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The map label for this gene is sqhC [H]

Identifier: 218233099

GI number: 218233099

Start: 3580054

End: 3581907

Strand: Reverse

Name: sqhC [H]

Synonym: BCB4264_A3665

Alternate gene names: 218233099

Gene position: 3581907-3580054 (Counterclockwise)

Preceding gene: 218232000

Following gene: 218234645

Centisome position: 66.1

GC content: 37.65

Gene sequence:

>1854_bases
TTGTTATTATATGAAAAAGTGCATGAAGAAATAGCGAGAAGAACAACTGCACTTCAAACAATGCAACGGCAAGATGGTAC
GTGGCGGTTTTGTTTTGAAGGAGCGCCACTAACAGATTGTCATATGATTTTTTTATTAAAATTATTAGGTAAAGATAAAG
AGATAGAACCGTTTGTAAAAAGATTAGCATCACTCCAAACAAATGAAGGAACATGGAAATTGTATGAAGATGAAGTGGGT
GGTAATTTATCTGCTACAATTCAATCTTATGCTGCCTTACTTGCATCGGAAAAATATACAAAAGAAGATGCGAATATGAA
GCGAGCGGAAATGTTTATAAATGAGCGCGGTGGGGTAGCGCGTGCTCATTTTATGACGAAGTTTTTATTAGCGATTCATG
GAGAATATGAATATCCTTCTCTCTTTCATTTGCCAACACCAATTATGTTTCTGCAGAATGATTCCCCTCTCAGTATTTTT
GAACTGAGTAGCTCAGCACGTATTCATTTAATTCCGATGATGTTGTGTTTAAATAAAAGATTCCGAGTAGGGAAAAAGTT
ATTGCCAAATTTAAATCACATTGCAGGCGGGGGCGGAGAATGGTTTCGGGAGGATCGGTCTCCAGTTTTTCAAACGTTAG
TAAGTGACGTGAAGAAAATTATAACGTATCCACTTTCTTTGCATCATAAAGGATATGAGGAAGTAGAACGTTTTATGAAA
GAGCGTATTGATGAAAATGGAACATTATATAGCTACGCAACTGCCTCGTTTTATATGATTTATGCTTTACTTGCATTAGG
ACATTCTATTCAATCACCAATTATTCAAAAAGCTATAACGGGAATCACATCTTATATATGGAAGATGGAGAGAGGGAGCC
ATTTGCAAAACTCTCCATCAACTGTATGGGATACAGCTTTACTCAGTTATGCTTTGCAAGAAGCTCAAGTTCCGAAAGCA
AGTAAAGTGATTCACAATGCATCAGCATATTTATTAAGAAAACAGCAAACGAAGAAAGTAGATTGGAGTGTACATGCACC
GGATCTCTTCCCAGGTGGTTGGGGCTTTTCGGATGTGAATACGACGATTCCAGATATTGATGATACAACTGCTGCGTTAA
GAGCATTGGCGCGAAGTAGAGGGAACGAAAATGTAGACACTGCTTGGAAGCGAGCGGTTAATTGGGTTAAAGGATTGCAA
AATAATGATGGTGGTTGGGGGGCTTTTGAAAAAGGGGTAACGAGCCGTATATTAGCAAATTTACCAATCGAAAATGCAAG
TGATATGATTACAGATCCTTCTACACCAGATATTACAGGAAGAGTATTAGAATTTTTCGGAACGTATACGCAAAATGAAT
TGCCCGAGAAACAAAAACAAAGTGCGATAAATTGGTTAATGAATGTACAAGAGGAAAATGGATCGTGGTATGGGAAATGG
GGAATTTGTTATATATATGGTACGTGGGCAGTGTTGACTGGTTTACGGTCACTAGGAATACCATCTAGCGATCCATCAGT
GAAACGAGCAGCTTTATGGCTTGAACATATACAGCATGAAGATGGTGGCTGGGGAGAATCTTGCCAAAGTAGTGTGGAAA
AAAGATTTGTTACTTTGCCATTTAGTACACCATCCCAAACAGCATGGGCGTTAGATGCCCTCATTTCTTACTATGATAAA
GAAACGCCAGTTATTCGAAAAGGTATTTCATATTTGCTCTCCAACTCTTATATAAATGAAAAATATCCTACTGGAACAGG
TTTACCAGGTGGGTTTTATATTCGTTATCATAGTTATGCTCATATATATCCGTTGCTTACTTTGGCTCATTATGCAAAAA
AATATAGAAAATAA

Upstream 100 bases:

>100_bases
AGCAGAACATTTTATATGTTCTGCTTTTCTTTGTTTTTATACATATTCAGCTACCTTTTTGAATATCGTTATACGGATTT
CGAAAGGGTGGGTGAGCAAC

Downstream 100 bases:

>100_bases
ACCGAGAGATGTCTCTCGGTTTATTTTGTTGGGTAGTAGGTCCCTTTTGAAAAGAATAAGGTTGTGATGTACCTTATTTT
TCGGTTGATTGGCGCTTTTG

Product: putative squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MLLYEKVHEEIARRTTALQTMQRQDGTWRFCFEGAPLTDCHMIFLLKLLGKDKEIEPFVKRLASLQTNEGTWKLYEDEVG
GNLSATIQSYAALLASEKYTKEDANMKRAEMFINERGGVARAHFMTKFLLAIHGEYEYPSLFHLPTPIMFLQNDSPLSIF
ELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLVSDVKKIITYPLSLHHKGYEEVERFMK
ERIDENGTLYSYATASFYMIYALLALGHSIQSPIIQKAITGITSYIWKMERGSHLQNSPSTVWDTALLSYALQEAQVPKA
SKVIHNASAYLLRKQQTKKVDWSVHAPDLFPGGWGFSDVNTTIPDIDDTTAALRALARSRGNENVDTAWKRAVNWVKGLQ
NNDGGWGAFEKGVTSRILANLPIENASDMITDPSTPDITGRVLEFFGTYTQNELPEKQKQSAINWLMNVQEENGSWYGKW
GICYIYGTWAVLTGLRSLGIPSSDPSVKRAALWLEHIQHEDGGWGESCQSSVEKRFVTLPFSTPSQTAWALDALISYYDK
ETPVIRKGISYLLSNSYINEKYPTGTGLPGGFYIRYHSYAHIYPLLTLAHYAKKYRK

Sequences:

>Translated_617_residues
MLLYEKVHEEIARRTTALQTMQRQDGTWRFCFEGAPLTDCHMIFLLKLLGKDKEIEPFVKRLASLQTNEGTWKLYEDEVG
GNLSATIQSYAALLASEKYTKEDANMKRAEMFINERGGVARAHFMTKFLLAIHGEYEYPSLFHLPTPIMFLQNDSPLSIF
ELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLVSDVKKIITYPLSLHHKGYEEVERFMK
ERIDENGTLYSYATASFYMIYALLALGHSIQSPIIQKAITGITSYIWKMERGSHLQNSPSTVWDTALLSYALQEAQVPKA
SKVIHNASAYLLRKQQTKKVDWSVHAPDLFPGGWGFSDVNTTIPDIDDTTAALRALARSRGNENVDTAWKRAVNWVKGLQ
NNDGGWGAFEKGVTSRILANLPIENASDMITDPSTPDITGRVLEFFGTYTQNELPEKQKQSAINWLMNVQEENGSWYGKW
GICYIYGTWAVLTGLRSLGIPSSDPSVKRAALWLEHIQHEDGGWGESCQSSVEKRFVTLPFSTPSQTAWALDALISYYDK
ETPVIRKGISYLLSNSYINEKYPTGTGLPGGFYIRYHSYAHIYPLLTLAHYAKKYRK
>Mature_617_residues
MLLYEKVHEEIARRTTALQTMQRQDGTWRFCFEGAPLTDCHMIFLLKLLGKDKEIEPFVKRLASLQTNEGTWKLYEDEVG
GNLSATIQSYAALLASEKYTKEDANMKRAEMFINERGGVARAHFMTKFLLAIHGEYEYPSLFHLPTPIMFLQNDSPLSIF
ELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLVSDVKKIITYPLSLHHKGYEEVERFMK
ERIDENGTLYSYATASFYMIYALLALGHSIQSPIIQKAITGITSYIWKMERGSHLQNSPSTVWDTALLSYALQEAQVPKA
SKVIHNASAYLLRKQQTKKVDWSVHAPDLFPGGWGFSDVNTTIPDIDDTTAALRALARSRGNENVDTAWKRAVNWVKGLQ
NNDGGWGAFEKGVTSRILANLPIENASDMITDPSTPDITGRVLEFFGTYTQNELPEKQKQSAINWLMNVQEENGSWYGKW
GICYIYGTWAVLTGLRSLGIPSSDPSVKRAALWLEHIQHEDGGWGESCQSSVEKRFVTLPFSTPSQTAWALDALISYYDK
ETPVIRKGISYLLSNSYINEKYPTGTGLPGGFYIRYHSYAHIYPLLTLAHYAKKYRK

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=626, Percent_Identity=24.1214057507987, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI47933397, Length=626, Percent_Identity=24.1214057507987, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI224177558, Length=626, Percent_Identity=24.1214057507987, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI224177556, Length=563, Percent_Identity=23.8010657193606, Blast_Score=120, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6321863, Length=346, Percent_Identity=28.3236994219653, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 69939; Mature: 69939

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLYEKVHEEIARRTTALQTMQRQDGTWRFCFEGAPLTDCHMIFLLKLLGKDKEIEPFVK
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHH
RLASLQTNEGTWKLYEDEVGGNLSATIQSYAALLASEKYTKEDANMKRAEMFINERGGVA
HHHHCCCCCCCEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHH
RAHFMTKFLLAIHGEYEYPSLFHLPTPIMFLQNDSPLSIFELSSSARIHLIPMMLCLNKR
HHHHHHHHHHHHCCCCCCCCEEECCCCEEEEECCCCCEEEEECCCCEEHHHHHHHHHHHH
FRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLVSDVKKIITYPLSLHHKGYEEVERFMK
HHHHHHHCCCCHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHH
ERIDENGTLYSYATASFYMIYALLALGHSIQSPIIQKAITGITSYIWKMERGSHLQNSPS
HHHCCCCCEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TVWDTALLSYALQEAQVPKASKVIHNASAYLLRKQQTKKVDWSVHAPDLFPGGWGFSDVN
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCC
TTIPDIDDTTAALRALARSRGNENVDTAWKRAVNWVKGLQNNDGGWGAFEKGVTSRILAN
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
LPIENASDMITDPSTPDITGRVLEFFGTYTQNELPEKQKQSAINWLMNVQEENGSWYGKW
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHECCCCCEEECC
GICYIYGTWAVLTGLRSLGIPSSDPSVKRAALWLEHIQHEDGGWGESCQSSVEKRFVTLP
EEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEECC
FSTPSQTAWALDALISYYDKETPVIRKGISYLLSNSYINEKYPTGTGLPGGFYIRYHSYA
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCHH
HIYPLLTLAHYAKKYRK
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLYEKVHEEIARRTTALQTMQRQDGTWRFCFEGAPLTDCHMIFLLKLLGKDKEIEPFVK
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHH
RLASLQTNEGTWKLYEDEVGGNLSATIQSYAALLASEKYTKEDANMKRAEMFINERGGVA
HHHHCCCCCCCEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHH
RAHFMTKFLLAIHGEYEYPSLFHLPTPIMFLQNDSPLSIFELSSSARIHLIPMMLCLNKR
HHHHHHHHHHHHCCCCCCCCEEECCCCEEEEECCCCCEEEEECCCCEEHHHHHHHHHHHH
FRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLVSDVKKIITYPLSLHHKGYEEVERFMK
HHHHHHHCCCCHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHH
ERIDENGTLYSYATASFYMIYALLALGHSIQSPIIQKAITGITSYIWKMERGSHLQNSPS
HHHCCCCCEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TVWDTALLSYALQEAQVPKASKVIHNASAYLLRKQQTKKVDWSVHAPDLFPGGWGFSDVN
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCC
TTIPDIDDTTAALRALARSRGNENVDTAWKRAVNWVKGLQNNDGGWGAFEKGVTSRILAN
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
LPIENASDMITDPSTPDITGRVLEFFGTYTQNELPEKQKQSAINWLMNVQEENGSWYGKW
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHECCCCCEEECC
GICYIYGTWAVLTGLRSLGIPSSDPSVKRAALWLEHIQHEDGGWGESCQSSVEKRFVTLP
EEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEECC
FSTPSQTAWALDALISYYDKETPVIRKGISYLLSNSYINEKYPTGTGLPGGFYIRYHSYA
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCHH
HIYPLLTLAHYAKKYRK
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]