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The map label for this gene is hslU [H]

Identifier: 218234543

GI number: 218234543

Start: 3848700

End: 3850091

Strand: Reverse

Name: hslU [H]

Synonym: BCB4264_A3927

Alternate gene names: 218234543

Gene position: 3850091-3848700 (Counterclockwise)

Preceding gene: 218233809

Following gene: 218231454

Centisome position: 71.05

GC content: 37.86

Gene sequence:

>1392_bases
ATGCATTTACATTTTACTCCGCGCCAAATTGTGGAAAAATTAGATCAATACATCATCGGTCAAAAAGACGCAAAGAAAGC
GGTTGCTGTAGCGTTGAGAAATCGATATCGCCGCAGTAAATTAGCTGAAAATTTACGTGACGAAATTGCACCTAAAAATA
TTTTAATGATTGGACCGACAGGTGTTGGGAAAACAGAGGTAGCACGACGAATGGCGAAACTCGTTGGAGCACCTTTTATT
AAGGTTGAGGCTACAAAATTCACAGAAGTTGGATATGTGGGTAGAGATGTAGAGTCGATGGTACGTGACTTGGTGGAAAC
ATCGGTTCGTATCGTAAAAGAAGAAATGGTAGTGAAAGTTCAAGATAAAGCAGAAGAGCAAGCGAATCAACGTCTTGTTG
AAATTTTAGTGCCGAGTCCGGAGAAGCAATCTGGATTCAAAAATCCATTAGAGATGCTTTTTGGAGGCGCTCAAAATTCG
AATCAAACGTCTGATACACAAGAAGATGTTGAAATCGAAAAGAAACGTCAAGATGTAGAGAGAAAGCTTGCTGCAGGGCT
TCTTGAAGAAGAAATTGTATCGATTGAAGTGACTGAACAACAGTCTTCCATGTTTGATATGTTACAAGGAACTGGCATGG
AACAAATGGGAATGAATTTCCAAGATGCGCTAGGAAGTTTTATGCCGAAAAAAACGAAAAAACGTAAACTTTCTGTAAAA
GAAGCAAGAAAACTCTTGACAAATGAAGAGGCACAGCGCTTAATTGATATGGATGAAGTTACACAAGAGGCTGTTTATCG
TGCTGAACAGCTCGGGATTATTTTTATCGATGAAATTGACAAAATTGCTGGTAAGCAGTCGAATAGCGTAGATGTATCAC
GTGAAGGTGTGCAACGTGACATTCTGCCAATTGTAGAAGGGTCGAATGTTGCGACAAAATACGGATCAGTAAAAACGGAT
TATATTTTATTCGTTGCAGCTGGAGCGTTCCATATGTCTAAACCGTCGGATTTAATTCCGGAATTGCAAGGGAGATTTCC
GATTCGAGTAGAATTAACAAAATTATCGACAGACGATTTTGTTAAAATATTAATCGAGCCTGACAATGCGTTAATTAAAC
AATATATGGCATTATTAGCGACTGAAGGTATAGAAATTGAATTTTCAGACGAAGCTATTCGTAAGATTGCTGAGATTGCT
TATCAAGTTAATCAGGATACAGATAATATTGGAGCAAGAAGACTTCATACGATTATGGAGAAGCTCCTTGAAGATTTATC
GTTTGAAGCATCTGAAATTACGTTAGAGAAAATAACGATAACACCTCAATACGTTGAGGAGAAATTAGCAACAATTGCTA
AAAATAAAGATGTGAGCCAGTTTATTTTGTAA

Upstream 100 bases:

>100_bases
ATTGCGAAAGCGAGTTTAGAGATTGCTGGCGATATTTGTGTTTATACGAATCACAACATAATTGTTGAAGAATTGTAGAA
TCGTAAGGGAGGCATTTTAT

Downstream 100 bases:

>100_bases
TAGTGTCATCAGGTGACTCGCCCTAGTTTCCAAGTGATGAAAAAATATGTGAGTAACATGTAGGAGGAACTTTTGAAATG
GAATTATTAGCAAAAACGAG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPTGVGKTEVARRMAKLVGAPFI
KVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKVQDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGAQNS
NQTSDTQEDVEIEKKRQDVERKLAAGLLEEEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSFMPKKTKKRKLSVK
EARKLLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRDILPIVEGSNVATKYGSVKTD
YILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDFVKILIEPDNALIKQYMALLATEGIEIEFSDEAIRKIAEIA
YQVNQDTDNIGARRLHTIMEKLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL

Sequences:

>Translated_463_residues
MHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPTGVGKTEVARRMAKLVGAPFI
KVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKVQDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGAQNS
NQTSDTQEDVEIEKKRQDVERKLAAGLLEEEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSFMPKKTKKRKLSVK
EARKLLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRDILPIVEGSNVATKYGSVKTD
YILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDFVKILIEPDNALIKQYMALLATEGIEIEFSDEAIRKIAEIA
YQVNQDTDNIGARRLHTIMEKLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL
>Mature_463_residues
MHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPTGVGKTEVARRMAKLVGAPFI
KVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKVQDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGAQNS
NQTSDTQEDVEIEKKRQDVERKLAAGLLEEEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSFMPKKTKKRKLSVK
EARKLLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRDILPIVEGSNVATKYGSVKTD
YILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDFVKILIEPDNALIKQYMALLATEGIEIEFSDEAIRKIAEIA
YQVNQDTDNIGARRLHTIMEKLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=111, Percent_Identity=36.9369369369369, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1790366, Length=460, Percent_Identity=50.4347826086956, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1786642, Length=227, Percent_Identity=33.4801762114537, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319704, Length=141, Percent_Identity=31.9148936170213, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24648291, Length=259, Percent_Identity=30.5019305019305, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24648289, Length=259, Percent_Identity=30.5019305019305, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 52212; Mature: 52212

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPT
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
GVGKTEVARRMAKLVGAPFIKVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKV
CCCHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGAQNSNQTSDTQEDVEIEKKRQDVE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
RKLAAGLLEEEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSFMPKKTKKRKLSVK
HHHHHHHHHHHHEEEEEEHHHHHHHHHHHCCCHHHHCCCHHHHHHHHCCCHHHHHHCCHH
EARKLLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRD
HHHHHHCCHHHHHHHCHHHHHHHHHHHHHHCCEEEEECHHHHHCCCCCCCCCCHHHHHHH
ILPIVEGSNVATKYGSVKTDYILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDF
CHHHCCCCCCEECCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCE
VKILIEPDNALIKQYMALLATEGIEIEFSDEAIRKIAEIAYQVNQDTDNIGARRLHTIME
EEEEECCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
KLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL
HHHHHHCCCHHHEEEEEEECCHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure
MHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPT
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
GVGKTEVARRMAKLVGAPFIKVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKV
CCCHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGAQNSNQTSDTQEDVEIEKKRQDVE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
RKLAAGLLEEEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSFMPKKTKKRKLSVK
HHHHHHHHHHHHEEEEEEHHHHHHHHHHHCCCHHHHCCCHHHHHHHHCCCHHHHHHCCHH
EARKLLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRD
HHHHHHCCHHHHHHHCHHHHHHHHHHHHHHCCEEEEECHHHHHCCCCCCCCCCHHHHHHH
ILPIVEGSNVATKYGSVKTDYILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDF
CHHHCCCCCCEECCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCE
VKILIEPDNALIKQYMALLATEGIEIEFSDEAIRKIAEIAYQVNQDTDNIGARRLHTIME
EEEEECCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
KLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL
HHHHHHCCCHHHEEEEEEECCHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA