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The map label for this gene is ffH [H]

Identifier: 218235010

GI number: 218235010

Start: 3863347

End: 3864696

Strand: Reverse

Name: ffH [H]

Synonym: BCB4264_A3944

Alternate gene names: 218235010

Gene position: 3864696-3863347 (Counterclockwise)

Preceding gene: 218234697

Following gene: 218235927

Centisome position: 71.32

GC content: 40.3

Gene sequence:

>1350_bases
ATGGCATTTGAAGGATTAGCCGACCGACTTCAACAGACAATGCAAAAAATCCGCGGCAAAGGAAAAGTTTCTGAAGCCGA
TGTGAAAGAAATGATGAGAGAAGTTCGTCTAGCTCTTTTAGAAGCAGATGTTAACTTTAAAGTAGTAAAAGATTTTGTGA
AGCGTGTGTCTGAACGTGCTGTCGGACAAGATGTAATGAAAAGTTTGACACCTGGACAACAAGTAATTAAAGTTGTACAG
GAAGAACTTACAGAACTTATGGGCGGAGAGCAAAGCAAAATTGCTGTTGCTAATAAGCCACCGACTGTTATTATGATGGT
TGGTCTGCAAGGTGCGGGTAAAACAACGACGACAGGTAAGCTTGCGAATTTGCTTCGTAAAAAGCATAACCGTAAACCGA
TGCTTGTTGCAGCGGATATTTACCGTCCAGCAGCGATTAAACAGCTTGAAACATTAGGGAAGCAATTGGACATGCCTGTA
TTCTCTTTAGGAGATCAAGTAAGTCCTGTTGAAATTGCGAAACAAGCGATTGCAAAAGCAAAAGAAGATCATCACGATTA
TGTTTTAATCGATACAGCGGGTCGCCTGCATATTGATGAAGAACTAATGGATGAATTAGCGAAAGTTAAAGAAGTTGCGA
AACCGGATGAAATTTTCCTTGTTGTCGATGCGATGACGGGACAAGACGCGGTAAATGTTGCACAAAGTTTCCATGAACAG
TTAGGTTTAACAGGTGTTGTATTAACGAAGTTAGATGGTGATACGCGCGGTGGTGCTGCATTATCTATTAAGGCTGTAAC
AAACACGCCGATTAAATTTGCTGGTATGGGTGAAAAACTAGATGCAATTGAAGCGTTCCATCCAGAGCGTATGGCATCCC
GTATTTTAGGGATGGGCGATGTCTTAACATTGATTGAAAAAGCGCAAGCTACAGTTGATGAAGAGAAAGCGAAAGAACTT
GAGCAAAAAATGCGTACGCTTTCGTTTACGCTTGACGATTTCCTAGAACAACTTGGACAAGTGCGTCAACTTGGGCCGCT
TGATGAATTGTTAGGAATGCTTCCTGGTGCAAATAAAATTAAAGGGCTGAAAAATGCACAAGTTGATGAAAAACAAATTG
GGCATATTGAGGCAATTATTCGTTCTATGACTAAATTAGAACGAGAACAACCGGAAATAATCAATGCTAGTCGCAAAAAG
CGCATTGCCAAAGGTAGCGGTACAACTGTACAAGAAATCAATCGTCTAATTAAACAATTCGATGACATGAAAAAAATGAT
GAAGACGATGACGGGAATGCAAAAAGGTAAGAAAAAAGGACTAGGTGGATTGAAGTTTCCATTCATGTAA

Upstream 100 bases:

>100_bases
TGCAAAGCTAAAACAGCTAATCAGCGAAGAAGAGCATGTGAATGAAGAAATGAAACAAGTTGTTGAAGCTATCGAAAAAT
TAGATTAGGAGGGCGGCAAT

Downstream 100 bases:

>100_bases
GGAAAAAAAGATGGCTCTGTTAAGAAAAAATACTTTACAAAGCAATAGTCTTTTTGCTAATATAATTATCTGTGTGAAAT
AAATTCGGAGGTGCTTTATA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MAFEGLADRLQQTMQKIRGKGKVSEADVKEMMREVRLALLEADVNFKVVKDFVKRVSERAVGQDVMKSLTPGQQVIKVVQ
EELTELMGGEQSKIAVANKPPTVIMMVGLQGAGKTTTTGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV
FSLGDQVSPVEIAKQAIAKAKEDHHDYVLIDTAGRLHIDEELMDELAKVKEVAKPDEIFLVVDAMTGQDAVNVAQSFHEQ
LGLTGVVLTKLDGDTRGGAALSIKAVTNTPIKFAGMGEKLDAIEAFHPERMASRILGMGDVLTLIEKAQATVDEEKAKEL
EQKMRTLSFTLDDFLEQLGQVRQLGPLDELLGMLPGANKIKGLKNAQVDEKQIGHIEAIIRSMTKLEREQPEIINASRKK
RIAKGSGTTVQEINRLIKQFDDMKKMMKTMTGMQKGKKKGLGGLKFPFM

Sequences:

>Translated_449_residues
MAFEGLADRLQQTMQKIRGKGKVSEADVKEMMREVRLALLEADVNFKVVKDFVKRVSERAVGQDVMKSLTPGQQVIKVVQ
EELTELMGGEQSKIAVANKPPTVIMMVGLQGAGKTTTTGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV
FSLGDQVSPVEIAKQAIAKAKEDHHDYVLIDTAGRLHIDEELMDELAKVKEVAKPDEIFLVVDAMTGQDAVNVAQSFHEQ
LGLTGVVLTKLDGDTRGGAALSIKAVTNTPIKFAGMGEKLDAIEAFHPERMASRILGMGDVLTLIEKAQATVDEEKAKEL
EQKMRTLSFTLDDFLEQLGQVRQLGPLDELLGMLPGANKIKGLKNAQVDEKQIGHIEAIIRSMTKLEREQPEIINASRKK
RIAKGSGTTVQEINRLIKQFDDMKKMMKTMTGMQKGKKKGLGGLKFPFM
>Mature_448_residues
AFEGLADRLQQTMQKIRGKGKVSEADVKEMMREVRLALLEADVNFKVVKDFVKRVSERAVGQDVMKSLTPGQQVIKVVQE
ELTELMGGEQSKIAVANKPPTVIMMVGLQGAGKTTTTGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPVF
SLGDQVSPVEIAKQAIAKAKEDHHDYVLIDTAGRLHIDEELMDELAKVKEVAKPDEIFLVVDAMTGQDAVNVAQSFHEQL
GLTGVVLTKLDGDTRGGAALSIKAVTNTPIKFAGMGEKLDAIEAFHPERMASRILGMGDVLTLIEKAQATVDEEKAKELE
QKMRTLSFTLDDFLEQLGQVRQLGPLDELLGMLPGANKIKGLKNAQVDEKQIGHIEAIIRSMTKLEREQPEIINASRKKR
IAKGSGTTVQEINRLIKQFDDMKKMMKTMTGMQKGKKKGLGGLKFPFM

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=452, Percent_Identity=31.858407079646, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI226371618, Length=351, Percent_Identity=34.4729344729345, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI89061728, Length=144, Percent_Identity=37.5, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI23308697, Length=293, Percent_Identity=27.6450511945392, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI295424842, Length=311, Percent_Identity=26.0450160771704, Blast_Score=99, Evalue=9e-21,
Organism=Escherichia coli, GI1788963, Length=424, Percent_Identity=53.7735849056604, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1789874, Length=251, Percent_Identity=36.2549800796813, Blast_Score=154, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17539958, Length=447, Percent_Identity=29.3064876957494, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI193206261, Length=285, Percent_Identity=30.5263157894737, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325345, Length=420, Percent_Identity=33.3333333333333, Blast_Score=232, Evalue=8e-62,
Organism=Saccharomyces cerevisiae, GI6320498, Length=311, Percent_Identity=28.6173633440514, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17647949, Length=454, Percent_Identity=30.6167400881057, Blast_Score=205, Evalue=6e-53,
Organism=Drosophila melanogaster, GI24641198, Length=310, Percent_Identity=26.1290322580645, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49518; Mature: 49387

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFEGLADRLQQTMQKIRGKGKVSEADVKEMMREVRLALLEADVNFKVVKDFVKRVSERA
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VGQDVMKSLTPGQQVIKVVQEELTELMGGEQSKIAVANKPPTVIMMVGLQGAGKTTTTGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHH
LANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPVFSLGDQVSPVEIAKQAIAKA
HHHHHHHHHCCCCEEEEHHHHCHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
KEDHHDYVLIDTAGRLHIDEELMDELAKVKEVAKPDEIFLVVDAMTGQDAVNVAQSFHEQ
HHCCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHH
LGLTGVVLTKLDGDTRGGAALSIKAVTNTPIKFAGMGEKLDAIEAFHPERMASRILGMGD
HCCCEEEEEECCCCCCCCCEEEEEEECCCCEEECCCCCHHHHHHHCCHHHHHHHHHCCHH
VLTLIEKAQATVDEEKAKELEQKMRTLSFTLDDFLEQLGQVRQLGPLDELLGMLPGANKI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHH
KGLKNAQVDEKQIGHIEAIIRSMTKLEREQPEIINASRKKRIAKGSGTTVQEINRLIKQF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCHHHHHHHHCCCCCCHHHHHHHHHHH
DDMKKMMKTMTGMQKGKKKGLGGLKFPFM
HHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AFEGLADRLQQTMQKIRGKGKVSEADVKEMMREVRLALLEADVNFKVVKDFVKRVSERA
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VGQDVMKSLTPGQQVIKVVQEELTELMGGEQSKIAVANKPPTVIMMVGLQGAGKTTTTGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHH
LANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPVFSLGDQVSPVEIAKQAIAKA
HHHHHHHHHCCCCEEEEHHHHCHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
KEDHHDYVLIDTAGRLHIDEELMDELAKVKEVAKPDEIFLVVDAMTGQDAVNVAQSFHEQ
HHCCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHH
LGLTGVVLTKLDGDTRGGAALSIKAVTNTPIKFAGMGEKLDAIEAFHPERMASRILGMGD
HCCCEEEEEECCCCCCCCCEEEEEEECCCCEEECCCCCHHHHHHHCCHHHHHHHHHCCHH
VLTLIEKAQATVDEEKAKELEQKMRTLSFTLDDFLEQLGQVRQLGPLDELLGMLPGANKI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHH
KGLKNAQVDEKQIGHIEAIIRSMTKLEREQPEIINASRKKRIAKGSGTTVQEINRLIKQF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCHHHHHHHHCCCCCCHHHHHHHHHHH
DDMKKMMKTMTGMQKGKKKGLGGLKFPFM
HHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]