Click here to switch to the map view.

The map label for this gene is dltA [H]

Identifier: 218234454

GI number: 218234454

Start: 1372291

End: 1373805

Strand: Reverse

Name: dltA [H]

Synonym: BCB4264_A1424

Alternate gene names: 218234454

Gene position: 1373805-1372291 (Counterclockwise)

Preceding gene: 218232587

Following gene: 218234039

Centisome position: 25.35

GC content: 37.89

Gene sequence:

>1515_bases
ATGAAGTTATTAGAACAAATTGAAAAGTGGGCTGCAGAAACGCCTGATCAAACCGCTTTTGTTTGGCGAGATGCGAAAAT
TACGTACAAACAATTAAAGGAAGATTCTGATGCGTTGGCACATTGGATTTCTTCTGAGTATCCAGACGATCGTTCACCAA
TTATGGTGTATGGCCATATGCAACCTGAAATGATTATTAACTTTTTAGGATGTGTAAAAGCTGGACATGCTTACATTCCT
GTAGATTTATCTATCCCAGCTGATCGTGTACAACGTATTGCTGAAAATTCTGGTGCGAAATTACTTTTATCGGCAACAGC
AGTAACTGTAACTGATTTACCAGTTCGCATCGTAAGTGAAGACAACTTAAAAGATATTTTCTTTACTCATAAAGGGAACA
CTCCAAATCCTGAACATGCGGTAAAAGGTGATGAGAACTTCTACATTATTTACACATCAGGAAGCACAGGTAATCCGAAA
GGGGTTCAGATTACTTATAACTGCCTTGTTAGCTTTACAAAATGGGCTGTAGAAGATTTCAACTTACAAACAGGGCAAGT
ATTCTTAAACCAAGCACCTTTCTCATTTGATTTATCTGTAATGGATATTTACCCATCATTAGTAACAGGTGGTACACTTT
GGGCAATCGATAAAGATATGATTGCGCGTCCAAAAGACTTGTTTGCTTCTTTAGAGCAATCGGATATTCAAGTATGGACT
TCCACACCTTCTTTCGCTGAAATGTGTTTAATGGAAGCATCTTTCTCTGAGAGTATGCTACCGAACATGAAAACATTCTT
ATTCTGCGGTGAAGTGTTACCAAATGAAGTAGCTAGAAAATTAATTGAGCGTTTCCCTAAAGCAACAATTATGAATACGT
ATGGTCCAACAGAAGCTACTGTCGCTGTAACAGGTATTCACGTTACAGAAGAAGTGCTTGATCAATACAAATCACTTCCA
GTTGGCTATTGTAAATCAGACTGTCGCCTTCTTATTATGAAAGAAGATGGCACGATCGCACCTGATGGTGAAAAAGGTGA
AATCGTAATTGTCGGTCCAAGCGTAAGCGTTGGATATTTAGGAAGCCCTGAATTAACAGAAAAAGCATTTACTATGATTG
ACGGTGAGCGCGCCTATAAAACAGGCGATGCTGGCTATGTTGAAAATGGTCTTCTATTCTATAATGGTCGTCTTGATTTC
CAAATTAAGCTGCATGGTTATCGAATGGAATTAGAAGAAATTGAGCATCACCTTCGTGCGTGTTCTTACGTAGAAGGAGC
AGTTATCGTTCCAATTAAAAAAGGTGAGAAATACGATTATTTATTAGCGGTTGTTGTTCCTGGGGAGCATTCGTTTGAAA
AAGAATTCAAATTAACATCTGCAATCAAAAAAGAACTCAATGAGCGATTACCAAACTACATGATTCCACGTAAATTCATG
TATCAATCTTCTATTCCAATGACACCAAATGGAAAGGTAGATCGCAAAAAATTATTGAGTGAGGTTACAGCATGA

Upstream 100 bases:

>100_bases
TTATTATCTTGCAATTTTATTTGCATTACTTTGGTTGTATGGATTCCATGATACAAACACAAGTACATTTATTTACAATG
AATTCTAGGGTGGGAACGTT

Downstream 100 bases:

>100_bases
CCGCATATGGATCATTTTATTTTTTCGCTATAGTGGGCATTTTATTAATACCTACTATCATAGCTGGATTAAAAGGTAAA
ATGTTGCGCAAATATAATGC

Product: D-alanine--poly(phosphoribitol) ligase subunit 1

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MKLLEQIEKWAAETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKAGHAYIP
VDLSIPADRVQRIAENSGAKLLLSATAVTVTDLPVRIVSEDNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPK
GVQITYNCLVSFTKWAVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWT
STPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEATVAVTGIHVTEEVLDQYKSLP
VGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDF
QIKLHGYRMELEEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFM
YQSSIPMTPNGKVDRKKLLSEVTA

Sequences:

>Translated_504_residues
MKLLEQIEKWAAETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKAGHAYIP
VDLSIPADRVQRIAENSGAKLLLSATAVTVTDLPVRIVSEDNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPK
GVQITYNCLVSFTKWAVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWT
STPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEATVAVTGIHVTEEVLDQYKSLP
VGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDF
QIKLHGYRMELEEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFM
YQSSIPMTPNGKVDRKKLLSEVTA
>Mature_504_residues
MKLLEQIEKWAAETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKAGHAYIP
VDLSIPADRVQRIAENSGAKLLLSATAVTVTDLPVRIVSEDNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPK
GVQITYNCLVSFTKWAVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWT
STPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEATVAVTGIHVTEEVLDQYKSLP
VGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDF
QIKLHGYRMELEEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFM
YQSSIPMTPNGKVDRKKLLSEVTA

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=361, Percent_Identity=26.0387811634349, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI187761345, Length=396, Percent_Identity=26.7676767676768, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI187761343, Length=396, Percent_Identity=26.7676767676768, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI156151445, Length=545, Percent_Identity=22.5688073394495, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI157311624, Length=500, Percent_Identity=24, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI157311622, Length=500, Percent_Identity=24, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI58082049, Length=504, Percent_Identity=23.6111111111111, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI38505220, Length=533, Percent_Identity=21.9512195121951, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI42544132, Length=524, Percent_Identity=22.7099236641221, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786801, Length=533, Percent_Identity=30.2063789868668, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI145693145, Length=530, Percent_Identity=23.5849056603774, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786810, Length=517, Percent_Identity=23.4042553191489, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI221142682, Length=466, Percent_Identity=22.3175965665236, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI32563687, Length=497, Percent_Identity=24.3460764587525, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=357, Percent_Identity=26.890756302521, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17556356, Length=486, Percent_Identity=26.7489711934156, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17558820, Length=502, Percent_Identity=23.9043824701195, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71985884, Length=368, Percent_Identity=22.8260869565217, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531443, Length=531, Percent_Identity=21.4689265536723, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17557194, Length=442, Percent_Identity=23.5294117647059, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17560308, Length=366, Percent_Identity=25.1366120218579, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17560140, Length=391, Percent_Identity=24.5524296675192, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17538037, Length=434, Percent_Identity=24.4239631336406, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=559, Percent_Identity=24.6869409660107, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319699, Length=358, Percent_Identity=22.0670391061453, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24648676, Length=508, Percent_Identity=25.7874015748031, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI18859661, Length=538, Percent_Identity=22.8624535315985, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355225, Length=532, Percent_Identity=21.8045112781955, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356441, Length=258, Percent_Identity=27.1317829457364, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24581924, Length=368, Percent_Identity=22.554347826087, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010072 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.1.1.13 [H]

Molecular weight: Translated: 56494; Mature: 56494

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLEQIEKWAAETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHM
CCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEECC
QPEMIINFLGCVKAGHAYIPVDLSIPADRVQRIAENSGAKLLLSATAVTVTDLPVRIVSE
CHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCCEEEEEEEEEEEECCCEEEECC
DNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPKGVQITYNCLVSFTKWAVEDF
CCCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHCC
NLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWT
CCCCCEEEEECCCCEECEEHHHHHHHHHCCCEEEEECHHHHCCCHHHHHHCCCCCEEEEE
STPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEAT
CCCHHHHHHHHHHCCCHHHCCCHHHHHHCCHHCHHHHHHHHHHHCCCEEEEECCCCCCEE
VAVTGIHVTEEVLDQYKSLPVGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYL
EEEEEEHHHHHHHHHHHCCCCCEECCCCEEEEEECCCCCCCCCCCCEEEEECCCCEECCC
GSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDFQIKLHGYRMELEEIEHHLRA
CCCCHHHHHHHEECCCHHEECCCCCEEECCEEEECCEEEEEEEEECEEECHHHHHHHHHH
CSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFM
HHHCCCEEEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YQSSIPMTPNGKVDRKKLLSEVTA
HCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKLLEQIEKWAAETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHM
CCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEECC
QPEMIINFLGCVKAGHAYIPVDLSIPADRVQRIAENSGAKLLLSATAVTVTDLPVRIVSE
CHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCCEEEEEEEEEEEECCCEEEECC
DNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPKGVQITYNCLVSFTKWAVEDF
CCCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHCC
NLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWT
CCCCCEEEEECCCCEECEEHHHHHHHHHCCCEEEEECHHHHCCCHHHHHHCCCCCEEEEE
STPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEAT
CCCHHHHHHHHHHCCCHHHCCCHHHHHHCCHHCHHHHHHHHHHHCCCEEEEECCCCCCEE
VAVTGIHVTEEVLDQYKSLPVGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYL
EEEEEEHHHHHHHHHHHCCCCCEECCCCEEEEEECCCCCCCCCCCCEEEEECCCCEECCC
GSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDFQIKLHGYRMELEEIEHHLRA
CCCCHHHHHHHEECCCHHEECCCCCEEECCEEEECCEEEEEEEEECEEECHHHHHHHHHH
CSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFM
HHHCCCEEEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YQSSIPMTPNGKVDRKKLLSEVTA
HCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA