGGMIVAGPTGFMKTHYRTFNIKSEELSPGDD
FGMMREVLTRRFKRLAKEAPRTPREGDAGEPQAPEKAVPTVAEVQDDPDAFPAWPDLVLIDGGAGQLEAARASLAEIGVT
GVPLVGIAKGRDRDAGRETFFVPGRSPFKLPPRDPVLYFVQRLRDEAHRFAIGTHRARRKREMTKNPLDEIAGIGPTRKR
ALLHHFGTVKAIERAALEDLAKAPGVNAATARAVYDFFHANA
>Mature_681_residues
SRATRSAFDDVPPDGFDEDETEAASLDEAPEIDFDFEPGAVQAGTEIIRRFWSTLPNSPGVYRMFDAKGDVLYVGKAKNL
KARVGSYARGQAHSNRIARMIAQTAAMEFVTTATETEALLLEANLIKQLKPRFNVLMRDDKSFPYILLTSDGPAPQIVKH
RGARRRKGNYYGPFANVWAVNRTVNALQRAFLMRTCSDSYYENRTRPCLLYQIKRCSGPCTGEIALEDYSALADSARAFL
SGKSNAVKDRMREEMQRASEALEFERAARFRDRIAALSAIQGVQGVNTQGVEEADVFAIDEQAGQFCIEVFFFRNFQNWG
NRAYFPKADRSMSADEVLASFISQFYDDKPAPKLVLVSHTIEDAELVAAALSSRVEHRVEVHQPQRGERKNLVDYAQRNA
KEALGRRLADTASQGKLLTALGQAFGLDKPPRRVEVYDNSHISGTAAVGGMIVAGPTGFMKTHYRTFNIKSEELSPGDDF
GMMREVLTRRFKRLAKEAPRTPREGDAGEPQAPEKAVPTVAEVQDDPDAFPAWPDLVLIDGGAGQLEAARASLAEIGVTG
VPLVGIAKGRDRDAGRETFFVPGRSPFKLPPRDPVLYFVQRLRDEAHRFAIGTHRARRKREMTKNPLDEIAGIGPTRKRA
LLHHFGTVKAIERAALEDLAKAPGVNAATARAVYDFFHANA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=634, Percent_Identity=38.801261829653, Blast_Score=443, Evalue=1e-125,
Organism=Escherichia coli, GI1788037, Length=202, Percent_Identity=30.6930693069307, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 75592; Mature: 75461

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRATRSAFDDVPPDGFDEDETEAASLDEAPEIDFDFEPGAVQAGTEIIRRFWSTLPNSP
CCCCHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
GVYRMFDAKGDVLYVGKAKNLKARVGSYARGQAHSNRIARMIAQTAAMEFVTTATETEAL
CEEEEEECCCCEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LLEANLIKQLKPRFNVLMRDDKSFPYILLTSDGPAPQIVKHRGARRRKGNYYGPFANVWA
HHHHHHHHHHCHHHCEEEECCCCCCEEEEECCCCCHHHHHHCCCHHCCCCCCCCCHHHHH
VNRTVNALQRAFLMRTCSDSYYENRTRPCLLYQIKRCSGPCTGEIALEDYSALADSARAF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHH
LSGKSNAVKDRMREEMQRASEALEFERAARFRDRIAALSAIQGVQGVNTQGVEEADVFAI
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
DEQAGQFCIEVFFFRNFQNWGNRAYFPKADRSMSADEVLASFISQFYDDKPAPKLVLVSH
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEC
TIEDAELVAAALSSRVEHRVEVHQPQRGERKNLVDYAQRNAKEALGRRLADTASQGKLLT
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
ALGQAFGLDKPPRRVEVYDNSHISGTAAVGGMIVAGPTGFMKTHYRTFNIKSEELSPGDD
HHHHHHCCCCCCCEEEEECCCCCCCHHHHCCEEEECCCCHHHHCEEEEECCCCCCCCCCC
FGMMREVLTRRFKRLAKEAPRTPREGDAGEPQAPEKAVPTVAEVQDDPDAFPAWPDLVLI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCHHHCCCCCCCCCCCCCEEEE
DGGAGQLEAARASLAEIGVTGVPLVGIAKGRDRDAGRETFFVPGRSPFKLPPRDPVLYFV
ECCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHH
QRLRDEAHRFAIGTHRARRKREMTKNPLDEIAGIGPTRKRALLHHFGTVKAIERAALEDL
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AKAPGVNAATARAVYDFFHANA
HHCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SRATRSAFDDVPPDGFDEDETEAASLDEAPEIDFDFEPGAVQAGTEIIRRFWSTLPNSP
CCCHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
GVYRMFDAKGDVLYVGKAKNLKARVGSYARGQAHSNRIARMIAQTAAMEFVTTATETEAL
CEEEEEECCCCEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LLEANLIKQLKPRFNVLMRDDKSFPYILLTSDGPAPQIVKHRGARRRKGNYYGPFANVWA
HHHHHHHHHHCHHHCEEEECCCCCCEEEEECCCCCHHHHHHCCCHHCCCCCCCCCHHHHH
VNRTVNALQRAFLMRTCSDSYYENRTRPCLLYQIKRCSGPCTGEIALEDYSALADSARAF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHH
LSGKSNAVKDRMREEMQRASEALEFERAARFRDRIAALSAIQGVQGVNTQGVEEADVFAI
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
DEQAGQFCIEVFFFRNFQNWGNRAYFPKADRSMSADEVLASFISQFYDDKPAPKLVLVSH
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEC
TIEDAELVAAALSSRVEHRVEVHQPQRGERKNLVDYAQRNAKEALGRRLADTASQGKLLT
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
ALGQAFGLDKPPRRVEVYDNSHISGTAAVGGMIVAGPTGFMKTHYRTFNIKSEELSPGDD
HHHHHHCCCCCCCEEEEECCCCCCCHHHHCCEEEECCCCHHHHCEEEEECCCCCCCCCCC
FGMMREVLTRRFKRLAKEAPRTPREGDAGEPQAPEKAVPTVAEVQDDPDAFPAWPDLVLI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCHHHCCCCCCCCCCCCCEEEE
DGGAGQLEAARASLAEIGVTGVPLVGIAKGRDRDAGRETFFVPGRSPFKLPPRDPVLYFV
ECCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHH
QRLRDEAHRFAIGTHRARRKREMTKNPLDEIAGIGPTRKRALLHHFGTVKAIERAALEDL
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AKAPGVNAATARAVYDFFHANA
HHCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA