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The map label for this gene is sph [H]

Identifier: 218235530

GI number: 218235530

Start: 699951

End: 700952

Strand: Direct

Name: sph [H]

Synonym: BCB4264_A0708

Alternate gene names: 218235530

Gene position: 699951-700952 (Clockwise)

Preceding gene: 218233076

Following gene: 218233648

Centisome position: 12.92

GC content: 35.63

Gene sequence:

>1002_bases
GTGAAATGTAAATTGCTAAAAGGTGTACTTAGCTTAGGTGTTGGTTTAGGAGCTTTATATAGCGGAACGTCAGCTCAAGC
AGAAGTGTCTACAAATCAAAATGATACATTAAAAGTGATGACGCATAATGTATATATGCTATCAACAAACTTATATCCGA
ACTGGGGACAAACTGAGCGTGCTGATTTAATCGGGGCGGCAGATTATATAAAGAATCAAGATGTAGTTATATTAAATGAA
GTGTTTGATAATAGCGCTTCAGATCGTTTATTAGGGAATTTGAAGAAAGAATATCCAAATCAAACAGCAGTATTAGGTCG
TAGTAGTGGAAGTGAATGGGATAAAACGTTAGGAAACTATTCATCTTCAACTCCTGAAGATGGTGGCGTTGCGATTGTGA
GCAAATGGCCAATCGCTGAAAAGATTCAATATGTATTTGCAAAAGGATGCGGGCCAGATAATTTATCGAATAAAGGATTT
GTATACACGAAAATTAAGAAAAATGATCGCTTCGTTCACGTGATTGGTACGCATTTGCAAGCGGAAGATAGTATGTGCGG
AAAAACTTCACCTGCATCTGTACGTACAGACCAATTAAAAGAAATTCAAGACTTTATTAAAAATAAAAATATACCAAATA
ATGAGTATGTGTTAATTGGCGGTGATATGAACGTAAATAAAATTAATGCAGAGAACAAGAATGATTCAGAGTATGCATCT
ATGTTTAAAACATTGAACGCTTCTGTACCATCTTATACTGGACATACAGCGACTTGGGACGCAACGACAAACAGTATTGC
AAAATATAATTTCCCTGATAGTCCTGCTGAGTATTTAGATTATATTATTGCAAGTAAAGACCATGCGAACCCATCATATA
TAGAGAATAAGGTGTTACAGCCGAAATCTCCACAATGGACTGTTACATCGTGGTTCCAAAAATATACGTATAATGATTAC
TCTGATCATTATCCAGTAGAGGCGACTATTTCTATGAAGTAG

Upstream 100 bases:

>100_bases
TTTGATACGTACGGAAATCGTTAAGTATTTAAAAAAGGTCAAATCTCAGAATAGAGTATTTGGCCTTTTTATCACTATAC
AATACATGGGGGTATGAAAC

Downstream 100 bases:

>100_bases
TTTCAAAAAGTTTCTTCGTAAAGAAGAAACTTTTTTTATTTGCAAACAGGAAAATCACACTTTCTTTCCAATATGTATAA
GACATATTGAGAAGAGGAGA

Product: sphingomyelin phosphodiesterase C

Products: NA

Alternate protein names: SMase; Cereolysin B; SMPLC; Sphingomyelin phosphodiesterase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKCKLLKGVLSLGVGLGALYSGTSAQAEVSTNQNDTLKVMTHNVYMLSTNLYPNWGQTERADLIGAADYIKNQDVVILNE
VFDNSASDRLLGNLKKEYPNQTAVLGRSSGSEWDKTLGNYSSSTPEDGGVAIVSKWPIAEKIQYVFAKGCGPDNLSNKGF
VYTKIKKNDRFVHVIGTHLQAEDSMCGKTSPASVRTDQLKEIQDFIKNKNIPNNEYVLIGGDMNVNKINAENKNDSEYAS
MFKTLNASVPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSYIENKVLQPKSPQWTVTSWFQKYTYNDY
SDHYPVEATISMK

Sequences:

>Translated_333_residues
MKCKLLKGVLSLGVGLGALYSGTSAQAEVSTNQNDTLKVMTHNVYMLSTNLYPNWGQTERADLIGAADYIKNQDVVILNE
VFDNSASDRLLGNLKKEYPNQTAVLGRSSGSEWDKTLGNYSSSTPEDGGVAIVSKWPIAEKIQYVFAKGCGPDNLSNKGF
VYTKIKKNDRFVHVIGTHLQAEDSMCGKTSPASVRTDQLKEIQDFIKNKNIPNNEYVLIGGDMNVNKINAENKNDSEYAS
MFKTLNASVPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSYIENKVLQPKSPQWTVTSWFQKYTYNDY
SDHYPVEATISMK
>Mature_333_residues
MKCKLLKGVLSLGVGLGALYSGTSAQAEVSTNQNDTLKVMTHNVYMLSTNLYPNWGQTERADLIGAADYIKNQDVVILNE
VFDNSASDRLLGNLKKEYPNQTAVLGRSSGSEWDKTLGNYSSSTPEDGGVAIVSKWPIAEKIQYVFAKGCGPDNLSNKGF
VYTKIKKNDRFVHVIGTHLQAEDSMCGKTSPASVRTDQLKEIQDFIKNKNIPNNEYVLIGGDMNVNKINAENKNDSEYAS
MFKTLNASVPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSYIENKVLQPKSPQWTVTSWFQKYTYNDY
SDHYPVEATISMK

Specific function: Required, with sphingomyelinase, to effect target cell lysis (hemolysis) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the neutral sphingomyelinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005135
- InterPro:   IPR017766 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.4.12 [H]

Molecular weight: Translated: 36985; Mature: 36985

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCKLLKGVLSLGVGLGALYSGTSAQAEVSTNQNDTLKVMTHNVYMLSTNLYPNWGQTER
CCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEEEEEEEEEECCCCCCCCCHH
ADLIGAADYIKNQDVVILNEVFDNSASDRLLGNLKKEYPNQTAVLGRSSGSEWDKTLGNY
HHHHHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCC
SSSTPEDGGVAIVSKWPIAEKIQYVFAKGCGPDNLSNKGFVYTKIKKNDRFVHVIGTHLQ
CCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEECCEE
AEDSMCGKTSPASVRTDQLKEIQDFIKNKNIPNNEYVLIGGDMNVNKINAENKNDSEYAS
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCCCHHHHHH
MFKTLNASVPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSYIENKVLQ
HHHHHCCCCCCCCCCEEEECCCCCCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCC
PKSPQWTVTSWFQKYTYNDYSDHYPVEATISMK
CCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MKCKLLKGVLSLGVGLGALYSGTSAQAEVSTNQNDTLKVMTHNVYMLSTNLYPNWGQTER
CCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEEEEEEEEEECCCCCCCCCHH
ADLIGAADYIKNQDVVILNEVFDNSASDRLLGNLKKEYPNQTAVLGRSSGSEWDKTLGNY
HHHHHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCC
SSSTPEDGGVAIVSKWPIAEKIQYVFAKGCGPDNLSNKGFVYTKIKKNDRFVHVIGTHLQ
CCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEECCEE
AEDSMCGKTSPASVRTDQLKEIQDFIKNKNIPNNEYVLIGGDMNVNKINAENKNDSEYAS
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCCCHHHHHH
MFKTLNASVPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSYIENKVLQ
HHHHHCCCCCCCCCCEEEECCCCCCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCC
PKSPQWTVTSWFQKYTYNDYSDHYPVEATISMK
CCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2536680 [H]