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The map label for this gene is zwf [H]

Identifier: 218233527

GI number: 218233527

Start: 3266225

End: 3267709

Strand: Reverse

Name: zwf [H]

Synonym: BCB4264_A3389

Alternate gene names: 218233527

Gene position: 3267709-3266225 (Counterclockwise)

Preceding gene: 218231401

Following gene: 218234257

Centisome position: 60.3

GC content: 37.71

Gene sequence:

>1485_bases
TTGGAATCAATGACCTTTGTTTTATTTGGAGCGACAGGGGACTTAGCGAAACGCAAAATTTACCCCGCACTATATAACTT
ATATAGAGATCAAAAGCTTCCAAAGCAAATATCTGTTATCGGGCTTGGGAGACGTGAAGTATCTCATGTAGATTTTCAAA
AAAGAATAAAAGAATCAATAGAGACGTTTTCTCGCCATAGAGAAGAAGGGACTTCAGATCTTGAAGGTTTTTTAGATAAT
TTTCGCTATTGTCCATTAGATGTGAGTAAGCCGGAAGACTATGAGAGATTATTACAAGTCGTTCGCGAAAGGGAAGAAGA
ACTACATATAAAAGGTAATAGAATGTTTTATCTTTCCGTTGCTCCTGAATTTTTCGAGACAATCGCTTTAAATATTAAGG
AAAGCGGACTTGATAAAACGGATGGATGGAAACGCCTAATGATTGAGAAACCGTTTGGGCACGACCTTACATCTGCTCGT
GAGCTGAATGATAAGCTTAGTCGCACGTTTGAAGAAGACGAGATATACCGTATTGATCATTATTTAGGTAAACCGATGAT
TCAAAATCTTGAAGCACTAGAATTTGCAAATCCTGTTCTCCAGTCTATTTGGAATAAAGAACATATAGCGAATGTACAAA
TCACAGCTAGTGAAACAGTTGGGGTTGAAGAAAGAGCAGGATATTATGATCAGGCAGGAGCCATTCGAGATATGGTTCAA
AATCATATGTTACAAATATTAATGATGACTGCTATGAATCTGCCGGAAAAGGTTAATGCATGTGAAATTCGAGAGGAAAA
GCGAAAGGTAATGGAAACGCTTCGTAAAGTGAAAAAAGAAGACGTTCAAAGCCATATCATTCGCGGACAATACGCTGCAG
GTGAGATAAAAGGCGGGCAAGTTGTAGCATACAAAGAGGAGCCAGGAGTAAATCCTTCTTCTAACATAGACACATTTGTT
GCTGCTCGCCTGTGGATCGATAATCCATTTTGGACTGGCGTTCCCTTCTATATACGAACAGGCAAACGAATGAAAGAAAA
GTCTACTCGTATTGTAATTGAATTTAAAAATACGTTAAAACAGCAATATCAAGATAGTAATCCAAATGCAGCACCTAACT
TGTTAATAATTGAAATTAGTCCAGGTGAGAACGTTTCATTACAGTTAAACAGTAAAAATCCATTGAAAAATGGAGAAATT
GAACCGATGCGTATTAACTTTACTTGTGAGCAAGCAGATGTGGGAGTACCTGAAGCGTATGAAAGACTCATTCATGATGC
TGTGAGTGGAGACGCTACATTCTTTGCACATTGGAAAGAAGTTGAATTGTCATGGGAATGGGTACAACCAATTCTTGAAG
CATTCGAGGAAAACTTATTACCACTTCATGAATATGAGTCTGGTTCATATGGTCCAGATGCGTCGAATGAATTATTGCAA
GAAAGTGGATTTAAATGGTGGTTAGATCAAGAAACGGAAAAATAA

Upstream 100 bases:

>100_bases
CTTTGTTTTTTATAAAAACAGGAAGTATAAGAGTATGAGCTTCTGTACAATTCATTTTTAGTATATTGAAGAGGATTATA
CAACAAGAGGGGGACTGAAA

Downstream 100 bases:

>100_bases
GTACTTTCTTTCATGAAAGCATGTAGGGGGACGATTACTATGACACAAAACATAAATCAATTAGCAGTGAATACAATTCG
TACGTTATCAATTGATGCTA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD; Vegetative protein 11; VEG11 [H]

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MESMTFVLFGATGDLAKRKIYPALYNLYRDQKLPKQISVIGLGRREVSHVDFQKRIKESIETFSRHREEGTSDLEGFLDN
FRYCPLDVSKPEDYERLLQVVREREEELHIKGNRMFYLSVAPEFFETIALNIKESGLDKTDGWKRLMIEKPFGHDLTSAR
ELNDKLSRTFEEDEIYRIDHYLGKPMIQNLEALEFANPVLQSIWNKEHIANVQITASETVGVEERAGYYDQAGAIRDMVQ
NHMLQILMMTAMNLPEKVNACEIREEKRKVMETLRKVKKEDVQSHIIRGQYAAGEIKGGQVVAYKEEPGVNPSSNIDTFV
AARLWIDNPFWTGVPFYIRTGKRMKEKSTRIVIEFKNTLKQQYQDSNPNAAPNLLIIEISPGENVSLQLNSKNPLKNGEI
EPMRINFTCEQADVGVPEAYERLIHDAVSGDATFFAHWKEVELSWEWVQPILEAFEENLLPLHEYESGSYGPDASNELLQ
ESGFKWWLDQETEK

Sequences:

>Translated_494_residues
MESMTFVLFGATGDLAKRKIYPALYNLYRDQKLPKQISVIGLGRREVSHVDFQKRIKESIETFSRHREEGTSDLEGFLDN
FRYCPLDVSKPEDYERLLQVVREREEELHIKGNRMFYLSVAPEFFETIALNIKESGLDKTDGWKRLMIEKPFGHDLTSAR
ELNDKLSRTFEEDEIYRIDHYLGKPMIQNLEALEFANPVLQSIWNKEHIANVQITASETVGVEERAGYYDQAGAIRDMVQ
NHMLQILMMTAMNLPEKVNACEIREEKRKVMETLRKVKKEDVQSHIIRGQYAAGEIKGGQVVAYKEEPGVNPSSNIDTFV
AARLWIDNPFWTGVPFYIRTGKRMKEKSTRIVIEFKNTLKQQYQDSNPNAAPNLLIIEISPGENVSLQLNSKNPLKNGEI
EPMRINFTCEQADVGVPEAYERLIHDAVSGDATFFAHWKEVELSWEWVQPILEAFEENLLPLHEYESGSYGPDASNELLQ
ESGFKWWLDQETEK
>Mature_494_residues
MESMTFVLFGATGDLAKRKIYPALYNLYRDQKLPKQISVIGLGRREVSHVDFQKRIKESIETFSRHREEGTSDLEGFLDN
FRYCPLDVSKPEDYERLLQVVREREEELHIKGNRMFYLSVAPEFFETIALNIKESGLDKTDGWKRLMIEKPFGHDLTSAR
ELNDKLSRTFEEDEIYRIDHYLGKPMIQNLEALEFANPVLQSIWNKEHIANVQITASETVGVEERAGYYDQAGAIRDMVQ
NHMLQILMMTAMNLPEKVNACEIREEKRKVMETLRKVKKEDVQSHIIRGQYAAGEIKGGQVVAYKEEPGVNPSSNIDTFV
AARLWIDNPFWTGVPFYIRTGKRMKEKSTRIVIEFKNTLKQQYQDSNPNAAPNLLIIEISPGENVSLQLNSKNPLKNGEI
EPMRINFTCEQADVGVPEAYERLIHDAVSGDATFFAHWKEVELSWEWVQPILEAFEENLLPLHEYESGSYGPDASNELLQ
ESGFKWWLDQETEK

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=491, Percent_Identity=35.234215885947, Blast_Score=308, Evalue=7e-84,
Organism=Homo sapiens, GI108773793, Length=491, Percent_Identity=35.234215885947, Blast_Score=308, Evalue=8e-84,
Organism=Homo sapiens, GI52145310, Length=479, Percent_Identity=29.8538622129436, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1788158, Length=493, Percent_Identity=37.7281947261663, Blast_Score=338, Evalue=5e-94,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=36.701030927835, Blast_Score=327, Evalue=9e-90,
Organism=Saccharomyces cerevisiae, GI6324088, Length=482, Percent_Identity=35.8921161825726, Blast_Score=290, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24643350, Length=488, Percent_Identity=37.5, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24643352, Length=488, Percent_Identity=37.5, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI221513548, Length=497, Percent_Identity=29.3762575452716, Blast_Score=215, Evalue=4e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57108; Mature: 57108

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESMTFVLFGATGDLAKRKIYPALYNLYRDQKLPKQISVIGLGRREVSHVDFQKRIKESI
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
ETFSRHREEGTSDLEGFLDNFRYCPLDVSKPEDYERLLQVVREREEELHIKGNRMFYLSV
HHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCEEEEEEE
APEFFETIALNIKESGLDKTDGWKRLMIEKPFGHDLTSARELNDKLSRTFEEDEIYRIDH
CHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEHHH
YLGKPMIQNLEALEFANPVLQSIWNKEHIANVQITASETVGVEERAGYYDQAGAIRDMVQ
HHCCHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEEECCCCCCHHHCCCHHHHHHHHHHHH
NHMLQILMMTAMNLPEKVNACEIREEKRKVMETLRKVKKEDVQSHIIRGQYAAGEIKGGQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
VVAYKEEPGVNPSSNIDTFVAARLWIDNPFWTGVPFYIRTGKRMKEKSTRIVIEFKNTLK
EEEECCCCCCCCCCCCHHHHEEHEEECCCCCCCCCCEEECCCHHHCCCCEEEEEEHHHHH
QQYQDSNPNAAPNLLIIEISPGENVSLQLNSKNPLKNGEIEPMRINFTCEQADVGVPEAY
HHHCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCHHH
ERLIHDAVSGDATFFAHWKEVELSWEWVQPILEAFEENLLPLHEYESGSYGPDASNELLQ
HHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
ESGFKWWLDQETEK
HCCCEEECCCCCCC
>Mature Secondary Structure
MESMTFVLFGATGDLAKRKIYPALYNLYRDQKLPKQISVIGLGRREVSHVDFQKRIKESI
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
ETFSRHREEGTSDLEGFLDNFRYCPLDVSKPEDYERLLQVVREREEELHIKGNRMFYLSV
HHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCEEEEEEE
APEFFETIALNIKESGLDKTDGWKRLMIEKPFGHDLTSARELNDKLSRTFEEDEIYRIDH
CHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEHHH
YLGKPMIQNLEALEFANPVLQSIWNKEHIANVQITASETVGVEERAGYYDQAGAIRDMVQ
HHCCHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEEECCCCCCHHHCCCHHHHHHHHHHHH
NHMLQILMMTAMNLPEKVNACEIREEKRKVMETLRKVKKEDVQSHIIRGQYAAGEIKGGQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
VVAYKEEPGVNPSSNIDTFVAARLWIDNPFWTGVPFYIRTGKRMKEKSTRIVIEFKNTLK
EEEECCCCCCCCCCCCHHHHEEHEEECCCCCCCCCCEEECCCHHHCCCCEEEEEEHHHHH
QQYQDSNPNAAPNLLIIEISPGENVSLQLNSKNPLKNGEIEPMRINFTCEQADVGVPEAY
HHHCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCHHH
ERLIHDAVSGDATFFAHWKEVELSWEWVQPILEAFEENLLPLHEYESGSYGPDASNELLQ
HHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
ESGFKWWLDQETEK
HCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 9298659 [H]