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The map label for this gene is nhaC [H]

Identifier: 218235297

GI number: 218235297

Start: 1426792

End: 1428108

Strand: Direct

Name: nhaC [H]

Synonym: BCB4264_A1490

Alternate gene names: 218235297

Gene position: 1426792-1428108 (Clockwise)

Preceding gene: 218233540

Following gene: 218235914

Centisome position: 26.33

GC content: 36.9

Gene sequence:

>1317_bases
TTGAAAGAAACGAGAGGAAATGGTTTAGCTTTATTACCACTTGGGATATTTTTGGCGCTATTTATTGGTTCTGGAATTAT
TACAGGTGATTTCTATAAATTGCCGATACTTGTAGCGATTTCAATTGCTGTAGGAGTCGCTTTAGTGATGAATCGTAAAG
AAAGTTTTAATGTGAAAGTAGAGCGGTTCGCTAAAGGTGCAGGAAATCCGGATATCATGATTATGGTATTAATTTTTGTG
CTTGCAGGTGCATTTTCTGAAACTGCTAAAGGAATGGGCGGAGTAGACTCAACTGTTAATTTAGCGTTAACTATTTTACC
GCCAGGATTTATCGTAGCTGGAATCTTTGTTATTGGTGCATTTATTTCATTAGCGATGGGAACTTCAATGGGAACAATTG
CAGCATTAGCGCCGATTGCTGTAGGTATTAGTGGTCAAACCGATATCTCAATTGCGCTTGCAATGGCTACTGTTGTTGGC
GGAGCGATGTTTGGTGATAATTTATCATTTATTTCAGATACAACAATCGCAGCTGTTCGTTCACAAGGAACAGAAATGAA
AGATAAGTTTAAAACGAACTTTTTAATTGTGTTACCAGCGGCTATTATTACAATTGTACTATTAGTAATAGTTACTTCAG
GAAGTGACACGCAGATTAAAGCACATAGCTTTGATTGGATAAAGATTTTACCGTACGCAGGAGTACTTATTACAGCGCTA
CTTGGCTGGAATGTGCTTATTGTATTAACTGGTGGAACTGTACTATCTGGTGTTATCGGCATTATAGATGGAAGTTACAC
GTTAGAAAGTTTCTTTAAAAGTGTAACGACTGGAATGGGCGGTATGATGGAGTTAGTATTACTTGCTATATTAATTGGCG
GTATGGTTGAATTAATCCAATATAATGGTGGTATTCAATATTTAATGAATGTATTAACACGTAATATTCGTTCGAAAAAA
GGAGCGGAATTTGGTATTGCTGGTTTAGTGAGTATGACGAATATGTGTACAGCGAATAATACGATTTCAATTATCTTTAC
AGGCCCGCTTGCAAAAAATATTGCAGATCAATATGAAATAGACCCTCGTAAATCAGCGAGTGTATTAGATCTTTTCTCAT
GTTGTGTGCAAGGATTAATTCCGTACGGTGCCCAAATGTTAACGGCAGCAGGATTTGCAGCGTTATCTCCGGTTGAATTG
TTGCCATATGCATTTTATCCAATCTTAGTTGGAGTATGTGGGATTGCTTCTATTTTAATTGGGTTTCCAAGGTTTTCGAA
AGTAGCTGAGAAAAAAGAGTATCATAAAACAGCTTAA

Upstream 100 bases:

>100_bases
TGAGAAGAGCGTTTCTTATAGATGTATAAGACCTCTTCTCATCGGAAGAGGTCTTTTGTTATTCATTAGAAAAAGGTTGA
AACTAGGGAGAGATGGTACT

Downstream 100 bases:

>100_bases
TTTAATATGAATGTTAGTAATTAAAAAACGTGCAGAGGATAGACTCTGCACGTTTTTTTGCGTAAAGGGCTGAATATGAC
TCGGTCTTAAGTCTGAGTTA

Product: Na+/H+ antiporter family protein

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MKETRGNGLALLPLGIFLALFIGSGIITGDFYKLPILVAISIAVGVALVMNRKESFNVKVERFAKGAGNPDIMIMVLIFV
LAGAFSETAKGMGGVDSTVNLALTILPPGFIVAGIFVIGAFISLAMGTSMGTIAALAPIAVGISGQTDISIALAMATVVG
GAMFGDNLSFISDTTIAAVRSQGTEMKDKFKTNFLIVLPAAIITIVLLVIVTSGSDTQIKAHSFDWIKILPYAGVLITAL
LGWNVLIVLTGGTVLSGVIGIIDGSYTLESFFKSVTTGMGGMMELVLLAILIGGMVELIQYNGGIQYLMNVLTRNIRSKK
GAEFGIAGLVSMTNMCTANNTISIIFTGPLAKNIADQYEIDPRKSASVLDLFSCCVQGLIPYGAQMLTAAGFAALSPVEL
LPYAFYPILVGVCGIASILIGFPRFSKVAEKKEYHKTA

Sequences:

>Translated_438_residues
MKETRGNGLALLPLGIFLALFIGSGIITGDFYKLPILVAISIAVGVALVMNRKESFNVKVERFAKGAGNPDIMIMVLIFV
LAGAFSETAKGMGGVDSTVNLALTILPPGFIVAGIFVIGAFISLAMGTSMGTIAALAPIAVGISGQTDISIALAMATVVG
GAMFGDNLSFISDTTIAAVRSQGTEMKDKFKTNFLIVLPAAIITIVLLVIVTSGSDTQIKAHSFDWIKILPYAGVLITAL
LGWNVLIVLTGGTVLSGVIGIIDGSYTLESFFKSVTTGMGGMMELVLLAILIGGMVELIQYNGGIQYLMNVLTRNIRSKK
GAEFGIAGLVSMTNMCTANNTISIIFTGPLAKNIADQYEIDPRKSASVLDLFSCCVQGLIPYGAQMLTAAGFAALSPVEL
LPYAFYPILVGVCGIASILIGFPRFSKVAEKKEYHKTA
>Mature_438_residues
MKETRGNGLALLPLGIFLALFIGSGIITGDFYKLPILVAISIAVGVALVMNRKESFNVKVERFAKGAGNPDIMIMVLIFV
LAGAFSETAKGMGGVDSTVNLALTILPPGFIVAGIFVIGAFISLAMGTSMGTIAALAPIAVGISGQTDISIALAMATVVG
GAMFGDNLSFISDTTIAAVRSQGTEMKDKFKTNFLIVLPAAIITIVLLVIVTSGSDTQIKAHSFDWIKILPYAGVLITAL
LGWNVLIVLTGGTVLSGVIGIIDGSYTLESFFKSVTTGMGGMMELVLLAILIGGMVELIQYNGGIQYLMNVLTRNIRSKK
GAEFGIAGLVSMTNMCTANNTISIIFTGPLAKNIADQYEIDPRKSASVLDLFSCCVQGLIPYGAQMLTAAGFAALSPVEL
LPYAFYPILVGVCGIASILIGFPRFSKVAEKKEYHKTA

Specific function: Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on g

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 45920; Mature: 45920

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS00133 CARBOXYPEPT_ZN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKETRGNGLALLPLGIFLALFIGSGIITGDFYKLPILVAISIAVGVALVMNRKESFNVKV
CCCCCCCCEEEHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEH
ERFAKGAGNPDIMIMVLIFVLAGAFSETAKGMGGVDSTVNLALTILPPGFIVAGIFVIGA
HHHHCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHH
FISLAMGTSMGTIAALAPIAVGISGQTDISIALAMATVVGGAMFGDNLSFISDTTIAAVR
HHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHH
SQGTEMKDKFKTNFLIVLPAAIITIVLLVIVTSGSDTQIKAHSFDWIKILPYAGVLITAL
HCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEHHHHHHHHHHHH
LGWNVLIVLTGGTVLSGVIGIIDGSYTLESFFKSVTTGMGGMMELVLLAILIGGMVELIQ
HCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
YNGGIQYLMNVLTRNIRSKKGAEFGIAGLVSMTNMCTANNTISIIFTGPLAKNIADQYEI
HCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHCCC
DPRKSASVLDLFSCCVQGLIPYGAQMLTAAGFAALSPVELLPYAFYPILVGVCGIASILI
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
GFPRFSKVAEKKEYHKTA
CCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKETRGNGLALLPLGIFLALFIGSGIITGDFYKLPILVAISIAVGVALVMNRKESFNVKV
CCCCCCCCEEEHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEH
ERFAKGAGNPDIMIMVLIFVLAGAFSETAKGMGGVDSTVNLALTILPPGFIVAGIFVIGA
HHHHCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHH
FISLAMGTSMGTIAALAPIAVGISGQTDISIALAMATVVGGAMFGDNLSFISDTTIAAVR
HHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHH
SQGTEMKDKFKTNFLIVLPAAIITIVLLVIVTSGSDTQIKAHSFDWIKILPYAGVLITAL
HCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEHHHHHHHHHHHH
LGWNVLIVLTGGTVLSGVIGIIDGSYTLESFFKSVTTGMGGMMELVLLAILIGGMVELIQ
HCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
YNGGIQYLMNVLTRNIRSKKGAEFGIAGLVSMTNMCTANNTISIIFTGPLAKNIADQYEI
HCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHCCC
DPRKSASVLDLFSCCVQGLIPYGAQMLTAAGFAALSPVELLPYAFYPILVGVCGIASILI
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
GFPRFSKVAEKKEYHKTA
CCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10903309; 11274110 [H]