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The map label for this gene is comC [H]

Identifier: 218234954

GI number: 218234954

Start: 1317548

End: 1318270

Strand: Direct

Name: comC [H]

Synonym: BCB4264_A1357

Alternate gene names: 218234954

Gene position: 1317548-1318270 (Clockwise)

Preceding gene: 218231800

Following gene: 218234372

Centisome position: 24.31

GC content: 32.92

Gene sequence:

>723_bases
ATGTTCACTTATTTATATGCACTGTTAGCAGGGATGGTGTTTGGTTCTTTTTTTATGTTAGTTGCGGTGAGGGTTCCATT
AGGTGCGTCTATTATTACCCCGCGTTCACATTGTTATTATTGCAAATATGTGCTAAGGCCAAAAGAACTAATCCCCATCA
TTTCATTTTATATACAAAGAGGCTGTTGTACGAATTGTAAGAGGAAAATTCCAATTATATATGTAGCATTTGAATGTATA
ACAGGAAGTATATTTCTTCTTACCGTGTATATGATTGGAATAGAACGAGAACTTATTATCATTTTATCCCTTTTTTCGCT
ACTTCTTATTATTTCAGTTACAGATTACTTCTATATGTTAATTCCTGATTGTATTTTAATTTCGTTTGCCGTTTTACTCA
TTCTCGAAAGTATTTTTGTACAATTAGTTACTTGGACAGATAGTATAGTTGGTAGTGGTGTTATATTCCTTTTGTTATAT
TGCATGCAAAAGATATATCCAGAAGGGCTTGGCGGAGGAGATATAAAACTACTTTCGTTACTTGGTTTTATAGTAGGAGT
GAAGGGAGTTTTTATCGTTTTATTTTTAGCATCTTGTTTTAGTCTTTGTTTTTTCGGGATTGGTATCGTATTAAAACGTA
TAGAAGTAGGAAAGCCAATTCCATTTGGTCCTTTTATTAGTCTTGGGGCAATGTGTTATGTATTGGCCGCATATTCAAAT
TAG

Upstream 100 bases:

>100_bases
AGGCCGGAAAATGGCCTGCTTTTTTAGTAGAATAAAGGATAATATGAAGTAGAAGTTCTCTCCTTTTTTTGCTATGTTTT
TTTGGAAAGGAGAGGAAGGG

Downstream 100 bases:

>100_bases
AGAGGGAGTCAAAAATGAACGTATATATGGATGATCAAAGAAGTTGCCCGTTCGGGTATGTGTCCGCAACTACGGTAGAA
TGTGCCTTGCAAATGGTTCG

Product: late competence protein comC

Products: NA

Alternate protein names: Late competence protein ComC; Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MFTYLYALLAGMVFGSFFMLVAVRVPLGASIITPRSHCYYCKYVLRPKELIPIISFYIQRGCCTNCKRKIPIIYVAFECI
TGSIFLLTVYMIGIERELIIILSLFSLLLIISVTDYFYMLIPDCILISFAVLLILESIFVQLVTWTDSIVGSGVIFLLLY
CMQKIYPEGLGGGDIKLLSLLGFIVGVKGVFIVLFLASCFSLCFFGIGIVLKRIEVGKPIPFGPFISLGAMCYVLAAYSN

Sequences:

>Translated_240_residues
MFTYLYALLAGMVFGSFFMLVAVRVPLGASIITPRSHCYYCKYVLRPKELIPIISFYIQRGCCTNCKRKIPIIYVAFECI
TGSIFLLTVYMIGIERELIIILSLFSLLLIISVTDYFYMLIPDCILISFAVLLILESIFVQLVTWTDSIVGSGVIFLLLY
CMQKIYPEGLGGGDIKLLSLLGFIVGVKGVFIVLFLASCFSLCFFGIGIVLKRIEVGKPIPFGPFISLGAMCYVLAAYSN
>Mature_240_residues
MFTYLYALLAGMVFGSFFMLVAVRVPLGASIITPRSHCYYCKYVLRPKELIPIISFYIQRGCCTNCKRKIPIIYVAFECI
TGSIFLLTVYMIGIERELIIILSLFSLLLIISVTDYFYMLIPDCILISFAVLLILESIFVQLVTWTDSIVGSGVIFLLLY
CMQKIYPEGLGGGDIKLLSLLGFIVGVKGVFIVLFLASCFSLCFFGIGIVLKRIEVGKPIPFGPFISLGAMCYVLAAYSN

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=264, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 26749; Mature: 26749

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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>Mature Secondary Structure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PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2553669; 9384377; 8419299 [H]