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The map label for this gene is gltT [H]

Identifier: 218235352

GI number: 218235352

Start: 1383798

End: 1385033

Strand: Reverse

Name: gltT [H]

Synonym: BCB4264_A1441

Alternate gene names: 218235352

Gene position: 1385033-1383798 (Counterclockwise)

Preceding gene: 218231434

Following gene: 218232016

Centisome position: 25.56

GC content: 38.59

Gene sequence:

>1236_bases
TTGAAACAAACAAAAGCAATCTTAATCGCATTATTTCTAGGTCTAGTTGTTGGACTCACTCTAAATTTAGCTGCTCCATC
TATCTTTGAGCCACTAAATCAATATGTGTTCAACCCAATTGGTCAATTGTTTATTCGACTTATTAAAATGCTAGTTGTTC
CTGTTGTGTTCATTTCTATCGTACTTGGTGCTGCCGGCCTTGGAGATCCGAAACAACTTGGAAGAATCGGTTTAAAATCA
ATTTCATTCTTTCTCGTAACAACTGCGGTTGCCATCTCTATAGCGGTTACATTTGCACTTATTATAAAACCAGGAGCTGG
CGGTAGTTTTAAAACAGAAGGTCTTAAGTATGAAGGTGCAAAAACTGAAACATCTTTCGTCGACACATTGCTAAATATCG
TACCAGATAACCCAGCAAAAGCGATGGCTGACGGAAACATGTTACAAATCATTGCCTTTGCCGTATTGATTGGACTCGGT
ATAGCTATTTTAGGAAAACGAGTTCAAGGTATCCATTCATTACTTGAACAGGGCAACGAATTAATGATGTATCTTGTTAA
TCTCGTTATGAAATTAGCCCCAATTGGAACATTCGGTTTGCTCGCTTCATCCGTTGGTAAAATGGGGCTTGCAGGCGTCG
CTGCGATGTTCAAGTATATGATTGTCGTTATGTTAGTACTCATTATTCACGGGGTCTTTGTATATGGCGGCTTATTAAAG
GTATTAGCAAAAGAAAGTATTGTTCGTTTCTTTAAACATTTCGGACCAGTAATGGCAATTGGATTTAGTACATCTAGCTC
TAATGCATCGCTTCCATTTGCAATGAAAACAGCACAAGATAAGCTTGGCGTTCCAAAAGCGATAAGCTCATTTGTACAAC
CACTAGGGGCAACTATTAATATGGATGGTACTGCCATTATGCAAGGGGTAGCAACTGTATTTATCGCTCAAGTATACGGA
GTTGAACTTACATTACCGCAATTAGCTATGGTCGTATTAACCGCTGTACTAGCTAGTATCGGTACTGCTGGTGTACCTGG
TGTTGGACTTGTAATGCTTACAATGGTTTTAAATCAAGTAAATCTACCAGTAGAAGGTATCGCTTTAATTATCGGTATTG
ACCGTATTTTAGATATGTCTAGAACAGCTGTAAACATTTCTGGTGATGCAATTTGCGCAATGATTGTCGCAAAATCAGAA
GAAAAATATAATACGGATCAATCGGCAGCATCGTAA

Upstream 100 bases:

>100_bases
AAACAAAAATGAAAAATTCAGAAAATATTGTAAAATTAGGTATTTTTTCGGTATAATTACTTTAGAAAGAAATTTCGCAA
AAACAAAAGGGGGGATTTTA

Downstream 100 bases:

>100_bases
ATCAAAAAAGGAGTGAATTATTTCACTCCTTTTTTGATTTACTCCCTTTTTTAGAACGATATTCTTTCCCTTTATTATCA
TTACCAGTTTCAAATTCAGT

Product: proton/glutamate symporter family protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MKQTKAILIALFLGLVVGLTLNLAAPSIFEPLNQYVFNPIGQLFIRLIKMLVVPVVFISIVLGAAGLGDPKQLGRIGLKS
ISFFLVTTAVAISIAVTFALIIKPGAGGSFKTEGLKYEGAKTETSFVDTLLNIVPDNPAKAMADGNMLQIIAFAVLIGLG
IAILGKRVQGIHSLLEQGNELMMYLVNLVMKLAPIGTFGLLASSVGKMGLAGVAAMFKYMIVVMLVLIIHGVFVYGGLLK
VLAKESIVRFFKHFGPVMAIGFSTSSSNASLPFAMKTAQDKLGVPKAISSFVQPLGATINMDGTAIMQGVATVFIAQVYG
VELTLPQLAMVVLTAVLASIGTAGVPGVGLVMLTMVLNQVNLPVEGIALIIGIDRILDMSRTAVNISGDAICAMIVAKSE
EKYNTDQSAAS

Sequences:

>Translated_411_residues
MKQTKAILIALFLGLVVGLTLNLAAPSIFEPLNQYVFNPIGQLFIRLIKMLVVPVVFISIVLGAAGLGDPKQLGRIGLKS
ISFFLVTTAVAISIAVTFALIIKPGAGGSFKTEGLKYEGAKTETSFVDTLLNIVPDNPAKAMADGNMLQIIAFAVLIGLG
IAILGKRVQGIHSLLEQGNELMMYLVNLVMKLAPIGTFGLLASSVGKMGLAGVAAMFKYMIVVMLVLIIHGVFVYGGLLK
VLAKESIVRFFKHFGPVMAIGFSTSSSNASLPFAMKTAQDKLGVPKAISSFVQPLGATINMDGTAIMQGVATVFIAQVYG
VELTLPQLAMVVLTAVLASIGTAGVPGVGLVMLTMVLNQVNLPVEGIALIIGIDRILDMSRTAVNISGDAICAMIVAKSE
EKYNTDQSAAS
>Mature_411_residues
MKQTKAILIALFLGLVVGLTLNLAAPSIFEPLNQYVFNPIGQLFIRLIKMLVVPVVFISIVLGAAGLGDPKQLGRIGLKS
ISFFLVTTAVAISIAVTFALIIKPGAGGSFKTEGLKYEGAKTETSFVDTLLNIVPDNPAKAMADGNMLQIIAFAVLIGLG
IAILGKRVQGIHSLLEQGNELMMYLVNLVMKLAPIGTFGLLASSVGKMGLAGVAAMFKYMIVVMLVLIIHGVFVYGGLLK
VLAKESIVRFFKHFGPVMAIGFSTSSSNASLPFAMKTAQDKLGVPKAISSFVQPLGATINMDGTAIMQGVATVFIAQVYG
VELTLPQLAMVVLTAVLASIGTAGVPGVGLVMLTMVLNQVNLPVEGIALIIGIDRILDMSRTAVNISGDAICAMIVAKSE
EKYNTDQSAAS

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=403, Percent_Identity=33.0024813895782, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI169790839, Length=457, Percent_Identity=30.8533916849015, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI5032093, Length=399, Percent_Identity=34.3358395989975, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI40254478, Length=448, Percent_Identity=30.8035714285714, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI66773030, Length=450, Percent_Identity=29.7777777777778, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI223468564, Length=250, Percent_Identity=36.8, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI223468566, Length=250, Percent_Identity=36.8, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4827012, Length=286, Percent_Identity=34.965034965035, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI194239697, Length=264, Percent_Identity=36.3636363636364, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI262359914, Length=377, Percent_Identity=28.1167108753316, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI301601644, Length=172, Percent_Identity=40.1162790697674, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI1790514, Length=416, Percent_Identity=37.0192307692308, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1789947, Length=410, Percent_Identity=30.9756097560976, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1788024, Length=393, Percent_Identity=30.2798982188295, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789473, Length=286, Percent_Identity=27.972027972028, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71983106, Length=415, Percent_Identity=32.5301204819277, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71983099, Length=415, Percent_Identity=32.5301204819277, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71996953, Length=462, Percent_Identity=31.1688311688312, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17537407, Length=433, Percent_Identity=31.6397228637413, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI193206505, Length=445, Percent_Identity=29.6629213483146, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI193206654, Length=396, Percent_Identity=30.3030303030303, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17541374, Length=398, Percent_Identity=27.1356783919598, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24583025, Length=429, Percent_Identity=29.1375291375291, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI17137668, Length=429, Percent_Identity=29.1375291375291, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24583023, Length=429, Percent_Identity=29.1375291375291, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI281360483, Length=457, Percent_Identity=27.1334792122538, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI17137666, Length=457, Percent_Identity=27.1334792122538, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI281360481, Length=457, Percent_Identity=27.1334792122538, Blast_Score=121, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43116; Mature: 43116

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHCCHHHCCCCCCCCC
>Mature Secondary Structure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CCCHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]