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The map label for this gene is mhpC [C]

Identifier: 218233891

GI number: 218233891

Start: 1032639

End: 1033511

Strand: Direct

Name: mhpC [C]

Synonym: BCB4264_A1057

Alternate gene names: 218233891

Gene position: 1032639-1033511 (Clockwise)

Preceding gene: 218232398

Following gene: 218231194

Centisome position: 19.06

GC content: 39.29

Gene sequence:

>873_bases
TTGAAAAGGTTTAAGTTTTATATGATTAGCGGTATTGTGCTCGTTTTGTTAATTGTTTGTAACTTCGTTGAGAAGCCGAT
TGCGAAGGTTGGCGAAGTGAAAGATACTGTTATGATGAAGCTGAATACGAAAGAGAGTATGGCGCAAATTGACGGGCAGA
CGATTTATTTTAAGCAAATTGGTGAGGGAAAACCCCCGTTACTCATGTTGCATGGGTTTGGTGGTTCATCTGATGGGTTT
AGTGATATTTATCCGGAACTAGTGCGAGATCATACGATTATTGCGGTTGATATTTTAGGGTTTGGGCGTTCTTCTAAGCC
GGTTGATTTTCAGTATTCGTTTCCTGCGCAAGTGAATTTATATTATAAGTTAATGAAGAAGCTCGGATACGATCAGTTTG
CAGTGCTCGGCCATTCGATGGGCGGAGAGATGTCCCTTAATTTAGCGTATTTATATCCGGATGCAGTGACGCATCTCATC
TTGGCGGATGCTACAGGGATAGAGTCTTTCCAACAAAAAGAAAGTTATGAAGTACCACCGCTATCGACGGACTTACAAAC
TGTAACTGAGATTACGAAGTATAATAAAAATGAAGTAAAAAATAGTCGTGATGATAAAGAGCATTATGATCAGCTTACGA
AAATGAGAGAGCGCCGCATTGCGATGGAAGCTGATAAAATTAAGGTACCGACTTTAATTATATGGGGACGACATGATAAA
AGTGTTTCTTGGAAAAATGGTGAACTGTATCATGGGCTATTTGCAAATAGTACGTTTCATATTATTGAAAAAGGATACCA
CGCACCGTTTCGTCAGGAACCAATTGAGTTTATGGAATATGTACAAGCATTTTTCGCGAAGCATCCACAATAA

Upstream 100 bases:

>100_bases
TATAATTGTAACTGTTTTAGTTACAATTGAAAAGAGAACATAAAATAACCAAAAAATGTAAAAGCTTTTAAATAGCAACA
AGAGAAAGGAGACGGGAACT

Downstream 100 bases:

>100_bases
AAATTTTAAGCATAAATCCACTTCTTTCCTCATAAAGTGAAACTAATAAGGCTTGTCTAAGGAAAGGAATGAAGTGATTT
GGAAACTTTACCATGGTGGG

Product: hydrolase, alpha/beta fold family

Products: 2-oxopent-4-enoate; succinate [C]

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MKRFKFYMISGIVLVLLIVCNFVEKPIAKVGEVKDTVMMKLNTKESMAQIDGQTIYFKQIGEGKPPLLMLHGFGGSSDGF
SDIYPELVRDHTIIAVDILGFGRSSKPVDFQYSFPAQVNLYYKLMKKLGYDQFAVLGHSMGGEMSLNLAYLYPDAVTHLI
LADATGIESFQQKESYEVPPLSTDLQTVTEITKYNKNEVKNSRDDKEHYDQLTKMRERRIAMEADKIKVPTLIIWGRHDK
SVSWKNGELYHGLFANSTFHIIEKGYHAPFRQEPIEFMEYVQAFFAKHPQ

Sequences:

>Translated_290_residues
MKRFKFYMISGIVLVLLIVCNFVEKPIAKVGEVKDTVMMKLNTKESMAQIDGQTIYFKQIGEGKPPLLMLHGFGGSSDGF
SDIYPELVRDHTIIAVDILGFGRSSKPVDFQYSFPAQVNLYYKLMKKLGYDQFAVLGHSMGGEMSLNLAYLYPDAVTHLI
LADATGIESFQQKESYEVPPLSTDLQTVTEITKYNKNEVKNSRDDKEHYDQLTKMRERRIAMEADKIKVPTLIIWGRHDK
SVSWKNGELYHGLFANSTFHIIEKGYHAPFRQEPIEFMEYVQAFFAKHPQ
>Mature_290_residues
MKRFKFYMISGIVLVLLIVCNFVEKPIAKVGEVKDTVMMKLNTKESMAQIDGQTIYFKQIGEGKPPLLMLHGFGGSSDGF
SDIYPELVRDHTIIAVDILGFGRSSKPVDFQYSFPAQVNLYYKLMKKLGYDQFAVLGHSMGGEMSLNLAYLYPDAVTHLI
LADATGIESFQQKESYEVPPLSTDLQTVTEITKYNKNEVKNSRDDKEHYDQLTKMRERRIAMEADKIKVPTLIIWGRHDK
SVSWKNGELYHGLFANSTFHIIEKGYHAPFRQEPIEFMEYVQAFFAKHPQ

Specific function: 3-hydroxyphenylpropionate degradation. [C]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dmpD/todF/xylF esterase family [H]

Homologues:

Organism=Escherichia coli, GI87081721, Length=278, Percent_Identity=23.3812949640288, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324392, Length=119, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.7.1.- [C]

Molecular weight: Translated: 33227; Mature: 33227

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRFKFYMISGIVLVLLIVCNFVEKPIAKVGEVKDTVMMKLNTKESMAQIDGQTIYFKQI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCCEEEEEEC
GEGKPPLLMLHGFGGSSDGFSDIYPELVRDHTIIAVDILGFGRSSKPVDFQYSFPAQVNL
CCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEECCCCHHHH
YYKLMKKLGYDQFAVLGHSMGGEMSLNLAYLYPDAVTHLILADATGIESFQQKESYEVPP
HHHHHHHCCCCCEEHHHHCCCCCEEEEEEEECHHHHHHHHHHCCCCHHHHHHHCCCCCCC
LSTDLQTVTEITKYNKNEVKNSRDDKEHYDQLTKMRERRIAMEADKIKVPTLIIWGRHDK
CCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCEEEEECCCCC
SVSWKNGELYHGLFANSTFHIIEKGYHAPFRQEPIEFMEYVQAFFAKHPQ
CCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKRFKFYMISGIVLVLLIVCNFVEKPIAKVGEVKDTVMMKLNTKESMAQIDGQTIYFKQI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCCEEEEEEC
GEGKPPLLMLHGFGGSSDGFSDIYPELVRDHTIIAVDILGFGRSSKPVDFQYSFPAQVNL
CCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEECCCCHHHH
YYKLMKKLGYDQFAVLGHSMGGEMSLNLAYLYPDAVTHLILADATGIESFQQKESYEVPP
HHHHHHHCCCCCEEHHHHCCCCCEEEEEEEECHHHHHHHHHHCCCCHHHHHHHCCCCCCC
LSTDLQTVTEITKYNKNEVKNSRDDKEHYDQLTKMRERRIAMEADKIKVPTLIIWGRHDK
CCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCEEEEECCCCC
SVSWKNGELYHGLFANSTFHIIEKGYHAPFRQEPIEFMEYVQAFFAKHPQ
CCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-hydroxy-6-ketononadienedicarboxylate; H2O [C]

Specific reaction: 2-hydroxy-6-ketononadienedicarboxylate + H2O = 2-oxopent-4-enoate + succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]