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The map label for this gene is hisC2 [H]

Identifier: 218233128

GI number: 218233128

Start: 2830378

End: 2831478

Strand: Reverse

Name: hisC2 [H]

Synonym: BCB4264_A2958

Alternate gene names: 218233128

Gene position: 2831478-2830378 (Counterclockwise)

Preceding gene: 218233180

Following gene: 218233603

Centisome position: 52.25

GC content: 37.6

Gene sequence:

>1101_bases
GTGCAAGTAAAAGATCAACTATCATCATTACAACCATATAAACCAGGTAAATCACCAGAACAAATGAAAGAAGTGTACGG
AGATCATTCGTTTGTGAAATTAGCATCGAATGAAAATCCATTCGGCTGTTCGCCACGTGTTTTAGATGAGTTGCAAAAAT
CGTGGTTGGAACATGCTTTATATCCTGACGGAGGTGCTACAACGCTCCGTCAAACAATCGCAGATAAGTTACATGTGAAA
ATGGAACAAGTACTTTGTGGTAGTGGTTTAGATGAAATCATTCAAATAATAAGCCGCGCCGTATTACGAGCGGGAGATAA
CATTGTAACAGCAGGTGAAACATTCCCACAGTATCGTCATCATGCCATTATAGAAGGTTGCGAAGTGAAGGAAGTTGCGT
TAAATAACGGTGTATACGACTTAGAAGAAATTTCTTCAGTAGTAGATAACGATACAAAAATTGTATGGATTTGTAACCCG
AACAATCCAACAGGCACATATGTGAATGACCGAAAATTGACTCAATTCATTGAAGGTATTAGTGAAAATACGTTAATTGT
CATTGATGAAGCGTACTATGAATACGTAACAGCAAAAGATTTCCCAGAGACATTACCGCTTTTAGAAAAACATAAAAATA
TTCTTGTACTTAGAACATTTTCTAAAGCGTACGGATTAGCTTCTTTCCGCGTTGGATATGCGGTTGGACAGGAAGAGTTA
ATCGAAAAATTAAATGTCGTTCGTTTGCCATTTAACGTATCTTCATTAGCGCAAAAAGCAGCGACGATTGCTTTTGGTGA
TGACGAGTTTATTGAAGAAATAGTTCGCGTGAATACAGAAGGATTACAACAATACGAGAGCTTTTGTAGGGAAAATGATA
TTCCATTTTATCCATCGCAAACAAATTTCATCTTCTTGCCAGTTGAGAATGCTGGAGAGATTTATGAAGCTTGTGCACAT
GCAGGATTTATTATTCGTCCGTTCCCGAATGGTATCCGTATTACAGTCGGAACAAGGGAGCAAAATGAAGGGGTGATTTC
AGTGTTACAACAACACTTTGAAAATAAAAAAAGAAAGTCTCGAGATGAGGAAAATGCGTAA

Upstream 100 bases:

>100_bases
AGTCGAACAATTCGGAAAAGATCGTATGGAATTATTAAAACAAAACATTATGCAACACAATAACTACGCAAAAGAATTTT
AATAAAAAGGTGGGTTTAAC

Downstream 100 bases:

>100_bases
AAAGGTAGTATTAATTGGAACTGGTTTAATCGGAGGCTCTCTCGCATTAGCAATTAAGAAAGAGCACGATATAACGATAA
CAGGTTATGATATATTTCAA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2 [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MQVKDQLSSLQPYKPGKSPEQMKEVYGDHSFVKLASNENPFGCSPRVLDELQKSWLEHALYPDGGATTLRQTIADKLHVK
MEQVLCGSGLDEIIQIISRAVLRAGDNIVTAGETFPQYRHHAIIEGCEVKEVALNNGVYDLEEISSVVDNDTKIVWICNP
NNPTGTYVNDRKLTQFIEGISENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGQEEL
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLQQYESFCRENDIPFYPSQTNFIFLPVENAGEIYEACAH
AGFIIRPFPNGIRITVGTREQNEGVISVLQQHFENKKRKSRDEENA

Sequences:

>Translated_366_residues
MQVKDQLSSLQPYKPGKSPEQMKEVYGDHSFVKLASNENPFGCSPRVLDELQKSWLEHALYPDGGATTLRQTIADKLHVK
MEQVLCGSGLDEIIQIISRAVLRAGDNIVTAGETFPQYRHHAIIEGCEVKEVALNNGVYDLEEISSVVDNDTKIVWICNP
NNPTGTYVNDRKLTQFIEGISENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGQEEL
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLQQYESFCRENDIPFYPSQTNFIFLPVENAGEIYEACAH
AGFIIRPFPNGIRITVGTREQNEGVISVLQQHFENKKRKSRDEENA
>Mature_366_residues
MQVKDQLSSLQPYKPGKSPEQMKEVYGDHSFVKLASNENPFGCSPRVLDELQKSWLEHALYPDGGATTLRQTIADKLHVK
MEQVLCGSGLDEIIQIISRAVLRAGDNIVTAGETFPQYRHHAIIEGCEVKEVALNNGVYDLEEISSVVDNDTKIVWICNP
NNPTGTYVNDRKLTQFIEGISENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGQEEL
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLQQYESFCRENDIPFYPSQTNFIFLPVENAGEIYEACAH
AGFIIRPFPNGIRITVGTREQNEGVISVLQQHFENKKRKSRDEENA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=345, Percent_Identity=29.5652173913043, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788627, Length=234, Percent_Identity=27.3504273504274, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786816, Length=212, Percent_Identity=22.1698113207547, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=387, Percent_Identity=26.8733850129199, Blast_Score=107, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41255; Mature: 41255

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVKDQLSSLQPYKPGKSPEQMKEVYGDHSFVKLASNENPFGCSPRVLDELQKSWLEHAL
CCCHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
YPDGGATTLRQTIADKLHVKMEQVLCGSGLDEIIQIISRAVLRAGDNIVTAGETFPQYRH
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHH
HAIIEGCEVKEVALNNGVYDLEEISSVVDNDTKIVWICNPNNPTGTYVNDRKLTQFIEGI
HHHHCCCCHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEECHHHHHHHHHCC
SENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGQEEL
CCCEEEEEEHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECHHHHCCHHHHHHHHCCHHHH
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLQQYESFCRENDIPFYPSQ
HHHHCEEECCCCHHHHHHHHHEEEECCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC
TNFIFLPVENAGEIYEACAHAGFIIRPFPNGIRITVGTREQNEGVISVLQQHFENKKRKS
CCEEEEECCCCHHHHHHHHHCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHC
RDEENA
CCCCCC
>Mature Secondary Structure
MQVKDQLSSLQPYKPGKSPEQMKEVYGDHSFVKLASNENPFGCSPRVLDELQKSWLEHAL
CCCHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
YPDGGATTLRQTIADKLHVKMEQVLCGSGLDEIIQIISRAVLRAGDNIVTAGETFPQYRH
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHH
HAIIEGCEVKEVALNNGVYDLEEISSVVDNDTKIVWICNPNNPTGTYVNDRKLTQFIEGI
HHHHCCCCHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEECHHHHHHHHHCC
SENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGQEEL
CCCEEEEEEHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECHHHHCCHHHHHHHHCCHHHH
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLQQYESFCRENDIPFYPSQ
HHHHCEEECCCCHHHHHHHHHEEEECCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC
TNFIFLPVENAGEIYEACAHAGFIIRPFPNGIRITVGTREQNEGVISVLQQHFENKKRKS
CCEEEEECCCCHHHHHHHHHCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHC
RDEENA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]