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The map label for this gene is mtnA [H]

Identifier: 218232552

GI number: 218232552

Start: 371520

End: 372566

Strand: Direct

Name: mtnA [H]

Synonym: BCB4264_A0394

Alternate gene names: 218232552

Gene position: 371520-372566 (Clockwise)

Preceding gene: 218234521

Following gene: 218235880

Centisome position: 6.86

GC content: 37.73

Gene sequence:

>1047_bases
ATGATGGAAGAGCAATTAATACCAATTCAGTGGAAAGATGATTCTTTAGTTTTATTAGATCAAACGTTATTACCGAATGA
AATTGTTTATGAATCTTTTAAAACAGCTGAAAGTGTGTGGGATGCCATTCAAGTAATGAAAGTACGAGGTGCACCAGCGA
TTGGTGTTTCAGCAGCTTATGGAGTGTATTTAGGGATAAAGGAATTTGCTGAAAGTACGGAAGAAGGATTTATGGATGAA
GTAAGAAAGGTATGTACATACTTGGCGACATCAAGACCGACTGCCGTAAATTTATTTTGGGCACTTGAAAGAATGGAAAG
TGTAGCGACAGATAATATTCATTTATCAATCTCACAGCTGAAAAATAGATTACTAGAAGAGGCAAAAGAGATTCATAGAG
AAGATGAAGAAATTAACCGTCAAATTGGAGAACATGCATTAACATTATTCCATGATGGAATGGGAGTATTAACACATTGT
AATGCTGGTGCGTTAGCGACGACTAAGTATGGTACTGCGACGGCTCCAATGTACTTAGCGAAAGAAAAAGGATGGGACTT
AAAAATCTTTTCGGATGAAACACGTCCAAGATTACAAGGGTCAACGTTAACGGCATTAGAACTACAGCGAGCGGGAATTG
ATGTTACTGTCATTACGGATAATATGGCGGCTATGGTCATGTCACAAGGGAAGATTGACGCTGTAATTGTTGGATGCGAC
CGTGTGGCAGCGAACGGTGATATAGCAAATAAAATTGGAACATTAGGCGTATCTATTTTAGCGAAATACTACAACATTCC
GTTTTATGTAGCGGCACCAACGCCGACAATTGATTTAAAGACATCGACAGGAAAAGAAATTCCGATTGAAGAAAGAGATG
CTTCTGAAGTGATTAATCGTTTCGGACAATATTCAGCTCCGACAGAAAGTAAAGTATATAATCCAGCATTTGATGTTACT
CCACATGAAAATGTAACAGCGATTATTACAGAAAAAGGGATTGTAAAGGCACCGTTTACGGAGAATTTAAAAAAGCTATT
TCAATAA

Upstream 100 bases:

>100_bases
GAAGAGTTTTATTTTACGAGCGAATCAATATAGAACGGGTACAAGTTTTGTAGAAACGTTAAAAGAACAGTCAATGCACT
ACGCGGAGTAAGGGGAGAAT

Downstream 100 bases:

>100_bases
GTAGATAAATGTAAAAGTCAGTCATCATAAGCTTCATACTTAGGGGGATGTATATGTTATTACAAAAAGAAAGAGAAGAA
ATTGTAGCGTATGGAAAGAA

Product: methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi 1; MTR-1-P isomerase 1; S-methyl-5-thioribose-1-phosphate isomerase 1 [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MMEEQLIPIQWKDDSLVLLDQTLLPNEIVYESFKTAESVWDAIQVMKVRGAPAIGVSAAYGVYLGIKEFAESTEEGFMDE
VRKVCTYLATSRPTAVNLFWALERMESVATDNIHLSISQLKNRLLEEAKEIHREDEEINRQIGEHALTLFHDGMGVLTHC
NAGALATTKYGTATAPMYLAKEKGWDLKIFSDETRPRLQGSTLTALELQRAGIDVTVITDNMAAMVMSQGKIDAVIVGCD
RVAANGDIANKIGTLGVSILAKYYNIPFYVAAPTPTIDLKTSTGKEIPIEERDASEVINRFGQYSAPTESKVYNPAFDVT
PHENVTAIITEKGIVKAPFTENLKKLFQ

Sequences:

>Translated_348_residues
MMEEQLIPIQWKDDSLVLLDQTLLPNEIVYESFKTAESVWDAIQVMKVRGAPAIGVSAAYGVYLGIKEFAESTEEGFMDE
VRKVCTYLATSRPTAVNLFWALERMESVATDNIHLSISQLKNRLLEEAKEIHREDEEINRQIGEHALTLFHDGMGVLTHC
NAGALATTKYGTATAPMYLAKEKGWDLKIFSDETRPRLQGSTLTALELQRAGIDVTVITDNMAAMVMSQGKIDAVIVGCD
RVAANGDIANKIGTLGVSILAKYYNIPFYVAAPTPTIDLKTSTGKEIPIEERDASEVINRFGQYSAPTESKVYNPAFDVT
PHENVTAIITEKGIVKAPFTENLKKLFQ
>Mature_348_residues
MMEEQLIPIQWKDDSLVLLDQTLLPNEIVYESFKTAESVWDAIQVMKVRGAPAIGVSAAYGVYLGIKEFAESTEEGFMDE
VRKVCTYLATSRPTAVNLFWALERMESVATDNIHLSISQLKNRLLEEAKEIHREDEEINRQIGEHALTLFHDGMGVLTHC
NAGALATTKYGTATAPMYLAKEKGWDLKIFSDETRPRLQGSTLTALELQRAGIDVTVITDNMAAMVMSQGKIDAVIVGCD
RVAANGDIANKIGTLGVSILAKYYNIPFYVAAPTPTIDLKTSTGKEIPIEERDASEVINRFGQYSAPTESKVYNPAFDVT
PHENVTAIITEKGIVKAPFTENLKKLFQ

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=338, Percent_Identity=41.1242603550296, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI23943880, Length=328, Percent_Identity=38.109756097561, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17557462, Length=336, Percent_Identity=34.5238095238095, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17557123, Length=267, Percent_Identity=27.3408239700375, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325375, Length=399, Percent_Identity=35.5889724310777, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6322878, Length=264, Percent_Identity=26.1363636363636, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21357667, Length=361, Percent_Identity=36.2880886426593, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24651647, Length=361, Percent_Identity=36.2880886426593, Blast_Score=219, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 38467; Mature: 38467

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEEQLIPIQWKDDSLVLLDQTLLPNEIVYESFKTAESVWDAIQVMKVRGAPAIGVSAAY
CCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
GVYLGIKEFAESTEEGFMDEVRKVCTYLATSRPTAVNLFWALERMESVATDNIHLSISQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHH
KNRLLEEAKEIHREDEEINRQIGEHALTLFHDGMGVLTHCNAGALATTKYGTATAPMYLA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCCCEEEE
KEKGWDLKIFSDETRPRLQGSTLTALELQRAGIDVTVITDNMAAMVMSQGKIDAVIVGCD
CCCCCEEEEECCCCCCCCCCCEEEEEEHHHCCCEEEEEECCHHHHHHCCCCEEEEEEECC
RVAANGDIANKIGTLGVSILAKYYNIPFYVAAPTPTIDLKTSTGKEIPIEERDASEVINR
EEECCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHH
FGQYSAPTESKVYNPAFDVTPHENVTAIITEKGIVKAPFTENLKKLFQ
HCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEECCHHHHHHHHCC
>Mature Secondary Structure
MMEEQLIPIQWKDDSLVLLDQTLLPNEIVYESFKTAESVWDAIQVMKVRGAPAIGVSAAY
CCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
GVYLGIKEFAESTEEGFMDEVRKVCTYLATSRPTAVNLFWALERMESVATDNIHLSISQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHH
KNRLLEEAKEIHREDEEINRQIGEHALTLFHDGMGVLTHCNAGALATTKYGTATAPMYLA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCCCEEEE
KEKGWDLKIFSDETRPRLQGSTLTALELQRAGIDVTVITDNMAAMVMSQGKIDAVIVGCD
CCCCCEEEEECCCCCCCCCCCEEEEEEHHHCCCEEEEEECCHHHHHHCCCCEEEEEEECC
RVAANGDIANKIGTLGVSILAKYYNIPFYVAAPTPTIDLKTSTGKEIPIEERDASEVINR
EEECCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHH
FGQYSAPTESKVYNPAFDVTPHENVTAIITEKGIVKAPFTENLKKLFQ
HCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEECCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA