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The map label for this gene is ubiB [H]

Identifier: 218235614

GI number: 218235614

Start: 2026465

End: 2028411

Strand: Reverse

Name: ubiB [H]

Synonym: BCB4264_A2127

Alternate gene names: 218235614

Gene position: 2028411-2026465 (Counterclockwise)

Preceding gene: 218234853

Following gene: 218233939

Centisome position: 37.43

GC content: 35.8

Gene sequence:

>1947_bases
ATGTTTTTTCAATTTTTTCTACTAGCAGTCATTATGTCTTTTATTAGTGGTCGACTAATTGGTACAAAACTAAATCTTGT
CAAACAAGCAAGTGCAGCCACTTTAGGTGTTTCACTTACATCAGCTCTGTATTGGTTTTTATATTTACGCTATCAAGATG
AATCTGTTGTCGGTGTTGATAGATATTTTTGGCTAGGAAGCTCATTAATTGTATCGATGCTATGTTACCTAGTTTTTGAA
TTATTTGATCCTATTAGGCGTGGCGAAATGGATGACGTAGTAACGGAAAGCCGAAATCCTATTTCAAAATTCTTCGCTAA
AATTGGTAGACAAAAAAGATATATGCGTGTCTCTTCTATTGCAATAAAACACGGAATGGGTAAATATTTAGCTTTAAAGC
GCTCGCCAGAAGCAGATCGTAAGCTCGCCACTTCCCTTCGAAATACACTAGAAGAATGCGGCGGTGTATTCATTAAATTC
GGACAAGTTTTATCAACTCGCTCTGATTTATTACCACCTGCTTTTATTCACGAGTTATCAAACCTTCAGGAAAATGTAAC
GCGTTTATCACAAAAACAAGTTGAAGAAATATTGAAAAAGGAACTACATATACCAAAAGATGAAATTTTCAGCTCCTTTG
AAATGGAACCGTTAGCTGCCGCCTCTATTGGCCAAGTACATAAAGCGAAGTTGAAAGAAAACGACCAGGATGTCGTCGTT
AAACTACTACGTCCTAATATTTCTGAGACAATTAAACGTGACTTAGATATTTTAATTCACTTTTCTTTATGGATTTCCAA
CAAATCAACTTGGGCTAAAAATATCGGATTTCTTGATTTAGCACATGGCTTCTCTATCGCAATGAAAGAAGAAATTGATT
TCAAAATTGAGGCTCGTAACTTCGAACAAGTGTCTGATTCACTAAAAAATAGCGAAACGAAAGTAAAAATACCGAAAGTA
TATCAAGAATACAGCAATTCAAAAATACTTGTGCTTGAATTTTTAGATGGAGTAAGCGTTAAAAGTGGGTCAGCATTATT
AAATGAATTACAAATTGATACGAAAAAAGTACAACGGCAACTCTTTGATTGTATTTTAGAGCAAATTTTCTTTAAAGGTA
TTTTCCATGCAGACCCTCATCCAGGTAATGTGTATATTCTTCGTGATGGCACTCCTGCATTACTTGATTTCGGTTCTGTT
GGACGATTAGGAACACTACAACAAGATGCATTCAAGCGACTACTTATCGGCTTTGAGCGCAAAAATTCATATGTCTTGCT
TGATGGATTGCTTCAATTAGTTGAAAAGAAACCAAATGTTGATAAAGAAGGATTAGAACAATCTATCAGTCAATTATTAA
TCCAAAGTACGTATGGTTCTACAAATGGTTCTGAAGAATTCATTCAGGGGCTATTTCAAATAATCGCTGAGTTTGAATTA
GCATTTTATCCAATGGTTGCAGGGGCTTTCCGCTCTCTAATTACGCTAGAAGGAACGATGCTGCAACTAAATCCTGAATT
CAATTTAATGGACGAAGCGAAGCGCTTTGCGAAAGATCATGCAGCTAGCTTCATGCCGGTTAACAATTATTCTAGTTTAA
AAGAAGCTGCAACAAACGAATTACTCGCTATGTTACCTGCCATGCGACGCATTCCTAGAAAACTAGATGATTTAAGTTCA
AAACTAGAAAACGGAGAATTATCCATAAAGGTCGGCTTTTTCTCTGACGAAACAAATGCATCGTTCATTACTACTTTTAT
CTCACAATTCCTCATTGCATTTATTGGAACTGCATTTGGTGGGATTTCGGTAGGCGTATTGCATTTAGCAAACAATGCGG
AAGAGCCAAATGATCAATTTTTAAGTGTCGTTGGTTACGGTGGTTTATTTATAAGTGCGATATTACTTGTAAGAGTAGCT
ATTCATGCGGTAAGGAAATTTAAGTAA

Upstream 100 bases:

>100_bases
TAATCGTGCAAGTCAAGGATTGTACTGCCTTGGCTTGTTTTTAGAATACTTATATTCCTGTATAATACAGTTATCGAATG
AAATTCGGAGGAATGATACA

Downstream 100 bases:

>100_bases
TAATAAAATGAGTATGAAATCACGTAGATTTTATACTCGTTTTTTATTGTGAAAATATTCAATATGCACTAGGAAATTTA
TGTTAAACTAAAGAAAATCG

Product: ABC1 family protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 648; Mature: 648

Protein sequence:

>648_residues
MFFQFFLLAVIMSFISGRLIGTKLNLVKQASAATLGVSLTSALYWFLYLRYQDESVVGVDRYFWLGSSLIVSMLCYLVFE
LFDPIRRGEMDDVVTESRNPISKFFAKIGRQKRYMRVSSIAIKHGMGKYLALKRSPEADRKLATSLRNTLEECGGVFIKF
GQVLSTRSDLLPPAFIHELSNLQENVTRLSQKQVEEILKKELHIPKDEIFSSFEMEPLAAASIGQVHKAKLKENDQDVVV
KLLRPNISETIKRDLDILIHFSLWISNKSTWAKNIGFLDLAHGFSIAMKEEIDFKIEARNFEQVSDSLKNSETKVKIPKV
YQEYSNSKILVLEFLDGVSVKSGSALLNELQIDTKKVQRQLFDCILEQIFFKGIFHADPHPGNVYILRDGTPALLDFGSV
GRLGTLQQDAFKRLLIGFERKNSYVLLDGLLQLVEKKPNVDKEGLEQSISQLLIQSTYGSTNGSEEFIQGLFQIIAEFEL
AFYPMVAGAFRSLITLEGTMLQLNPEFNLMDEAKRFAKDHAASFMPVNNYSSLKEAATNELLAMLPAMRRIPRKLDDLSS
KLENGELSIKVGFFSDETNASFITTFISQFLIAFIGTAFGGISVGVLHLANNAEEPNDQFLSVVGYGGLFISAILLVRVA
IHAVRKFK

Sequences:

>Translated_648_residues
MFFQFFLLAVIMSFISGRLIGTKLNLVKQASAATLGVSLTSALYWFLYLRYQDESVVGVDRYFWLGSSLIVSMLCYLVFE
LFDPIRRGEMDDVVTESRNPISKFFAKIGRQKRYMRVSSIAIKHGMGKYLALKRSPEADRKLATSLRNTLEECGGVFIKF
GQVLSTRSDLLPPAFIHELSNLQENVTRLSQKQVEEILKKELHIPKDEIFSSFEMEPLAAASIGQVHKAKLKENDQDVVV
KLLRPNISETIKRDLDILIHFSLWISNKSTWAKNIGFLDLAHGFSIAMKEEIDFKIEARNFEQVSDSLKNSETKVKIPKV
YQEYSNSKILVLEFLDGVSVKSGSALLNELQIDTKKVQRQLFDCILEQIFFKGIFHADPHPGNVYILRDGTPALLDFGSV
GRLGTLQQDAFKRLLIGFERKNSYVLLDGLLQLVEKKPNVDKEGLEQSISQLLIQSTYGSTNGSEEFIQGLFQIIAEFEL
AFYPMVAGAFRSLITLEGTMLQLNPEFNLMDEAKRFAKDHAASFMPVNNYSSLKEAATNELLAMLPAMRRIPRKLDDLSS
KLENGELSIKVGFFSDETNASFITTFISQFLIAFIGTAFGGISVGVLHLANNAEEPNDQFLSVVGYGGLFISAILLVRVA
IHAVRKFK
>Mature_648_residues
MFFQFFLLAVIMSFISGRLIGTKLNLVKQASAATLGVSLTSALYWFLYLRYQDESVVGVDRYFWLGSSLIVSMLCYLVFE
LFDPIRRGEMDDVVTESRNPISKFFAKIGRQKRYMRVSSIAIKHGMGKYLALKRSPEADRKLATSLRNTLEECGGVFIKF
GQVLSTRSDLLPPAFIHELSNLQENVTRLSQKQVEEILKKELHIPKDEIFSSFEMEPLAAASIGQVHKAKLKENDQDVVV
KLLRPNISETIKRDLDILIHFSLWISNKSTWAKNIGFLDLAHGFSIAMKEEIDFKIEARNFEQVSDSLKNSETKVKIPKV
YQEYSNSKILVLEFLDGVSVKSGSALLNELQIDTKKVQRQLFDCILEQIFFKGIFHADPHPGNVYILRDGTPALLDFGSV
GRLGTLQQDAFKRLLIGFERKNSYVLLDGLLQLVEKKPNVDKEGLEQSISQLLIQSTYGSTNGSEEFIQGLFQIIAEFEL
AFYPMVAGAFRSLITLEGTMLQLNPEFNLMDEAKRFAKDHAASFMPVNNYSSLKEAATNELLAMLPAMRRIPRKLDDLSS
KLENGELSIKVGFFSDETNASFITTFISQFLIAFIGTAFGGISVGVLHLANNAEEPNDQFLSVVGYGGLFISAILLVRVA
IHAVRKFK

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=286, Percent_Identity=30.4195804195804, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI41393593, Length=265, Percent_Identity=28.6792452830189, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI217035081, Length=206, Percent_Identity=32.5242718446602, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI27363457, Length=280, Percent_Identity=25.3571428571429, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI34147522, Length=279, Percent_Identity=25.4480286738351, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI217416386, Length=249, Percent_Identity=24.4979919678715, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI2367309, Length=389, Percent_Identity=28.0205655526992, Blast_Score=156, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17559152, Length=249, Percent_Identity=31.3253012048193, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI32565180, Length=290, Percent_Identity=30.3448275862069, Blast_Score=101, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325148, Length=262, Percent_Identity=32.0610687022901, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321319, Length=257, Percent_Identity=31.5175097276265, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323282, Length=293, Percent_Identity=27.6450511945392, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24662575, Length=252, Percent_Identity=30.1587301587302, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI22024280, Length=265, Percent_Identity=32.0754716981132, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI18859849, Length=261, Percent_Identity=24.5210727969349, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 72941; Mature: 72941

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFQFFLLAVIMSFISGRLIGTKLNLVKQASAATLGVSLTSALYWFLYLRYQDESVVGVD
CHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEHH
RYFWLGSSLIVSMLCYLVFELFDPIRRGEMDDVVTESRNPISKFFAKIGRQKRYMRVSSI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
AIKHGMGKYLALKRSPEADRKLATSLRNTLEECGGVFIKFGQVLSTRSDLLPPAFIHELS
HHHHCCCHHEEECCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHH
NLQENVTRLSQKQVEEILKKELHIPKDEIFSSFEMEPLAAASIGQVHKAKLKENDQDVVV
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHH
KLLRPNISETIKRDLDILIHFSLWISNKSTWAKNIGFLDLAHGFSIAMKEEIDFKIEARN
HHHCCCHHHHHHHHHHHEEEEEEEECCCCHHHHCCCCEECCCCCCEEEECCCCEEEECCC
FEQVSDSLKNSETKVKIPKVYQEYSNSKILVLEFLDGVSVKSGSALLNELQIDTKKVQRQ
HHHHHHHHHCCCCEEEHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
LFDCILEQIFFKGIFHADPHPGNVYILRDGTPALLDFGSVGRLGTLQQDAFKRLLIGFER
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHCCCCCCCCCCCHHHHHHHHHHHHHCC
KNSYVLLDGLLQLVEKKPNVDKEGLEQSISQLLIQSTYGSTNGSEEFIQGLFQIIAEFEL
CCCEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
AFYPMVAGAFRSLITLEGTMLQLNPEFNLMDEAKRFAKDHAASFMPVNNYSSLKEAATNE
HHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LLAMLPAMRRIPRKLDDLSSKLENGELSIKVGFFSDETNASFITTFISQFLIAFIGTAFG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
GISVGVLHLANNAEEPNDQFLSVVGYGGLFISAILLVRVAIHAVRKFK
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFFQFFLLAVIMSFISGRLIGTKLNLVKQASAATLGVSLTSALYWFLYLRYQDESVVGVD
CHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEHH
RYFWLGSSLIVSMLCYLVFELFDPIRRGEMDDVVTESRNPISKFFAKIGRQKRYMRVSSI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
AIKHGMGKYLALKRSPEADRKLATSLRNTLEECGGVFIKFGQVLSTRSDLLPPAFIHELS
HHHHCCCHHEEECCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHH
NLQENVTRLSQKQVEEILKKELHIPKDEIFSSFEMEPLAAASIGQVHKAKLKENDQDVVV
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHH
KLLRPNISETIKRDLDILIHFSLWISNKSTWAKNIGFLDLAHGFSIAMKEEIDFKIEARN
HHHCCCHHHHHHHHHHHEEEEEEEECCCCHHHHCCCCEECCCCCCEEEECCCCEEEECCC
FEQVSDSLKNSETKVKIPKVYQEYSNSKILVLEFLDGVSVKSGSALLNELQIDTKKVQRQ
HHHHHHHHHCCCCEEEHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
LFDCILEQIFFKGIFHADPHPGNVYILRDGTPALLDFGSVGRLGTLQQDAFKRLLIGFER
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHCCCCCCCCCCCHHHHHHHHHHHHHCC
KNSYVLLDGLLQLVEKKPNVDKEGLEQSISQLLIQSTYGSTNGSEEFIQGLFQIIAEFEL
CCCEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
AFYPMVAGAFRSLITLEGTMLQLNPEFNLMDEAKRFAKDHAASFMPVNNYSSLKEAATNE
HHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LLAMLPAMRRIPRKLDDLSSKLENGELSIKVGFFSDETNASFITTFISQFLIAFIGTAFG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
GISVGVLHLANNAEEPNDQFLSVVGYGGLFISAILLVRVAIHAVRKFK
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA