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The map label for this gene is flp [H]

Identifier: 218232912

GI number: 218232912

Start: 2120533

End: 2121990

Strand: Reverse

Name: flp [H]

Synonym: BCB4264_A2218

Alternate gene names: 218232912

Gene position: 2121990-2120533 (Counterclockwise)

Preceding gene: 218235560

Following gene: 218234526

Centisome position: 39.16

GC content: 35.87

Gene sequence:

>1458_bases
ATGTCTAAAATTGAAACGCCTGTTATGACTTCTTTACAAACAACGGTTGAAAAAATGATGAAGGATTTAAATGTTCCTGG
TGCTGCTGTCGCTGTTATAAAAGACGGTGAAGTTATTATTTCAGAAGGTTTTGGCTATCGTAATATAGAAACAAAAGAGG
CTGTTACACCGAATACTCGATTCGCAATCGGTTCCTCAACGAAAGCATTTGGCACACTTTCATTAAGCTTGTTAGCACAG
CAAAAAAAGTTTAATTGGGATACCCCTATCCAGTCTTATATACCTAACTTTACTTTATCTGAACTACTTGCTAGCTCACA
AGTTACAGGACGGGATTTAGCTTCTCATCGAACTGGAGTGAGTCGTCATGAGGCTCTTTGGTACAGTTCTTCCTTATCTC
GAAAAGATCTCGTTGAAAAAATAAAACATTTACCACTTGATGCACCGTTCCGGACTGCATTTCTATATAACAACTTAATG
TATGCAACAATTAGCTACATTGTTGAAAACATTACAAATCAAACGTGGGAGCAATACACTACAGAACATATTTTAGAACC
TTTAAATATGAGACATACAAACTTCTCTGTTAACGATTCACAAACTACAGATGATTATGCTTTACCTTACATTGAAAATG
ACGGTGAAATAAAAGCAGTTCCATTCCGTAACATCGATACAGTTGGCGCTGCTGGGTGTATTAATTCCACAATTGAAGAT
ATGGCAAATTGGGTACTTCTCCACTTAAATGAAGGAAAATTTGGAGATCATGAATTAATCTCCTCTGAATTATTACAACA
AATGTATACACCACACAATTCAATTCCAGACCAACCGGTTTTATCACTCCCTGAATCTCCATTAAATAGTTACGGTCTTG
GTTGGTTTATTAGCGCTTATCGTGGTAAAAAAGTGATTCATCATGGCGGTAATATCGATGGATTTTCAGCGCTTGTTTCA
TTCATACCAACAGAAAACATAGGCCTTGTCATTTTAACGAATGCTGGAGGAACATTACTTCCTACTTATCTCGCTAATCA
AATTTATGACGAACTACTTGAATTAGAATCCATTGATTGGCATAAACGTGCTGTAGAAGATACTAAAAAAATGAAGGAAA
TGATGAAAGAAGCAACTGAATCCCTCCCTGAACAAATTAAAGGGACTACACCTTCGCACAAGTTAGAGGATTATACTGGT
ACTTTTGAACATCCTGCATACGGAACATTACAAGTATACAAACGAGATGATTCGTTATATGTACAATTTATGGAAATGGA
TATTCAATTAGGGCATCATCATTACGACATCTTCTCCGCAAAAGTTGACTTATTCCAAATGAAAATGAGCTTATTATTCG
CTTATGAAATGAATGTAAGTGGTGAATTCCCATCCCTTCAGTTACATGTACCAACTACATTAAGTACTCAGCCGCTTACA
TTTAAGAAAATTAAATAA

Upstream 100 bases:

>100_bases
CTTACAAAATTATTAACTTTCCGAATATAAAAAGGTTTTCATTTTCTATTACCGAAAGTATAGTGCGGTAGAACAAAATT
TATATTTGGAGGTTAGAAGT

Downstream 100 bases:

>100_bases
GTATCTTGATGGTAAAAAATAAAGGTAGGTGCGAATCACACCTACCTTTTCTATTTCATATCAATCTTATCTGGTTGAAA
CCAAATTGGCTTCGATAACT

Product: hypothetical protein

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSKIETPVMTSLQTTVEKMMKDLNVPGAAVAVIKDGEVIISEGFGYRNIETKEAVTPNTRFAIGSSTKAFGTLSLSLLAQ
QKKFNWDTPIQSYIPNFTLSELLASSQVTGRDLASHRTGVSRHEALWYSSSLSRKDLVEKIKHLPLDAPFRTAFLYNNLM
YATISYIVENITNQTWEQYTTEHILEPLNMRHTNFSVNDSQTTDDYALPYIENDGEIKAVPFRNIDTVGAAGCINSTIED
MANWVLLHLNEGKFGDHELISSELLQQMYTPHNSIPDQPVLSLPESPLNSYGLGWFISAYRGKKVIHHGGNIDGFSALVS
FIPTENIGLVILTNAGGTLLPTYLANQIYDELLELESIDWHKRAVEDTKKMKEMMKEATESLPEQIKGTTPSHKLEDYTG
TFEHPAYGTLQVYKRDDSLYVQFMEMDIQLGHHHYDIFSAKVDLFQMKMSLLFAYEMNVSGEFPSLQLHVPTTLSTQPLT
FKKIK

Sequences:

>Translated_485_residues
MSKIETPVMTSLQTTVEKMMKDLNVPGAAVAVIKDGEVIISEGFGYRNIETKEAVTPNTRFAIGSSTKAFGTLSLSLLAQ
QKKFNWDTPIQSYIPNFTLSELLASSQVTGRDLASHRTGVSRHEALWYSSSLSRKDLVEKIKHLPLDAPFRTAFLYNNLM
YATISYIVENITNQTWEQYTTEHILEPLNMRHTNFSVNDSQTTDDYALPYIENDGEIKAVPFRNIDTVGAAGCINSTIED
MANWVLLHLNEGKFGDHELISSELLQQMYTPHNSIPDQPVLSLPESPLNSYGLGWFISAYRGKKVIHHGGNIDGFSALVS
FIPTENIGLVILTNAGGTLLPTYLANQIYDELLELESIDWHKRAVEDTKKMKEMMKEATESLPEQIKGTTPSHKLEDYTG
TFEHPAYGTLQVYKRDDSLYVQFMEMDIQLGHHHYDIFSAKVDLFQMKMSLLFAYEMNVSGEFPSLQLHVPTTLSTQPLT
FKKIK
>Mature_484_residues
SKIETPVMTSLQTTVEKMMKDLNVPGAAVAVIKDGEVIISEGFGYRNIETKEAVTPNTRFAIGSSTKAFGTLSLSLLAQQ
KKFNWDTPIQSYIPNFTLSELLASSQVTGRDLASHRTGVSRHEALWYSSSLSRKDLVEKIKHLPLDAPFRTAFLYNNLMY
ATISYIVENITNQTWEQYTTEHILEPLNMRHTNFSVNDSQTTDDYALPYIENDGEIKAVPFRNIDTVGAAGCINSTIEDM
ANWVLLHLNEGKFGDHELISSELLQQMYTPHNSIPDQPVLSLPESPLNSYGLGWFISAYRGKKVIHHGGNIDGFSALVSF
IPTENIGLVILTNAGGTLLPTYLANQIYDELLELESIDWHKRAVEDTKKMKEMMKEATESLPEQIKGTTPSHKLEDYTGT
FEHPAYGTLQVYKRDDSLYVQFMEMDIQLGHHHYDIFSAKVDLFQMKMSLLFAYEMNVSGEFPSLQLHVPTTLSTQPLTF
KKIK

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI239747261, Length=381, Percent_Identity=24.6719160104987, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI239752721, Length=381, Percent_Identity=24.6719160104987, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI239741085, Length=381, Percent_Identity=24.6719160104987, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790593, Length=342, Percent_Identity=26.6081871345029, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87082101, Length=314, Percent_Identity=22.9299363057325, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17550934, Length=332, Percent_Identity=24.0963855421687, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 54669; Mature: 54538

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIETPVMTSLQTTVEKMMKDLNVPGAAVAVIKDGEVIISEGFGYRNIETKEAVTPNTR
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCE
FAIGSSTKAFGTLSLSLLAQQKKFNWDTPIQSYIPNFTLSELLASSQVTGRDLASHRTGV
EEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCC
SRHEALWYSSSLSRKDLVEKIKHLPLDAPFRTAFLYNNLMYATISYIVENITNQTWEQYT
CHHHHHEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEHILEPLNMRHTNFSVNDSQTTDDYALPYIENDGEIKAVPFRNIDTVGAAGCINSTIED
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEECCCCCCCCCCHHHHHHHHHH
MANWVLLHLNEGKFGDHELISSELLQQMYTPHNSIPDQPVLSLPESPLNSYGLGWFISAY
HHCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHH
RGKKVIHHGGNIDGFSALVSFIPTENIGLVILTNAGGTLLPTYLANQIYDELLELESIDW
CCCEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCH
HKRAVEDTKKMKEMMKEATESLPEQIKGTTPSHKLEDYTGTFEHPAYGTLQVYKRDDSLY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEE
VQFMEMDIQLGHHHYDIFSAKVDLFQMKMSLLFAYEMNVSGEFPSLQLHVPTTLSTQPLT
EEEEEHHHHHCCEEEEHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEECCCCCCCCCCE
FKKIK
EECCC
>Mature Secondary Structure 
SKIETPVMTSLQTTVEKMMKDLNVPGAAVAVIKDGEVIISEGFGYRNIETKEAVTPNTR
CCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCE
FAIGSSTKAFGTLSLSLLAQQKKFNWDTPIQSYIPNFTLSELLASSQVTGRDLASHRTGV
EEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCC
SRHEALWYSSSLSRKDLVEKIKHLPLDAPFRTAFLYNNLMYATISYIVENITNQTWEQYT
CHHHHHEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEHILEPLNMRHTNFSVNDSQTTDDYALPYIENDGEIKAVPFRNIDTVGAAGCINSTIED
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEECCCCCCCCCCHHHHHHHHHH
MANWVLLHLNEGKFGDHELISSELLQQMYTPHNSIPDQPVLSLPESPLNSYGLGWFISAY
HHCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHH
RGKKVIHHGGNIDGFSALVSFIPTENIGLVILTNAGGTLLPTYLANQIYDELLELESIDW
CCCEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCH
HKRAVEDTKKMKEMMKEATESLPEQIKGTTPSHKLEDYTGTFEHPAYGTLQVYKRDDSLY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEE
VQFMEMDIQLGHHHYDIFSAKVDLFQMKMSLLFAYEMNVSGEFPSLQLHVPTTLSTQPLT
EEEEEHHHHHCCEEEEHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEECCCCCCCCCCE
FKKIK
EECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA