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The map label for this gene is htrA [H]

Identifier: 218235841

GI number: 218235841

Start: 3629311

End: 3630552

Strand: Reverse

Name: htrA [H]

Synonym: BCB4264_A3708

Alternate gene names: 218235841

Gene position: 3630552-3629311 (Counterclockwise)

Preceding gene: 218235232

Following gene: 218231714

Centisome position: 67.0

GC content: 37.2

Gene sequence:

>1242_bases
ATGGGATATTACGACGGACCAAATTTAAATGAAGAGCATAGTGAAACGAGAGAAGTGAGAAAATCAGGTAGTAAAAAAGG
CTATTTCTTCACAGGTTTAGTGGGAGCTGTAGTCGGAGCGGTTTCGATTAGTTTTGCAGCACCATATATGCCATGGGCTC
AAAATAATGGAGCGCCAGTATCATCATTTAGTTCGGATTCAAAAGTAGAAGGTACTGTAGTTCCTGTTGTAAATAAAGCG
AAAAATGAAACTGATTTACCTGGTATGATTGAAGGGGCGAAAGATGTTGTTGTAGGTGTTATTAATATGCAACAAAGTGT
TGATCCATTTGCAATGCAACCGACAGGTCAAGAACAACAAGCTGGTTCAGGATCAGGTGTTATTTATAAAAAAGCAGGGA
ATAAAGCATATATTGTAACAAACAACCACGTAGTAGATGGAGCAAATAAACTTGCTGTGAAGCTGAGCGACGGAAAGCAA
GTTGATGCGAAATTAGTTGGTAAGGACCCTTGGTTAGACTTAGCAGTTGTTGAAATTGATGGATCTAATGTAAATAAAGT
TGCCACTTTAGGTGATTCAAGTAAACTTCGTGCGGGTGAAAAAGCAATTGCAATCGGTAATCCACTAGGGTTTGATGGAA
GTGTAACGGAAGGTATTATTAGTAGTAAAGAACGTGAAATTCCAGTTGATATTGATGGCGATAAACGACCAGATTGGCAA
GCACAAGTTATTCAAACAGATGCAGCGATTAACCCTGGTAACAGTGGTGGTGCATTATTTAACCAAAATGGTGAAATAAT
TGGGATTAACTCAAGTAAAATTGCACAACAAGAAGTTGAAGGAATTGGTTTTGCTATTCCAATTAATATCGCAAAGCCAG
TTATTGAATCACTTGAAAAAGACGGAGTAGTGAAACGTCCAGCGCTTGGAGTAGGTGTCGTTTCATTAGAAGATGTGCAA
GCTTATGCAGTCAATCAATTGAAAGTACCGAAAGAAGTAACTAATGGTGTTGTATTAGGTAAAATTTACCCAATATCACC
GGCTGAAAAAGCTGGTTTAGAGCAATATGATATTGTAGTAGCATTAGATAATCAAAAAGTAGAGAATGCTCTTCAATTCC
GTAAATATTTATATGAAAAGAAAAAAGTAGGCGAGAAAGTAGAAGTTACATTCTACCGTAACGGTCAAAAAATGACGAAA
TCGGCTACTTTAGCAGATAATTCAGCTACAAAGAATCAATAA

Upstream 100 bases:

>100_bases
AAGTGTATTTTTTTAATTGGATTTCACGATGAGTTCACAAGAAGGACACAAAACGTGACTATACTGAAAATACGAATTCA
CCAGAGAGGGGAAATAAAAC

Downstream 100 bases:

>100_bases
TCGAAATAAAAGAAAGTCTCTTTCATATTGAAAGAGACTTTCTTTATCGGCTATACTAAAGGAATAGGAGGGATTAATTA
TGACAATTGAAAACCCAACT

Product: serine protease HtrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MGYYDGPNLNEEHSETREVRKSGSKKGYFFTGLVGAVVGAVSISFAAPYMPWAQNNGAPVSSFSSDSKVEGTVVPVVNKA
KNETDLPGMIEGAKDVVVGVINMQQSVDPFAMQPTGQEQQAGSGSGVIYKKAGNKAYIVTNNHVVDGANKLAVKLSDGKQ
VDAKLVGKDPWLDLAVVEIDGSNVNKVATLGDSSKLRAGEKAIAIGNPLGFDGSVTEGIISSKEREIPVDIDGDKRPDWQ
AQVIQTDAAINPGNSGGALFNQNGEIIGINSSKIAQQEVEGIGFAIPINIAKPVIESLEKDGVVKRPALGVGVVSLEDVQ
AYAVNQLKVPKEVTNGVVLGKIYPISPAEKAGLEQYDIVVALDNQKVENALQFRKYLYEKKKVGEKVEVTFYRNGQKMTK
SATLADNSATKNQ

Sequences:

>Translated_413_residues
MGYYDGPNLNEEHSETREVRKSGSKKGYFFTGLVGAVVGAVSISFAAPYMPWAQNNGAPVSSFSSDSKVEGTVVPVVNKA
KNETDLPGMIEGAKDVVVGVINMQQSVDPFAMQPTGQEQQAGSGSGVIYKKAGNKAYIVTNNHVVDGANKLAVKLSDGKQ
VDAKLVGKDPWLDLAVVEIDGSNVNKVATLGDSSKLRAGEKAIAIGNPLGFDGSVTEGIISSKEREIPVDIDGDKRPDWQ
AQVIQTDAAINPGNSGGALFNQNGEIIGINSSKIAQQEVEGIGFAIPINIAKPVIESLEKDGVVKRPALGVGVVSLEDVQ
AYAVNQLKVPKEVTNGVVLGKIYPISPAEKAGLEQYDIVVALDNQKVENALQFRKYLYEKKKVGEKVEVTFYRNGQKMTK
SATLADNSATKNQ
>Mature_412_residues
GYYDGPNLNEEHSETREVRKSGSKKGYFFTGLVGAVVGAVSISFAAPYMPWAQNNGAPVSSFSSDSKVEGTVVPVVNKAK
NETDLPGMIEGAKDVVVGVINMQQSVDPFAMQPTGQEQQAGSGSGVIYKKAGNKAYIVTNNHVVDGANKLAVKLSDGKQV
DAKLVGKDPWLDLAVVEIDGSNVNKVATLGDSSKLRAGEKAIAIGNPLGFDGSVTEGIISSKEREIPVDIDGDKRPDWQA
QVIQTDAAINPGNSGGALFNQNGEIIGINSSKIAQQEVEGIGFAIPINIAKPVIESLEKDGVVKRPALGVGVVSLEDVQA
YAVNQLKVPKEVTNGVVLGKIYPISPAEKAGLEQYDIVVALDNQKVENALQFRKYLYEKKKVGEKVEVTFYRNGQKMTKS
ATLADNSATKNQ

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=263, Percent_Identity=35.7414448669202, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI7019477, Length=296, Percent_Identity=33.445945945946, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI22129776, Length=291, Percent_Identity=30.2405498281787, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI24308541, Length=265, Percent_Identity=32.0754716981132, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1786356, Length=286, Percent_Identity=38.8111888111888, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI1789629, Length=285, Percent_Identity=37.5438596491228, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1789630, Length=293, Percent_Identity=33.4470989761092, Blast_Score=150, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24646839, Length=335, Percent_Identity=32.8358208955224, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 43907; Mature: 43776

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYYDGPNLNEEHSETREVRKSGSKKGYFFTGLVGAVVGAVSISFAAPYMPWAQNNGAPV
CCCCCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
SSFSSDSKVEGTVVPVVNKAKNETDLPGMIEGAKDVVVGVINMQQSVDPFAMQPTGQEQQ
CCCCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCEEEEEEEECCCCCCCEEECCCCCHHC
AGSGSGVIYKKAGNKAYIVTNNHVVDGANKLAVKLSDGKQVDAKLVGKDPWLDLAVVEID
CCCCCCEEEEECCCEEEEEECCEEECCCCEEEEEECCCCEECEEEECCCCCEEEEEEEEC
GSNVNKVATLGDSSKLRAGEKAIAIGNPLGFDGSVTEGIISSKEREIPVDIDGDKRPDWQ
CCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCEECCCCCCCCCC
AQVIQTDAAINPGNSGGALFNQNGEIIGINSSKIAQQEVEGIGFAIPINIAKPVIESLEK
EEEEEECCCCCCCCCCCEEECCCCCEEEECCHHHHHHHHHCCCEEEEHHHHHHHHHHHHH
DGVVKRPALGVGVVSLEDVQAYAVNQLKVPKEVTNGVVLGKIYPISPAEKAGLEQYDIVV
CCCEECCCCCEEEEEHHHHHHHHHHHEECCHHHHCCEEEEEEECCCCHHHCCCCEEEEEE
ALDNQKVENALQFRKYLYEKKKVGEKVEVTFYRNGQKMTKSATLADNSATKNQ
EECCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEECCEEEECCCCCCCCC
>Mature Secondary Structure 
GYYDGPNLNEEHSETREVRKSGSKKGYFFTGLVGAVVGAVSISFAAPYMPWAQNNGAPV
CCCCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
SSFSSDSKVEGTVVPVVNKAKNETDLPGMIEGAKDVVVGVINMQQSVDPFAMQPTGQEQQ
CCCCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCEEEEEEEECCCCCCCEEECCCCCHHC
AGSGSGVIYKKAGNKAYIVTNNHVVDGANKLAVKLSDGKQVDAKLVGKDPWLDLAVVEID
CCCCCCEEEEECCCEEEEEECCEEECCCCEEEEEECCCCEECEEEECCCCCEEEEEEEEC
GSNVNKVATLGDSSKLRAGEKAIAIGNPLGFDGSVTEGIISSKEREIPVDIDGDKRPDWQ
CCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCEECCCCCCCCCC
AQVIQTDAAINPGNSGGALFNQNGEIIGINSSKIAQQEVEGIGFAIPINIAKPVIESLEK
EEEEEECCCCCCCCCCCEEECCCCCEEEECCHHHHHHHHHCCCEEEEHHHHHHHHHHHHH
DGVVKRPALGVGVVSLEDVQAYAVNQLKVPKEVTNGVVLGKIYPISPAEKAGLEQYDIVV
CCCEECCCCCEEEEEHHHHHHHHHHHEECCHHHHCCEEEEEEECCCCHHHCCCCEEEEEE
ALDNQKVENALQFRKYLYEKKKVGEKVEVTFYRNGQKMTKSATLADNSATKNQ
EECCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEECCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8113162 [H]