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The map label for this gene is mtaD [H]

Identifier: 218233043

GI number: 218233043

Start: 1772781

End: 1774088

Strand: Direct

Name: mtaD [H]

Synonym: BCB4264_A1866

Alternate gene names: 218233043

Gene position: 1772781-1774088 (Clockwise)

Preceding gene: 218233958

Following gene: 218231654

Centisome position: 32.71

GC content: 38.3

Gene sequence:

>1308_bases
TTGAAAACAACTTATGTAAACGCTACAATTGTAACGATGAATGAACAAAACGAAGTGATAGAAAATGGATATATCATTGT
AGAAAATGATCAAATTATAGATGTAAAGAGCGGAAAATTCGCTAATGATTTTGAAGTAGATGAAGTAATTGACATGAAAG
GAAAGTGGGTTTTACCAGGGCTTGTAAATACACATACACACGTTGTAATGAGTCTCCTAAGAGGTATTGGCGATGATATG
TTATTACAGCCGTGGCTTGAGACGAGAATTTGGCCACTGGAAAGTCAATTTACTCCCCAAATTGCGGTCGCTAGTACGGA
ATTAGGATTACTTGAGATGGTGAAAAGTGGTACAACATCATTCTCTGACATGTTTAATCCAATTGGAGTAGATCAAGACG
CAATTATGGAAACGGTATCAAGGAGCGGGATGCGAGCTGCTGTTTCAAGGACTTTATTTAGCTTCGGAACGAAAGACGAT
GAAAAGAAAGCGATTGAAGAAGCTGAGAAATATGTGAAGCGTTACTATAACGAAAGTGGCATGTTAACTACGATGGTTGC
ACCACATAGTCCATATACATGTAGTACAGAATTGTTAGAAGAGTGCGCACGGATTGCAGTAGAGAATCAAACGATGGTTC
ATATCCATCTTTCTGAAACAGAGCGTGAAGTACGTGATATTGAAGCACAATATGGAAAACGTCCAGTAGAATATGCAGCG
AGCTGCGGATTGTTTAAACGCCCAACAGTTATTGCACACGGTGTAGTATTAAATGACGATGAGCGTGCATTTTTAGCAGA
AAATGACGTTCGAGTAGCTCATAATCCGAATAGTAATTTAAAACTAGGTTCTGGTATAGCGAATGTAAAAGCGATGCTAG
AAGCAGGAATAAAAGTAGGAATTGCAACAGATAGTGTTGCGTCTAACAATAATTTAGACATGTTTGAAGAAATGCGCATA
GCGACTTTACTACAAAAAGGTATTCACCAAGATGCAACAGCATTACCAGTTGAAACAGCTCTTACACTTGCGACAAAAGG
AGCTGCTGAAGTAATCGGGATGAAACAAACAGGATCACTTGAGATTGGAAAATGTGCTGATTTCATTACAATTGATCCGT
CTAATAAGCCGCATTTACAACCAGCGGATGAAGTGTTATCACACCTTGTATATGCTGCTAGTGGAAAAGATATAAGCGAT
GTAATTATTAACGGAAAACATGTCGTTTGGAATGGCGAATGTAAAACGTTAGATGAAGAGCGTATTATATTTGAAGCAAG
TCGTTATAAACGAGGTTTGCAAAGATAG

Upstream 100 bases:

>100_bases
AAGAATTCAAATTATCTTTTGACTCTTAATCTTTAATAAGTTACTATAATGGTGGTAACTTATTAAAGGGAACTTCATAG
AGTTGAAAGGGGAAATACTT

Downstream 100 bases:

>100_bases
ATAATTATGTGGCAGTTGAAAAAGCTATCCTTTTAAAGGATAGCTTTTTTCTTGAACGAATAAATATTCAAAAGAATGTC
GCATCTTTCTGTTAGTATTT

Product: chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKTTYVNATIVTMNEQNEVIENGYIIVENDQIIDVKSGKFANDFEVDEVIDMKGKWVLPGLVNTHTHVVMSLLRGIGDDM
LLQPWLETRIWPLESQFTPQIAVASTELGLLEMVKSGTTSFSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTKDD
EKKAIEEAEKYVKRYYNESGMLTTMVAPHSPYTCSTELLEECARIAVENQTMVHIHLSETEREVRDIEAQYGKRPVEYAA
SCGLFKRPTVIAHGVVLNDDERAFLAENDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVGIATDSVASNNNLDMFEEMRI
ATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSLEIGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISD
VIINGKHVVWNGECKTLDEERIIFEASRYKRGLQR

Sequences:

>Translated_435_residues
MKTTYVNATIVTMNEQNEVIENGYIIVENDQIIDVKSGKFANDFEVDEVIDMKGKWVLPGLVNTHTHVVMSLLRGIGDDM
LLQPWLETRIWPLESQFTPQIAVASTELGLLEMVKSGTTSFSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTKDD
EKKAIEEAEKYVKRYYNESGMLTTMVAPHSPYTCSTELLEECARIAVENQTMVHIHLSETEREVRDIEAQYGKRPVEYAA
SCGLFKRPTVIAHGVVLNDDERAFLAENDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVGIATDSVASNNNLDMFEEMRI
ATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSLEIGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISD
VIINGKHVVWNGECKTLDEERIIFEASRYKRGLQR
>Mature_435_residues
MKTTYVNATIVTMNEQNEVIENGYIIVENDQIIDVKSGKFANDFEVDEVIDMKGKWVLPGLVNTHTHVVMSLLRGIGDDM
LLQPWLETRIWPLESQFTPQIAVASTELGLLEMVKSGTTSFSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTKDD
EKKAIEEAEKYVKRYYNESGMLTTMVAPHSPYTCSTELLEECARIAVENQTMVHIHLSETEREVRDIEAQYGKRPVEYAA
SCGLFKRPTVIAHGVVLNDDERAFLAENDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVGIATDSVASNNNLDMFEEMRI
ATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSLEIGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISD
VIINGKHVVWNGECKTLDEERIIFEASRYKRGLQR

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=379, Percent_Identity=26.9129287598945, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI1789249, Length=339, Percent_Identity=27.1386430678466, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI87082177, Length=448, Percent_Identity=25.2232142857143, Blast_Score=104, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17540282, Length=389, Percent_Identity=24.6786632390745, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319963, Length=351, Percent_Identity=27.6353276353276, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24643849, Length=443, Percent_Identity=26.1851015801354, Blast_Score=136, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 48096; Mature: 48096

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTYVNATIVTMNEQNEVIENGYIIVENDQIIDVKSGKFANDFEVDEVIDMKGKWVLPG
CCEEEEEEEEEEECCCCHHHHCCEEEEECCEEEEECCCCCCCCCCHHHHHCCCCCEECCC
LVNTHTHVVMSLLRGIGDDMLLQPWLETRIWPLESQFTPQIAVASTELGLLEMVKSGTTS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCC
FSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTKDDEKKAIEEAEKYVKRYYNESG
HHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
MLTTMVAPHSPYTCSTELLEECARIAVENQTMVHIHLSETEREVRDIEAQYGKRPVEYAA
CEEEEECCCCCCCCHHHHHHHHHHHEECCCEEEEEEECCHHHHHHHHHHHHCCCCHHHHH
SCGLFKRPTVIAHGVVLNDDERAFLAENDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVG
HCCCCCCCCEEEECEEECCCCCEEEECCCEEEEECCCCCCEECCCHHHHHHHHHCCCEEE
IATDSVASNNNLDMFEEMRIATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSL
EEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHEEECCCCCE
EIGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISDVIINGKHVVWNGECKTLDEE
EECCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHEEECCCEEEECCCCCCCCCH
RIIFEASRYKRGLQR
HHEEEHHHHHHCCCC
>Mature Secondary Structure
MKTTYVNATIVTMNEQNEVIENGYIIVENDQIIDVKSGKFANDFEVDEVIDMKGKWVLPG
CCEEEEEEEEEEECCCCHHHHCCEEEEECCEEEEECCCCCCCCCCHHHHHCCCCCEECCC
LVNTHTHVVMSLLRGIGDDMLLQPWLETRIWPLESQFTPQIAVASTELGLLEMVKSGTTS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCC
FSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTKDDEKKAIEEAEKYVKRYYNESG
HHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
MLTTMVAPHSPYTCSTELLEECARIAVENQTMVHIHLSETEREVRDIEAQYGKRPVEYAA
CEEEEECCCCCCCCHHHHHHHHHHHEECCCEEEEEEECCHHHHHHHHHHHHCCCCHHHHH
SCGLFKRPTVIAHGVVLNDDERAFLAENDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVG
HCCCCCCCCEEEECEEECCCCCEEEECCCEEEEECCCCCCEECCCHHHHHHHHHCCCEEE
IATDSVASNNNLDMFEEMRIATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSL
EEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHEEECCCCCE
EIGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISDVIINGKHVVWNGECKTLDEE
EECCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHEEECCCEEEECCCCCCCCCH
RIIFEASRYKRGLQR
HHEEEHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA