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The map label for this gene is glcR [H]

Identifier: 218233260

GI number: 218233260

Start: 2676484

End: 2677269

Strand: Reverse

Name: glcR [H]

Synonym: BCB4264_A2776

Alternate gene names: 218233260

Gene position: 2677269-2676484 (Counterclockwise)

Preceding gene: 218232006

Following gene: 218233857

Centisome position: 49.4

GC content: 33.97

Gene sequence:

>786_bases
ATGTTTACTGAAGAACGTCGAGAGAAAATTTTAGAACTACTTAATACAGATGGAAGAGTAATCGCAAAGGATCTTGCGGA
AAGATTTGATATGTCTATTGATTCTATAAGAAGAGATTTGTCTATTATGGAAAAGGATGGTTTATTAAAAAGAACGCACG
GAGGTGCAATTGAACTTACGCGAGTGAGAAATTTAGCTGCGGAACCAGCTAAACGTTATAGTGATAGCTCAATATATGAG
GACACAATTGCAAGAGTTGCGGTATCTTATATACAAGAAGGTGATTCAATTTTTATTGGCGGGGCTCCCGTTCATAATGC
GATGCTGAAATATTTACCGGAAGTATCATTTACGGTTATTACGAATTCTATAGAAATAGCTGGTTATCTACGAGAATATA
AGAATATTGATACGTATTTAATTGGCGGAAAAGTAAAACCTTCAGGGAATATTACTGATACACTTGCCTCTGAATTGATA
AGTAGATTTTCTATTGACCTTTATTTCTCCACAGGTGGAGGCATTTCATTACAAGGTATTAGTACTGCAACACCTGAAGT
TGCTTATTTTAGTAAAAGAGTAAGTGAAATTGCTAGAAGAAATATTTGTTTAGTTCCGCATAATAAACTTGGAATAGATT
GTTTTATAAGAGGAGAGTCTCTAAAAGAAATTGACATTATTATAACTGACGAAGAGGCTAGTAAAGAAACTGTTCAGGAC
TTTGAGAAACAAGGTAAACAAGTTGTAATAGCACCATTATATTCATTTGAAAGGAGTTTGACATGA

Upstream 100 bases:

>100_bases
CGGAATAAATAAGAATTGAAAATATTGTAAAACGGAAGAGGCATGCATATAATTAAAATAAAGTTTAAGTTTCTGAATCT
TCAATAACGGTGGTGATAAC

Downstream 100 bases:

>100_bases
TTGTAAAAGAGCAAGAGTTTTATATAAATGGATTAACTTATACAATTCGTTCTGCAGCTGAGAAAGATGCTGAGCAGTTA
TCGAAAATTAGAGTTCAGAT

Product: transcriptional regulator, DeoR family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MFTEERREKILELLNTDGRVIAKDLAERFDMSIDSIRRDLSIMEKDGLLKRTHGGAIELTRVRNLAAEPAKRYSDSSIYE
DTIARVAVSYIQEGDSIFIGGAPVHNAMLKYLPEVSFTVITNSIEIAGYLREYKNIDTYLIGGKVKPSGNITDTLASELI
SRFSIDLYFSTGGGISLQGISTATPEVAYFSKRVSEIARRNICLVPHNKLGIDCFIRGESLKEIDIIITDEEASKETVQD
FEKQGKQVVIAPLYSFERSLT

Sequences:

>Translated_261_residues
MFTEERREKILELLNTDGRVIAKDLAERFDMSIDSIRRDLSIMEKDGLLKRTHGGAIELTRVRNLAAEPAKRYSDSSIYE
DTIARVAVSYIQEGDSIFIGGAPVHNAMLKYLPEVSFTVITNSIEIAGYLREYKNIDTYLIGGKVKPSGNITDTLASELI
SRFSIDLYFSTGGGISLQGISTATPEVAYFSKRVSEIARRNICLVPHNKLGIDCFIRGESLKEIDIIITDEEASKETVQD
FEKQGKQVVIAPLYSFERSLT
>Mature_261_residues
MFTEERREKILELLNTDGRVIAKDLAERFDMSIDSIRRDLSIMEKDGLLKRTHGGAIELTRVRNLAAEPAKRYSDSSIYE
DTIARVAVSYIQEGDSIFIGGAPVHNAMLKYLPEVSFTVITNSIEIAGYLREYKNIDTYLIGGKVKPSGNITDTLASELI
SRFSIDLYFSTGGGISLQGISTATPEVAYFSKRVSEIARRNICLVPHNKLGIDCFIRGESLKEIDIIITDEEASKETVQD
FEKQGKQVVIAPLYSFERSLT

Specific function: Plays a role in carbon catabolite repression (CCR). Specifically required for transcriptional repression of the levanase operon by glucose but not by other sugars [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789059, Length=258, Percent_Identity=30.6201550387597, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1789519, Length=253, Percent_Identity=24.901185770751, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI226510968, Length=255, Percent_Identity=27.0588235294118, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790635, Length=252, Percent_Identity=23.8095238095238, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789829, Length=248, Percent_Identity=26.6129032258064, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1788069, Length=254, Percent_Identity=26.7716535433071, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87082344, Length=241, Percent_Identity=25.7261410788382, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790753, Length=176, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1789170, Length=230, Percent_Identity=26.5217391304348, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 29171; Mature: 29171

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTEERREKILELLNTDGRVIAKDLAERFDMSIDSIRRDLSIMEKDGLLKRTHGGAIELT
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCEEEEH
RVRNLAAEPAKRYSDSSIYEDTIARVAVSYIQEGDSIFIGGAPVHNAMLKYLPEVSFTVI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCEEEEE
TNSIEIAGYLREYKNIDTYLIGGKVKPSGNITDTLASELISRFSIDLYFSTGGGISLQGI
ECCHHHHHHHHHHCCCCEEEECCEECCCCCCHHHHHHHHHHHHEEEEEEECCCCEEECCC
STATPEVAYFSKRVSEIARRNICLVPHNKLGIDCFIRGESLKEIDIIITDEEASKETVQD
CCCCCHHHHHHHHHHHHHHCCEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCHHHHHH
FEKQGKQVVIAPLYSFERSLT
HHHCCCEEEEEEHHHHHHCCC
>Mature Secondary Structure
MFTEERREKILELLNTDGRVIAKDLAERFDMSIDSIRRDLSIMEKDGLLKRTHGGAIELT
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCEEEEH
RVRNLAAEPAKRYSDSSIYEDTIARVAVSYIQEGDSIFIGGAPVHNAMLKYLPEVSFTVI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCEEEEE
TNSIEIAGYLREYKNIDTYLIGGKVKPSGNITDTLASELISRFSIDLYFSTGGGISLQGI
ECCHHHHHHHHHHCCCCEEEECCEECCCCCCHHHHHHHHHHHHEEEEEEECCCCEEECCC
STATPEVAYFSKRVSEIARRNICLVPHNKLGIDCFIRGESLKEIDIIITDEEASKETVQD
CCCCCHHHHHHHHHHHHHHCCEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCHHHHHH
FEKQGKQVVIAPLYSFERSLT
HHHCCCEEEEEEHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]