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The map label for this gene is tkt2 [H]

Identifier: 218233032

GI number: 218233032

Start: 3700323

End: 3702323

Strand: Reverse

Name: tkt2 [H]

Synonym: BCB4264_A3790

Alternate gene names: 218233032

Gene position: 3702323-3700323 (Counterclockwise)

Preceding gene: 218231478

Following gene: 218233936

Centisome position: 68.32

GC content: 41.28

Gene sequence:

>2001_bases
ATGTCACATTCAATCGAACAACTTTCTATCAACACGATTCGCACATTATCCATCGATGCGATTGAAAAAGCAAACTCTGG
TCACCCAGGAATGCCAATGGGTGCAGCACCAATGGCTTATACATTATGGACTCAATTTATGAAACACAATCCAAATAACC
CAACGTGGTTTAACCGTGATCGTTTCGTATTATCTGCAGGTCATGGTTCAATGTTATTATACAGCCTACTTCACCTATCT
GGTTATGATGTAACAATGGATGACTTAAAGAACTTCCGTCAATGGGGAAGCAAAACTCCAGGACATCCTGAGTACGGTCA
TACAGCTGGTGTAGATGCAACGACTGGTCCACTTGGACAAGGTATTGCAACTGCTGTAGGTATGGCAATGGCTGAAAGAC
ATTTAGCTGCTAAATATAACCGTGATGCGTATAATGTAGTAGATCATTATACATACGCTATTTGTGGTGATGGAGATTTA
ATGGAGGGCGTTTCTGCTGAAGCATCTTCATTAGCTGCTCATTTACAATTAGGTCGTCTTGTTGTGCTTTACGATTCAAA
CGATATTTCATTAGATGGCGATTTAAATCGTTCATTCTCTGAAAGTGTAGAAGATCGTTACAAAGCATACGGATGGCAAG
TAATCCGTGTTGAGGATGGAAACGATATTGAAGCAATCGCGAAAGCAATTGAAGAAGCGAAAGCTGACGAAAAACGCCCA
ACGCTAATTGAAGTAAGAACGACAATTGGTTTCGGTTCTCCAAACAAATCAGGAAAATCAGCTTCACATGGTTCTCCACT
TGGTGTAGAAGAAACAAAATTAACGAAAGAAGCATATGCTTGGACTGCTGAGCAAGACTTCCACGTAGCAGAAGAAGTAT
ATGACAACTTCCGTAAAACAGTACAAGATGTTGGTGAAACTGCGCAAGCTGAGTGGAACACGATGCTAGGTGAATATGCA
CAAGCATACCCAGAATTAGCAAACGAATTCCAAGCAGCAATGAACGGTCAACTTCCAGAAGGTTGGGAGCAAAACTTACC
GACTTATGAATTAGGATCAAAAGCAGCAACTCGTAATTCTTCTGGTGCTGTAATTAATGCAATTGCAGAGTCTGTACCAT
CATTCTTCGGTGGATCTGCTGACCTTGCTGGTTCTAACAAAACATACATGAATAACGAAAAAGACTTTACAAGAGATGAT
TACAGCGGTAAAAACATTTGGTACGGTGTACGTGAGTTCGCAATGGGTGCAGCAATGAACGGTATTGCACTACATGGTGG
TTTAAAAACTTACGGTGGTACGTTCTTCGTATTCTCTGATTACTTACGTCCAGCAATTCGCCTTGCAGCATTAATGCAAT
TGCCAGTAACGTATGTATTCACACATGACAGTATCGCTGTTGGTGAAGATGGTCCAACACATGAACCAATCGAGCAATTA
GCAGCGCTTCGTGCAATGCCAAACGTTTCTGTTATTCGTCCTGCTGATGGTAACGAATCTGTTGCAGCTTGGAGACTAGC
TTTAGAATCTACAAACAAACCAACTGCTTTAGTATTAACTCGTCAAGACCTTCCAACATTAGAAGGTGCAAAAGATGATA
CGTATGAAAAAGTAGCAAAAGGTGCATATGTAGTTTCTGCAAGCAAGAAAGAAACGGCTGATGTAATCTTACTTGCAACT
GGATCTGAAGTAAGCCTAGCTGTTGAAGCTCAAAAAGCATTAGCAGTAGACGGCGTTGACGTAGCTGTTGTCAGCATGCC
ATCTATGGATCGCTTCGAAGCTCAAACTGCAGAGTACAAAGAATCTGTATTACCAAAAGCAGTAACAAAACGTTTCGCAA
TCGAAATGGGTGCTACATTCGGATGGCACCGTTACGTAGGTCTTGAAGGAGATGTGTTAGGTATCGATACATTCGGTGCT
TCTGCTCCTGGTGAGAAGATTATGGAAGAGTATGGATTTACTGTAGAGAACGTTGTTCGTAAAGTAAAAGAAATGCTTTA
A

Upstream 100 bases:

>100_bases
ATATCAACATATTTGTCGATACATGTTGTATAATCTTGCGTGGGAAGCTATCATATAAATGTATAAAACGTTTACTAATA
TAAGCGAAGGGAAGAATAGC

Downstream 100 bases:

>100_bases
TGATTTCAGAAAAATCTCTCCGGCATGGAGAGGTTTTTCTATGTAAATGAGTTTTTTCGACAGAAAAAGTTTTTTATCTC
TCCGCAGTCAGACAATCATT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MSHSIEQLSINTIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTQFMKHNPNNPTWFNRDRFVLSAGHGSMLLYSLLHLS
GYDVTMDDLKNFRQWGSKTPGHPEYGHTAGVDATTGPLGQGIATAVGMAMAERHLAAKYNRDAYNVVDHYTYAICGDGDL
MEGVSAEASSLAAHLQLGRLVVLYDSNDISLDGDLNRSFSESVEDRYKAYGWQVIRVEDGNDIEAIAKAIEEAKADEKRP
TLIEVRTTIGFGSPNKSGKSASHGSPLGVEETKLTKEAYAWTAEQDFHVAEEVYDNFRKTVQDVGETAQAEWNTMLGEYA
QAYPELANEFQAAMNGQLPEGWEQNLPTYELGSKAATRNSSGAVINAIAESVPSFFGGSADLAGSNKTYMNNEKDFTRDD
YSGKNIWYGVREFAMGAAMNGIALHGGLKTYGGTFFVFSDYLRPAIRLAALMQLPVTYVFTHDSIAVGEDGPTHEPIEQL
AALRAMPNVSVIRPADGNESVAAWRLALESTNKPTALVLTRQDLPTLEGAKDDTYEKVAKGAYVVSASKKETADVILLAT
GSEVSLAVEAQKALAVDGVDVAVVSMPSMDRFEAQTAEYKESVLPKAVTKRFAIEMGATFGWHRYVGLEGDVLGIDTFGA
SAPGEKIMEEYGFTVENVVRKVKEML

Sequences:

>Translated_666_residues
MSHSIEQLSINTIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTQFMKHNPNNPTWFNRDRFVLSAGHGSMLLYSLLHLS
GYDVTMDDLKNFRQWGSKTPGHPEYGHTAGVDATTGPLGQGIATAVGMAMAERHLAAKYNRDAYNVVDHYTYAICGDGDL
MEGVSAEASSLAAHLQLGRLVVLYDSNDISLDGDLNRSFSESVEDRYKAYGWQVIRVEDGNDIEAIAKAIEEAKADEKRP
TLIEVRTTIGFGSPNKSGKSASHGSPLGVEETKLTKEAYAWTAEQDFHVAEEVYDNFRKTVQDVGETAQAEWNTMLGEYA
QAYPELANEFQAAMNGQLPEGWEQNLPTYELGSKAATRNSSGAVINAIAESVPSFFGGSADLAGSNKTYMNNEKDFTRDD
YSGKNIWYGVREFAMGAAMNGIALHGGLKTYGGTFFVFSDYLRPAIRLAALMQLPVTYVFTHDSIAVGEDGPTHEPIEQL
AALRAMPNVSVIRPADGNESVAAWRLALESTNKPTALVLTRQDLPTLEGAKDDTYEKVAKGAYVVSASKKETADVILLAT
GSEVSLAVEAQKALAVDGVDVAVVSMPSMDRFEAQTAEYKESVLPKAVTKRFAIEMGATFGWHRYVGLEGDVLGIDTFGA
SAPGEKIMEEYGFTVENVVRKVKEML
>Mature_665_residues
SHSIEQLSINTIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTQFMKHNPNNPTWFNRDRFVLSAGHGSMLLYSLLHLSG
YDVTMDDLKNFRQWGSKTPGHPEYGHTAGVDATTGPLGQGIATAVGMAMAERHLAAKYNRDAYNVVDHYTYAICGDGDLM
EGVSAEASSLAAHLQLGRLVVLYDSNDISLDGDLNRSFSESVEDRYKAYGWQVIRVEDGNDIEAIAKAIEEAKADEKRPT
LIEVRTTIGFGSPNKSGKSASHGSPLGVEETKLTKEAYAWTAEQDFHVAEEVYDNFRKTVQDVGETAQAEWNTMLGEYAQ
AYPELANEFQAAMNGQLPEGWEQNLPTYELGSKAATRNSSGAVINAIAESVPSFFGGSADLAGSNKTYMNNEKDFTRDDY
SGKNIWYGVREFAMGAAMNGIALHGGLKTYGGTFFVFSDYLRPAIRLAALMQLPVTYVFTHDSIAVGEDGPTHEPIEQLA
ALRAMPNVSVIRPADGNESVAAWRLALESTNKPTALVLTRQDLPTLEGAKDDTYEKVAKGAYVVSASKKETADVILLATG
SEVSLAVEAQKALAVDGVDVAVVSMPSMDRFEAQTAEYKESVLPKAVTKRFAIEMGATFGWHRYVGLEGDVLGIDTFGAS
APGEKIMEEYGFTVENVVRKVKEML

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=587, Percent_Identity=26.4054514480409, Blast_Score=164, Evalue=3e-40,
Organism=Homo sapiens, GI4507521, Length=587, Percent_Identity=26.4054514480409, Blast_Score=164, Evalue=3e-40,
Organism=Homo sapiens, GI133778974, Length=589, Percent_Identity=25.9762308998302, Blast_Score=146, Evalue=7e-35,
Organism=Homo sapiens, GI225637459, Length=675, Percent_Identity=21.1851851851852, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI225637463, Length=577, Percent_Identity=22.0103986135182, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI225637461, Length=577, Percent_Identity=22.0103986135182, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI48994911, Length=661, Percent_Identity=50.9833585476551, Blast_Score=675, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=661, Percent_Identity=49.9243570347958, Blast_Score=655, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=668, Percent_Identity=24.7005988023952, Blast_Score=148, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6325331, Length=670, Percent_Identity=48.955223880597, Blast_Score=634, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319593, Length=671, Percent_Identity=47.5409836065574, Blast_Score=608, Evalue=1e-175,
Organism=Drosophila melanogaster, GI45551847, Length=669, Percent_Identity=24.2152466367713, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45550715, Length=669, Percent_Identity=24.2152466367713, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24666278, Length=578, Percent_Identity=27.1626297577855, Blast_Score=163, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24645119, Length=641, Percent_Identity=23.8689547581903, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72443; Mature: 72312

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2 ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSIEQLSINTIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTQFMKHNPNNPTWFNRD
CCCCCHHEECCEEEEEEHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
RFVLSAGHGSMLLYSLLHLSGYDVTMDDLKNFRQWGSKTPGHPEYGHTAGVDATTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
GIATAVGMAMAERHLAAKYNRDAYNVVDHYTYAICGDGDLMEGVSAEASSLAAHLQLGRL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHCEEEEEECCCHHHHCCCHHHHHHHHHHHHCCE
VVLYDSNDISLDGDLNRSFSESVEDRYKAYGWQVIRVEDGNDIEAIAKAIEEAKADEKRP
EEEECCCCEEECCCCCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHCCCCCC
TLIEVRTTIGFGSPNKSGKSASHGSPLGVEETKLTKEAYAWTAEQDFHVAEEVYDNFRKT
CEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHH
VQDVGETAQAEWNTMLGEYAQAYPELANEFQAAMNGQLPEGWEQNLPTYELGSKAATRNS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCEECCCCHHCCCC
SGAVINAIAESVPSFFGGSADLAGSNKTYMNNEKDFTRDDYSGKNIWYGVREFAMGAAMN
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
GIALHGGLKTYGGTFFVFSDYLRPAIRLAALMQLPVTYVFTHDSIAVGEDGPTHEPIEQL
CEEEECCHHHCCCEEEEHHHHHHHHHHHHHHHHCCEEEEEECCCEEECCCCCCHHHHHHH
AALRAMPNVSVIRPADGNESVAAWRLALESTNKPTALVLTRQDLPTLEGAKDDTYEKVAK
HHHHCCCCCEEEECCCCCCCCEEEEEEHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHC
GAYVVSASKKETADVILLATGSEVSLAVEAQKALAVDGVDVAVVSMPSMDRFEAQTAEYK
CEEEEECCCCCCCCEEEEEECCCEEEEEEHHHHHEECCCCEEEEECCCCHHHHHHHHHHH
ESVLPKAVTKRFAIEMGATFGWHRYVGLEGDVLGIDTFGASAPGEKIMEEYGFTVENVVR
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHH
KVKEML
HHHHHC
>Mature Secondary Structure 
SHSIEQLSINTIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTQFMKHNPNNPTWFNRD
CCCCHHEECCEEEEEEHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
RFVLSAGHGSMLLYSLLHLSGYDVTMDDLKNFRQWGSKTPGHPEYGHTAGVDATTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
GIATAVGMAMAERHLAAKYNRDAYNVVDHYTYAICGDGDLMEGVSAEASSLAAHLQLGRL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHCEEEEEECCCHHHHCCCHHHHHHHHHHHHCCE
VVLYDSNDISLDGDLNRSFSESVEDRYKAYGWQVIRVEDGNDIEAIAKAIEEAKADEKRP
EEEECCCCEEECCCCCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHCCCCCC
TLIEVRTTIGFGSPNKSGKSASHGSPLGVEETKLTKEAYAWTAEQDFHVAEEVYDNFRKT
CEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHH
VQDVGETAQAEWNTMLGEYAQAYPELANEFQAAMNGQLPEGWEQNLPTYELGSKAATRNS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCEECCCCHHCCCC
SGAVINAIAESVPSFFGGSADLAGSNKTYMNNEKDFTRDDYSGKNIWYGVREFAMGAAMN
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
GIALHGGLKTYGGTFFVFSDYLRPAIRLAALMQLPVTYVFTHDSIAVGEDGPTHEPIEQL
CEEEECCHHHCCCEEEEHHHHHHHHHHHHHHHHCCEEEEEECCCEEECCCCCCHHHHHHH
AALRAMPNVSVIRPADGNESVAAWRLALESTNKPTALVLTRQDLPTLEGAKDDTYEKVAK
HHHHCCCCCEEEECCCCCCCCEEEEEEHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHC
GAYVVSASKKETADVILLATGSEVSLAVEAQKALAVDGVDVAVVSMPSMDRFEAQTAEYK
CEEEEECCCCCCCCEEEEEECCCEEEEEEHHHHHEECCCCEEEEECCCCHHHHHHHHHHH
ESVLPKAVTKRFAIEMGATFGWHRYVGLEGDVLGIDTFGASAPGEKIMEEYGFTVENVVR
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHH
KVKEML
HHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]