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The map label for this gene is phoR [H]

Identifier: 218233456

GI number: 218233456

Start: 1450733

End: 1452547

Strand: Reverse

Name: phoR [H]

Synonym: BCB4264_A1517

Alternate gene names: 218233456

Gene position: 1452547-1450733 (Counterclockwise)

Preceding gene: 218231159

Following gene: 218232685

Centisome position: 26.8

GC content: 32.07

Gene sequence:

>1815_bases
GTGAAAAACAGAAGTATCGTCTTTAAACTATTTTTATTAACATCCACTTTATTTACAATCATATTCCTACTTTTTTTCCT
AGGACAATCTCTATTTTTAGAGAAATTTTATATTAATAAGAAAGTAAAAACAGTCCAAACTGCTTTTGAAAAATTCGTAG
ATAATTATGATAAAAGTGATAAAAGTTATGAGCAGGTTAGAAAACTAAAACAAGAATTTCATGATAAAACAAATGCCGAT
ATGCAGTTTTTGGATTCTAACGGTATTATTAAAAGTGATAACAATTACTATATCGATGTATTTAATCCCAACAATAATAA
ACAGTATTCCATTCCACTCAATAATCTTTTAACACCAGAAGAATATAATAAATTCGAAAATTTAGGTTTAAAAAAAGATG
TAATAATCAATGTTGATGGAGTCGTACAAGAGAATAATATAATCACACCACAAAAATTAGGAACGAATTATAATCAATGG
CAGAACGAACATTTCTATTCGGATTTTCAGTCAATTAATGGTAACCCTTCTAAGAACAGACTTGCAAGCCGATACAAATC
TACAACTCGAATCGTCTTTACAGGTGTTATAACTAAGTTACAGCTCCCATCCAAAGCGGAGGTTCGTCTTGCAAATGATA
TTGAAACATTACAAGCCGTTCAATATTTTGCAGATATGATTAGAGAGGGAACTTCTAACTCGAACCAATTAAGTACTTTC
ATATTAGATGGTGGAGAAAATATAAAAAATAGTATCTTTGTAAAACCGATTATAGAAAATGGAAGGATTACAGAATACGC
TTTTGCGATAGCATCTTTGCAGCCTGTTAATGAAGCGATGCTCGTTTTAAAAGATTATTATGTCTATGCCTTAATCATCG
TGTTTCTCGTAATTATTTTGTTATCCTTCTACTACTCAAAAATCATTGTTAAGCCATTAATTAAAATAAATCGTGTTACA
AAAAAAATGGCTAATTTTGATTTCAGCGAGAAATTACCTGTTACAGCTGACGATGAAATTGGCGGGCTTTCTGGCAGTAT
CAATACATTATCTGTAAATTTAAAAGATCGCATCGATCGATTAAATGTTGCTAATACAAAGTTACAACAAGATATTGAAC
GTGAACGTCAATTAGAAAAAACAAGAAAAGAATTCATTTCTGGCGTATCACACGAATTAAAAACACCGCTAAGTGTAATT
AGAAGTTTTGCAGAAGGAATTAAAGATGGTGTTAGTAAGGATACTTCGTATTATACTGATGTTATTTTAGAAGAAACAGA
AAATATGAACAGGCTGATTGTTGAAATGTTAGAATTAGCAAAGTTGGAATCTGGTACTTACAAACTAGATATGACGACGT
TCTCAATCGGTGAATTAACGCAACAAGTCTACACAAAATTATTATTTAGCATGGAAGAAAAACATTTACAAGTGAACATC
GATGCAGACCCTTCTATACTTGTTAAAGCAAATCGCAGTCGCATTGAGCAAGTAGTTGTGAACTTACTAAGTAATGCAAT
CCGTTATACGCCAGAGGGAGAAAAAATACAAGTCTCCATTATAGAAGCAGAAGATACCGTAAAAGTCGAAATCGAGAATA
CAGGAAACCCTATCCCTGAAGAAAGTCTTGAAAAAATTTGGGATCGCTTCTATCGTCTAGATGCATCACGTAGCCGTCAC
ACTGGAGGTACCGGTCTCGGATTATCTATTGTAAAAAACATTTTAGACCTCCATCATGCCGAGTATGGTGTGTATAATAC
GACTAACAGTGTTGTATTCTATTTCAATTTACAAAAAGTAAAAGAAGTCAAATAA

Upstream 100 bases:

>100_bases
TAACTCCCTTGTATTCGCCGAATTTTGAAGTGGGAGTCTTATTGCCCGTTAAAGCGGGATAAAGAAATCATTTACAGTAT
TTCTCATAAGAGGTGACGCA

Downstream 100 bases:

>100_bases
TTTGTCTTAATTTCACTAGGAGTTCACATGAAATTCACACTCTCCCTTTATAGTAAGAAACAAGTTAATCCTTTCCTTTA
CACATATAAAAGAGGAGAGT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MKNRSIVFKLFLLTSTLFTIIFLLFFLGQSLFLEKFYINKKVKTVQTAFEKFVDNYDKSDKSYEQVRKLKQEFHDKTNAD
MQFLDSNGIIKSDNNYYIDVFNPNNNKQYSIPLNNLLTPEEYNKFENLGLKKDVIINVDGVVQENNIITPQKLGTNYNQW
QNEHFYSDFQSINGNPSKNRLASRYKSTTRIVFTGVITKLQLPSKAEVRLANDIETLQAVQYFADMIREGTSNSNQLSTF
ILDGGENIKNSIFVKPIIENGRITEYAFAIASLQPVNEAMLVLKDYYVYALIIVFLVIILLSFYYSKIIVKPLIKINRVT
KKMANFDFSEKLPVTADDEIGGLSGSINTLSVNLKDRIDRLNVANTKLQQDIERERQLEKTRKEFISGVSHELKTPLSVI
RSFAEGIKDGVSKDTSYYTDVILEETENMNRLIVEMLELAKLESGTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNI
DADPSILVKANRSRIEQVVVNLLSNAIRYTPEGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRSRH
TGGTGLGLSIVKNILDLHHAEYGVYNTTNSVVFYFNLQKVKEVK

Sequences:

>Translated_604_residues
MKNRSIVFKLFLLTSTLFTIIFLLFFLGQSLFLEKFYINKKVKTVQTAFEKFVDNYDKSDKSYEQVRKLKQEFHDKTNAD
MQFLDSNGIIKSDNNYYIDVFNPNNNKQYSIPLNNLLTPEEYNKFENLGLKKDVIINVDGVVQENNIITPQKLGTNYNQW
QNEHFYSDFQSINGNPSKNRLASRYKSTTRIVFTGVITKLQLPSKAEVRLANDIETLQAVQYFADMIREGTSNSNQLSTF
ILDGGENIKNSIFVKPIIENGRITEYAFAIASLQPVNEAMLVLKDYYVYALIIVFLVIILLSFYYSKIIVKPLIKINRVT
KKMANFDFSEKLPVTADDEIGGLSGSINTLSVNLKDRIDRLNVANTKLQQDIERERQLEKTRKEFISGVSHELKTPLSVI
RSFAEGIKDGVSKDTSYYTDVILEETENMNRLIVEMLELAKLESGTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNI
DADPSILVKANRSRIEQVVVNLLSNAIRYTPEGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRSRH
TGGTGLGLSIVKNILDLHHAEYGVYNTTNSVVFYFNLQKVKEVK
>Mature_604_residues
MKNRSIVFKLFLLTSTLFTIIFLLFFLGQSLFLEKFYINKKVKTVQTAFEKFVDNYDKSDKSYEQVRKLKQEFHDKTNAD
MQFLDSNGIIKSDNNYYIDVFNPNNNKQYSIPLNNLLTPEEYNKFENLGLKKDVIINVDGVVQENNIITPQKLGTNYNQW
QNEHFYSDFQSINGNPSKNRLASRYKSTTRIVFTGVITKLQLPSKAEVRLANDIETLQAVQYFADMIREGTSNSNQLSTF
ILDGGENIKNSIFVKPIIENGRITEYAFAIASLQPVNEAMLVLKDYYVYALIIVFLVIILLSFYYSKIIVKPLIKINRVT
KKMANFDFSEKLPVTADDEIGGLSGSINTLSVNLKDRIDRLNVANTKLQQDIERERQLEKTRKEFISGVSHELKTPLSVI
RSFAEGIKDGVSKDTSYYTDVILEETENMNRLIVEMLELAKLESGTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNI
DADPSILVKANRSRIEQVVVNLLSNAIRYTPEGEKIQVSIIEAEDTVKVEIENTGNPIPEESLEKIWDRFYRLDASRSRH
TGGTGLGLSIVKNILDLHHAEYGVYNTTNSVVFYFNLQKVKEVK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=298, Percent_Identity=27.5167785234899, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1786600, Length=232, Percent_Identity=29.3103448275862, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1786783, Length=314, Percent_Identity=27.3885350318471, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1789149, Length=261, Percent_Identity=27.5862068965517, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1790861, Length=238, Percent_Identity=30.2521008403361, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1788279, Length=327, Percent_Identity=27.5229357798165, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87082128, Length=332, Percent_Identity=22.8915662650602, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1786912, Length=249, Percent_Identity=24.8995983935743, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI145693157, Length=223, Percent_Identity=26.9058295964126, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788713, Length=215, Percent_Identity=28.8372093023256, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1787894, Length=225, Percent_Identity=28.8888888888889, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790551, Length=312, Percent_Identity=26.2820512820513, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1790346, Length=204, Percent_Identity=28.4313725490196, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI87081816, Length=315, Percent_Identity=23.8095238095238, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=28.1818181818182, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788549, Length=239, Percent_Identity=25.5230125523013, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790300, Length=276, Percent_Identity=27.8985507246377, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI48994928, Length=215, Percent_Identity=25.5813953488372, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789808, Length=205, Percent_Identity=28.780487804878, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1789403, Length=303, Percent_Identity=23.4323432343234, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1787374, Length=333, Percent_Identity=21.021021021021, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 69293; Mature: 69293

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNRSIVFKLFLLTSTLFTIIFLLFFLGQSLFLEKFYINKKVKTVQTAFEKFVDNYDKSD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KSYEQVRKLKQEFHDKTNADMQFLDSNGIIKSDNNYYIDVFNPNNNKQYSIPLNNLLTPE
HHHHHHHHHHHHHCCCCCCCEEEECCCCEEECCCCEEEEEEECCCCCEEECCHHHCCCCH
EYNKFENLGLKKDVIINVDGVVQENNIITPQKLGTNYNQWQNEHFYSDFQSINGNPSKNR
HHHHHHHCCCCCEEEEEECCEEECCCCCCHHHHCCCHHHHCCCHHHHHHHHCCCCCCHHH
LASRYKSTTRIVFTGVITKLQLPSKAEVRLANDIETLQAVQYFADMIREGTSNSNQLSTF
HHHHHHCCCEEEEEEHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
ILDGGENIKNSIFVKPIIENGRITEYAFAIASLQPVNEAMLVLKDYYVYALIIVFLVIIL
EEECCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LSFYYSKIIVKPLIKINRVTKKMANFDFSEKLPVTADDEIGGLSGSINTLSVNLKDRIDR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHH
LNVANTKLQQDIERERQLEKTRKEFISGVSHELKTPLSVIRSFAEGIKDGVSKDTSYYTD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
VILEETENMNRLIVEMLELAKLESGTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNI
HHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHHHHHHHHCCCCEEEEE
DADPSILVKANRSRIEQVVVNLLSNAIRYTPEGEKIQVSIIEAEDTVKVEIENTGNPIPE
CCCCCEEEECCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEECCCEEEEEECCCCCCCCH
ESLEKIWDRFYRLDASRSRHTGGTGLGLSIVKNILDLHHAEYGVYNTTNSVVFYFNLQKV
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCEEEEEEHHHH
KEVK
HCCC
>Mature Secondary Structure
MKNRSIVFKLFLLTSTLFTIIFLLFFLGQSLFLEKFYINKKVKTVQTAFEKFVDNYDKSD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KSYEQVRKLKQEFHDKTNADMQFLDSNGIIKSDNNYYIDVFNPNNNKQYSIPLNNLLTPE
HHHHHHHHHHHHHCCCCCCCEEEECCCCEEECCCCEEEEEEECCCCCEEECCHHHCCCCH
EYNKFENLGLKKDVIINVDGVVQENNIITPQKLGTNYNQWQNEHFYSDFQSINGNPSKNR
HHHHHHHCCCCCEEEEEECCEEECCCCCCHHHHCCCHHHHCCCHHHHHHHHCCCCCCHHH
LASRYKSTTRIVFTGVITKLQLPSKAEVRLANDIETLQAVQYFADMIREGTSNSNQLSTF
HHHHHHCCCEEEEEEHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
ILDGGENIKNSIFVKPIIENGRITEYAFAIASLQPVNEAMLVLKDYYVYALIIVFLVIIL
EEECCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LSFYYSKIIVKPLIKINRVTKKMANFDFSEKLPVTADDEIGGLSGSINTLSVNLKDRIDR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHH
LNVANTKLQQDIERERQLEKTRKEFISGVSHELKTPLSVIRSFAEGIKDGVSKDTSYYTD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
VILEETENMNRLIVEMLELAKLESGTYKLDMTTFSIGELTQQVYTKLLFSMEEKHLQVNI
HHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHHHHHHHHCCCCEEEEE
DADPSILVKANRSRIEQVVVNLLSNAIRYTPEGEKIQVSIIEAEDTVKVEIENTGNPIPE
CCCCCEEEECCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEECCCEEEEEECCCCCCCCH
ESLEKIWDRFYRLDASRSRHTGGTGLGLSIVKNILDLHHAEYGVYNTTNSVVFYFNLQKV
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCEEEEEEHHHH
KEVK
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]