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The map label for this gene is glmU [H]

Identifier: 218235092

GI number: 218235092

Start: 51024

End: 52403

Strand: Direct

Name: glmU [H]

Synonym: BCB4264_A0054

Alternate gene names: 218235092

Gene position: 51024-52403 (Clockwise)

Preceding gene: 218235644

Following gene: 218231348

Centisome position: 0.94

GC content: 38.55

Gene sequence:

>1380_bases
ATGTCAAACAGATTTGCAGTGATTCTAGCTGCAGGTAAAGGCACACGTATGAAGTCTAAGCTATACAAAGTGCTGCATCC
TGTATGTGGAAAACCTATGGTACAACACGTAGTCGATCAAGTATCTCAATTAGGATTGCAGAAACTTGTAACGGTTGTTG
GACATGGTGCTGAAATGGTACAAGAACAGCTAGGGAACGTAAGTGAGTTTGCATTACAAGCAGAACAACTTGGTACAGCA
CATGCTGTAGATCAAGCTGCAAGTGTACTTGCAAATGAAGAAGGAACAACTTTAGTTATTTGTGGTGATACGCCTCTAAT
AACTGCTGAAACAATGGAAGCATTACTTCAGCAACATAAAGAAGCAGGAGCAATGGCGACGGTGCTAACAGCATACATAG
AAGAGCCTGCTGGATATGGCCGTATTGTTCGTAATGAGAATGGTCATGTTGAAAAGATTGTTGAGCATAAAGATGCAAAT
GAGAAAGAATTAGCTATTAAAGAAATCAATACAGGTACGTATTGTTTTGATAATAAGGCTTTATTTGCTTCACTTTCTAA
AGTTTCAAATGATAACGTGCAAGGTGAATATTACCTTCCAGATGTTATTGAGATTTTAAAAAATGAAGGTCATATCGTAT
CAGCTTATCAAACAGAGCAGTTCGACGAAACGTTAGGTGTTAACGACAGAGTCGCTCTATCGCAAGCGGAAATTATTATG
AAAAACCGTATCAACCGAAAGAACATGGTAAACGGTGTTACAATTATTGATCCAAGTAACACTTATATTTCTGCTGATGC
AGTTATCGGTAGTGATACAGTTCTTCATCCAGGAACAATTATTGAGGGGAACACTGTAATTGGCTCTGATTGTGAAATTG
GACCGCATACAGTAATTCGCGATAGTGAAATTGGAGATCGTACGACAATTCGACAATCTACTGTACATGATAGTAAGCTT
GGTACAGAAGTATCGGTTGGTCCATTTGCACATATTCGCCCAGATTCAGTTATTGGAGACGAAGTACGCGTTGGAAACTT
CGTGGAAATCAAAAAAACTGTCTTTGGTAATAGAAGTAAAGCTTCACACTTGAGTTATATCGGGGATGCACAAGTTGGAG
AAGACGTGAATCTTGGTTGTGGTTCAATTACGGTGAACTATGACGGTAAGAATAAATTCAAAACTGTGATTGGTAATGGG
GTATTTATTGGATGTAATTCAAACCTTGTTGCTCCAGTAACAGTTGAAGATGGTGCTTATGTGGCAGCAGGCTCTACAAT
TACAGAGAATGTTCCATCAAAAGCATTATCGGTAGCACGTGCACGTCAAGTTAACAAAGAAGACTATGTTGATCAATTGC
TGAATAAGAAAAAATCATAA

Upstream 100 bases:

>100_bases
AATTATGGTAAAATTTAATAGTTAAAATGTGTTTCTTGAAATATATGATGATTTAGGATAATATCTTTAATGGATAAATA
GGTTGCGATGGAGGGTCTAT

Downstream 100 bases:

>100_bases
TGTGGAGGGTTAATCTAGATGTCGACTCAATATCTAAATTCTAATTTGAAAGTATTCTCTTTAAACTCTAATAAGGAACT
TGCTGAGCAGATTGCAAAGC

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEMVQEQLGNVSEFALQAEQLGTA
HAVDQAASVLANEEGTTLVICGDTPLITAETMEALLQQHKEAGAMATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDAN
EKELAIKEINTGTYCFDNKALFASLSKVSNDNVQGEYYLPDVIEILKNEGHIVSAYQTEQFDETLGVNDRVALSQAEIIM
KNRINRKNMVNGVTIIDPSNTYISADAVIGSDTVLHPGTIIEGNTVIGSDCEIGPHTVIRDSEIGDRTTIRQSTVHDSKL
GTEVSVGPFAHIRPDSVIGDEVRVGNFVEIKKTVFGNRSKASHLSYIGDAQVGEDVNLGCGSITVNYDGKNKFKTVIGNG
VFIGCNSNLVAPVTVEDGAYVAAGSTITENVPSKALSVARARQVNKEDYVDQLLNKKKS

Sequences:

>Translated_459_residues
MSNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEMVQEQLGNVSEFALQAEQLGTA
HAVDQAASVLANEEGTTLVICGDTPLITAETMEALLQQHKEAGAMATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDAN
EKELAIKEINTGTYCFDNKALFASLSKVSNDNVQGEYYLPDVIEILKNEGHIVSAYQTEQFDETLGVNDRVALSQAEIIM
KNRINRKNMVNGVTIIDPSNTYISADAVIGSDTVLHPGTIIEGNTVIGSDCEIGPHTVIRDSEIGDRTTIRQSTVHDSKL
GTEVSVGPFAHIRPDSVIGDEVRVGNFVEIKKTVFGNRSKASHLSYIGDAQVGEDVNLGCGSITVNYDGKNKFKTVIGNG
VFIGCNSNLVAPVTVEDGAYVAAGSTITENVPSKALSVARARQVNKEDYVDQLLNKKKS
>Mature_458_residues
SNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEMVQEQLGNVSEFALQAEQLGTAH
AVDQAASVLANEEGTTLVICGDTPLITAETMEALLQQHKEAGAMATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDANE
KELAIKEINTGTYCFDNKALFASLSKVSNDNVQGEYYLPDVIEILKNEGHIVSAYQTEQFDETLGVNDRVALSQAEIIMK
NRINRKNMVNGVTIIDPSNTYISADAVIGSDTVLHPGTIIEGNTVIGSDCEIGPHTVIRDSEIGDRTTIRQSTVHDSKLG
TEVSVGPFAHIRPDSVIGDEVRVGNFVEIKKTVFGNRSKASHLSYIGDAQVGEDVNLGCGSITVNYDGKNKFKTVIGNGV
FIGCNSNLVAPVTVEDGAYVAAGSTITENVPSKALSVARARQVNKEDYVDQLLNKKKS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=359, Percent_Identity=23.9554317548747, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI11761619, Length=340, Percent_Identity=24.1176470588235, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790168, Length=445, Percent_Identity=44.4943820224719, Blast_Score=369, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI133931050, Length=357, Percent_Identity=25.4901960784314, Blast_Score=88, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6320148, Length=364, Percent_Identity=25, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355443, Length=362, Percent_Identity=24.0331491712707, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24644084, Length=362, Percent_Identity=24.0331491712707, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep; PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 49430; Mature: 49299

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEMV
CCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
QEQLGNVSEFALQAEQLGTAHAVDQAASVLANEEGTTLVICGDTPLITAETMEALLQQHK
HHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEHHHHHHHHHHHH
EAGAMATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDANEKELAIKEINTGTYCFDNKA
HHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHCCCCCHHEEEEECCCCEEEECCHH
LFASLSKVSNDNVQGEYYLPDVIEILKNEGHIVSAYQTEQFDETLGVNDRVALSQAEIIM
HHHHHHHHCCCCCCCEEECHHHHHHHHCCCCEEEEEEHHHHHHHCCCCCCEEHHHHHHHH
KNRINRKNMVNGVTIIDPSNTYISADAVIGSDTVLHPGTIIEGNTVIGSDCEIGPHTVIR
HHCCCCCHHCCCEEEECCCCCEEEECEEECCCCEECCCEEEECCEEECCCCCCCCCEEEE
DSEIGDRTTIRQSTVHDSKLGTEVSVGPFAHIRPDSVIGDEVRVGNFVEIKKTVFGNRSK
CCCCCCCHHHHHHHCCHHHCCCEEECCCCCCCCCCCCCCCCEECCCEEEEHHHHCCCCCC
ASHLSYIGDAQVGEDVNLGCGSITVNYDGKNKFKTVIGNGVFIGCNSNLVAPVTVEDGAY
CCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEECCCEEEEECCCEEEEEEECCCCE
VAAGSTITENVPSKALSVARARQVNKEDYVDQLLNKKKS
EEECCCHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEMV
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
QEQLGNVSEFALQAEQLGTAHAVDQAASVLANEEGTTLVICGDTPLITAETMEALLQQHK
HHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEHHHHHHHHHHHH
EAGAMATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDANEKELAIKEINTGTYCFDNKA
HHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHCCCCCHHEEEEECCCCEEEECCHH
LFASLSKVSNDNVQGEYYLPDVIEILKNEGHIVSAYQTEQFDETLGVNDRVALSQAEIIM
HHHHHHHHCCCCCCCEEECHHHHHHHHCCCCEEEEEEHHHHHHHCCCCCCEEHHHHHHHH
KNRINRKNMVNGVTIIDPSNTYISADAVIGSDTVLHPGTIIEGNTVIGSDCEIGPHTVIR
HHCCCCCHHCCCEEEECCCCCEEEECEEECCCCEECCCEEEECCEEECCCCCCCCCEEEE
DSEIGDRTTIRQSTVHDSKLGTEVSVGPFAHIRPDSVIGDEVRVGNFVEIKKTVFGNRSK
CCCCCCCHHHHHHHCCHHHCCCEEECCCCCCCCCCCCCCCCEECCCEEEEHHHHCCCCCC
ASHLSYIGDAQVGEDVNLGCGSITVNYDGKNKFKTVIGNGVFIGCNSNLVAPVTVEDGAY
CCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEECCCEEEEECCCEEEEEEECCCCE
VAAGSTITENVPSKALSVARARQVNKEDYVDQLLNKKKS
EEECCCHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA