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The map label for this gene is trpA [H]

Identifier: 218235176

GI number: 218235176

Start: 1257904

End: 1258680

Strand: Direct

Name: trpA [H]

Synonym: BCB4264_A1297

Alternate gene names: 218235176

Gene position: 1257904-1258680 (Clockwise)

Preceding gene: 218234944

Following gene: 218233755

Centisome position: 23.21

GC content: 39.38

Gene sequence:

>777_bases
ATGGGAGTAGAAAAAATTAAAGCAGCGTTTGAAAATGGAAAGAAAGCATTTATTCCGTACGTAATGGGCGGAGATGGCGG
CTTTGAAAAATTAAAAGAAAGAATTCGTTTTCTTGATGAAGCAGGAGCGAGCATCGTTGAAATCGGCATTCCTTTTTCGG
ATCCAGTCGCAGACGGTCCAACGATTCAAAGAGCAGGGAAACGAGCGCTAGATAGCGGCGTAACAGTAAAAGGTATTTTT
CAAGCATTAATAGAGGTAAGGAAAGAAGTGCAAATTCCGTTTGTACTCATGACATATTTAAATCCGGTACTTGCATTCGG
AAAAGAGAGATTCATTGAGAACTGTATAGAAGCAGGTGTAGACGGCATCATCGTTCCAGACTTACCGTATGAAGAACAAA
ATATTATTGCGTCGTTACTTCGAGAGGTAAACATTGCGCTCATTCCACTCGTTACCGTAACGAGTCCTATTGAAAGAATT
GAAAAAATTACGAGTGAATCAGAAGGGTTCGTTTATGCTGTTACAGTAGCGGGCGTAACGGGAGTACGTCAAAACTTTAA
AGAGGAGATTCATAGTTACTTAGAAAAAGTAAAATCACACGTCAACTTACCAGTAGTCGCTGGATTCGGCATCTCAACAA
AAGAACATGTAGAAGAAATGGTTACAATATGCGACGGAGTTGTCGTTGGAAGTAAGGTCATTGAGCTTTTAGAAAATGAA
AAGCGAGAAGAAATATGTGAATTAATATATGCAACAAAACAAAAAGAAGAGGCGTAG

Upstream 100 bases:

>100_bases
GCCGCAAATGAAGAAAGATGAAGGGCTTGTCATTTGTTTATCTGGCCGCGGTGATAAAGATGTAGAGAGTATAAAACGTT
ATATGGAAGAGGTGTAAAAA

Downstream 100 bases:

>100_bases
TCTCTTCTTTTTGTTTTGCGTAATAAATGTTAAAATATACAGAAAATACATATAATTCAGAGGAGGAGAAGGCATGCTAA
GACGTAAATTACTATATCTA

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MGVEKIKAAFENGKKAFIPYVMGGDGGFEKLKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDSGVTVKGIF
QALIEVRKEVQIPFVLMTYLNPVLAFGKERFIENCIEAGVDGIIVPDLPYEEQNIIASLLREVNIALIPLVTVTSPIERI
EKITSESEGFVYAVTVAGVTGVRQNFKEEIHSYLEKVKSHVNLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENE
KREEICELIYATKQKEEA

Sequences:

>Translated_258_residues
MGVEKIKAAFENGKKAFIPYVMGGDGGFEKLKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDSGVTVKGIF
QALIEVRKEVQIPFVLMTYLNPVLAFGKERFIENCIEAGVDGIIVPDLPYEEQNIIASLLREVNIALIPLVTVTSPIERI
EKITSESEGFVYAVTVAGVTGVRQNFKEEIHSYLEKVKSHVNLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENE
KREEICELIYATKQKEEA
>Mature_257_residues
GVEKIKAAFENGKKAFIPYVMGGDGGFEKLKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDSGVTVKGIFQ
ALIEVRKEVQIPFVLMTYLNPVLAFGKERFIENCIEAGVDGIIVPDLPYEEQNIIASLLREVNIALIPLVTVTSPIERIE
KITSESEGFVYAVTVAGVTGVRQNFKEEIHSYLEKVKSHVNLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENEK
REEICELIYATKQKEEA

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=235, Percent_Identity=34.8936170212766, Blast_Score=132, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321412, Length=242, Percent_Identity=35.9504132231405, Blast_Score=173, Evalue=2e-44,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 28366; Mature: 28235

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVEKIKAAFENGKKAFIPYVMGGDGGFEKLKERIRFLDEAGASIVEIGIPFSDPVADGP
CCHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCC
TIQRAGKRALDSGVTVKGIFQALIEVRKEVQIPFVLMTYLNPVLAFGKERFIENCIEAGV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
DGIIVPDLPYEEQNIIASLLREVNIALIPLVTVTSPIERIEKITSESEGFVYAVTVAGVT
CCEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHH
GVRQNFKEEIHSYLEKVKSHVNLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENE
HHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
KREEICELIYATKQKEEA
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GVEKIKAAFENGKKAFIPYVMGGDGGFEKLKERIRFLDEAGASIVEIGIPFSDPVADGP
CHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCC
TIQRAGKRALDSGVTVKGIFQALIEVRKEVQIPFVLMTYLNPVLAFGKERFIENCIEAGV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
DGIIVPDLPYEEQNIIASLLREVNIALIPLVTVTSPIERIEKITSESEGFVYAVTVAGVT
CCEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHH
GVRQNFKEEIHSYLEKVKSHVNLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENE
HHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
KREEICELIYATKQKEEA
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA