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The map label for this gene is fumA [H]

Identifier: 218232931

GI number: 218232931

Start: 473746

End: 475266

Strand: Direct

Name: fumA [H]

Synonym: BCB4264_A0488

Alternate gene names: 218232931

Gene position: 473746-475266 (Clockwise)

Preceding gene: 218233713

Following gene: 218231287

Centisome position: 8.74

GC content: 39.45

Gene sequence:

>1521_bases
ATGGAAAAGCTTCAAGAAAGCATGTATCAACTAATTGTTGAAACGTCAACGAACTTACCGAAAGATGTTCGTCGTGCGAT
TCAACAAGCGAAAGAGCGAGAAAATGCAGGGACTCGTTCTGCGATGGCACTTGGCACAATTACAAATAATATTAAAATGG
CTGATGATAACATCTCGCCGATTTGCCAAGATACAGGGATGCCAACGTTTAAAATTTATACACCAGTTGGTGTGAATCAA
TTAAAGTTGAAGGAAGCTATCTATAATGCGCTTGAGCGGGCGACAAAAGATGGTAAACTTCGTCCCAATTCTGTTGATTC
TCTTTTTGGAGATAATAGTGGAAATAATTTAGGACCAGGTACACCGGTGATTAAGTTTGAACAATGGGAAAAAGATTATA
TTGATGCACGTTTAATCCTAAAAGGTGGTGGCTGTGAGAATAAAAATATTCAATATAGCTTACCGTGTGAACTAGAAGGG
CTTGGACGAGCTGGCCGTGATTTAGAAGGGATTCGTAAATGCCTTCTTCATGCAGTATATCAAGCACAAGGGCAAGGATG
TAGCGCTGGTGTAATTGGTGTTGGTATCGGGGGAGACCGCACATCAGGTTATGAATTAGCAAAAAATCAATTATTCCGTA
CATTAGATGATGTCAATCCAGTACCAGAGTTACAACATCTTGAAGAGTACGTATTAGAAAATGCGAATAAGCTTGGCATT
GGTACGATGGGATTTGGCGGAGAAACAACTTTACTTGGTTGTAAAATTGGCGTCTATAATCGTTTGCCAGCTAGTTTCTA
TGTATCTGTTGCGTATAATTGCTGGGCATATCGTCGCCTTGGTGTGAAAATCCATCCTGAAACAGGAGACATTATGGATT
GGCTATATCAAGAAGGTGAAGATACACTTCAGCATGAAGTACAAGAAAAAACAGAGCAACGTGAGATTGTATTACAAGCA
CCAATTACAGAAGAGCAAATTCGTGAACTTCGCGTTGGTGATGTTGTAACAATTAATGGCATGATGTATACAGGTCGTGA
CGCAATCCATAAGCATTTAATGGATAATGATTGTCCAGTAGATTTAAATGGACAAATTATTTACCACTGTGGTCCAGTTG
TTGTGAAAGATGAAAATGACAATTGGCAAATTAAAGCGGCTGGTCCAACGACAAGTATTCGTGAAGAACCGTACCAAGGC
GATATTATGAAGAAATTCGGTATTCGCGCTGTCATTGGAAAAGGCGGTATGGGTGCGAAAACATTAGCGGCTTTAGAAGA
ACACGGCGGTGTATATTTAAACGCAATCGGTGGTGCAGCGCAATATTATGCTGAATGTATTAAAGAAGTGAAAGATGTTG
ATTTCTTACAATTTGGTATTCCAGAAGCAATGTGGCATTTACGTATCGACGGGTTTAAAGCAGTTGTAACGATGGACTCG
CATGGTAATAGCTTACATGCAGATGTTGATAAAACATCACTTGAAAAATTAGCTAGCTTTAAAGAGCCAGTATTTAAGTA
A

Upstream 100 bases:

>100_bases
GCTCTAATAGCGTGAAACAAATAAATAGCTAAAGAGCATAACAATTGAATTTTCAGCTCATAACGTTTTGGTAGCGTTCA
CAATTGAGGGGGAAGTAACA

Downstream 100 bases:

>100_bases
ATAAAAAATGCATCTCGAATGATTCGAGATGCATTTTTTTGGTATATATAGAAAAACATGTTCAGCATGAAAGAATGCGT
AGCAACAGAAACTACAAGTA

Product: fumarate hydratase, class I

Products: NA

Alternate protein names: Fumarase [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MEKLQESMYQLIVETSTNLPKDVRRAIQQAKERENAGTRSAMALGTITNNIKMADDNISPICQDTGMPTFKIYTPVGVNQ
LKLKEAIYNALERATKDGKLRPNSVDSLFGDNSGNNLGPGTPVIKFEQWEKDYIDARLILKGGGCENKNIQYSLPCELEG
LGRAGRDLEGIRKCLLHAVYQAQGQGCSAGVIGVGIGGDRTSGYELAKNQLFRTLDDVNPVPELQHLEEYVLENANKLGI
GTMGFGGETTLLGCKIGVYNRLPASFYVSVAYNCWAYRRLGVKIHPETGDIMDWLYQEGEDTLQHEVQEKTEQREIVLQA
PITEEQIRELRVGDVVTINGMMYTGRDAIHKHLMDNDCPVDLNGQIIYHCGPVVVKDENDNWQIKAAGPTTSIREEPYQG
DIMKKFGIRAVIGKGGMGAKTLAALEEHGGVYLNAIGGAAQYYAECIKEVKDVDFLQFGIPEAMWHLRIDGFKAVVTMDS
HGNSLHADVDKTSLEKLASFKEPVFK

Sequences:

>Translated_506_residues
MEKLQESMYQLIVETSTNLPKDVRRAIQQAKERENAGTRSAMALGTITNNIKMADDNISPICQDTGMPTFKIYTPVGVNQ
LKLKEAIYNALERATKDGKLRPNSVDSLFGDNSGNNLGPGTPVIKFEQWEKDYIDARLILKGGGCENKNIQYSLPCELEG
LGRAGRDLEGIRKCLLHAVYQAQGQGCSAGVIGVGIGGDRTSGYELAKNQLFRTLDDVNPVPELQHLEEYVLENANKLGI
GTMGFGGETTLLGCKIGVYNRLPASFYVSVAYNCWAYRRLGVKIHPETGDIMDWLYQEGEDTLQHEVQEKTEQREIVLQA
PITEEQIRELRVGDVVTINGMMYTGRDAIHKHLMDNDCPVDLNGQIIYHCGPVVVKDENDNWQIKAAGPTTSIREEPYQG
DIMKKFGIRAVIGKGGMGAKTLAALEEHGGVYLNAIGGAAQYYAECIKEVKDVDFLQFGIPEAMWHLRIDGFKAVVTMDS
HGNSLHADVDKTSLEKLASFKEPVFK
>Mature_506_residues
MEKLQESMYQLIVETSTNLPKDVRRAIQQAKERENAGTRSAMALGTITNNIKMADDNISPICQDTGMPTFKIYTPVGVNQ
LKLKEAIYNALERATKDGKLRPNSVDSLFGDNSGNNLGPGTPVIKFEQWEKDYIDARLILKGGGCENKNIQYSLPCELEG
LGRAGRDLEGIRKCLLHAVYQAQGQGCSAGVIGVGIGGDRTSGYELAKNQLFRTLDDVNPVPELQHLEEYVLENANKLGI
GTMGFGGETTLLGCKIGVYNRLPASFYVSVAYNCWAYRRLGVKIHPETGDIMDWLYQEGEDTLQHEVQEKTEQREIVLQA
PITEEQIRELRVGDVVTINGMMYTGRDAIHKHLMDNDCPVDLNGQIIYHCGPVVVKDENDNWQIKAAGPTTSIREEPYQG
DIMKKFGIRAVIGKGGMGAKTLAALEEHGGVYLNAIGGAAQYYAECIKEVKDVDFLQFGIPEAMWHLRIDGFKAVVTMDS
HGNSLHADVDKTSLEKLASFKEPVFK

Specific function: Unknown

COG id: COG1951

COG function: function code C; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I fumarase family [H]

Homologues:

Organism=Escherichia coli, GI1789443, Length=183, Percent_Identity=34.9726775956284, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789442, Length=289, Percent_Identity=27.681660899654, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1787897, Length=469, Percent_Identity=25.1599147121535, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1790564, Length=468, Percent_Identity=25, Blast_Score=98, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004646
- InterPro:   IPR004647
- InterPro:   IPR011167 [H]

Pfam domain/function: PF05681 Fumerase; PF05683 Fumerase_C [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 55952; Mature: 55952

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLQESMYQLIVETSTNLPKDVRRAIQQAKERENAGTRSAMALGTITNNIKMADDNISP
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHEEEEEEECCEEECCCCCCC
ICQDTGMPTFKIYTPVGVNQLKLKEAIYNALERATKDGKLRPNSVDSLFGDNSGNNLGPG
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCC
TPVIKFEQWEKDYIDARLILKGGGCENKNIQYSLPCELEGLGRAGRDLEGIRKCLLHAVY
CCEEEECCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
QAQGQGCSAGVIGVGIGGDRTSGYELAKNQLFRTLDDVNPVPELQHLEEYVLENANKLGI
HHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCE
GTMGFGGETTLLGCKIGVYNRLPASFYVSVAYNCWAYRRLGVKIHPETGDIMDWLYQEGE
EEECCCCCCEEEEEEECCCCCCCHHEEEEEHHHHEEEEEECEEECCCCCHHHHHHHHCCH
DTLQHEVQEKTEQREIVLQAPITEEQIRELRVGDVVTINGMMYTGRDAIHKHLMDNDCPV
HHHHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCEEEECCEEECCHHHHHHHHCCCCCCC
DLNGQIIYHCGPVVVKDENDNWQIKAAGPTTSIREEPYQGDIMKKFGIRAVIGKGGMGAK
CCCCEEEEEECCEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHHCCCEEEECCCCCCHH
TLAALEEHGGVYLNAIGGAAQYYAECIKEVKDVDFLQFGIPEAMWHLRIDGFKAVVTMDS
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHCCCHHHEEEEECCEEEEEEECC
HGNSLHADVDKTSLEKLASFKEPVFK
CCCEEECCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEKLQESMYQLIVETSTNLPKDVRRAIQQAKERENAGTRSAMALGTITNNIKMADDNISP
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHEEEEEEECCEEECCCCCCC
ICQDTGMPTFKIYTPVGVNQLKLKEAIYNALERATKDGKLRPNSVDSLFGDNSGNNLGPG
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCC
TPVIKFEQWEKDYIDARLILKGGGCENKNIQYSLPCELEGLGRAGRDLEGIRKCLLHAVY
CCEEEECCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
QAQGQGCSAGVIGVGIGGDRTSGYELAKNQLFRTLDDVNPVPELQHLEEYVLENANKLGI
HHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCE
GTMGFGGETTLLGCKIGVYNRLPASFYVSVAYNCWAYRRLGVKIHPETGDIMDWLYQEGE
EEECCCCCCEEEEEEECCCCCCCHHEEEEEHHHHEEEEEECEEECCCCCHHHHHHHHCCH
DTLQHEVQEKTEQREIVLQAPITEEQIRELRVGDVVTINGMMYTGRDAIHKHLMDNDCPV
HHHHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCEEEECCEEECCHHHHHHHHCCCCCCC
DLNGQIIYHCGPVVVKDENDNWQIKAAGPTTSIREEPYQGDIMKKFGIRAVIGKGGMGAK
CCCCEEEEEECCEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHHCCCEEEECCCCCCHH
TLAALEEHGGVYLNAIGGAAQYYAECIKEVKDVDFLQFGIPEAMWHLRIDGFKAVVTMDS
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHCCCHHHEEEEECCEEEEEEECC
HGNSLHADVDKTSLEKLASFKEPVFK
CCCEEECCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8473853 [H]