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The map label for this gene is proC2 [H]

Identifier: 218235333

GI number: 218235333

Start: 3009043

End: 3009825

Strand: Reverse

Name: proC2 [H]

Synonym: BCB4264_A3132

Alternate gene names: 218235333

Gene position: 3009825-3009043 (Counterclockwise)

Preceding gene: 218231095

Following gene: 218232872

Centisome position: 55.54

GC content: 33.59

Gene sequence:

>783_bases
ATGGGTATTGCTATGATAGGTGGGATGATAAAAAAAAATATAGTTTTTCCAGATCAAATAATTTGTTCAGATTTAAACGT
CATTAATTTAAAAAATGCTAGTAATGAATATGGCATAACTATAACTACTAACAACAATGAAGTCGCTAACAGTGCTGACA
TTTTAATTTTATCAATCAAACCAGATTTATACTCATCGGTAATTAACCAAATAAAAGATCAAATAAAAAATGATGTAATC
GTTGTAACTATTGCTGCAGGAAAAAGTATTAAGAGCACTGAGAATGAATTTGGTAGAAAGTTAAAAGTTGTTAGAGTAAT
GCCTAATACACCGGCACTTGTTGGAGAAGGAATGTCTGCGTTATGTTTTAATGAAATGGTTACAGAAAAAGATATAAAAG
AGGTACTGAACATATTTAATATTTTCGGCCAGACGGAGGTCATAAATGAAAAGCTAATGGATGTTGTTACATCTATTAGT
GGTTCTTCTCCAGCATATGTGTATATGTTTATAGAAGCCATGGCAGATGCTGCTGTACTTGGTGGTATGCCGAGAAAACA
AGCTTATAAATTTGCGGCTCAGGCTGTATTAGGTTCTGCAAAAATGGTATTGGAAACAGGAATACATCCAGGTGAATTGA
AGGATATGGTTTGTTCTCCAGGTGGAACGACGATAGAAGCTGTAGTAACGCTAGAAGAAAAAGGTTTAAGAACAGCTATC
ATTTCAGCTATGAAACGTTGTACGCAAAAATCTATGGAAATGTCTAGTTTAACTAGTAAGTGA

Upstream 100 bases:

>100_bases
TTATTTAGAATAATAATTTCAAAATCAATAAAATTTAGAGTAGAAGGAGCAAGAGCAAATTATTATGAATAAACAAATAG
GATTCATCGGATGTGGAAAC

Downstream 100 bases:

>100_bases
GAAGCGAATTTATATAATATTTCAAATCTATTTAATGTAAAAGAAATATTATGAGGCTAGTTAATAACTAAGTAAATTTA
TATACAACACTAACGAGAAG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MGIAMIGGMIKKNIVFPDQIICSDLNVINLKNASNEYGITITTNNNEVANSADILILSIKPDLYSSVINQIKDQIKNDVI
VVTIAAGKSIKSTENEFGRKLKVVRVMPNTPALVGEGMSALCFNEMVTEKDIKEVLNIFNIFGQTEVINEKLMDVVTSIS
GSSPAYVYMFIEAMADAAVLGGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAVVTLEEKGLRTAI
ISAMKRCTQKSMEMSSLTSK

Sequences:

>Translated_260_residues
MGIAMIGGMIKKNIVFPDQIICSDLNVINLKNASNEYGITITTNNNEVANSADILILSIKPDLYSSVINQIKDQIKNDVI
VVTIAAGKSIKSTENEFGRKLKVVRVMPNTPALVGEGMSALCFNEMVTEKDIKEVLNIFNIFGQTEVINEKLMDVVTSIS
GSSPAYVYMFIEAMADAAVLGGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAVVTLEEKGLRTAI
ISAMKRCTQKSMEMSSLTSK
>Mature_259_residues
GIAMIGGMIKKNIVFPDQIICSDLNVINLKNASNEYGITITTNNNEVANSADILILSIKPDLYSSVINQIKDQIKNDVIV
VTIAAGKSIKSTENEFGRKLKVVRVMPNTPALVGEGMSALCFNEMVTEKDIKEVLNIFNIFGQTEVINEKLMDVVTSISG
SSPAYVYMFIEAMADAAVLGGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAVVTLEEKGLRTAII
SAMKRCTQKSMEMSSLTSK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=265, Percent_Identity=34.7169811320755, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI24797097, Length=265, Percent_Identity=33.2075471698113, Blast_Score=161, Evalue=4e-40,
Organism=Homo sapiens, GI24797095, Length=265, Percent_Identity=33.2075471698113, Blast_Score=161, Evalue=5e-40,
Organism=Homo sapiens, GI198041662, Length=258, Percent_Identity=34.4961240310078, Blast_Score=159, Evalue=2e-39,
Organism=Escherichia coli, GI1786585, Length=255, Percent_Identity=53.3333333333333, Blast_Score=277, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17569021, Length=252, Percent_Identity=36.5079365079365, Blast_Score=160, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17540664, Length=224, Percent_Identity=35.7142857142857, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320861, Length=211, Percent_Identity=30.3317535545024, Blast_Score=112, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24648116, Length=266, Percent_Identity=36.4661654135338, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21358587, Length=259, Percent_Identity=34.7490347490347, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24647700, Length=172, Percent_Identity=41.2790697674419, Blast_Score=144, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28065; Mature: 27934

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIAMIGGMIKKNIVFPDQIICSDLNVINLKNASNEYGITITTNNNEVANSADILILSIK
CCHHHHHHHHHCCCCCCCHHHHCCCCEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEEC
PDLYSSVINQIKDQIKNDVIVVTIAAGKSIKSTENEFGRKLKVVRVMPNTPALVGEGMSA
CHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHCCEEEEEEECCCCCHHHHCCHHH
LCFNEMVTEKDIKEVLNIFNIFGQTEVINEKLMDVVTSISGSSPAYVYMFIEAMADAAVL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHH
GGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAVVTLEEKGLRTAI
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEEEHHCCHHHHH
ISAMKRCTQKSMEMSSLTSK
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GIAMIGGMIKKNIVFPDQIICSDLNVINLKNASNEYGITITTNNNEVANSADILILSIK
CHHHHHHHHHCCCCCCCHHHHCCCCEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEEC
PDLYSSVINQIKDQIKNDVIVVTIAAGKSIKSTENEFGRKLKVVRVMPNTPALVGEGMSA
CHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHCCEEEEEEECCCCCHHHHCCHHH
LCFNEMVTEKDIKEVLNIFNIFGQTEVINEKLMDVVTSISGSSPAYVYMFIEAMADAAVL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHH
GGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAVVTLEEKGLRTAI
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEEEHHCCHHHHH
ISAMKRCTQKSMEMSSLTSK
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]