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The map label for this gene is hssS [H]

Identifier: 218235769

GI number: 218235769

Start: 3138843

End: 3140219

Strand: Reverse

Name: hssS [H]

Synonym: BCB4264_A3248

Alternate gene names: 218235769

Gene position: 3140219-3138843 (Counterclockwise)

Preceding gene: 218233754

Following gene: 218236000

Centisome position: 57.95

GC content: 35.73

Gene sequence:

>1377_bases
ATGAAATCACTATATTCTAGATTTGTATTTATGACGGTCGGTATTATGCTACTTAGTAGTATTATCGGCTTTTTATTAAC
GAACGTATATTATCAAGTGAAGTTAAAACCGTATAATAGTGAAAAGATTTTAAAGTATGCGGAAGAAGTTAAGTCATTAT
ATGAAAAGCAAAGTGAAGAAAATCAAGAGGCGTACTTACAATCTATTGCGAAGTTAGGGTATGAAATTTATATTGTAGAT
GATCAAAAGAATGGAAAGCGTATCGGCAATGCGTTTCGTAAGACGTCTATTAGCGATGCTACTGTTCATAAAGTATTGCA
AGGGGAAACGTTTAATGGTGTTTCTACGTATCCAACGCGTCTCTTTATTACAGGTTTTTTCGATAATGAATTAATAAATA
GCGTCGGTGTACCGGTAAAGCACGGTGATAAACAGTACGCTTTATTTATTCGTCCCGACATTCAGAACCAATTTGGCGAG
ATGCGAATTTTCTTAGCGGTATTACTTGGGTTTATCGTACTATTAAGCATTATCTTTATAGTGATTGCAGCAGGTTACAT
CGTTCGCCCAATTCGTAAATTTACGAAGGCTACGCAAAAAATTGCGAGTGGGGAATATGAAATTGAATTAGACGTAAAAC
GAAAAGATGAAATAGGCACATTATCTACAAGCTTCCAAAAGATGACGAAAAGTATAAAAGAACTAGATGAAATGAGACAA
GAATTTGTTTCGAACGTTTCACATGAATTCCAGTCGCCGCTTTCTTCTATACAAGGTTTTTCGAAAACATTGCAAACAGA
AAAGATGAGTGAGGAAGAAAGAAACCATTACTTACAAATTATTGAGGGGGAAAGTAAGCGAATGTCTAGTTTATGTAAAC
AGTTACTGACGCTCGCTTCATTAGATAAAGAAGAGAAAGTTTTACAAATAAAAGAATTCAATTTGCAGAAGCAAATTAAA
GACGTCATTTTTATGCTCGAATGGAAATGGCGTGAGAAAGATATCGCTGTTGAGTTTGATGTGCCGGACATTACAATTAA
AGGTGATGAAAACTTGCTTCATCAAGTGTGGAGTAATATTTTTACGAATAGTATTAAGTTTTCAAACGATGCTGGGACGA
TTGAGTTTTTCGTGGAAGAGTTAGAGTATAGTGTCATTATCTCTATATCCGATAACGGAATCGGAATGGAAAAAGAAGAG
ATGGAACGTATTTTTGATCGTTTTTACAAAGTAGATACAGCAAGGGCAAGAAACGTAGAAGGTAGCGGTTTAGGATTGTC
GATTGTGCAGAAGATTGTTGAACTGCATAACGGAACTGTTTCAGTTTATAGCACGAAAGGGGAAGGGACGACTGTACGGG
TGGAACTTCCTAAATAG

Upstream 100 bases:

>100_bases
GTTCATGTGAAAAGGCTCCGAGATCGTTTCTCAAAACGAACGGATGATTTTCAAATTACGACAGTACGCGGACTCGGATA
TAAGTTGGAGCTGAAATAAA

Downstream 100 bases:

>100_bases
ATGGAAGAGGCTGTTTGAAAATAGCCTCTTCTTTTTTGTTGCTAGTATACGTGTGAAATGAAAAAATATGAGTCATTTTA
ATTGCATAATCGGATGAGTT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MKSLYSRFVFMTVGIMLLSSIIGFLLTNVYYQVKLKPYNSEKILKYAEEVKSLYEKQSEENQEAYLQSIAKLGYEIYIVD
DQKNGKRIGNAFRKTSISDATVHKVLQGETFNGVSTYPTRLFITGFFDNELINSVGVPVKHGDKQYALFIRPDIQNQFGE
MRIFLAVLLGFIVLLSIIFIVIAAGYIVRPIRKFTKATQKIASGEYEIELDVKRKDEIGTLSTSFQKMTKSIKELDEMRQ
EFVSNVSHEFQSPLSSIQGFSKTLQTEKMSEEERNHYLQIIEGESKRMSSLCKQLLTLASLDKEEKVLQIKEFNLQKQIK
DVIFMLEWKWREKDIAVEFDVPDITIKGDENLLHQVWSNIFTNSIKFSNDAGTIEFFVEELEYSVIISISDNGIGMEKEE
MERIFDRFYKVDTARARNVEGSGLGLSIVQKIVELHNGTVSVYSTKGEGTTVRVELPK

Sequences:

>Translated_458_residues
MKSLYSRFVFMTVGIMLLSSIIGFLLTNVYYQVKLKPYNSEKILKYAEEVKSLYEKQSEENQEAYLQSIAKLGYEIYIVD
DQKNGKRIGNAFRKTSISDATVHKVLQGETFNGVSTYPTRLFITGFFDNELINSVGVPVKHGDKQYALFIRPDIQNQFGE
MRIFLAVLLGFIVLLSIIFIVIAAGYIVRPIRKFTKATQKIASGEYEIELDVKRKDEIGTLSTSFQKMTKSIKELDEMRQ
EFVSNVSHEFQSPLSSIQGFSKTLQTEKMSEEERNHYLQIIEGESKRMSSLCKQLLTLASLDKEEKVLQIKEFNLQKQIK
DVIFMLEWKWREKDIAVEFDVPDITIKGDENLLHQVWSNIFTNSIKFSNDAGTIEFFVEELEYSVIISISDNGIGMEKEE
MERIFDRFYKVDTARARNVEGSGLGLSIVQKIVELHNGTVSVYSTKGEGTTVRVELPK
>Mature_458_residues
MKSLYSRFVFMTVGIMLLSSIIGFLLTNVYYQVKLKPYNSEKILKYAEEVKSLYEKQSEENQEAYLQSIAKLGYEIYIVD
DQKNGKRIGNAFRKTSISDATVHKVLQGETFNGVSTYPTRLFITGFFDNELINSVGVPVKHGDKQYALFIRPDIQNQFGE
MRIFLAVLLGFIVLLSIIFIVIAAGYIVRPIRKFTKATQKIASGEYEIELDVKRKDEIGTLSTSFQKMTKSIKELDEMRQ
EFVSNVSHEFQSPLSSIQGFSKTLQTEKMSEEERNHYLQIIEGESKRMSSLCKQLLTLASLDKEEKVLQIKEFNLQKQIK
DVIFMLEWKWREKDIAVEFDVPDITIKGDENLLHQVWSNIFTNSIKFSNDAGTIEFFVEELEYSVIISISDNGIGMEKEE
MERIFDRFYKVDTARARNVEGSGLGLSIVQKIVELHNGTVSVYSTKGEGTTVRVELPK

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=25.1824817518248, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1786783, Length=338, Percent_Identity=26.9230769230769, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1786600, Length=262, Percent_Identity=28.6259541984733, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1789149, Length=232, Percent_Identity=31.0344827586207, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=28.5714285714286, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1790436, Length=339, Percent_Identity=25.9587020648968, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790346, Length=326, Percent_Identity=26.3803680981595, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1788279, Length=407, Percent_Identity=22.8501228501229, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790861, Length=302, Percent_Identity=26.158940397351, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787894, Length=302, Percent_Identity=22.5165562913907, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87082128, Length=289, Percent_Identity=20.4152249134948, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789808, Length=288, Percent_Identity=23.2638888888889, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=28.3783783783784, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788713, Length=226, Percent_Identity=25.2212389380531, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1787374, Length=269, Percent_Identity=23.4200743494424, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87081816, Length=461, Percent_Identity=22.3427331887202, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1786912, Length=238, Percent_Identity=24.7899159663866, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789403, Length=285, Percent_Identity=24.9122807017544, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI48994928, Length=217, Percent_Identity=23.963133640553, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790551, Length=288, Percent_Identity=24.3055555555556, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52553; Mature: 52553

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLYSRFVFMTVGIMLLSSIIGFLLTNVYYQVKLKPYNSEKILKYAEEVKSLYEKQSEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
NQEAYLQSIAKLGYEIYIVDDQKNGKRIGNAFRKTSISDATVHKVLQGETFNGVSTYPTR
HHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCE
LFITGFFDNELINSVGVPVKHGDKQYALFIRPDIQNQFGEMRIFLAVLLGFIVLLSIIFI
EEEEEECCHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIAAGYIVRPIRKFTKATQKIASGEYEIELDVKRKDEIGTLSTSFQKMTKSIKELDEMRQ
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
EFVSNVSHEFQSPLSSIQGFSKTLQTEKMSEEERNHYLQIIEGESKRMSSLCKQLLTLAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHH
LDKEEKVLQIKEFNLQKQIKDVIFMLEWKWREKDIAVEFDVPDITIKGDENLLHQVWSNI
CCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCEEEECCCHHHHHHHHHHH
FTNSIKFSNDAGTIEFFVEELEYSVIISISDNGIGMEKEEMERIFDRFYKVDTARARNVE
HHCCCEECCCCCHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
GSGLGLSIVQKIVELHNGTVSVYSTKGEGTTVRVELPK
CCCCCHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCC
>Mature Secondary Structure
MKSLYSRFVFMTVGIMLLSSIIGFLLTNVYYQVKLKPYNSEKILKYAEEVKSLYEKQSEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
NQEAYLQSIAKLGYEIYIVDDQKNGKRIGNAFRKTSISDATVHKVLQGETFNGVSTYPTR
HHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCE
LFITGFFDNELINSVGVPVKHGDKQYALFIRPDIQNQFGEMRIFLAVLLGFIVLLSIIFI
EEEEEECCHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIAAGYIVRPIRKFTKATQKIASGEYEIELDVKRKDEIGTLSTSFQKMTKSIKELDEMRQ
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
EFVSNVSHEFQSPLSSIQGFSKTLQTEKMSEEERNHYLQIIEGESKRMSSLCKQLLTLAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHH
LDKEEKVLQIKEFNLQKQIKDVIFMLEWKWREKDIAVEFDVPDITIKGDENLLHQVWSNI
CCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCEEEECCCHHHHHHHHHHH
FTNSIKFSNDAGTIEFFVEELEYSVIISISDNGIGMEKEEMERIFDRFYKVDTARARNVE
HHCCCEECCCCCHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
GSGLGLSIVQKIVELHNGTVSVYSTKGEGTTVRVELPK
CCCCCHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA