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The map label for this gene is vanR [H]

Identifier: 218233819

GI number: 218233819

Start: 3051236

End: 3051925

Strand: Reverse

Name: vanR [H]

Synonym: BCB4264_A3169

Alternate gene names: 218233819

Gene position: 3051925-3051236 (Counterclockwise)

Preceding gene: 218232981

Following gene: 218234352

Centisome position: 56.32

GC content: 30.29

Gene sequence:

>690_bases
ATGATGCAGAAAGAAAAAATTTTGATTGTAGATGATGATATAGAGATAAGAAAAATCGTATCCATTTATTTAAAAAATGA
AGGGTATGAAATTATAGATGCATCGGATGCTATAGAAGCTTTAGAAACTTTAAGAAATAAAACAATTGATTTAATCATTT
TAGATATTATGTTACCGAAAATGGATGGCATAGAGGCTTGTTTAAAAATAAGAGAACAGTATCAAATGCCTATAATTTTT
TTGTCAGCTAAAGATGAGGATATAGATAAGATCCAGGGATTAATGAGTGGGGCAGAAGACTACATTACCAAACCGTTTAA
TCCACTTGAATTAATGGCAAGAATTAAATCTCAATTACGAAGATATCGTGTTTATCAAACAGAAGAAGTAAAACAATTTA
TTCATGAAATAGGCCATCTTAAGGTAGACGAGGAGACAAGACAAGTTTTCATTAGAAATGAAGAAGTAAGGTTAACTCCA
AAGGAATTTGACATACTTTCTTTATTAGTGAGAAATAAAGGAAAGGTTTTTAGTGTAGAAAAAATATACGAGATGGTCTG
GGAAGATTCATTTTATAAATCAGATAATACAGTCATGGTTCATATTACTAAAATACGGGAAAAAATTGAAGAAAACCCTC
GTCAGCCTGTTTATTTAAAAACAGTATGGGGAGTTGGCTATAGAGTATGA

Upstream 100 bases:

>100_bases
CGATTGGTGAAGGCTGATTAAAGTTTCACTTTATACGTGTAAGGTAAAACTAAATGTATAATACTACAGCATAGAACGAG
ATGTCAGAGAGGAAGAAAAT

Downstream 100 bases:

>100_bases
TCGATCGTACGAAATTAAGGGATAATATATTCTTTTCTACACGCTTAAATATAAAGCTTATTTTAATTTTTTTGCTCTGT
TTCATCGTTGCGGTTGTTAC

Product: regulatory protein VanR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MMQKEKILIVDDDIEIRKIVSIYLKNEGYEIIDASDAIEALETLRNKTIDLIILDIMLPKMDGIEACLKIREQYQMPIIF
LSAKDEDIDKIQGLMSGAEDYITKPFNPLELMARIKSQLRRYRVYQTEEVKQFIHEIGHLKVDEETRQVFIRNEEVRLTP
KEFDILSLLVRNKGKVFSVEKIYEMVWEDSFYKSDNTVMVHITKIREKIEENPRQPVYLKTVWGVGYRV

Sequences:

>Translated_229_residues
MMQKEKILIVDDDIEIRKIVSIYLKNEGYEIIDASDAIEALETLRNKTIDLIILDIMLPKMDGIEACLKIREQYQMPIIF
LSAKDEDIDKIQGLMSGAEDYITKPFNPLELMARIKSQLRRYRVYQTEEVKQFIHEIGHLKVDEETRQVFIRNEEVRLTP
KEFDILSLLVRNKGKVFSVEKIYEMVWEDSFYKSDNTVMVHITKIREKIEENPRQPVYLKTVWGVGYRV
>Mature_229_residues
MMQKEKILIVDDDIEIRKIVSIYLKNEGYEIIDASDAIEALETLRNKTIDLIILDIMLPKMDGIEACLKIREQYQMPIIF
LSAKDEDIDKIQGLMSGAEDYITKPFNPLELMARIKSQLRRYRVYQTEEVKQFIHEIGHLKVDEETRQVFIRNEEVRLTP
KEFDILSLLVRNKGKVFSVEKIYEMVWEDSFYKSDNTVMVHITKIREKIEENPRQPVYLKTVWGVGYRV

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=36.0869565217391, Blast_Score=164, Evalue=4e-42,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=37.219730941704, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=35.3982300884956, Blast_Score=143, Evalue=9e-36,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=34.0807174887892, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1790860, Length=229, Percent_Identity=32.7510917030568, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=35.5855855855856, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=35.4260089686099, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=33.7662337662338, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=31.7180616740088, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=31.390134529148, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=32.4444444444444, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=33.6322869955157, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=29.6943231441048, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=31.0043668122271, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1790299, Length=126, Percent_Identity=30.952380952381, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1788550, Length=112, Percent_Identity=33.9285714285714, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=31.5789473684211, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=34.3137254901961, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788713, Length=120, Percent_Identity=33.3333333333333, Blast_Score=61, Evalue=8e-11,
Organism=Escherichia coli, GI1788905, Length=100, Percent_Identity=33, Blast_Score=60, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27092; Mature: 27092

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQKEKILIVDDDIEIRKIVSIYLKNEGYEIIDASDAIEALETLRNKTIDLIILDIMLPK
CCCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCHHEEEEEHHCCC
MDGIEACLKIREQYQMPIIFLSAKDEDIDKIQGLMSGAEDYITKPFNPLELMARIKSQLR
CCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHH
RYRVYQTEEVKQFIHEIGHLKVDEETRQVFIRNEEVRLTPKEFDILSLLVRNKGKVFSVE
HHHCCCHHHHHHHHHHHCCEEECCHHHEEEEECCCEEECCHHHHHHHHHHHCCCCEEEHH
KIYEMVWEDSFYKSDNTVMVHITKIREKIEENPRQPVYLKTVWGVGYRV
HHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MMQKEKILIVDDDIEIRKIVSIYLKNEGYEIIDASDAIEALETLRNKTIDLIILDIMLPK
CCCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCHHEEEEEHHCCC
MDGIEACLKIREQYQMPIIFLSAKDEDIDKIQGLMSGAEDYITKPFNPLELMARIKSQLR
CCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHH
RYRVYQTEEVKQFIHEIGHLKVDEETRQVFIRNEEVRLTPKEFDILSLLVRNKGKVFSVE
HHHCCCHHHHHHHHHHHCCEEECCHHHEEEEECCCEEECCHHHHHHHHHHHCCCCEEEHH
KIYEMVWEDSFYKSDNTVMVHITKIREKIEENPRQPVYLKTVWGVGYRV
HHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]