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The map label for this gene is ksgA [H]

Identifier: 218232555

GI number: 218232555

Start: 45191

End: 46069

Strand: Direct

Name: ksgA [H]

Synonym: BCB4264_A0046

Alternate gene names: 218232555

Gene position: 45191-46069 (Clockwise)

Preceding gene: 218232086

Following gene: 218233695

Centisome position: 0.83

GC content: 34.81

Gene sequence:

>879_bases
ATGAAGGATATCGCAACGCCAAATCGTACAAAAGACATTGTTGAAAAGTATGGATTTTCATTCAAAAAAAGTTTAGGACA
AAACTTTTTAATTGATACAAATGTATTAAATCGTATTGTCGATCATGCAGAAATTGGTTCAGAAAGTGGTGCAATTGAAA
TTGGACCAGGTATTGGTGCATTAACAGAGCAATTAGCAAAGCGTGCTAAAAAAGTAGTGGCTTTTGAAATTGATCAAAGA
CTATTACCAATTTTAGATGAGACGTTAGCGCCATATGGTAACGTTACAGTTATTAATAAAGACGTACTAAAAGCAGATGT
ACATGAAGTATTTAATGAGCAATTTGAAGAAGGGCAAGATGTAATGGTAGTAGCTAACTTACCATACTATATTACAACGC
CAATTTTATTTAAATTGCTTGAAGAAAAGTTACCAGTTCGTGGATTTGTTGTTATGATGCAAAAAGAAGTTGGAGATCGT
TTAGCTGCTAAACCTGGAACGAAAGAGTATGGTTCTTTATCGATTGCCATTCAGTATTATACAGAGGTTGAAACAGTTAT
GACTGTACCGCGTACAGTGTTTGTACCACAGCCAAACGTTGATTCTGCAATTATCCGCCTTCTAAAGCGTCCTAAACCGG
TTGTAGAGGTGACAGATGAAACGTTCTTCTTTGAAGTAGTACGAGCAAGTTTCGCACAGCGCCGTAAAACTTTAATGAAT
AATTTATCAAATAATTTAAATGGTTTCCCGAAAGATAAGGAGTTATTGGATCGAATTTTAACAGAAGTAGGAATTGATCC
AAAGCGAAGAGGCGAAACGCTATCTATTGAAGAGTTTGCAACATTAAGTAATGCATTAGTTCTTCATAAATTATCATAA

Upstream 100 bases:

>100_bases
ATACAAATGCAAAACAGTTACATAAACGATTACAGATGTTTCAAGTTTCAAAGGAATCATTTGCAGAAGCTTATAAGCAA
GTAATACAGGAGGAAAAAAA

Downstream 100 bases:

>100_bases
GAATATGAAAGGGACAGTTCAACTTGAACTGTCCCTTTTGTCACCTTTCTCTCTCTAAATTCATACTTTAAAAACAGGTA
AGATGGCCTAATGAGTTTGG

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MKDIATPNRTKDIVEKYGFSFKKSLGQNFLIDTNVLNRIVDHAEIGSESGAIEIGPGIGALTEQLAKRAKKVVAFEIDQR
LLPILDETLAPYGNVTVINKDVLKADVHEVFNEQFEEGQDVMVVANLPYYITTPILFKLLEEKLPVRGFVVMMQKEVGDR
LAAKPGTKEYGSLSIAIQYYTEVETVMTVPRTVFVPQPNVDSAIIRLLKRPKPVVEVTDETFFFEVVRASFAQRRKTLMN
NLSNNLNGFPKDKELLDRILTEVGIDPKRRGETLSIEEFATLSNALVLHKLS

Sequences:

>Translated_292_residues
MKDIATPNRTKDIVEKYGFSFKKSLGQNFLIDTNVLNRIVDHAEIGSESGAIEIGPGIGALTEQLAKRAKKVVAFEIDQR
LLPILDETLAPYGNVTVINKDVLKADVHEVFNEQFEEGQDVMVVANLPYYITTPILFKLLEEKLPVRGFVVMMQKEVGDR
LAAKPGTKEYGSLSIAIQYYTEVETVMTVPRTVFVPQPNVDSAIIRLLKRPKPVVEVTDETFFFEVVRASFAQRRKTLMN
NLSNNLNGFPKDKELLDRILTEVGIDPKRRGETLSIEEFATLSNALVLHKLS
>Mature_292_residues
MKDIATPNRTKDIVEKYGFSFKKSLGQNFLIDTNVLNRIVDHAEIGSESGAIEIGPGIGALTEQLAKRAKKVVAFEIDQR
LLPILDETLAPYGNVTVINKDVLKADVHEVFNEQFEEGQDVMVVANLPYYITTPILFKLLEEKLPVRGFVVMMQKEVGDR
LAAKPGTKEYGSLSIAIQYYTEVETVMTVPRTVFVPQPNVDSAIIRLLKRPKPVVEVTDETFFFEVVRASFAQRRKTLMN
NLSNNLNGFPKDKELLDRILTEVGIDPKRRGETLSIEEFATLSNALVLHKLS

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=289, Percent_Identity=32.1799307958478, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI156415992, Length=294, Percent_Identity=30.2721088435374, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1786236, Length=271, Percent_Identity=34.6863468634686, Blast_Score=154, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI25146882, Length=286, Percent_Identity=33.5664335664336, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI25141369, Length=295, Percent_Identity=28.8135593220339, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6324989, Length=281, Percent_Identity=29.5373665480427, Blast_Score=115, Evalue=6e-27,
Organism=Drosophila melanogaster, GI21358017, Length=235, Percent_Identity=35.3191489361702, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI21357273, Length=299, Percent_Identity=28.0936454849498, Blast_Score=100, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 32795; Mature: 32795

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDIATPNRTKDIVEKYGFSFKKSLGQNFLIDTNVLNRIVDHAEIGSESGAIEIGPGIGA
CCCCCCCCHHHHHHHHHCCHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCEEECCCCHH
LTEQLAKRAKKVVAFEIDQRLLPILDETLAPYGNVTVINKDVLKADVHEVFNEQFEEGQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCC
VMVVANLPYYITTPILFKLLEEKLPVRGFVVMMQKEVGDRLAAKPGTKEYGSLSIAIQYY
EEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEH
TEVETVMTVPRTVFVPQPNVDSAIIRLLKRPKPVVEVTDETFFFEVVRASFAQRRKTLMN
HHHHHHHHCCCEEECCCCCCCHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
NLSNNLNGFPKDKELLDRILTEVGIDPKRRGETLSIEEFATLSNALVLHKLS
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHCCCEECHHHHHHHHHHHEEEECC
>Mature Secondary Structure
MKDIATPNRTKDIVEKYGFSFKKSLGQNFLIDTNVLNRIVDHAEIGSESGAIEIGPGIGA
CCCCCCCCHHHHHHHHHCCHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCEEECCCCHH
LTEQLAKRAKKVVAFEIDQRLLPILDETLAPYGNVTVINKDVLKADVHEVFNEQFEEGQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCC
VMVVANLPYYITTPILFKLLEEKLPVRGFVVMMQKEVGDRLAAKPGTKEYGSLSIAIQYY
EEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEH
TEVETVMTVPRTVFVPQPNVDSAIIRLLKRPKPVVEVTDETFFFEVVRASFAQRRKTLMN
HHHHHHHHCCCEEECCCCCCCHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
NLSNNLNGFPKDKELLDRILTEVGIDPKRRGETLSIEEFATLSNALVLHKLS
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHCCCEECHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA