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The map label for this gene is yvaE [H]

Identifier: 218233538

GI number: 218233538

Start: 349955

End: 350278

Strand: Direct

Name: yvaE [H]

Synonym: BCB4264_A0374

Alternate gene names: 218233538

Gene position: 349955-350278 (Clockwise)

Preceding gene: 218233344

Following gene: 218234466

Centisome position: 6.46

GC content: 32.1

Gene sequence:

>324_bases
ATGGTATATTGGCTATTATTACTTGTTACAATTATTTTTGAAGTAGCTGGAACAATTGCGATGAAACTATCAAATGGTTT
AACAAAGCTCGTTCCAAGTGTACTGATTTTCGTGTTTTATGGAATTTGTTTCAGCGTGTTCGCCATCGTTGTGAAAAAGA
TTCATTTAAGTATTGCTTATGCTATTTGGTCTGGCGTTGGAACATTACTTATTACAATCATTAGTGTGTACTTTTTTAAA
GAGCATATTAGTTTATTTCAAGCATTTTGTATTCTTTTTATTGTTTTGGGTGTCATTGGACTTAAGGTTTCATCGGCATC
ATGA

Upstream 100 bases:

>100_bases
ATTTCGGCATCGAGGAATATTTAGAAATTAAATATATTTCATTGGGACTATAAGTAGTATACTAGAATCTCTATAAGGTA
ACAGAGAAGGAGATTCTAGT

Downstream 100 bases:

>100_bases
AAGCTATCTTTTGTAGAAGATAGCTTTTTTCTATTTGTGCAGTTAGCAATTAATACGACAAAATATGACAAGAAAGAGTA
AAGCGTTTTGTTATGATACA

Product: multidrug resistance protein, Smr family

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 107; Mature: 107

Protein sequence:

>107_residues
MVYWLLLLVTIIFEVAGTIAMKLSNGLTKLVPSVLIFVFYGICFSVFAIVVKKIHLSIAYAIWSGVGTLLITIISVYFFK
EHISLFQAFCILFIVLGVIGLKVSSAS

Sequences:

>Translated_107_residues
MVYWLLLLVTIIFEVAGTIAMKLSNGLTKLVPSVLIFVFYGICFSVFAIVVKKIHLSIAYAIWSGVGTLLITIISVYFFK
EHISLFQAFCILFIVLGVIGLKVSSAS
>Mature_107_residues
MVYWLLLLVTIIFEVAGTIAMKLSNGLTKLVPSVLIFVFYGICFSVFAIVVKKIHLSIAYAIWSGVGTLLITIISVYFFK
EHISLFQAFCILFIVLGVIGLKVSSAS

Specific function: Multidrug Transporter. Confers Resistance To A Wide Range Of Toxic Compounds By Removing Them For The Cells. The Efflux Is Coupled To An Influx Of Protons. Probably Prevents The Incorporation Of Methyl VIologen Into Cells. Involved In Ethidium Bromide Ef

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=97, Percent_Identity=40.2061855670103, Blast_Score=61, Evalue=1e-11,
Organism=Escherichia coli, GI1787884, Length=101, Percent_Identity=34.6534653465347, Blast_Score=60, Evalue=4e-11,
Organism=Escherichia coli, GI87082378, Length=102, Percent_Identity=28.4313725490196, Blast_Score=60, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11794; Mature: 11794

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYWLLLLVTIIFEVAGTIAMKLSNGLTKLVPSVLIFVFYGICFSVFAIVVKKIHLSIAY
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIWSGVGTLLITIISVYFFKEHISLFQAFCILFIVLGVIGLKVSSAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVYWLLLLVTIIFEVAGTIAMKLSNGLTKLVPSVLIFVFYGICFSVFAIVVKKIHLSIAY
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIWSGVGTLLITIISVYFFKEHISLFQAFCILFIVLGVIGLKVSSAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]