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The map label for this gene is mro [H]

Identifier: 218531049

GI number: 218531049

Start: 3278603

End: 3279643

Strand: Reverse

Name: mro [H]

Synonym: Mchl_3099

Alternate gene names: 218531049

Gene position: 3279643-3278603 (Counterclockwise)

Preceding gene: 218531050

Following gene: 218531048

Centisome position: 56.76

GC content: 67.63

Gene sequence:

>1041_bases
ATGCGGTCAGAGCCATTCGGAACGACGCGGGCCGGTGAGCGCGTCACGCGGCACACCCTCGTGCGCGACGATCTACGGGT
TCAGGTCATCGATTACGGCGCGATCGTCACCGCCATTGAGGTGCCGGATCGGGAGGGCCGCCGCGCCAACGTCGTCCTCG
CCCTCGATACGGTGGAGGGTTACGAGACGGTGAGCCCGCATTTCGGGGCGATTGCCGGGCGTTACGCCAACCGCATCGCC
AAGGGGCGCTTCACCCTCGACGGGACCACCTTCGAACTGCCGATCAACGAGCCGCCCAATTCCATGCATGGCGGTCCCGA
GGGTTTCGCCAAGCGCCTCTGGCAGGTGGCGGAGGCGGACGACACAAAGGTTGTGCTGAGGCGGCGCAGCCCCGACGGCG
AGGAGGGCTTTCCGGGCAATCTCGACGTCGAGGTCGTCTACAGCCTGCCCGAGCCCGGAACGCTGCGCATCGACTACCGC
GCCGAGACCGACCGGCCGACGGTGCTGAACCTGACCAATCACAGCTACTTCAACCTCGCCGGCGAGGGCACCGGCGACGT
GATGGATCACGTCGTGCAGATCGTCGCCGATGCCTACGCGCCGACGGACGCAACGCAGATCCCGACCGGAAACATCGCGC
CGGTTGCCGGCACGCCCCTCGATTTCCGTGAGCCCACGCCGCTCGGTGCGCGAATTCGGCAGGGTGACGAGCAGATCGTG
ATCGCGGGCGGCTACGACCATACCTACGCTCTGCGAGAACCCGCCGGCACGCTGCGCCCGGCAGCCTCCTGCTTCTGCCC
GGCCAGCGGGCGGCGCCTCGACGTCGCGACGACCCAGCCGGCGCTGCAACTCTACAGCGGCAACAATCTCGACGGCTCGC
TGCTTGGCCCGTCTGGCCGCACCTACCGCTCGGGCGACGGCGTCTGCTTCGAGACGCAGGGGTTTCCCGATGCGCCGAAC
CACCCGAACTTTCCGAGCACCGTCCTGAGGCCGGGAGAGGTTTTCACCTCGATCAGCACCTACCGGTTCTCGATCGGCTG
A

Upstream 100 bases:

>100_bases
CTGACGGTGCCAGCATGAAATCGGCCGGCGCGATTCGACCGGCCTTATGCCACCCGCGCGGCCTCTCACGCGTAGTTCCC
GGTCACGACGGGAGCCAGAA

Downstream 100 bases:

>100_bases
GCGGACGAGCCCATCACAAAGCGAGGACCGAGACGAGCCTGAACCGGGGAGCTTGACATCCGTCTCGTTTGGTCTGAAGT
TTCTGTCATGACAGAAACTT

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MRSEPFGTTRAGERVTRHTLVRDDLRVQVIDYGAIVTAIEVPDREGRRANVVLALDTVEGYETVSPHFGAIAGRYANRIA
KGRFTLDGTTFELPINEPPNSMHGGPEGFAKRLWQVAEADDTKVVLRRRSPDGEEGFPGNLDVEVVYSLPEPGTLRIDYR
AETDRPTVLNLTNHSYFNLAGEGTGDVMDHVVQIVADAYAPTDATQIPTGNIAPVAGTPLDFREPTPLGARIRQGDEQIV
IAGGYDHTYALREPAGTLRPAASCFCPASGRRLDVATTQPALQLYSGNNLDGSLLGPSGRTYRSGDGVCFETQGFPDAPN
HPNFPSTVLRPGEVFTSISTYRFSIG

Sequences:

>Translated_346_residues
MRSEPFGTTRAGERVTRHTLVRDDLRVQVIDYGAIVTAIEVPDREGRRANVVLALDTVEGYETVSPHFGAIAGRYANRIA
KGRFTLDGTTFELPINEPPNSMHGGPEGFAKRLWQVAEADDTKVVLRRRSPDGEEGFPGNLDVEVVYSLPEPGTLRIDYR
AETDRPTVLNLTNHSYFNLAGEGTGDVMDHVVQIVADAYAPTDATQIPTGNIAPVAGTPLDFREPTPLGARIRQGDEQIV
IAGGYDHTYALREPAGTLRPAASCFCPASGRRLDVATTQPALQLYSGNNLDGSLLGPSGRTYRSGDGVCFETQGFPDAPN
HPNFPSTVLRPGEVFTSISTYRFSIG
>Mature_346_residues
MRSEPFGTTRAGERVTRHTLVRDDLRVQVIDYGAIVTAIEVPDREGRRANVVLALDTVEGYETVSPHFGAIAGRYANRIA
KGRFTLDGTTFELPINEPPNSMHGGPEGFAKRLWQVAEADDTKVVLRRRSPDGEEGFPGNLDVEVVYSLPEPGTLRIDYR
AETDRPTVLNLTNHSYFNLAGEGTGDVMDHVVQIVADAYAPTDATQIPTGNIAPVAGTPLDFREPTPLGARIRQGDEQIV
IAGGYDHTYALREPAGTLRPAASCFCPASGRRLDVATTQPALQLYSGNNLDGSLLGPSGRTYRSGDGVCFETQGFPDAPN
HPNFPSTVLRPGEVFTSISTYRFSIG

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=334, Percent_Identity=47.0059880239521, Blast_Score=299, Evalue=2e-81,
Organism=Escherichia coli, GI1786971, Length=323, Percent_Identity=40.2476780185758, Blast_Score=239, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17557428, Length=320, Percent_Identity=30.625, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI115533334, Length=320, Percent_Identity=30.625, Blast_Score=173, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324399, Length=310, Percent_Identity=30, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322004, Length=351, Percent_Identity=30.1994301994302, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319493, Length=317, Percent_Identity=29.6529968454259, Blast_Score=106, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24659048, Length=353, Percent_Identity=38.2436260623229, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24668278, Length=357, Percent_Identity=35.0140056022409, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24583720, Length=344, Percent_Identity=37.5, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24668282, Length=346, Percent_Identity=36.9942196531792, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24641876, Length=357, Percent_Identity=30.2521008403361, Blast_Score=167, Evalue=9e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 37486; Mature: 37486

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSEPFGTTRAGERVTRHTLVRDDLRVQVIDYGAIVTAIEVPDREGRRANVVLALDTVEG
CCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCEEEEEEECCCCCCCEEEEEEEEECCCC
YETVSPHFGAIAGRYANRIAKGRFTLDGTTFELPINEPPNSMHGGPEGFAKRLWQVAEAD
CCCCCCCHHHHHHHHHHHHHCCEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCC
DTKVVLRRRSPDGEEGFPGNLDVEVVYSLPEPGTLRIDYRAETDRPTVLNLTNHSYFNLA
CCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCCCEEEEE
GEGTGDVMDHVVQIVADAYAPTDATQIPTGNIAPVAGTPLDFREPTPLGARIRQGDEQIV
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCEEE
IAGGYDHTYALREPAGTLRPAASCFCPASGRRLDVATTQPALQLYSGNNLDGSLLGPSGR
EECCCCCEEEECCCCCCCCCCHHEECCCCCCEEEEECCCCEEEEECCCCCCCEEECCCCC
TYRSGDGVCFETQGFPDAPNHPNFPSTVLRPGEVFTSISTYRFSIG
CEECCCCEEEECCCCCCCCCCCCCCHHHCCCCHHHHEEEEEEEECC
>Mature Secondary Structure
MRSEPFGTTRAGERVTRHTLVRDDLRVQVIDYGAIVTAIEVPDREGRRANVVLALDTVEG
CCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCEEEEEEECCCCCCCEEEEEEEEECCCC
YETVSPHFGAIAGRYANRIAKGRFTLDGTTFELPINEPPNSMHGGPEGFAKRLWQVAEAD
CCCCCCCHHHHHHHHHHHHHCCEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCC
DTKVVLRRRSPDGEEGFPGNLDVEVVYSLPEPGTLRIDYRAETDRPTVLNLTNHSYFNLA
CCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCCCEEEEE
GEGTGDVMDHVVQIVADAYAPTDATQIPTGNIAPVAGTPLDFREPTPLGARIRQGDEQIV
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCEEE
IAGGYDHTYALREPAGTLRPAASCFCPASGRRLDVATTQPALQLYSGNNLDGSLLGPSGR
EECCCCCEEEECCCCCCCCCCHHEECCCCCCEEEEECCCCEEEEECCCCCCCEEECCCCC
TYRSGDGVCFETQGFPDAPNHPNFPSTVLRPGEVFTSISTYRFSIG
CEECCCCEEEECCCCCCCCCCCCCCHHHCCCCHHHHEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]