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The map label for this gene is maP2 [H]

Identifier: 218234969

GI number: 218234969

Start: 1544461

End: 1545207

Strand: Direct

Name: maP2 [H]

Synonym: BCB4264_A1623

Alternate gene names: 218234969

Gene position: 1544461-1545207 (Clockwise)

Preceding gene: 218234439

Following gene: 218235546

Centisome position: 28.5

GC content: 37.35

Gene sequence:

>747_bases
ATGATTACAATTAAAACGAAAAATGAAATAGATTTGATGCATGAATCTGGAAAATTACTTGCTTCATGTCATAAAGAAAT
TGCGAAAATGATAAAGCCAGGCATAACGACACAAGAGATTGATACGTTTGTTGAAATGTATTTAAAAAAGTATGGTGCCA
AATCTGAACAGAAAGGTTATAATGGGTATCCATATGCGATATGTGCATCTGTAAACGATGAAATGTGTCATGCGTTTCCG
GCCGATGTTCCTTTAACTGAGGGTGATATTGTAACAATTGACATGGTAGTAAACTTAAATGGGGGTCTTTCAGATTCTGC
TTGGACGTATAGAGTTGGAAAAGTTTCTGATGAAGCAGAAAAGTTGTTGCTAGTAGCTGAGAATGCTTTATATAAAGGGG
TTGATCAGGCGGTAATCGGTAATCATGTAGGAGACATTGGCTATGCAATTGAAAGTTATGTAACAAATGAAGGTTTTTCT
GTCGCAAGAGACTTTACGGGACATGGAATCGGTAAAGAGATTCATGAAGAACCAGCAATTTTTCATTTTGGGAAACAAGG
ACAAGGGCCTCAGTTACAAGAAGGGATGGTGATTACGATTGAGCCGATTGTCAATGTAGGTATGCGATATTCGAAAGTAG
ATTTAAATGGGTGGACTGCACGAACGATGGATGGGAAATTATCAGCTCAATATGAGCATACACTTGCGATTACAAAAGAT
GGGCCAATCATTTTAACGAAGTTGTAA

Upstream 100 bases:

>100_bases
TTACTTGTTGTAATTGAGGGTTTTGAAATTTTGGTAGAGGATGTGTATGATAGAAGTTTAGTAGCAAATAGTAGGTTTAG
CAAGGAAAGGTAGAGGTAGT

Downstream 100 bases:

>100_bases
TTGGAAATGAAAGAGTTTACAAAACTCGAACGAAAATAGTAGTTTTTAAAAATTCGTACGTGTTTTTTCGATAAATGCTT
TTCAAAGTATAAAAAGTGCG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP 1; Peptidase M [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MITIKTKNEIDLMHESGKLLASCHKEIAKMIKPGITTQEIDTFVEMYLKKYGAKSEQKGYNGYPYAICASVNDEMCHAFP
ADVPLTEGDIVTIDMVVNLNGGLSDSAWTYRVGKVSDEAEKLLLVAENALYKGVDQAVIGNHVGDIGYAIESYVTNEGFS
VARDFTGHGIGKEIHEEPAIFHFGKQGQGPQLQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTLAITKD
GPIILTKL

Sequences:

>Translated_248_residues
MITIKTKNEIDLMHESGKLLASCHKEIAKMIKPGITTQEIDTFVEMYLKKYGAKSEQKGYNGYPYAICASVNDEMCHAFP
ADVPLTEGDIVTIDMVVNLNGGLSDSAWTYRVGKVSDEAEKLLLVAENALYKGVDQAVIGNHVGDIGYAIESYVTNEGFS
VARDFTGHGIGKEIHEEPAIFHFGKQGQGPQLQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTLAITKD
GPIILTKL
>Mature_248_residues
MITIKTKNEIDLMHESGKLLASCHKEIAKMIKPGITTQEIDTFVEMYLKKYGAKSEQKGYNGYPYAICASVNDEMCHAFP
ADVPLTEGDIVTIDMVVNLNGGLSDSAWTYRVGKVSDEAEKLLLVAENALYKGVDQAVIGNHVGDIGYAIESYVTNEGFS
VARDFTGHGIGKEIHEEPAIFHFGKQGQGPQLQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTLAITKD
GPIILTKL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=36.4372469635627, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI164420681, Length=252, Percent_Identity=36.5079365079365, Blast_Score=159, Evalue=3e-39,
Organism=Escherichia coli, GI1786364, Length=247, Percent_Identity=39.6761133603239, Blast_Score=186, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71996291, Length=248, Percent_Identity=34.2741935483871, Blast_Score=141, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6323273, Length=246, Percent_Identity=35.7723577235772, Blast_Score=145, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24583427, Length=244, Percent_Identity=37.2950819672131, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI21355531, Length=247, Percent_Identity=37.6518218623482, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27202; Mature: 27202

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIKTKNEIDLMHESGKLLASCHKEIAKMIKPGITTQEIDTFVEMYLKKYGAKSEQKGY
CEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
NGYPYAICASVNDEMCHAFPADVPLTEGDIVTIDMVVNLNGGLSDSAWTYRVGKVSDEAE
CCCCEEEEECCCCHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCCCCHH
KLLLVAENALYKGVDQAVIGNHVGDIGYAIESYVTNEGFSVARDFTGHGIGKEIHEEPAI
EEEEEEHHHHHHCCHHHHHCCCCCHHHHHHHHHHCCCCCEEEHHCCCCCCCHHHHCCCCE
FHFGKQGQGPQLQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTLAITKD
EEECCCCCCCCCCCCEEEEEEHHHCCCCEEEEEECCCCEEEECCCCEEEEEEEEEEEECC
GPIILTKL
CCEEEEEC
>Mature Secondary Structure
MITIKTKNEIDLMHESGKLLASCHKEIAKMIKPGITTQEIDTFVEMYLKKYGAKSEQKGY
CEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
NGYPYAICASVNDEMCHAFPADVPLTEGDIVTIDMVVNLNGGLSDSAWTYRVGKVSDEAE
CCCCEEEEECCCCHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCCCCHH
KLLLVAENALYKGVDQAVIGNHVGDIGYAIESYVTNEGFSVARDFTGHGIGKEIHEEPAI
EEEEEEHHHHHHCCHHHHHCCCCCHHHHHHHHHHCCCCCEEEHHCCCCCCCHHHHCCCCE
FHFGKQGQGPQLQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTLAITKD
EEECCCCCCCCCCCCEEEEEEHHHCCCCEEEEEECCCCEEEECCCCEEEEEEEEEEEECC
GPIILTKL
CCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2113521; 8635744; 9384377 [H]