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The map label for this gene is glpK [H]

Identifier: 218235134

GI number: 218235134

Start: 1039903

End: 1041393

Strand: Direct

Name: glpK [H]

Synonym: BCB4264_A1066

Alternate gene names: 218235134

Gene position: 1039903-1041393 (Clockwise)

Preceding gene: 218235696

Following gene: 218234213

Centisome position: 19.19

GC content: 39.97

Gene sequence:

>1491_bases
ATGAAAAAATATATTCTTTCATTAGACCAAGGAACAACAAGCTCACGCGCAATTCTTTTCAATAAAAAAGGTGAAATTGT
TCATTCAGCTCAAAAAGAGTTTACACAACATTTTCCAAAGCCGGGCTGGGTAGAGCATAATGCACAAGAAATTTGGGGAT
CTATTTTAGCAGTTATCGCAACTTGCTTAAGCGAAGCGGATGTAAAACCAGAACAAATCGCTGGTATCGGTATTACGAAC
CAACGTGAAACAACGGTTGTATGGGATAAAACAACTAGTAAACCAATTTACAACGCAATCGTATGGCAATCTCGCCAAAC
AGCTGAAATTTGTGATGAGTTAAAAGAAAAAGGTTATAGCGAAATGGTTCGCGAAAAAACAGGTCTTTTAATTGATGCAT
ACTTCTCTGGTACGAAAGTAAAATGGATTTTAGATAACGTTGAAGGTGCAAGAGAGAAAGCAGAAAACGGCGATCTATTA
TTCGGAACAATTGATTCGTGGCTTGTATGGAAACTATCTGGTGGTAAAGCACACGTAACAGATTACTCAAACGCATCACG
TACGTTAATGTTTAACATTCACGACTTACAGTGGGATGATGAGCTTCTAGAAATGTTAACAGTACCAAAGAGCATGCTTC
CAGAAGTGCGTCCATCATCTGAAATTTACGGAGAAACAATTGATTATCACTTCTTCGGCCAAAATGTACCGATTGCAGGT
GTAGCTGGTGACCAACAAGCAGCATTATTTGGACAAGCTTGTTTCGGTGAAGGTATGGCGAAAAATACTTACGGAACTGG
TTGTTTCATGTTAATGAACACTGGTGAAAAAGCAGTAGCTTCTGAGCACGGCCTATTAACAACAATTGCATGGGGAATAG
ATGGTAAAGTAAACTACGCATTAGAAGGAAGTATTTTCGTAGCAGGTTCTGCAATTCAGTGGTTACGCGACGGAATGCGC
ATGTTTAAAGATGCAAGTGAGAGTGAAGTATATGCTTCTCGCGTTGAATCAACTGACGGTGTATACGTTGTACCAGCATT
CGTAGGTTTAGGAACACCTTATTGGGATAGTGAAGTACGCGGCGCTATGTTTGGTGTAACGCGCGGTACGACGAAAGAGC
ATTTCATTCGTGCAACGCTAGAATCTTTAGCTTACCAAACGAAAGATGTATTATGCGCAATGGAAGCAGATTCAGGTATT
GAGCTGAAAACATTACGCGTTGATGGCGGAGCAGTTAAAAATAACTTCTTAATGAAGTTCCAAAGTGATATTTTAGATGT
TCCTGTAGAGCGTCCAGTAATCAACGAAACAACGGCTCTAGGTGCAGCATACTTAGCTGGTCTTGCGGTTGGATATTGGA
AAAACCAAGATGAAATTAAAGAACAGTGGCATATGGACAAACGCTTTGAACCAACGATGGAAGCGAAAACAAGCGAAGAG
CTATATGCTGGATGGAAAAAAGCAATTGAAGCAACAAAAGCTTTCAAATAA

Upstream 100 bases:

>100_bases
ATTATCGCAACTGTGATTGTACTAGCAATCTCTTATATGACAAGTAAAAAAAGCGGAAGCAATACAAATAGTAGAAAAGT
AGCATAAGGGGGAAACCGAT

Downstream 100 bases:

>100_bases
TCATAAACAGTGTTATAATGGTGACAAGTTAATAATTCGGTAGGAGATTTGGAGAGACCACAACGCGCTATAGAGGCGAA
ATCTATAGCGGAGTTTGTGG

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MKKYILSLDQGTTSSRAILFNKKGEIVHSAQKEFTQHFPKPGWVEHNAQEIWGSILAVIATCLSEADVKPEQIAGIGITN
QRETTVVWDKTTSKPIYNAIVWQSRQTAEICDELKEKGYSEMVREKTGLLIDAYFSGTKVKWILDNVEGAREKAENGDLL
FGTIDSWLVWKLSGGKAHVTDYSNASRTLMFNIHDLQWDDELLEMLTVPKSMLPEVRPSSEIYGETIDYHFFGQNVPIAG
VAGDQQAALFGQACFGEGMAKNTYGTGCFMLMNTGEKAVASEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGMR
MFKDASESEVYASRVESTDGVYVVPAFVGLGTPYWDSEVRGAMFGVTRGTTKEHFIRATLESLAYQTKDVLCAMEADSGI
ELKTLRVDGGAVKNNFLMKFQSDILDVPVERPVINETTALGAAYLAGLAVGYWKNQDEIKEQWHMDKRFEPTMEAKTSEE
LYAGWKKAIEATKAFK

Sequences:

>Translated_496_residues
MKKYILSLDQGTTSSRAILFNKKGEIVHSAQKEFTQHFPKPGWVEHNAQEIWGSILAVIATCLSEADVKPEQIAGIGITN
QRETTVVWDKTTSKPIYNAIVWQSRQTAEICDELKEKGYSEMVREKTGLLIDAYFSGTKVKWILDNVEGAREKAENGDLL
FGTIDSWLVWKLSGGKAHVTDYSNASRTLMFNIHDLQWDDELLEMLTVPKSMLPEVRPSSEIYGETIDYHFFGQNVPIAG
VAGDQQAALFGQACFGEGMAKNTYGTGCFMLMNTGEKAVASEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGMR
MFKDASESEVYASRVESTDGVYVVPAFVGLGTPYWDSEVRGAMFGVTRGTTKEHFIRATLESLAYQTKDVLCAMEADSGI
ELKTLRVDGGAVKNNFLMKFQSDILDVPVERPVINETTALGAAYLAGLAVGYWKNQDEIKEQWHMDKRFEPTMEAKTSEE
LYAGWKKAIEATKAFK
>Mature_496_residues
MKKYILSLDQGTTSSRAILFNKKGEIVHSAQKEFTQHFPKPGWVEHNAQEIWGSILAVIATCLSEADVKPEQIAGIGITN
QRETTVVWDKTTSKPIYNAIVWQSRQTAEICDELKEKGYSEMVREKTGLLIDAYFSGTKVKWILDNVEGAREKAENGDLL
FGTIDSWLVWKLSGGKAHVTDYSNASRTLMFNIHDLQWDDELLEMLTVPKSMLPEVRPSSEIYGETIDYHFFGQNVPIAG
VAGDQQAALFGQACFGEGMAKNTYGTGCFMLMNTGEKAVASEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGMR
MFKDASESEVYASRVESTDGVYVVPAFVGLGTPYWDSEVRGAMFGVTRGTTKEHFIRATLESLAYQTKDVLCAMEADSGI
ELKTLRVDGGAVKNNFLMKFQSDILDVPVERPVINETTALGAAYLAGLAVGYWKNQDEIKEQWHMDKRFEPTMEAKTSEE
LYAGWKKAIEATKAFK

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI41393575, Length=493, Percent_Identity=47.2616632860041, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI42794763, Length=500, Percent_Identity=46.8, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI189409120, Length=496, Percent_Identity=47.1774193548387, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI4504007, Length=496, Percent_Identity=47.1774193548387, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI88196792, Length=503, Percent_Identity=32.6043737574553, Blast_Score=308, Evalue=7e-84,
Organism=Escherichia coli, GI1790361, Length=495, Percent_Identity=63.2323232323232, Blast_Score=680, Evalue=0.0,
Organism=Escherichia coli, GI1790005, Length=526, Percent_Identity=23.7642585551331, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1789168, Length=494, Percent_Identity=24.0890688259109, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1789987, Length=486, Percent_Identity=23.2510288065844, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1787789, Length=495, Percent_Identity=23.6363636363636, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17535599, Length=500, Percent_Identity=40.8, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI71986140, Length=520, Percent_Identity=25.7692307692308, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI71986147, Length=272, Percent_Identity=30.8823529411765, Blast_Score=140, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6321755, Length=515, Percent_Identity=36.3106796116505, Blast_Score=310, Evalue=4e-85,
Organism=Drosophila melanogaster, GI17864214, Length=501, Percent_Identity=42.5149700598802, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24654573, Length=432, Percent_Identity=44.212962962963, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24655555, Length=465, Percent_Identity=40, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24655560, Length=465, Percent_Identity=40, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24655570, Length=465, Percent_Identity=40, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24655574, Length=465, Percent_Identity=40, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24655565, Length=465, Percent_Identity=40, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19922058, Length=522, Percent_Identity=30.8429118773946, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24652871, Length=489, Percent_Identity=31.4928425357873, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24656367, Length=508, Percent_Identity=27.1653543307087, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI21357867, Length=523, Percent_Identity=26.1950286806883, Blast_Score=208, Evalue=8e-54,
Organism=Drosophila melanogaster, GI24656372, Length=343, Percent_Identity=27.9883381924198, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI45552909, Length=290, Percent_Identity=26.2068965517241, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55118; Mature: 55118

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYILSLDQGTTSSRAILFNKKGEIVHSAQKEFTQHFPKPGWVEHNAQEIWGSILAVIA
CCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
TCLSEADVKPEQIAGIGITNQRETTVVWDKTTSKPIYNAIVWQSRQTAEICDELKEKGYS
HHHHHCCCCHHHEEECCCCCCCCEEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHCCHH
EMVREKTGLLIDAYFSGTKVKWILDNVEGAREKAENGDLLFGTIDSWLVWKLSGGKAHVT
HHHHHHCCCEEEEEECCCEEEEEEECCHHHHHHCCCCCEEEEECCCEEEEEECCCEEEEE
DYSNASRTLMFNIHDLQWDDELLEMLTVPKSMLPEVRPSSEIYGETIDYHFFGQNVPIAG
ECCCCCEEEEEEEECCCCHHHHHHHHHCCHHHCCCCCCCHHHCCCCEEEEEECCCCCEEE
VAGDQQAALFGQACFGEGMAKNTYGTGCFMLMNTGEKAVASEHGLLTTIAWGIDGKVNYA
ECCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHCCCCCEEEEEECCCCEEEEE
LEGSIFVAGSAIQWLRDGMRMFKDASESEVYASRVESTDGVYVVPAFVGLGTPYWDSEVR
EECCEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEHHHCCCCCCCCCCC
GAMFGVTRGTTKEHFIRATLESLAYQTKDVLCAMEADSGIELKTLRVDGGAVKNNFLMKF
CEEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEECCCCCCCHHHHEE
QSDILDVPVERPVINETTALGAAYLAGLAVGYWKNQDEIKEQWHMDKRFEPTMEAKTSEE
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHCCCHHH
LYAGWKKAIEATKAFK
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKYILSLDQGTTSSRAILFNKKGEIVHSAQKEFTQHFPKPGWVEHNAQEIWGSILAVIA
CCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
TCLSEADVKPEQIAGIGITNQRETTVVWDKTTSKPIYNAIVWQSRQTAEICDELKEKGYS
HHHHHCCCCHHHEEECCCCCCCCEEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHCCHH
EMVREKTGLLIDAYFSGTKVKWILDNVEGAREKAENGDLLFGTIDSWLVWKLSGGKAHVT
HHHHHHCCCEEEEEECCCEEEEEEECCHHHHHHCCCCCEEEEECCCEEEEEECCCEEEEE
DYSNASRTLMFNIHDLQWDDELLEMLTVPKSMLPEVRPSSEIYGETIDYHFFGQNVPIAG
ECCCCCEEEEEEEECCCCHHHHHHHHHCCHHHCCCCCCCHHHCCCCEEEEEECCCCCEEE
VAGDQQAALFGQACFGEGMAKNTYGTGCFMLMNTGEKAVASEHGLLTTIAWGIDGKVNYA
ECCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHCCCCCEEEEEECCCCEEEEE
LEGSIFVAGSAIQWLRDGMRMFKDASESEVYASRVESTDGVYVVPAFVGLGTPYWDSEVR
EECCEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEHHHCCCCCCCCCCC
GAMFGVTRGTTKEHFIRATLESLAYQTKDVLCAMEADSGIELKTLRVDGGAVKNNFLMKF
CEEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEECCCCCCCHHHHEE
QSDILDVPVERPVINETTALGAAYLAGLAVGYWKNQDEIKEQWHMDKRFEPTMEAKTSEE
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHCCCHHH
LYAGWKKAIEATKAFK
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA