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The map label for this gene is mtnA [H]

Identifier: 218233756

GI number: 218233756

Start: 4047699

End: 4048760

Strand: Reverse

Name: mtnA [H]

Synonym: BCB4264_A4139

Alternate gene names: 218233756

Gene position: 4048760-4047699 (Counterclockwise)

Preceding gene: 218235612

Following gene: 218234345

Centisome position: 74.71

GC content: 36.44

Gene sequence:

>1062_bases
ATGAGTACAATTGTTACTGTTCCGAGATCTGTAAGTTGGAAAGGTGATGCAATTGCAGTATTAAATCAAACGAAATTGCC
ACATAGCACAGAATACAAAACATTAACGACTATTGAAGGGGTTTGGAAAAGTATCATAATGTTAGAAGTACGTGGAGCGC
CTGCAATTGGAATTGTAGCTGCATTTGGCTTGGCGCTTGCAGCGAAAAAATATAATACTTTACATATCGAAGAATTTCAA
AAGAAGTTTAATAGAGACTGTAACTATTTAGGGACATCACGCCCAACGGCAGTAAATTTATTTTGGGCAATTGATCGTAT
GAGAGAATCTATTCGAGAGATTACTACAATAAAAGAAGCACAAAAAATATTAGAAGAAGAAGCGCTTCGCATTCAACAGG
AAGATGAAGAGGTGTGTCGAAATATTGGGGAATATGCGTTAACATGTTTTAAAGATGGCGATAATATTTTAACAATCTGT
AACGCTGGAAGTATCGCAACTGCCAGATATGGAACTGCATTAGCTCCCTTTTATATTGGAAAAGAGAAAGGTGTGCGTTT
ACATGCATATGCGTGTGAAACGAGACCAGTTTTACAAGGTGGTCGCTTAACGACGTGGGAATTGAAGCAAGCAAATATTG
ATGTGACCCTTATAACAGATAATACTGCAGCTCATGCTATTCAAACGAAAGAAATAAACGCAATTATTGTGGGGGCGGAT
CGAATTGTCGCAAATGGAGATACAGCCAATAAAATAGGGACAATGAATTTAGCTATTTTAGCAAAGTACTTTAATATCCC
ATTTTACGTTGCTGCGCCACTGTCAACATTTGATGTTACGAAAGAAACTGGAGCCGAAATTATTATTGAAGAAAGAGATG
AAACAGAAGTTACGAAAATCTTTGGAAAACAAGTAGCACCAATTGGAACGGATGTTTATAATCCAGCATTTGACATAACG
CCGAATGAATTAATTACAGGAATTATTACTGAGAAAGGTATTATACGCGGGGACTATAAACGAGAAATTGCATCATTATT
TGAAAAACAAGCTAATACATAA

Upstream 100 bases:

>100_bases
TATCCTTAGGAAAAGAACTAATAAAATATGAATCTAAAAGTGCTGATATTCAACTGTTTCGAACATTATTTCAACAGACA
GTTTCAAGGGGTGTAAAAGC

Downstream 100 bases:

>100_bases
TAGCTTGTTTTTTTATGCCTAAATGCAGTGTTTTCTCTTACTTATATAATGAAAGGAGGGGAAGAGGGTGGAAGAGTGGA
TCAAGATGATAGGTAATGTA

Product: methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi 2; MTR-1-P isomerase 2; S-methyl-5-thioribose-1-phosphate isomerase 2 [H]

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSTIVTVPRSVSWKGDAIAVLNQTKLPHSTEYKTLTTIEGVWKSIIMLEVRGAPAIGIVAAFGLALAAKKYNTLHIEEFQ
KKFNRDCNYLGTSRPTAVNLFWAIDRMRESIREITTIKEAQKILEEEALRIQQEDEEVCRNIGEYALTCFKDGDNILTIC
NAGSIATARYGTALAPFYIGKEKGVRLHAYACETRPVLQGGRLTTWELKQANIDVTLITDNTAAHAIQTKEINAIIVGAD
RIVANGDTANKIGTMNLAILAKYFNIPFYVAAPLSTFDVTKETGAEIIIEERDETEVTKIFGKQVAPIGTDVYNPAFDIT
PNELITGIITEKGIIRGDYKREIASLFEKQANT

Sequences:

>Translated_353_residues
MSTIVTVPRSVSWKGDAIAVLNQTKLPHSTEYKTLTTIEGVWKSIIMLEVRGAPAIGIVAAFGLALAAKKYNTLHIEEFQ
KKFNRDCNYLGTSRPTAVNLFWAIDRMRESIREITTIKEAQKILEEEALRIQQEDEEVCRNIGEYALTCFKDGDNILTIC
NAGSIATARYGTALAPFYIGKEKGVRLHAYACETRPVLQGGRLTTWELKQANIDVTLITDNTAAHAIQTKEINAIIVGAD
RIVANGDTANKIGTMNLAILAKYFNIPFYVAAPLSTFDVTKETGAEIIIEERDETEVTKIFGKQVAPIGTDVYNPAFDIT
PNELITGIITEKGIIRGDYKREIASLFEKQANT
>Mature_352_residues
STIVTVPRSVSWKGDAIAVLNQTKLPHSTEYKTLTTIEGVWKSIIMLEVRGAPAIGIVAAFGLALAAKKYNTLHIEEFQK
KFNRDCNYLGTSRPTAVNLFWAIDRMRESIREITTIKEAQKILEEEALRIQQEDEEVCRNIGEYALTCFKDGDNILTICN
AGSIATARYGTALAPFYIGKEKGVRLHAYACETRPVLQGGRLTTWELKQANIDVTLITDNTAAHAIQTKEINAIIVGADR
IVANGDTANKIGTMNLAILAKYFNIPFYVAAPLSTFDVTKETGAEIIIEERDETEVTKIFGKQVAPIGTDVYNPAFDITP
NELITGIITEKGIIRGDYKREIASLFEKQANT

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=339, Percent_Identity=41.2979351032448, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI23943880, Length=334, Percent_Identity=38.0239520958084, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI78000158, Length=346, Percent_Identity=24.8554913294798, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI78000156, Length=346, Percent_Identity=24.8554913294798, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI187607323, Length=346, Percent_Identity=24.8554913294798, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17557462, Length=332, Percent_Identity=35.5421686746988, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17557123, Length=166, Percent_Identity=28.9156626506024, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6325375, Length=397, Percent_Identity=36.5239294710327, Blast_Score=211, Evalue=1e-55,
Organism=Drosophila melanogaster, GI21357667, Length=360, Percent_Identity=37.2222222222222, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24651647, Length=360, Percent_Identity=37.2222222222222, Blast_Score=229, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 39052; Mature: 38921

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIVTVPRSVSWKGDAIAVLNQTKLPHSTEYKTLTTIEGVWKSIIMLEVRGAPAIGIVA
CCCEEECCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHEEEEEEECCCCHHHHHH
AFGLALAAKKYNTLHIEEFQKKFNRDCNYLGTSRPTAVNLFWAIDRMRESIREITTIKEA
HHHHHHHHHCCCEEEHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
QKILEEEALRIQQEDEEVCRNIGEYALTCFKDGDNILTICNAGSIATARYGTALAPFYIG
HHHHHHHHHHHCCCHHHHHHHHHHHEEEEEECCCCEEEEECCCCEEEECCCCEECCEEEC
KEKGVRLHAYACETRPVLQGGRLTTWELKQANIDVTLITDNTAAHAIQTKEINAIIVGAD
CCCCEEEEEEEECCCCCCCCCCEEEEEEEECCEEEEEEECCCHHHEEEECCCCEEEEECC
RIVANGDTANKIGTMNLAILAKYFNIPFYVAAPLSTFDVTKETGAEIIIEERDETEVTKI
EEEECCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCHHCCCEEEEECCCCHHHHHH
FGKQVAPIGTDVYNPAFDITPNELITGIITEKGIIRGDYKREIASLFEKQANT
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STIVTVPRSVSWKGDAIAVLNQTKLPHSTEYKTLTTIEGVWKSIIMLEVRGAPAIGIVA
CCEEECCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHEEEEEEECCCCHHHHHH
AFGLALAAKKYNTLHIEEFQKKFNRDCNYLGTSRPTAVNLFWAIDRMRESIREITTIKEA
HHHHHHHHHCCCEEEHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
QKILEEEALRIQQEDEEVCRNIGEYALTCFKDGDNILTICNAGSIATARYGTALAPFYIG
HHHHHHHHHHHCCCHHHHHHHHHHHEEEEEECCCCEEEEECCCCEEEECCCCEECCEEEC
KEKGVRLHAYACETRPVLQGGRLTTWELKQANIDVTLITDNTAAHAIQTKEINAIIVGAD
CCCCEEEEEEEECCCCCCCCCCEEEEEEEECCEEEEEEECCCHHHEEEECCCCEEEEECC
RIVANGDTANKIGTMNLAILAKYFNIPFYVAAPLSTFDVTKETGAEIIIEERDETEVTKI
EEEECCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCHHCCCEEEEECCCCHHHHHH
FGKQVAPIGTDVYNPAFDITPNELITGIITEKGIIRGDYKREIASLFEKQANT
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721630 [H]