Click here to switch to the map view.

The map label for this gene is trpC [H]

Identifier: 218232195

GI number: 218232195

Start: 1255338

End: 1256099

Strand: Direct

Name: trpC [H]

Synonym: BCB4264_A1294

Alternate gene names: 218232195

Gene position: 1255338-1256099 (Clockwise)

Preceding gene: 218234472

Following gene: 218231595

Centisome position: 23.17

GC content: 35.04

Gene sequence:

>762_bases
GTGGGGACGATTTTAGATGAAATTGTAGAACAGAAGCAAAGGGAAGTTGCGGAGTTGTATGAAATATATACACCAGTAAA
AACAAAAAGAAAGACACATTCACTTGTAGAAGCGTTACAGCAGTTTACTGTCATTGCAGAAGTAAAGCGAGCATCACCAT
CAAAAGGAGATATCAATTTACACGTTGACGTACGAAAACAAGTGGGAACATATGAGAAATGTGGTGCAGGAGCAGTATCT
GTTTTAACAGATGGTCAATTTTTTAAAGGGTCGTTTCACGATTTACAAACAGCAAGAGAAGAAAGTAACATTCCGCTTTT
ATGTAAAGATTTCATAATCGATAAGATTCAAATTGATAGAGCATATGAAGCGGGAGCAGATATTATTTTACTAATTGTAG
CAGCGTTAACGAAAGAGAAGTTAAAAGAGTTGTATAGCTACGTGTTAGAAAAAGGATTGGAAGTGATTGTTGAAGTTCAT
GATGAACAGGAATTAGAAACTGCGATTGTATTAAATCCGCACGTTATTGGCATTAATAATCGTAATTTAAAAACGTTCGA
AGTAGATTTAAGCCAAACGGAAAAGCTTGGAAAAAGATTGAATGAGGAGAAACTACTTTGGATTAGTGAAAGTGGCATTC
ATTCAAAAGAAGATATTATTCGTGTTAAAAGAGCTGGGGCCAAAGGTGTATTAGTTGGAGAGGCGCTTATGACATCATCT
TCTATTAGTAGTTTTTTTGAAGATTGTAAGGTGAATATATGA

Upstream 100 bases:

>100_bases
ATTAAACTCGCGGCACATAGCATTGACTCTGGAAAAGCATTAACCAAATTAAACTTATTAATTGCAGCAAGCAATGAAAA
ATTAGAAAGGGTGAACTAAA

Downstream 100 bases:

>100_bases
AAGTGAAAATTTGCGGCATCACTGATGTGGAAACAGCGAAAAGTGCGTGCGAATACGGCGCAGATGCACTCGGATTTGTT
TTTGCAGAAAGTAAACGGAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MGTILDEIVEQKQREVAELYEIYTPVKTKRKTHSLVEALQQFTVIAEVKRASPSKGDINLHVDVRKQVGTYEKCGAGAVS
VLTDGQFFKGSFHDLQTAREESNIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGLEVIVEVH
DEQELETAIVLNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLWISESGIHSKEDIIRVKRAGAKGVLVGEALMTSS
SISSFFEDCKVNI

Sequences:

>Translated_253_residues
MGTILDEIVEQKQREVAELYEIYTPVKTKRKTHSLVEALQQFTVIAEVKRASPSKGDINLHVDVRKQVGTYEKCGAGAVS
VLTDGQFFKGSFHDLQTAREESNIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGLEVIVEVH
DEQELETAIVLNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLWISESGIHSKEDIIRVKRAGAKGVLVGEALMTSS
SISSFFEDCKVNI
>Mature_252_residues
GTILDEIVEQKQREVAELYEIYTPVKTKRKTHSLVEALQQFTVIAEVKRASPSKGDINLHVDVRKQVGTYEKCGAGAVSV
LTDGQFFKGSFHDLQTAREESNIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGLEVIVEVHD
EQELETAIVLNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLWISESGIHSKEDIIRVKRAGAKGVLVGEALMTSSS
ISSFFEDCKVNI

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=251, Percent_Identity=35.8565737051793, Blast_Score=126, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322638, Length=270, Percent_Identity=39.2592592592593, Blast_Score=155, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28356; Mature: 28225

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTILDEIVEQKQREVAELYEIYTPVKTKRKTHSLVEALQQFTVIAEVKRASPSKGDINL
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
HVDVRKQVGTYEKCGAGAVSVLTDGQFFKGSFHDLQTAREESNIPLLCKDFIIDKIQIDR
EEEEHHHCCCHHHCCCCEEEEEECCCHHCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHH
AYEAGADIILLIVAALTKEKLKELYSYVLEKGLEVIVEVHDEQELETAIVLNPHVIGINN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCCCEEEEECCEEEECCC
RNLKTFEVDLSQTEKLGKRLNEEKLLWISESGIHSKEDIIRVKRAGAKGVLVGEALMTSS
CCCEEEEECHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEHHHHHHHH
SISSFFEDCKVNI
HHHHHHHHHCCCC
>Mature Secondary Structure 
GTILDEIVEQKQREVAELYEIYTPVKTKRKTHSLVEALQQFTVIAEVKRASPSKGDINL
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
HVDVRKQVGTYEKCGAGAVSVLTDGQFFKGSFHDLQTAREESNIPLLCKDFIIDKIQIDR
EEEEHHHCCCHHHCCCCEEEEEECCCHHCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHH
AYEAGADIILLIVAALTKEKLKELYSYVLEKGLEVIVEVHDEQELETAIVLNPHVIGINN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCCCEEEEECCEEEECCC
RNLKTFEVDLSQTEKLGKRLNEEKLLWISESGIHSKEDIIRVKRAGAKGVLVGEALMTSS
CCCEEEEECHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEHHHHHHHH
SISSFFEDCKVNI
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA