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The map label for this gene is gabT [H]

Identifier: 218232749

GI number: 218232749

Start: 345541

End: 346980

Strand: Direct

Name: gabT [H]

Synonym: BCB4264_A0371

Alternate gene names: 218232749

Gene position: 345541-346980 (Clockwise)

Preceding gene: 218232601

Following gene: 218232734

Centisome position: 6.38

GC content: 39.24

Gene sequence:

>1440_bases
ATGCTAGAAAAGAAAGTTGGCATATATTTTGCAATAAAAAGAGAAAACAATGTAAAGAAAAGGATGGGGTACGCAATGAA
CACAAAAAAATTTGCTAAAGTAAATGAACAAATTCCAGGACCGAAAGCGGCATCTTTATTAGAACGCCGTCAAAATATAG
TACCAAAAGGAGTAAGTAACGGCATCCCAACGTTTGTACAATCTGCCAATGGTGCTCTTGTAACAGATGTTGATGGCAAT
CAGTACATTGATTTTGCAGGAGCAATCGGGACAATTAACGTAGGGCATTGTCATCCAAAGGTTAAAGAAGCGCTCCATAA
ACAAGTCGATCAATACATTCATACTGGATTTAACGTCATGATGTATGAGCCATATATTGAATTAGCAGAAAAGCTTGCGG
CATTGGCACCAGGAAGTTTCGATAAGCAAGTCCTGTTTTTAAATAGTGGTGCAGAAGCAGTTGAGAACGCGGTGAAAATC
GCTCGTAAATATACGAAGAGACCTGGTATTATCGCATTTTCTAAAGGTTTCCACGGGCGTACATTAATGACAATGACGAT
GACAAGTAAAGTGAAGCCATATAAATTTGGGTTTGGTCCCTTTGCTCCAGAAGTATATAAAGCGCCATTTCCATACGAAT
ACCGTCGCCCAGAGGGATTAACGGAAGAGCAGTATGATGATTTTATTATTGAAGAGTTTAAGAACTTCTTCATATCGGAA
GTAGCACCAGAAACAATTGCAGCTGTTGTAATGGAACCTGTTCAAGGGGAAGGTGGATTTATCGTCCCAAGTAAGAAATT
TGTTCAAGAAGTACGCCGCATTTGTTCAGAGAACGGCATCTTATTTGTAGCGGATGAAATACAAACAGGCTTTAGTCGTA
CAGGAAAATATTTTGCAATTGATCACTATGATGTCGTTCCAGATTTAATTACAGTGTCTAAATCATTAGGTGCTGGTGTA
CCGATAAGTGGTGTCATTGGACGTAAAGAAATTATGAATGAGTCTGCACCAGGTGAACTTGGTGGAACGTATGCAGGAAG
TCCATTAGGATGTGCGGCTGCATTAGCTGTTCTCGATGTAATAGAAAATGAGAAATTAAATGATAGAGCGATAGAATTAG
GAAAAGTCGTAATGAACCGATTCGAAGAGATGAAAAATAAATATCATTGCATCGGTGATGTGCGTGGGTTAGGCGCAATG
TGTGCATTTGAGGTCGTTCAAGATCGTAAGACGAAAGCACCTGACAAAACGTTAACGGCTAATCTATGTGCAGAAGCAAA
TAAGCGTGGGTTACTGTTATTATCAGCAGGGACATATGGAAATGTTATCCGTGTGTTAATGCCTTTAGTTATTACAGATG
AGCAACTTGAAGAAGGTTTAACAATAATTGAAGAATCGTTGCAAGCTTGCTATGAGCAAACAAACATCGCTCGCGTTTAA

Upstream 100 bases:

>100_bases
AAAGAAAAGTCTAATGTGTAAGGAAAATAAGTCTATAAAGACTCTTAATGAGTCTTTATAGACTTATTTTTTATGCCTGG
ATACAAAGAATATAGGATAA

Downstream 100 bases:

>100_bases
AAACTGAAGTATAAATAGCAAACATTCTAGCTGACTCTATGTTAAATGCAGAAAATTCACTTTATAATAAAGGTAGTGAA
GTGGATCGATGGATTTGAAG

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MLEKKVGIYFAIKRENNVKKRMGYAMNTKKFAKVNEQIPGPKAASLLERRQNIVPKGVSNGIPTFVQSANGALVTDVDGN
QYIDFAGAIGTINVGHCHPKVKEALHKQVDQYIHTGFNVMMYEPYIELAEKLAALAPGSFDKQVLFLNSGAEAVENAVKI
ARKYTKRPGIIAFSKGFHGRTLMTMTMTSKVKPYKFGFGPFAPEVYKAPFPYEYRRPEGLTEEQYDDFIIEEFKNFFISE
VAPETIAAVVMEPVQGEGGFIVPSKKFVQEVRRICSENGILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGV
PISGVIGRKEIMNESAPGELGGTYAGSPLGCAAALAVLDVIENEKLNDRAIELGKVVMNRFEEMKNKYHCIGDVRGLGAM
CAFEVVQDRKTKAPDKTLTANLCAEANKRGLLLLSAGTYGNVIRVLMPLVITDEQLEEGLTIIEESLQACYEQTNIARV

Sequences:

>Translated_479_residues
MLEKKVGIYFAIKRENNVKKRMGYAMNTKKFAKVNEQIPGPKAASLLERRQNIVPKGVSNGIPTFVQSANGALVTDVDGN
QYIDFAGAIGTINVGHCHPKVKEALHKQVDQYIHTGFNVMMYEPYIELAEKLAALAPGSFDKQVLFLNSGAEAVENAVKI
ARKYTKRPGIIAFSKGFHGRTLMTMTMTSKVKPYKFGFGPFAPEVYKAPFPYEYRRPEGLTEEQYDDFIIEEFKNFFISE
VAPETIAAVVMEPVQGEGGFIVPSKKFVQEVRRICSENGILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGV
PISGVIGRKEIMNESAPGELGGTYAGSPLGCAAALAVLDVIENEKLNDRAIELGKVVMNRFEEMKNKYHCIGDVRGLGAM
CAFEVVQDRKTKAPDKTLTANLCAEANKRGLLLLSAGTYGNVIRVLMPLVITDEQLEEGLTIIEESLQACYEQTNIARV
>Mature_479_residues
MLEKKVGIYFAIKRENNVKKRMGYAMNTKKFAKVNEQIPGPKAASLLERRQNIVPKGVSNGIPTFVQSANGALVTDVDGN
QYIDFAGAIGTINVGHCHPKVKEALHKQVDQYIHTGFNVMMYEPYIELAEKLAALAPGSFDKQVLFLNSGAEAVENAVKI
ARKYTKRPGIIAFSKGFHGRTLMTMTMTSKVKPYKFGFGPFAPEVYKAPFPYEYRRPEGLTEEQYDDFIIEEFKNFFISE
VAPETIAAVVMEPVQGEGGFIVPSKKFVQEVRRICSENGILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGV
PISGVIGRKEIMNESAPGELGGTYAGSPLGCAAALAVLDVIENEKLNDRAIELGKVVMNRFEEMKNKYHCIGDVRGLGAM
CAFEVVQDRKTKAPDKTLTANLCAEANKRGLLLLSAGTYGNVIRVLMPLVITDEQLEEGLTIIEESLQACYEQTNIARV

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=419, Percent_Identity=35.0835322195704, Blast_Score=225, Evalue=9e-59,
Organism=Homo sapiens, GI13994255, Length=425, Percent_Identity=32.4705882352941, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI37574042, Length=429, Percent_Identity=31.4685314685315, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI226442709, Length=398, Percent_Identity=31.9095477386935, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI24119277, Length=422, Percent_Identity=30.5687203791469, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI284507298, Length=330, Percent_Identity=35.4545454545455, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI226442705, Length=429, Percent_Identity=30.7692307692308, Blast_Score=182, Evalue=9e-46,
Organism=Homo sapiens, GI188536080, Length=467, Percent_Identity=25.2676659528908, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI38679950, Length=467, Percent_Identity=25.2676659528908, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI38679946, Length=467, Percent_Identity=25.2676659528908, Blast_Score=142, Evalue=6e-34,
Organism=Escherichia coli, GI1789016, Length=429, Percent_Identity=46.6200466200466, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1787560, Length=420, Percent_Identity=48.5714285714286, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1789759, Length=397, Percent_Identity=34.2569269521411, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1788044, Length=396, Percent_Identity=33.8383838383838, Blast_Score=222, Evalue=5e-59,
Organism=Escherichia coli, GI145693181, Length=422, Percent_Identity=33.175355450237, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI1786991, Length=424, Percent_Identity=27.5943396226415, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1786349, Length=359, Percent_Identity=30.6406685236769, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71992977, Length=448, Percent_Identity=31.25, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI32564660, Length=412, Percent_Identity=32.2815533980583, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI25144271, Length=415, Percent_Identity=30.8433734939759, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI25144274, Length=298, Percent_Identity=29.8657718120805, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17541228, Length=469, Percent_Identity=23.6673773987207, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71981843, Length=161, Percent_Identity=31.6770186335404, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323470, Length=423, Percent_Identity=33.3333333333333, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6324432, Length=414, Percent_Identity=32.1256038647343, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6321456, Length=403, Percent_Identity=25.3101736972705, Blast_Score=103, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6324386, Length=338, Percent_Identity=26.6272189349112, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI161085790, Length=447, Percent_Identity=32.2147651006711, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI28574759, Length=431, Percent_Identity=32.7146171693735, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI21357415, Length=417, Percent_Identity=33.0935251798561, Blast_Score=218, Evalue=9e-57,
Organism=Drosophila melanogaster, GI21356575, Length=424, Percent_Identity=31.6037735849057, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI281366494, Length=452, Percent_Identity=27.212389380531, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24667139, Length=452, Percent_Identity=27.212389380531, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24667143, Length=452, Percent_Identity=27.212389380531, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 52766; Mature: 52766

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKKVGIYFAIKRENNVKKRMGYAMNTKKFAKVNEQIPGPKAASLLERRQNIVPKGVSN
CCCCCEEEEEEEECCCCHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
GIPTFVQSANGALVTDVDGNQYIDFAGAIGTINVGHCHPKVKEALHKQVDQYIHTGFNVM
CCCHHHHCCCCCEEEECCCCCEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCEEE
MYEPYIELAEKLAALAPGSFDKQVLFLNSGAEAVENAVKIARKYTKRPGIIAFSKGFHGR
EECHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
TLMTMTMTSKVKPYKFGFGPFAPEVYKAPFPYEYRRPEGLTEEQYDDFIIEEFKNFFISE
EEEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VAPETIAAVVMEPVQGEGGFIVPSKKFVQEVRRICSENGILFVADEIQTGFSRTGKYFAI
HCHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCEEEE
DHYDVVPDLITVSKSLGAGVPISGVIGRKEIMNESAPGELGGTYAGSPLGCAAALAVLDV
ECHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IENEKLNDRAIELGKVVMNRFEEMKNKYHCIGDVRGLGAMCAFEVVQDRKTKAPDKTLTA
HHCCCCCHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
NLCAEANKRGLLLLSAGTYGNVIRVLMPLVITDEQLEEGLTIIEESLQACYEQTNIARV
HHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLEKKVGIYFAIKRENNVKKRMGYAMNTKKFAKVNEQIPGPKAASLLERRQNIVPKGVSN
CCCCCEEEEEEEECCCCHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
GIPTFVQSANGALVTDVDGNQYIDFAGAIGTINVGHCHPKVKEALHKQVDQYIHTGFNVM
CCCHHHHCCCCCEEEECCCCCEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCEEE
MYEPYIELAEKLAALAPGSFDKQVLFLNSGAEAVENAVKIARKYTKRPGIIAFSKGFHGR
EECHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
TLMTMTMTSKVKPYKFGFGPFAPEVYKAPFPYEYRRPEGLTEEQYDDFIIEEFKNFFISE
EEEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VAPETIAAVVMEPVQGEGGFIVPSKKFVQEVRRICSENGILFVADEIQTGFSRTGKYFAI
HCHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCEEEE
DHYDVVPDLITVSKSLGAGVPISGVIGRKEIMNESAPGELGGTYAGSPLGCAAALAVLDV
ECHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IENEKLNDRAIELGKVVMNRFEEMKNKYHCIGDVRGLGAMCAFEVVQDRKTKAPDKTLTA
HHCCCCCHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
NLCAEANKRGLLLLSAGTYGNVIRVLMPLVITDEQLEEGLTIIEESLQACYEQTNIARV
HHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]